diabetes

Ozempic, the injectable weight loss drug, is discussed by Calley Means and Robert F. Kennedy Jr is this short episode.

A second longer episode with Calley Means is coming soon. Please share and subscribe.

Calley Means is on a mission to steer more healthcare dollars to incentivize metabolic habits at the root of disease (healthy food, exercise, sleep, stress management).

View the Show Notes For This Episode

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A decrease in libido or difficulty in achieving or maintaining an erection during sex are tell-tale signs of erectile dysfunction, and they can be uncomfortable to address. Sure, aging and performance anxiety are part of the story, but believe it or not, erectile dysfunction is not just about sexual health. It’s often the first clue of bigger health issues.

In this episode of my Health Bites series, I explore the root causes of erectile dysfunction, delving into the limitations of conventional medicine, the little blue pill, and how we can utilize the power of Functional Medicine by making changes to our diet, lifestyle, and even trying things like supplements, peptides, and hormone therapy. 

This episode is brought to you by Mitopure and Rupa Health.

Support essential mitochondrial health and save 10% on Mitopure. Visit TimelineNutrition.com/Drhyman and use code DRHYMAN10.

Streamline your lab orders with Rupa Health. Access more than 3,000 specialty lab tests and register for a FREE live demo at RupaHealth.com.

In this episode, I discuss (audio version / Apple Subscriber version):

• The prevalence of erectile dysfunction (4:34 / 2:04)
• The root cause of low testosterone (9:38 / 7:08)
• The conventional medicine approach to treating erectile dysfunction (11:51 / 9:21)
• How do Viagra and ED drugs work? (16:34 / 14:04)
• The Functional Medicine approach to treating erectile dysfunction: diagnostic testing (18:58 / 16:28)
• Root causes of sexual dysfunction (29:42 / 27:12)
• Diet, lifestyle, and supplements to improve sexual dysfunction (42:22 / 39:52)

Hosted on Acast. See acast.com/privacy for more information.

Last year Novo Nordisk, the Danish pharmaceutical company behind Ozempic and Wegovy, overtook LVMH to become Europe’s most valuable company. And the pull for Acquired to finally tackle healthcare (18% of US GDP!) became too strong for us to resist. While we didn’t know much about Novo Nordisk before diving in, our first thought was, “wow, seems like these new diabetes and obesity drugs mean serious trouble for big insulin companies.”

And then… we realized that Novo Nordisk IS the big insulin company. And in a story befitting of Steve Jobs and Apple, they’d just disrupted themselves with the drug equivalent of an iPhone moment. Once we dug further, we quickly realized this company has it all: an incredible 100+ year history filled with Nobel Prizes, bitter personal rivalries, board room dramas, a generation-defining silicon valley innovation, lone voices persevering against all odds — and oh yeah, the world’s largest charitable foundation at its helm. Tune in for one incredible story!

Sponsors:

Many thanks to our fantastic Season 14 partners:

• J.P. Morgan Payments
• ServiceNow
• Vanta

More Acquired:

• Get email updates with hints on next episode and follow-ups from recent episodes
• Join the Slack
• Subscribe to ACQ2
• Check out the latest swag in the ACQ Merch Store!

Links:

• Chart: US Healthcare Spend by Category
• Chart: US Distribution and Reimbursement System (for pharmaceutical drugs)
• Chart: Insulin Supply Chain
• YouTube Talk: What People Get Wrong about the Finances of the Drug Industry
• Alex Telford: The pharma industry from Paul Janssen to today: why drugs got harder to develop and what we can do about it
• Out-of-Pocket Health: Obesity Drugs
• Out-of-Pocket Health: US Healthcare System Problems
• All episode sources

Carve Outs:

• Noxgear Tracer 2 running vest
• Drops of God
• Wool by Hugh Howey
• Mere Mortals at San Francisco Ballet
• Blackberry

‍Note: Acquired hosts and guests may hold assets discussed in this episode. This podcast is not investment advice, and is intended for informational and entertainment purposes only. You should do your own research and make your own independent decisions when considering any financial transactions.

View the Show Notes For This Episode

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In today’s episode of my series I’m calling Health Bites, I am tackling a topic that has left an indelible mark on the world: the COVID-19 pandemic. As we navigate through new variants and climbing cases, it's crucial to unravel the reasons why so many Americans got so sick and died during the pandemic. We dig into the questions of why we as a nation were so susceptible to COVID-19’s deadly effects. I also explore why and how Functional Medicine steps in where conventional approaches stumble.

This episode is brought to you by AG1, Rupa Health, and Seed.

