gut microbiome

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Dr. Steven Gundry is one of the world’s top cardiothoracic surgeons and a pioneer in nutrition. He hosts a top-rated health show, The Dr. Gundry Podcast, is the founder and Director of The International Heart and Lung Institute Center for Restorative Medicine, and is the founder of Gundry MD, a line of wellness products and supplements. He is the author of New York Times bestsellers The Plant Paradox, The Plant Paradox Cookbook, The Plant Paradox Quick & Easy, and The Longevity Paradox, along with national bestsellers The Plant Paradox Family Cookbook, The Energy Paradox, Dr. Gundry’s Diet Evolution, and Unlocking the Keto Code, and has had more than three hundred articles published in peer-reviewed journals on using diet and supplements to eliminate heart disease, diabetes, autoimmune disease, and multiple other diseases. He just released his latest book, Gut Check: Unleash the Power of Your Microbiome to Reverse Disease and Transform Your Mental, Physical, and Emotional Health.

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In this episode we discuss (audio version / Apple Subscriber version):

• How Dr. Gundry and I discovered the significance of the gut microbiome (8:05 / 5:29)
• Hallmarks of a healthy microbiome (15:21 / 12:45)
• Feeding the microbiome (17:11 / 14:35)
• Maintaining a healthy, impenetrable gut wall through mitochondrial uncoupling (23:03 / 20:27)
• The role of polyphenols in the gut microbiome (32:50 / 27:55)
• Research on the microbiomes of centenarians and their ability to produce Urolithin A (48:23 / 43:28)
• The mood, brain, gut connection (1:02:32 / 57:37)
• Cancer and the gut microbiome (1:05:42 / 1:00:47)
• Dr. Gundry’s tips for gut health (1:18:31 / 1:13:36)

Get a copy of Gut Check: Unleash the Power of Your Microbiome to Reverse Disease and Transform Your Mental, Physical, and Emotional Health.

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Dr. Uma Naidoo is a Harvard-trained psychiatrist, a professional chef graduating with her culinary school’s most coveted award, and a trained Nutrition Specialist. Michelin-starred chef David Bouley described her as the world’s first “triple threat” in the food and medicine space. Dr. Naidoo founded and directs the first hospital-based Nutritional Psychiatry Service in the United States. She is the Director of Nutritional and Lifestyle Psychiatry at Massachusetts General Hospital (MGH) and Director of Nutritional Psychiatry at MGH Academy while serving on the faculty at Harvard Medical School.

This episode is brought to you by Rupa Health, ButcherBox, Pendulum, and BiOptimizers.

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In this episode we discuss (audio version / Apple Subscriber version):

• Understanding the role that food and diet play in mental health issues and treatment (12:53 / 10:55)
• Exploring the root cause of anxiety and depression (18:23 / 16:27)
• How to eat to calm anxiety (21:12 / 19:15)
• The link between inflammation, mental health, and gut health (24:52 / 22:55)
• The bidirectional relationship between anxiety and gut and autoimmune connections (47:01 / 42:41)
• The link between psychiatric conditions and food sensitivities and allergies (50:44 / 46:24)
• The connection between metabolism and anxiety (57:07 / 52:47)
• Nutrients and micronutrients to help reduce anxiety (1:01:27 / 57:08)
• Putting together a low-anxiety plate (1:15:41 / 1:11:19)

Get a copy of Calm Your Mind With Food.

Connect with Dr. Mark Hyman on Twitter, Instagram, Facebook, and YouTube

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Hey podcast community, Dr. Mark here. My team and I are so excited to offer you a 7 Day Free trial of the Dr. Hyman+ subscription for Apple Podcast. For 7 days, you get access to all this and more entirely for free!  It's so easy to sign up. Just go click the Try Free button on the Doctor’s Farmacy Podcast page in Apple Podcast. 

In this teaser episode, you’ll hear a preview of our monthly Ask A Doctor Anything episode with Dr. Elizabeth Boham.

