genetics

23andMe has seen its valuation plummet from $6 billion to close to zero, with the Nasdaq threatening to delist the company’s stock. Still, company leaders have high hopes for medical research and a pivot to biotech. Rolfe Winkler has been writing about what happened for The Wall Street Journal, and discussed the company’s financial woes and future roadmap with Marketplace’s Lily Jamali.

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Dr. Nir Barzilai is a geroscientist, Chaired Professor of Medicine and Genetics, and the founder and principal investigator of the Einstein Nathan Shock Center and the Glenn Center for Excellence in Biology of Aging. He also studies families of centenarians that have provided genetic and biological insights on the protection against aging—with several drugs developed based, in part, on these paradigm-changing studies. He is also leading the TAME (Targeting/Taming Aging with Metformin) trial to prove to the FDA that aging can be delayed and to allow for next-generation interventions. 

This episode is brought to you by Sunlighten, Cozy Earth, BiOptimizers, and Fatty 15.

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In this episode we discuss (audio version / Apple Subscriber version):

• The hallmarks of aging (9:01 / 7:10)
• What causes the hallmarks of aging? (15:40 / 13:49)
• Dr. Barzilai’s research on centenarians (23:16 / 21:25)
• Why living to 100+ years is good for the economy (24:54 / 23:03)
• What enables someone to live to 100 years old? (29:30 / 25:20)
• Taking growth hormone and Metformin have different effects based on your age (36:58 / 32:48)
• The connection between HDL cholesterol and longevity (43:36 / 39:26)
• Dr. Barzilai’s research on Metformin (56:23 / 52:13)
• How Metformin works in the body and on muscle growth (1:04:51 / 1:00:41)
• Dr. Barzilai’s personal longevity (1:42:05 / 1:37:55)

Learn more about the Longevity Genes Project and the TAME Trial. 

Get a copy of Age Later: Health Span, Life Span, and the New Science of Longevity

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Hosted on Acast. See acast.com/privacy for more information.

In this series of special editions of BBC Radio 4 podcast Just One Thing, Michael Mosley quizzes the world’s leading health experts on the best ways to live well. In this Weight Loss Special, we hear from Professor Giles Yeo, a leading expert in the genetics of obesity at the University of Cambridge. We hear the top tips Professor Yeo swears by to help you shed the pounds. What’s the best way to lose weight? What should you be eating and how should you be exercising? And what’s the best way to keep it off?

And as this is a Just One Thing special, we'll end each interview by asking Professor Yeo for the one single most effective health hack to shift a few pounds.

Producer: Dom Byrne Production Manager: Maria Simons Exec Producer: Zoe Heron Specially composed music by Richard Atkinson (Mcasso) A BBC Studios production for BBC Sounds / BBC Radio 4.

This Week in Startups is brought to you by…

CLA - Get started with CLA's CPAs, consultants, and wealth advisors now at https://www.claconnect.com/tech

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Today’s show:

23andMe's Anne Wojcicki joins Jason for a deep dive on genome testing and healthcare. They cover the dramatic reduction in genome sequencing costs from billions to just $99 (3:15), the role of blood testing and sequencing in shaping 23andMe's health approach (27:02), the curious case of the venomous Gila monster (42:09), and much more!

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Timestamps:

(0:00) Anne Wojcicki of 23andMe joins Jason for an insightful discussion.

(1:28) Exploring the impact of 23andMe and the trend of genome sequencing for proactive health management.

(3:15) Tracing the dramatic reduction in genome sequencing costs from billions to just $99.

(10:58) CLA - Get started with CLA's CPAs, consultants, and wealth advisors now at https://www.claconnect.com/tech

(12:24) Discussing a pivotal moment in advancing our understanding of health and genetics.

(18:41) Strategies for integrating new health initiatives in the U.S. and international healthcare systems.

(22:26) House of Macadamias is the next big health trend! Get a free month's supply of Macadamia Milk with any order at https://www.houseofmacadamias.com/twist by using code TWIST20!

(23:54) Addressing the need for a paradigm shift in healthcare policies and incentive structures.

(27:02) The role of blood testing and exome sequencing in shaping 23andMe's comprehensive health approach.

(30:45) Embracing a holistic perspective in personal health and wellness.

(32:57) .Tech Domains has a new program called startups.tech, where you can get your startup featured on This Week in Startups. Go to http://www.startups.tech/jason to find out how!

(34:02) Emphasizing the significance of regular blood tests for health monitoring.

(41:55) A lesson in healthcare for everyone and the curious case of the venomous Gila monster.

(48:59) Connecting the dots between modern healthcare, science, and technology: A real-life 'choose-your-own-adventure'.