Get your daily serving of vitamins, minerals, adaptogens, and more with AG1. Head to DrinkAG1.com/Hyman and get 10 FREE travel packs and a FREE Welcome Kit with your first order.

Streamline your lab orders with Rupa Health. Access more than 3,000 specialty lab tests and register for a FREE live demo at RupaHealth.com.

Seed is offering my community 25% off to try DS-01® for themselves. Visit seed.com/hyman and use code HYMAN25 for 25% off your first month of Seed's DS-01® Daily Synbiotic.

In this episode, I discuss (audio version / Apple Subscriber version):

• Why the U.S. had some of the worst COVID-19 outcomes (7:07 / 5:24)
• The conventional medicine approach to the COVID-19 pandemic (25:46 / 22:41)
• My take on COVID vaccines (28:30 / 25:25)
• Optimizing our immune system to prevent serious infection and disease (39:09 / 36:04)
• Preventing and recovering from illness using diet and lifestyle (47:19 / 44:14)
• Supplements to support your immune system during cold and flu season (57:00 / 53:55)
• Strategies for COVID infection and exposure (59:34 / 56:29)
• Long-COVID (1:02:51 / 59:46)

Connect with Dr. Mark Hyman on Twitter, Instagram, Facebook, and YouTube

Hosted on Acast. See acast.com/privacy for more information.

The runaway success of diabetes and weight-loss drugs Ozempic and Wegovy have turned their maker, Novo Nordisk, into a juggernaut. Last year the Danish drugmaker claimed the title of Europe’s most valuable company. But the development of these drugs was a long, uphill battle.The FT’s global pharmaceutical editor Hannah Kuchler explains how the company’s unique ownership structure played a critical role in the company’s achievements and looks at the challenges ahead.  

Clips from CNBC, CBS, Reuters

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Subscribe and listen to Untold: The Retreat on Apple Podcasts, Spotify or wherever you get your podcasts.

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For further reading:

FT Person of the Year: Lars Fruergaard Jørgensen of Novo Nordisk

How anti-obesity drugs built the world’s largest charitable foundation

Obesity drugs: broadly good for investors, with some strictures

Covid-19 vaccine winners suffer reversal of fortune

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On X, follow Hannah Kuchler (@hannahkuchler) and Michela Tindera (@mtindera07), or follow Michela on LinkedIn for updates about the show and more. 

Read a transcript of this episode on FT.com

Hosted on Acast. See acast.com/privacy for more information.

Freedom Schools were set up in Mississippi in the heart of the Civil Rights Movement, with the aim of giving young black school children agency and a future. They remain one of the more inspiring and progressive programs in American History, yet so few know about them. We're hoping to change that. Learn all about them in this classic episode.

See omnystudio.com/listener for privacy information.

This episode is brought to you by Rupa University, AG1, and Pendulum. 

Dietary cholesterol from saturated fat is often thought to be the cause of high LDL cholesterol and blocked arteries. But we now know from updated research that it’s much more complicated than that. Standard cholesterol testing is outdated because it doesn’t check for particle size and particle number, information that is needed to tell what’s really going on with your cholesterol. Statins are often prescribed to lower LDL cholesterol, but often do not address the root of the problem and can cause very uncomfortable side effects.

In today’s episode, I talk with Drs. Elizabeth Boham, Ronald Krauss, and Aseem Malhotra about the true role of cholesterol and what is really behind heart disease.

Dr. Elizabeth Boham is a physician and nutritionist who practices Functional Medicine at The UltraWellness Center in Lenox, MA. Through her practice and lecturing she has helped thousands of people achieve their goals of optimum health and wellness. She witnesses the power of nutrition every day in her practice and is committed to training other physicians to utilize nutrition in healing.

Dr. Ronald Krauss is a Senior Scientist at Children’s Hospital Oakland Research Institute, a Professor of Medicine at UCSF, and an Adjunct Professor of Nutritional Sciences at UC Berkeley. Dr. Krauss’s research aims to understand how to best prevent cardiovascular disease through early detection and management of its major risk factors: most notably, elevated levels of blood cholesterol and lipoproteins. He has published more than 450 research articles and reviews on metabolic, genetic, dietary, and drug effects on plasma lipoproteins and the risk of coronary artery disease, with more than 100,000 citations of this work.

Dr. Aseem Malhotra is an NHS-trained consultant cardiologist and visiting Professor of Evidence-Based Medicine at the Bahiana School of Medicine and Public Health in Salvador, Brazil. He is a founding member of Action on Sugar. In 2015, he became the youngest member to be appointed to the board of trustees of UK health charity The King's Fund. He is a pioneer of the lifestyle medicine movement in the UK and in 2018 was ranked by software company Onalytica as the number one doctor in the world influencing obesity thinking.