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Colleen Cutcliffe is an expert in molecular biology and co-founder of Pendulum Therapeutics, a company working to develop treatments for a variety of diseases by targeting the microbiome. In this episode, Colleen delves into the complexity of the microbiome, how it is tested, and how it changes over time. She explores how probiotics, prebiotics, and postbiotics affect the gut and makes a compelling case that well-developed products have the potential not only to enhance gut health but also to positively influence overall metabolic well-being. Colleen emphasizes the significance of a high-fiber diet in sustaining a thriving gut microbiome, shares insights on minimizing microbiome damage during antibiotic use, provides tips for fostering and preserving a healthy gut, and much more.

We discuss:

• Colleen’s background and current focus [4:45];
• The basics of the microbiome [7:15];
• The study of the human microbiome [15:15];
• Categories of bacteria, and the implications on health of the rapid evolution of bacteria [19:45];
• Methods for measuring and understanding the microbiome, and key indicators of microbiome health [28:30];
• The important role of fiber for promoting gut health through the production of butyrate [38:30];
• The case for manipulating gut bacteria via fecal microbiota transplant (FMT) [45:00];
• Dynamics of the microbiome: the gut-brain connection and how antibiotics, nutrition, stress, and more impact the microbiome's diversity and function [50:15];
• Factors that influence the vaginal microbiome [55:15];
• The effect of gut microbes on obesity and challenges with fecal transplants in people [58:45];
• Beneficial strains of gut bacteria and strains commonly found in probiotics [1:01:15];
• The difference between a probiotic and prebiotic, and how CFUs are a measure of the “active ingredient” [1:09:45];
• Considerations about how probiotic strains are produced, and more on the meaning of CFU [1:14:15];
• Mitigating the effect of antibiotics on the microbiome [1:22:30];
• What do we know about the effect of artificial sweeteners on the gut microbiome? [1:30:00];
• Why Akkermansia is a keystone strain with implications for metabolic health and an individual’s response to dietary interventions [1:36:15];
• The essential steps necessary to develop a robust probiotic for optimal health support [1:45:45];
• How Akkermansia helps control blood glucose, and potential implications of Akkermansia in weight loss, diabetes management, and more [1:48:45];
• Pendulum Therapeutics’ commitment to rigorous product develop [2:06:30];
• Details about the probiotic “Glucose Control” and other probiotics developed by Pendulum Therapeutics [2:13:00];
• Further studies of Akkermansia that have been proposed or are underway [2:20:30]; and
• More.

Connect With Peter on Twitter, Instagram, Facebook and YouTube

Do you make your gut health a priority? Consultant surgeon Dr James Kinross, who specialises in the gut microbiome, joins Liz on this episode of the podcast to share why we urgently need to rethink our relationship with our microbes.

Liz and James discuss the different stages and ages of the microbiome, why bugs are not always the enemy, whether we’re staying ‘too clean’, and the importance of eating well when we’re sick.

The episode covers the gut-brain axis, cancer and microbes, and takes a look at the sexual microbiome and how it may influence our ability to pick a partner. James also shares his advice on creating a diverse microbiome.

Links mentioned in the episode:

• Follow James Kinross on Instagram
• Visit James Kinross' website
• Order Dark Matter by James Kinross
• Pre-order A Better Second Half by Liz Earle

Hosted on Acast. See acast.com/privacy for more information.

This episode is brought to you by Rupa Health, Beekeepers, and Cozy Earth. 

Inflammation is our body’s natural defense system and can be a good thing. However, when your immune system shifts out of balance, inflammation can run rampant—leading to every one of the major chronic diseases of aging: heart disease, cancer, diabetes, dementia, and more.  

In today’s episode, I talk with Dr. Shilpa Ravella, Dr. Rupa Marya and Raj Patel, and Dhru Purohit about why chronic inflammation is a precursor to disease and how we can live a more anti-inflammatory lifestyle.

Dr. Shilpa Ravella is a gastroenterologist and assistant professor of medicine at Columbia University Medical Center. She is the author of A Silent Fire: The Story of Inflammation, Diet & Disease, which investigates inflammation, the hidden force at the heart of modern disease. Her writing has appeared in The Atlantic, New York Magazine, The Wall Street Journal, TIME, Slate, Discover, and USA Today, among other publications.