(52:39) Exploring the benefits of Lemonaid Health's acquisition by 23andMe.

(58:32) Anne Wojcicki reflects on her 17-year journey in the field and shares her vision for the future of health and genetics.

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Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp

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Check out 23andMe: https://www.23andme.com

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Follow Anne:

X: https://twitter.com/annewoj23

LinkedIn: https://www.linkedin.com/in/annewojcicki

Follow Jason:

X: https://twitter.com/jason

Instagram: https://www.instagram.com/jason

LinkedIn: https://www.linkedin.com/in/jasoncalacanis

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Thanks to our partners:

(10:58) CLA - Get started with CLA's CPAs, consultants, and wealth advisors now at https://www.claconnect.com/tech

(22:26) House of Macadamias is the next big health trend! Get a free month's supply of Macadamia Milk with any order at https://www.houseofmacadamias.com/twist by using code TWIST20!

(32:57) .Tech Domains has a new program called startups.tech, where you can get your startup featured on This Week in Startups. Go to http://www.startups.tech/jason to find out how!

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Great 2023 interviews: Steve Huffman, Brian Chesky, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland

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Check out Jason’s suite of newsletters: https://substack.com/@calacanis

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Follow TWiST:

Substack: https://twistartups.substack.com

Twitter: https://twitter.com/TWiStartups

YouTube: https://www.youtube.com/thisweekin

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Subscribe to the Founder University Podcast: https://www.founder.university/podcast

Gary Brecka is a human biologist and co-founder of 10X Health System.
https://www.garybrecka.com

https://www.theultimatehuman.com/
https://www.instagram.com/garybrecka/

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Harold (Hal) Burstein is an internationally renowned breast cancer expert. In this episode, Hal discusses a broad range of topics related to breast cancer, starting with the intricacies of breast anatomy and the endocrinological factors at play. He covers the spectrum of breast cancer, from precancerous lesions to invasive breast cancer, classifying these conditions into a helpful framework. He delves into various screening methods, including self-exams, mammograms, ultrasounds, and MRIs, and addresses the ongoing debate surrounding early screening and detection. Hal provides insights into the latest advancements in cancer treatment, offering valuable guidance for individuals to understand their unique circumstances within the three primary categories of breast cancer. Finally, Hal delves into the role of genetics in breast cancer and brings attention to the less commonly addressed issue of male breast cancer.

We discuss:

• The prevalence and mortality rate of breast cancer in women [4:15];
• The anatomy of the breast and the complex factors behind breast cancer development [6:30];
• The three main categories of breast cancer [16:45];
• Breast cancer risk: the impact of menopause, estrogen, breast density, obesity, and more [21:15];
• Finding and evaluating lumps in the breast [25:30];
• Identifying and treating precancerous lesions like ductal carcinoma in situ (DCIS) [31:00];
• Post-lumpectomy for DCIS: standard of care, future risk of cancer, and pros and cons of radiation and other preventative options [41:15];
• Lobular carcinoma in situ (LCIS): how it differs from DCIS in terms of treatment and future risk of invasive cancer [55:00];
• Breast cancer screening: mammography, ultrasound, MRI, and more [1:03:45];
• Invasive breast cancer: pathology report, surgery, and survival [1:11:00];
• The argument for aggressive screening for breast cancer [1:22:15];
• Advances in the treatment of breast cancer, adjuvant therapy, and neoadjuvant therapy [1:27:00];
• The use of hormone replacement therapy in women who are in remission from breast cancer [1:41:15];
• The role of genetics in breast cancer [1:44:45];
• The importance of multidisciplinary care delivered by cancer centers [1:53:15];
• Breast cancer in men [2:03:30];
• Parting thoughts and takeaways [2:05:45]; and
• More.

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Joe List is a stand-up comic and co-host, along with Mark Normand, of the "Tuesdays with Stories!" podcast. His latest special, "Enough for Everybody," is now available on YouTube.
www.comedianjoelist.com

This is Episode 83. It’s all about birds in the family Odontophoridae. These are the New World quails.

Why is this the family of "New World" quails?

Because there’s a whole mess of birds we call quails that live in Europe, Asia, Africa, and Australia. But those birds all belong to the pheasant family, Phasianidae.

New World quails are shy birds ground-dwelling birds that walk or run around in the daytime, looking for tidbits of food in the leaf litter.

If they sense any kind of stranger danger, they hunker down and hide in bushes or other vegetation. Their first instinct is to sit still and rely on their camouflage, rather than to fly away.

These birds may be shy around strangers, but they’re generally very social with members of their own kind. They’re gregarious little buggers.

In this episode, I go into detail about what New World quails look and sound like, about their diversity, and about the ways they live their lives.

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Link to this episode on the Science of Birds website