This episode is brought to you by Rupa University, AG1, and Pendulum.

Rupa University is hosting FREE classes and bootcamps for healthcare providers who want to learn more about Functional Medicine testing. Sign up at RupaUniversity.com.

Get your daily serving of vitamins, minerals, adaptogens, and more with AG1. Head to DrinkAG1.com/Hyman and get 10 FREE travel packs with your first order.

Pendulum is offering listeners 20% off their first month’s subscription of Akkermansia for gut health. Visit PendulumLife.com and use code HYMAN.

Full-length episodes of these interviews can be found here:

Dr. Elizabeth Boham

Dr. Ronald Krauss

Dr. Aseem Malhotra

Hosted on Acast. See acast.com/privacy for more information.

This episode is brought to you by Mitopure and LMNT.

For nearly all of our history, humans consumed no grains, and our bodies are designed to work very well without them. Today, however, grain-based foods are by far the number one source of calories in the American diet. While whole grains can be a great source of vitamins, minerals, and fiber, the toxic amounts we eat contribute to obesity, diabetes, heart disease, cancer, and dementia. Plus, most of the grains we eat—even whole wheat—are turned into flour products which have a higher glycemic index than table sugar.

In today’s episode of my series I’m calling Health Bites, I talk about why grains are such a contentious food, how to tackle the pros and cons of whether it belongs in your diet, and which grains are actually okay to eat. 

This episode is brought to you by Mitopure and LMNT.

Support the growth of new, healthy mitochondria and get 10% off Mitopure. Head to timelinenutrition.com/drmark and use code DRMARK at checkout.

Right now, LMNT is offering my listeners a free sample pack with any purchase. Head over to DrinkLMNT.com/hyman today.

Here are more details from our interview (audio version / Apple Subscriber version):

• You don’t have to eat grains to be healthy (8:40 / 5:41)
• “Whole grain” is a marketing term (10:31 / 7:32)
• Why starch and sugar are essentially the same thing (11:22 / 8:23)
• You’re not eating the same grains your grandparents ate (11:58 / 8:59)
• Is oatmeal good for you? (14:22 / 11:23)
• Should everyone avoid gluten? (15:36 / 12:37)
• Not all grains are bad (20:02 / 17:03)
• Do we really have to give up bread? (21:09 / 18:10)
• What types of grains are okay and what should be avoided? (23:20 / 20:21)
• Who should avoid grains altogether? (24:59 / 22:00)

Hosted on Acast. See acast.com/privacy for more information.

Are you missing the one thing that would make all the difference in your effort to be healthier? I was. And the thing I was missing was weight training.

In this episode, you will learn from Dr. Gabrielle Lyon, a medical doctor who is fellowship-trained in nutritional sciences and geriatrics. 

Dr. Lyon is a renowned researcher, pioneer, and founder of the Institute for Muscle Centric Medicine. She is the New York Times best-selling author of Forever Strong: A New, Science-Based Strategy for Aging Well and has decades of experience to share with you.

In this conversation, Dr. Lyon discusses topics like:

• What the heck muscle-centric medicine is.
• How your muscles are the largest organ in your body and why that matters.
• The way muscles improve your brain and body health.
• The connection between your waistline measurement and brain output.
• The power of protein and what it does for your muscles.
• What type of protein counts and what doesn’t.
• How to get the right amount of protein if you are vegan or vegetarian.
• The amount of protein you need for better hormone balance.
• Dr. Lyon’s protein recommendations for every meal.
• The surprising cause of disease and obesity, according to research.
• How disease may begin in the skeletal muscle.
• Why building muscle helps you sleep better.
• The minimum amount of weight resistance that will still give you results.
• How to begin strength training if the gym intimidates you.
• Why yoga might not be making your muscles stronger.
• What leucine is and why you need it to build muscle.
• Why myokines are so important for muscles, energy, and immune function.

You can purchase Dr. Lyon’s book, ‘Forever Strong: A New, Science-Based Strategy for Aging Well’, here: https://a.co/d/3zgEDLB

Follow Dr. Lyon:

Instagram: instagram.com/drgabriellelyon

Webpage: drgabriellelyon.com

Watch the episodes on YouTube: https://bit.ly/45OWCNr

Check out my book, The High 5 Habit: https://a.co/d/g1DQ8Pt

Follow me:

Instagram: https://bit.ly/3QfG8bb

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TikTok: https://bit.ly/46Kpw2v

Sign up for my newsletter: https://bit.ly/46PVnPs 

Want more resources? Go to my podcast page at melrobbins.com/podcast.

