Metabolic Health

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Often, when patients have high cholesterol or high blood pressure, the treatment focus is on statins or anti-hypertensive medications. However, these are just the symptoms of poor metabolic health, which requires a closer look at the root cause and a treatment model that reflects that.

In this episode, Dr. Hyman speaks with Dr. Elizabeth Boham and Dr. George Papanicolaou about our lifestyle choices that affect our cholesterol levels, blood pressure, and waist circumference.

This episode is brought to you by Rupa University, AG1, and Momentous.

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Our bodies naturally follow a roughly 24-hour cycle, called our circadian rhythm. And every cell has a rhythm.

As we get older, we tend to lose muscle, making us more prone to falls and less able to live independently. Though we can't stop aging, staying active helps keep our muscles strong and our bodies healthy for longer.

Prof. Karyn Esser is a specialist in how the body's natural rhythms affect muscles. Today, she guides us through the latest research and shows that it's always possible to harness the power of your muscles to enhance your quality of life. She is a professor in the Department of Physiology and Aging at the University of Florida, where she’s also the co-director of the University of Florida Older Americans Independence Center.

In today's episode of ZOE Science & Nutrition, Jonathan and Karyn explore the body's internal clocks and ask: why do our muscles have their own schedule, and is there an ideal time of day to exercise?

If you want to uncover the right foods for your body, head to zoe.com/podcast, and get 10% off your personalized nutrition program.

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Timecodes

00:00   Introduction

00:18    Quickfire questions

02:01    Why are muscles important, particularly as we get older?

08:45   Why we all lose strength as we age

11:07    What type of exercise do we need to maintain our muscle strength as we age?

14:55    What is a circadian clock?

19:25    Everything has a circadian rhythm

21:32    Why do our muscles work on a 24-hour cycle?

24:20    Humans are stronger in the afternoon

30:24    Is there a best time to exercise?

35:01    Can exercise before or after work help shift workers with jet lag?

37:33    Is there a difference between men and women’s responses to circadian rhythms?  

41:44    What are the effects of time-restricted eating on muscle mass?

53:42    Summary

Mentioned in today's episode:

Defining the age-dependent and tissue-specific circadian transcriptome in male mice from Cell Reports

Related studies: 

Timing is everything: Circadian clocks set the rhythm for vital functions in bacteria from the University of Chicago

Effects of resveratrol on in vitro circadian clock gene expression in young and older human adipose-derived progenitor cells in Aging

Age is associated with dampened circadian patterns of rest and activity: The Study of Muscle, Mobility and Aging (SOMMA) in medRxiv

Is there a nutrition topic you’d like us to explore? Email us at <a href="mailto:podcast@joinzoe.com" rel="noopener noreferrer"...

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There are several different schools of thought behind obesity and metabolic dysfunction, for example, the energy balance model or “calories-in, calories-out” perspective that many people have felt fooled by. While calories certainly are one piece, there is much more to the puzzle of weight management and metabolic health, like hormonal cascades and oxidative stress.

My guest today is Dr. Robert Lustig, an author and neuroendocrinologist with expertise in metabolism, obesity, and nutrition. He has dedicated his retirement from clinical medicine to help fix the food supply in any way he can, to reduce human suffering, and to promote a collective vision of metabolic health: protect the liver, feed the gut, support the brain. 

In this episode we discuss:

• Is a calorie really just a calorie? (7:24)
• The surprising truth: All models of energy intake are a little right and a little wrong (9:20)
• Proven methods for reducing insulin to support weight loss (29:39)
• What are obesogens and how are they hijacking our metabolic health? (32:00)
• Reactive oxygen species and aging (and how to reduce them) (38:05)
• Why glucose and insulin monitoring are powerful levers for metabolic health (42:15)
• Summing up the facts and our beliefs around calories and weight (47:00)
• The cellular impact of oxidative stress and chronic stress (54:00)
• Monch Monch: a new fiber solution for absorbing simple sugars and preventing glucose spikes as well as increasing satiety and boosting microbial diversity (1:02:20)
• Food addiction in adults and children and addressing the root cause (1:10:45)
• What actions can we take based on scientific advances to make our lives better? (1:24:15)
• Why any food that feeds the gut, protects the liver, and supports the brain is a healthy food (1:33:35)
• Perfact and how to use it to understand what is metabolically healthy at your exact grocery store (1:40:20)

This episode is brought to you by Rupa Health, Pendulum, ARMRA Colostrum, and Wonderfeel. 

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Do you want more energy?

Are you done with the constant anxiety? Can’t seem to climb out of your funk?

In today’s episode, you’ll learn the exact steps to optimize both your mental and physical health.

Joining Mel today is Harvard’s Chris Palmer, MD, whose work lies at the intersection of nutrition, metabolism, and mental health. He will explain how he believes your diet is causing your brain to misfire, which is why simple changes to your diet and lifestyle can help you improve your mental health.

Dr. Palmer is a psychiatrist who has practiced at Harvard’s McLean Hospital, the #1 psychiatric hospital in the nation, for almost 30 years. He is also the Founder and Director of the recently launched Metabolic & Mental Health Program at McLean Hospital. 

His innovative approaches to treatment-resistant mental health challenges have brought his patients relief and hope, which is why his waitlist is years long. Today, you’ll learn Dr. Palmer’s exact protocol he shares with his patients in Boston.
 