Dr. Rupa Marya is an associate professor of medicine at the University of California, San Francisco, where she practices and teaches internal medicine. Her research examines the health impacts of social systems from agriculture to policing. She is a cofounder of the Do No Harm Coalition, a collective of health workers committed to addressing disease through structural change. 

Raj Patel is a research professor at the University of Texas at Austin’s Lyndon B Johnson School of Public Affairs, a professor in the university’s Department of Nutrition, and a research associate at Rhodes University, South Africa. He serves on the International Panel of Experts on Sustainable Food Systems and has advised governments on the causes of and solutions to crises of sustainability worldwide.

Dhru Purohit is a podcast host, serial entrepreneur, and investor in the health and wellness industry. His podcast, The Dhru Purohit Podcast, is a top 50 global health podcast with over 30 million unique downloads. His interviews focus on the inner workings of the brain and the body and feature the brightest minds in wellness, medicine, and mindset.

This episode is brought to you by Rupa Health, Beekeepers, and Cozy Earth.

Access more than 3,000 specialty lab tests with Rupa Health. You can check out a free, live demo with a Q&A or create an account at RupaHealth.com today.

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Full-length episodes of these interviews can be found here:

Dr. Shilpa Ravella

Dr. Rupa Marya and Raj Patel

Dhru Purohit

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For as many problems that still exist in today’s world, in the past, there were a whole lot more question marks than there are now – especially in the field of nutrition and physiology. The biggest reason for this is the science behind how our bodies work and function becoming more sophisticated year after year. Nowadays, we’re able to zero in on how each of our bodies react to certain foods and lifestyle choices, allowing us to personalize our diets and other areas of our lives accordingly.

I’m always on the lookout for ways to take my nutrition and the overall performance of my body to the next level. That’s why, for this special episode, I wanted to bring together some of my all-time favorite SOG moments when it comes to this topic. We’ll be hearing from the great Dr. William Li, Dr. David Sinclair, and Dr. Casey Means. Please help me welcome all three of them back to The School of Greatness!

In this episode you will learn,

• The top three foods to boost your immune system.
• The keys to regulating your blood sugar levels.
• The importance of taking a blood test to get to know your body chemistry better.
• How diet and lifestyle is influenced by modern western culture.
• Why humans are consuming more sugar than we ever have.

For more information go to www.lewishowes.com/1510

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Your gut microbiome, a bustling community of microorganisms, is a vital player in your overall health. It doesn’t just impact your digestive system — it has a profound influence on your brain health and well-being.

However, the gut microbiome is a complex, long misunderstood realm, and figuring out how it affects daily life can leave even the most dedicated health enthusiasts scratching their heads. 

Here at ZOE, we’ve transformed our understanding of this bustling microbial world, where both “good” and “bad” gut bacteria reside.

In today’s episode, Jonathan speaks with Prof. Nicola Segata and Prof. Tim Spector to explore how ZOE's microbiome testing and unique microbiome health scores provide personalized insights into your gut health.

Download our FREE guide — Top 10 Tips to Live Healthier: https://zoe.com/freeguide

If you want to uncover the right foods for your body, head to joinzoe.com/podcast and get 10% off your personalized nutrition program.

• Nicola Segata is a professor and principal investigator at the Laboratory of Computational Metagenomics, at the CIBIO department of the University of Trento. His background is in metagenomics, machine learning, microbiome research, and microbial genomics.
• Tim Spector is ZOE's scientific co-founder and one of the world's top 100 most cited scientists.

Timecodes:

00:00 Introduction

01:41 Quick fire questions

03:38 Why should we care about gut microbes?

07:00 How many different microbes do we have in our gut?

11:37 Why would we want to measure our microbiome?

13:15 Can we change our microbiome?

18:00 Is it possible to make a dramatic change in your microbiome over time?

20:21 What does the latest data tell us about improving our diet?

23:24 How does the ZOE micobiome gut test work?

27:07 What goes on in the lab to get these results?