Disclaimer

Do you know what brings you joy? GB Olympian, personal trainer, and life coach Michelle Griffith-Robinson joins Liz on this episode to share how to approach the menopause like an Olympian.

In this Menopause Month episode, Michelle shares why fitness is a non-negotiable for her physical and mental health, the importance of strength training for midlife women, and how to find out what makes you spark.

Michelle also shares her personal experience of the menopause and the symptoms she experienced, such as low libido, brain fog and anxiety, as well as being diagnosed as pre-diabetic in 2018.

The episode also covers the inequalities in menopause healthcare, and the differences between ethnicities in developing health conditions, such as type 2 diabetes.

Links mentioned in the episode:

• Follow Michelle on Instagram
• Learn more about The Menopause Charity
• Visit the Diabetes UK website 
• Visit the Women's Aid website
• Listen to our podcast on menopause care inequalities with Dr Nighat Arif and Dr Kuki Avery
• Listen to our podcast on type 2 diabetes with Dr Jason Fung 

Hosted on Acast. See acast.com/privacy for more information.

More than 50 systemic health conditions — including Alzheimer’s, diabetes, and heart disease — are associated with oral disease. 

The link between systemic and oral conditions is always microbial, inflammatory, or both. So, how can we look after our gums to improve our health?

In today’s episode, Jonathan and Prof. Alp Kantarci pose the question: How does the health of your oral cavity shape your general health?

Dr. Alp Kantarci is a professor, scientist, dentist, oral health researcher, periodontist, dental implant surgeon, and senior member of staff at the Forsyth Institute, an independent research institute that focuses on the connections between oral health and overall wellness. Dr. Kantarci is also a faculty member at Harvard University School of Dental Medicine. He has published more than 190 articles in peer-reviewed scientific journals and has presented more than 170 talks and posters at dental and medical congresses.

Download our FREE guide — Top 10 Tips to Live Healthier: https://zoe.com/freeguide

If you want to uncover the right foods for your body, head to joinzoe.com/podcast and get 10% off your personalized nutrition program.

Follow ZOE on Instagram.

Timecodes:

01:35 - Quickfire questions

04:11 - What is oral health?

08:35 - How is our oral health connected to the health of the rest of our body?

11:01 - Oral microbiome

18:48 - Why does bad oral health affect the rest of the body?

22:47 - How much does the state of our oral health contribute to dementia?

25:48 - The link between oral health and diabetes

28:31 - The link between oral health and cardiovascular diseases

32:41 - What are the key steps to look after our oral health?

35:36 - Alp’s view on mouthwash

37:51 - Oral health & probiotics

42:22 - Impact of food on our oral health

45:45 - Does sparkling water affect our oral health?

50:04 - Summary

52:34 - Goodbyes

52:41 - Outro

Mentioned in today’s episode: 

Dementia and the risk of periodontitis: A population-based cohort study from the Journal of Dental Research.

Microglial response to experimental periodontitis in a murine model of Alzheimer’s disease from Scientific Reports.

Fusobacterium nucleatum dissemination by neutrophils from the Journal of Oral Microbiology.

Safety and preliminary efficacy of a novel host-modulatory therapy for reducing gingival inflammation from Frontiers in Immunology.

Episode transcripts are available here.

Is there a nutrition topic you’d like us to explore? Email us at podcast@joinzoe.com, and we’ll do our best to cover it. 

It’s a diabetic drug that recently became a weight loss diet fad for the rich because of its ability to suppress hunger. Now, Wegovy, a drug similar to Ozempic, has been approved specifically for weight loss for the clinically obese in the UK. But is an injection our best bet at tackling obesity?

This podcast was brought to you thanks to the support of readers of The Times and The Sunday Times. Subscribe today: thetimes.co.uk/storiesofourtimes.

Guests: 

• Charlotte Ivers, Staff Writer, The Sunday Times. 
• Dr Amir Khan, NHS GP and Broadcaster.

Host: Manveen Rana. 

Article: How celebrities’ favourite drug Ozempic made Denmark enormously rich: https://www.thetimes.co.uk/article/how-weight-loss-drug-ozempic-made-denmark-enormously-rich-bbv80sz06

Clips: Global News Canada, CBS, E News.

Get in touch: storiesofourtimes@thetimes.co.uk 

Hosted on Acast. See acast.com/privacy for more information.