In this episode, you will learn:

• What your metabolism is and what it has to do with your mental and physical health.
• The shocking patient results and personal story that fueled Dr. Palmer’s passion.
• The 7 signs that you probably have a metabolic disorder.
• How the Brain Energy protocol could help your mind and body heal.
• The exact tools and action steps that Dr. Palmer shares with his patients for better mental health.
• What mitochondria are and how they are the key to your mental health.
• How the ketogenic diet was discovered as a medical protocol by doctors.
• How to know if you’re getting enough sleep.
• What exercise has to do with your mental health.
• How to help someone in your life who’s struggling with their mental health.
• What you need to hear if you’re the one who needs support.

Dr. Palmer goes deep into the science and his protocols. All additional resources to learn about Dr. Palmer and his science are linked on this page of Mel’s website:

https://www.melrobbins.com/podcast.

Watch the episodes on YouTube: https://bit.ly/45OWCNr
 

Check out Mel’s book, The High 5 Habit: https://a.co/d/g1DQ8Pt

Follow Mel:

Instagram: https://bit.ly/3QfG8bb

The Mel Robbins Podcast Instagram: https://bit.ly/49bg4GP

LinkedIn: https://bit.ly/46Mh0QB

TikTok: https://bit.ly/46Kpw2v
 

Sign up for my newsletter: https://bit.ly/46PVnPs

Want more resources? Go to the podcast page here. 

Disclaimer

Last year Novo Nordisk, the Danish pharmaceutical company behind Ozempic and Wegovy, overtook LVMH to become Europe’s most valuable company. And the pull for Acquired to finally tackle healthcare (18% of US GDP!) became too strong for us to resist. While we didn’t know much about Novo Nordisk before diving in, our first thought was, “wow, seems like these new diabetes and obesity drugs mean serious trouble for big insulin companies.”

And then… we realized that Novo Nordisk IS the big insulin company. And in a story befitting of Steve Jobs and Apple, they’d just disrupted themselves with the drug equivalent of an iPhone moment. Once we dug further, we quickly realized this company has it all: an incredible 100+ year history filled with Nobel Prizes, bitter personal rivalries, board room dramas, a generation-defining silicon valley innovation, lone voices persevering against all odds — and oh yeah, the world’s largest charitable foundation at its helm. Tune in for one incredible story!

Sponsors:

Many thanks to our fantastic Season 14 partners:

• J.P. Morgan Payments
• ServiceNow
• Vanta

More Acquired:

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Links:

• Chart: US Healthcare Spend by Category
• Chart: US Distribution and Reimbursement System (for pharmaceutical drugs)
• Chart: Insulin Supply Chain
• YouTube Talk: What People Get Wrong about the Finances of the Drug Industry
• Alex Telford: The pharma industry from Paul Janssen to today: why drugs got harder to develop and what we can do about it
• Out-of-Pocket Health: Obesity Drugs
• Out-of-Pocket Health: US Healthcare System Problems
• All episode sources

Carve Outs:

• Noxgear Tracer 2 running vest
• Drops of God
• Wool by Hugh Howey
• Mere Mortals at San Francisco Ballet
• Blackberry

‍Note: Acquired hosts and guests may hold assets discussed in this episode. This podcast is not investment advice, and is intended for informational and entertainment purposes only. You should do your own research and make your own independent decisions when considering any financial transactions.

Dr. Susanna Søberg is a leading expert in the world of cold and heat exposure therapy. With years of dedicated research, she has become a trailblazer in understanding the profound effects of deliberate temperature exposure on the human body and mind. Her groundbreaking findings and contributions to the field have positioned her as a visionary in the realm of metabolism, psychology, and holistic well-being. Dr. Søberg's expertise is not only shaping our understanding of cold and heat therapy but also empowering individuals to optimize their physical and mental health through these transformative practices.

Learn more about Dr. Søberg's research and programs at soeberginstitute.com

In this episode you will learn

• How Dr. Susanna Søberg's groundbreaking research is changing the way we view cold and heat therapy.
• The key findings in her research that can revolutionize your metabolism.
• The distinction between white fat and brown fat, and how cold therapy affects both.
• The profound psychological effects of cold therapy on your mood and mental well-being.
• The optimal frequency, duration, and benefits of cold plunges and saunas for your health.

For more information go to www.lewishowes.com/1558

For more Greatness text PODCAST to +1 (614) 350-3960

More SOG episodes we think you’ll love:

Wim Hof – https://link.chtbl.com/1043-guest

Dr. David Sinclair – https://link.chtbl.com/1232-pod

This episode is brought to you by Rupa Health and BiOptimizers.

Scientists now call Alzheimer’s disease “Type 3 diabetes.” What’s the link between Alzheimer’s and diabetes? Well, new research shows insulin resistance, or what I call diabesity (from eating too many carbs and sugar and not enough fat), is one of the major factors that starts the brain-damage cascade that robs the memory of millions of people.

In today’s episode of my series I’m calling Health Bites, I discuss the link between insulin resistance and memory loss and the top strategies I use with my patients to reverse or prevent dementia. 

This episode is brought to you by Rupa Health and BiOptimizers.

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Tackle an overlooked root cause of stress with Magnesium Breakthrough. Visit MagBreakthrough.com/Hyman and use code HYMAN10 to save 10%.

Here are more details from the episode (audio version / Apple Subscriber version):

• The prevalence of Alzheimer’s and dementia (3:11 / 1:28)
• The link between Alzheimer’s, pre-diabetes, and diabetes (4:27 / 2:44)
• Cognitive loss reversal (8:35 / 6:52)
• How to eat to support the brain (11:18 / 9:36)
• Causes of Alzheimer’s (11:45 / 10:02)
• A patient case study (13:44 / 12:01)
• Strategies to reverse memory loss (19:01 / 17:18)

Mentioned in this episode

Dr. Hyman’s Free Sleep Master Class

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