30:54 Is there enough information in the gut microbiome to make a full health assessment?

34:20 What can our microbes tell us about diseases?

35:55 What useful information does the microbiome test show us?

36:51 Are we still making new discoveries in the microbiome?

41:03 Do different microbes prefer specific foods?

43:14 How do different lifestyles around the world change your microbiome?

47:44 5 simple tips to improve gut health

50:45 How rapidly can you damage your microbiome?

53:58 Can taking painkillers regularly negatively impact the microbiome?

56:10 Summary

60:03 Goodbyes/Outro

Mentioned in today’s episode: 

• The person-to-person transmission landscape of the gut and oral microbiomes from Nature 
• Sharing of gut microbial strains between selected individual sets of twins cohabitating for decades from PLoS One
• A genetic gift for sushi eaters from Nature

Find Nicola on ResearchGate and X.

Episode transcripts are available <a...

There’s been a surge in our consumption of ultra-processed foods, especially in the United Kingdom and the United States, where these foods contribute about two-thirds of people’s caloric intake.

Also a cause for concern is emerging evidence of ultra-processed foods’ detrimental effect on our brain health and overall well-being.

When most of our calories come from ultra-processed foods, the risk of chronic physical and mental health conditions escalates. Scientists are now uncovering the intricate mechanisms behind this relationship, particularly concerning the effects of these foods on our brains.

In today’s episode, we welcome back Prof. Felice Jacka, OAM. Felice is an Alfred Deakin professor of nutritional psychiatry and the director of the Food & Mood Centre at Deakin University, in Australia. She’s also the founder of the International Society for Nutritional Psychiatry Research and the world’s leading researcher on food’s impact on our brain and mental health.

Now, she’s back on the show to delve deeper into the effects of ultra-processed foods on mental health and the brain, specifically the hippocampus, an area responsible for learning and memory.

Download our FREE guide — Top 10 Tips to Live Healthier: https://zoe.com/freeguide

Timecodes:

00:00 Intro

01:19 Quick fire questions

04:17 What is ultra processed food?

05:37 What is the NOVA classification?

08:18 How does food impact the brain?

10:33 What does the hippocampus do to influence our brain function?

12:58 Is there a link between the size of the hippocampus and quality of diet?

13:45 Is there a link between the quality of diet and depression?

20:37 What are the effects of long term dietary habits?

21:33 Is there a link between poor diet and dementia

23:18 Is there a link between autism and diet?

24:00 How real is the link between diet and dementia?

24:57 What is the oral microbiome?

28:16 New trial between whole foods and vitamin enriched nutritional foods

29:28 How does processing foods impact the makeup of foods on a molecular level?

32:10 How does the biodiversity around us affect our body?

33:08 How does the industrialized food environment impact us?

35:50 How strong is the evidence for this? is it comparable to smoking?

39:12 Practical tips to help with our diet

40:07 How does reducing consumption of UPF affect us?

41:25 How to cut down on UPF

44:04 Is it too late to change your diet?

45:39 Does exercise impact our brain?

47:41 Summary

52:57 Goodbyes/Outro

Mentioned in today’s episode: 

• The SMILES trial published in BMC Medicine 
• Ultra-Processed Food Consumption and Mental Health published in Nutrients
• Western diet is associated with a smaller hippocampus also in BMC Medicine 

Learn more about Felice on the Food & Mood Centre’s website.

Follow Felice on Instagram.

Episode transcripts are available here.

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About this interview:

Dr. Eashwarran Kohilathas is a medical doctor, qualified personal trainer, and professional author with the sole purpose of helping mankind reach physiological, psychological, and spiritual freedom through total biopsychosocial alignment, fear-extinction, and the loss of “self.” In this podcast we talk about why he left the profession of medicine, what led him to write his book "Calling out the shots" and so much more. This is Part 2 of our conversation. But I swear I could have 10 more parts. So many things to talk about with this young man. I'll be sure to have him back! Enjoy and as ever love to you all x ​ Links - Twitter
Eashwarran Kohilathas Website
Generation Grounded Books and guides
Books and guides link here Calling out the Shots Book
Book link here

About Doc Malik: Orthopaedic surgeon Ahmad Malik is on a journey of discovery when it comes to health and wellness. Through honest conversations with captivating individuals, Ahmad explores an array of topics that profoundly impact our well-being and health.