View the Show Notes Page for This Episode

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Andrew Huberman, Professor of Neurobiology at Stanford University and host of the Huberman Lab podcast joins us in a special journal club episode. Peter and Andrew each present a recent paper that sparked their interests, delving into the findings, dissecting their significance, discussing potential confounders and limitations, and exploring remaining questions. Importantly, they share their methodologies for comprehending research studies, providing valuable insights for listeners to navigate this process independently. Peter presents an epidemiological study reevaluating a noteworthy metformin result that intrigued the anti-aging community, leading to discussions on metformin's geroprotective potential (or lack thereof) and the current lack of aging biomarkers. Andrew introduces a paper examining how our beliefs about the medications we take influence their biological effects, distinguishing the "belief effect" from a placebo effect and highlighting its exciting implications for the future.

We discuss:

• The motivation behind this journal club conversation [2:45];
• Why Peter chose a paper on metformin, how metformin works, and why it generated excitement as a longevity-enhancing agent [9:00];
• Defining insulin resistance and its underlying causes [16:15];
• Metformin as a first-line treatment for type 2 diabetes, and Peter’s evolving interest in metformin as a geroprotective drug [22:00];
• Defining the term “geroprotection” [24:45];
• The 2014 study that got the anti-aging community interested in metformin [26:00];
• Peter presents the 2022 paper that repeats the analytical approach from the 2014 Bannister study [33:15];
• Greater mortality in the metformin group: how results differed between the 2022 paper and the 2014 paper [40:00];
• Understanding statistical significance, statistical power, sample size, and why epidemiology uses enormous cohorts [51:45];
• Interpreting the hazard ratios from the 2022 metformin study, and the notable takeaways from the study [56:45];
• Drugs that may extend lifespan, why Peter stopped taking metformin, and a discussion of caloric restriction [1:08:45];
• Current thoughts on the use of metformin for longevity [1:21:00];
• Could there be any longevity benefit to short periods of caloric restriction? [1:22:45];
• Peter and Andrew’s process for reading scientific papers [1:26:45];
• The biological effects of belief, and how “belief effects” differ from placebo effects [1:32:30];
• The neurobiology of nicotine: a precursor conversation before delving into the paper Andrew chose [1:39:45];
• Andrew presents a paper that demonstrates the impact of belief [1:45:30];
• Analyzing the fascinating results of the Perl paper [1:54:30];
• Exciting implications of the findings about “belief” reported by Perl and colleagues [2:03:15]; and
• More.

Connect With Peter on Twitter, Instagram, Facebook and YouTube

Check out these fun things:

Patreon: ⁠https://www.patreon.com/calebhammer⁠ 

My socials: ⁠https://linktr.ee/calebhammer⁠ 

Do you want to be in a Financial Audit and you're in the Austin area? Email castingcalebhammer@gmail.com

Sponsorship and business inquiries: calebhammer@creatorsagency.co 

_______________________ 

Timestamps:

00:00 Job and income 06:25 How did this happen?! 12:06 This debt is INSANE 17:53 SOFI 18:50 I'm terrified for you 22:30 You need to bust your A**! 27:39 What a mess 32:03 Stop paying your mom's rent! 39:31 Straight to collections! 43:46 AURA 46:40 You need to budget... BADLY 49:49 Clean up this mess 55:08 Time to play catch up! 01:46:21 Hammer Financial Score

This week's Addicted to Fitness investigates which wellness trends are worth watching in 2023. Nick and Shannon discuss the recent popularity of weight loss medication, sauna use, th every expanding world of supplements, and more. They also compare these trends to the wellness trend predictions they made at the end of 2022. Follow the podcast profile on Instagram @TheATFPodcast. Give it a listen and let us know what you think by leaving a rating & review in Apple Podcasts.

Since 1980, the number of people around the world with type 2 diabetes has quadrupled. Kidney specialist Dr Jason Fung joins Liz for this episode of the podcast to cover the rise in obesity and type 2 diabetes - and what can be done about it.

In this episode, Jason explains how dietary interventions such as intermittent fasting or low-carb eating may be able to reverse the dietary disease, plus why all calories aren't equal.

Liz and Jason discuss how we can avoid spiking our blood sugars, how hormones such as cortisol and insulin can cause weight gain, and why fats shouldn't be considered the enemy when it comes to eating well.

Links mentioned in the episode:

• Purchase The Obesity Code
• Purchase The Diabetes Code
• Follow Dr Jason Fung on Instagram 
• Follow Dr Jason Fung on Twitter 
• Subscribe to Liz Earle Wellbeing Magazine

Hosted on Acast. See acast.com/privacy for more information.