You can follow us on social media, we are on the following platforms: 
⁠Twitter Ahmad⁠ | ⁠Twitter Podcast⁠ | ⁠Instagram Ahmad⁠ | ⁠Instagram Podcast

Do you count your calories? On this episode of The Liz Earle Wellbeing Show, Liz is joined by Dr Giles Yeo to learn why it might be time to stop focussing so much on calorie intake. Dr Giles shares the history behind these little numbers, and why all calories aren’t exactly equal. Liz and Dr Giles also discuss ultra-processed foods, how to make smarter food choices, and the importance of eating protein.

Links mentioned in the episode:

• Follow Dr Giles Yeo on Instagram
• Purchase Why Calories Don't Count by Dr Giles Yeo here
• Subscribe to Liz Earle Wellbeing Magazine

Hosted on Acast. See acast.com/privacy for more information.

In a lab in Ireland, a group of scientists stand around a stainless steel table. One of them is holding a device, not unlike a small turkey baster. His free hand plunges into a box on the table and retrieves a mouse.  

Using his device, he administers the brown solution within…rectally. 

This unfortunate soul has just received a fecal microbiota transplant. The donor was not another mouse but a human being. And the person in question had symptoms of severe depression. 

Jonathan speaks to John Cryan, author of the study that showed a relationship between gut and brain. In this episode, we learn more about his fascinating research, how microbes may affect our brain, and to eat to appease your gut bugs. 

• John Cryan is a professor at University College Cork and a world-leading researcher into the relationship between our brain and our gut microbiome.

Download our FREE guide — Top 10 Tips to Live Healthier: https://zoe.com/freeguide

Timecodes:

00:00 - Introduction

02:05 - Quickfire questions

03:26 - Are there links between the gut and the brain?

06:31 - The gut-brain axis

09:17 - How do gut bacteria affect our brains?

11:12 - Why does John call the microbiome “the chamber of secrets”?

14:20 - Does the microbiome explain drug side effects?

15:51 - Are there links between our microbiomes and mental health?

20:40 - If we improve our microbiome health can we improve our mental health?

24:58 - Can food help improve the microbiome and thus improve mental health?

28:33 - Microbiome’s effect on behavior

29:54 - Actionable advice

34:43 - Microbiome in adolescence

37:18 - Summary

38:26 - Goodbyes

38:48 - Outro

Episode transcripts are available here.

Follow John: https://twitter.com/jfcryan

Follow ZOE on Instagram: https://www.instagram.com/zoe/

This podcast was produced by Fascinate Productions.

How many different plant foods have you eaten this week? On this episode of The Liz Earle Wellbeing Show, Liz is joined by medical scientist and nutritionist Dr Federica Amati to chat about how food can support you through the menopause.

Liz and Federica discuss the impact that the menopause has on our metabolic health and the gut microbiome, and why we may experience sugar cravings during this often trying transition.

Federica shares how increasing the number of plants in your diet may reduce the menopause symptoms you experience, and protect your future health. Plus, the episode covers why we should all aim to eat at least 30 different plants every week, and why we need to be mindful of ultra-processed foods.

Links mentioned in the episode:

• Follow Dr Federica on Instagram
• Learn more about the results of the ZOE PREDICT study
• Purchase Food for Life: The New Science of Eating Well
• Sign up to our FREE newsletter
• Subscribe to Liz Earle Wellbeing Magazine

Hosted on Acast. See acast.com/privacy for more information.

0:00 Bestie intros!

1:25 Twitter's former head of security makes allegations against the company

22:08 Foreign countries placing government agents in US tech companies, cloud security vulnerabilities

33:54 Student loan forgiveness

1:03:25 Red wave or red ripple?

1:07:57 Science corner: Gut microbiome, fecal transplants

Follow the besties:

https://twitter.com/chamath

https://linktr.ee/calacanis

https://twitter.com/DavidSacks

https://twitter.com/friedberg

Follow the pod:

https://twitter.com/theallinpod

https://linktr.ee/allinpodcast

Intro Music Credit:

https://rb.gy/tppkzl

https://twitter.com/yung_spielburg

Intro Video Credit:

https://twitter.com/TheZachEffect

Referenced in the show:

https://www.washingtonpost.com/technology/interactive/2022/twitter-whistleblower-sec-spam

https://www.npr.org/2022/08/23/1119071586/twitter-whistleblower-complaint-elon-musk-security-bots-fake-users

https://www.cnn.com/2022/08/23/tech/twitter-whistleblower-peiter-zatko-security/index.html

https://time.com/6207996/twitter-whistleblower-allegations/

https://twitter.com/DavidSacks/status/1562179576800763904

https://twitter.com/DavidSacks/status/1562179705322684416

https://www.reuters.com/world/india/india-forced-twitter-put-agent-payroll-whistleblower-says-2022-08-23

https://twitter.com/elonmusk/status/1562105413977493504

https://www.dailymaverick.co.za/article/2022-08-24-musk-gets-a-potential-boost-with-twitter-whistle-blowers-claims-2

https://www.cnn.com/2022/08/23/tech/twitter-whistleblower-peiter-zatko-security/index.html

https://www.zuckermanlaw.com/sp_faq/largest-sec-whistleblower-awards

https://blogs.microsoft.com/on-the-issues/2021/06/30/the-need-for-legislative-reform-on-secrecy-orders

https://theliberalpatriot.substack.com/p/the-democrats-shifting-coalition

https://fortune.com/2022/08/24/biden-changing-income-driven-repayment-plan-student-debt-borrowers

https://twitter.com/LHSummers/status/1562040653432999936

https://www.socialcapital.com/ideas/2021-annual-letter

https://www.cookpolitical.com/analysis/house/2022-primaries/red-wave-looks-more-ripple

https://www.cell.com/cell/pdf/S0092-8674(22)00919-9.pdf

https://grow.google

Kanchan Koya grew up in a house filled with wonderful fragrances from the spices simmering on her grandmother’s stove. In India, it was a common belief that spices were more than just pleasant tastes. Ancient wisdom said they had medicinal properties, and it was common for household medicine cabinets to store dried spices, not pills.

Kanchan grew up to become a molecular biologist, studying in the US at Harvard Medical School. When her lab began to investigate turmeric’s healing properties, the ancient wisdom from her childhood met the scientific inquiry of her adult life - beginning a lifelong obsession with the health benefits of spice. 

In today’s episode, Kanchan and regular guest Tim Spector help us understand whether there is any scientific evidence to support the health benefits of spices, the easiest way to add spice to our diet, and which ones to choose.

• Kanchan Koya is the founder of SpiceSpiceBaby and The Radical Vitality Podcast with a Ph.D. in Biomedicine from Harvard University and training from the Institute of Integrative Nutrition.
• Tim Spector is a co-founder at ZOE and one of the top 100 most cited scientists in the world.

Download our FREE guide — Top 10 Tips to Live Healthier: https://zoe.com/freeguide

Timecodes:

00:00 - Intro

00:10 - Topic introduction

01:19 - Quickfire questions

02:17 - What is a spice

04:23 - How did Kanchan’s passion for spices begin?

06:56 - What do we know about how spices affect our health?

12:16 - The latest science on spices

17:07 - Which spices are best?

24:46 - How to start using spices?

27:56 - Hacks to start using spices for the best health benefits possible

30:55 - Quality of spices 

35:45 - Storage of spices

36:53 - Summary

37:53 - Goodbyes

38:47 - Outro

Episode transcripts are available here.

Read ZOE’s PREDICT Studies here.

Know more about the 5 spices you should embrace here.

Follow Kanchan: https://www.instagram.com/chiefspicemama

Follow ZOE on Instagram: https://www.instagram.com/zoe/

This podcast was produced by Fascinate Productions.