funding

The Biden Administration announces sweeping changes to Title IX which will impact gender identity and due process. Get the facts first with Morning Wire.

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OpenAI is one of the fastest-growing companies ever, thanks to its artificial intelligence chatbot, ChatGPT. But costs to train and run the models that underpin that technology are steep. And chief executive Sam Altman has said he has even bigger aims. The FT’s Madhumita Murgia and George Hammond examine whether the start-up’s existing business model can achieve its long-term goals. 

Plus, do you have a question about markets, finance or economics? Get in touch with Michela, and we may use it in an upcoming joint show with Unhedged. 

Email Michela at michela.tindera@ft.com, or message her on X at @mtindera07.

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For further reading:

Can OpenAI create superintelligence before it runs out of cash?

OpenAI on track to hit $2bn revenue milestone as growth rockets

OpenAI’s Sam Altman in talks with Middle East backers over chip venture

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On X, follow Madhumita Murgia (@madhumita29), George Hammond (@GeorgeNHammond) and Michela Tindera (@mtindera07), or follow Michela on LinkedIn for updates about the show and more. 

Read a transcript of this episode on FT.com

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We discuss:

* what it takes to process $1 trillion/year

* how to build multi-decade APIs, companies, and relationships

* what's next for Stripe (increasing the GDP of the internet is quite an open ended prompt, and the Collison brothers are just getting started).

Plus the amazing stuff they're doing at Arc Institute, the financial infrastructure for AI agents, playing devil's advocate against progress studies, and much more.

Watch on YouTube. Listen on Apple Podcasts, Spotify, or any other podcast platform. Read the full transcript here. Follow me on Twitter for updates on future episodes.

Timestamps

(00:00:00) - Advice for 20-30 year olds

(00:12:12) - Progress studies

(00:22:21) - Arc Institute

(00:34:27) - AI & Fast Grants

(00:43:46) - Stripe history

(00:55:44) - Stripe Climate

(01:01:39) - Beauty & APIs

(01:11:51) - Financial innards

(01:28:16) - Stripe culture & future

(01:41:56) - Virtues of big businesses

(01:51:41) - John

Welcome to the Business Broadcast Podcast! Each week James brings on the show an entrepreneur who shares their biggest challenges and struggles in business.

James coaches the business owner through these challenges by asking those hard hitting questions in order to get to the bottom of these problems and help the business owner soar to success.

Find out more from Dean Booty here: https://www.linkedin.com/in/deanbooty 

Try Entrepreneurs University 14 Day FREE Trial Here ► 

https://jamessinclair.net/entrepreneurs-university-free-trial/

Get your tickets to our next event here ► https://jamessinclair.net/seminars/

Apply to be on my podcast here ► https://jamessinclair.net/podcasts/

Watch the podcast on YouTube ► https://www.youtube.com/@jamessinclairspodcast

Apply to be on my podcast here ► https://jamessinclair.net/podcasts/

My Socials:

Website - https://jamessinclair.net

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Instagram - https://www.instagram.com/jamessinclairentrepreneur/

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Within the world of startups, you'll find lots of discourse online about the experiences of founders bootstrapping their startups versus the founders who have raised venture capital to fund their companies. Is one better than the other? Truth is, it may not be so black and white. Dalton Caldwell and Michael Seibel discuss the virtues and struggles of both paths. Apply to Y Combinator: https://yc.link/DandM-apply Work at a Startup: https://yc.link/DandM-jobs

This Week in Startups is brought to you by…

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The Paintbrush Loan is the earliest startup financing on the internet. No pitch deck, no business plan, no minimum time in business, and no warm intros. Plus, you get to keep your equity. Visit http://getpaintbrush.com to see if you qualify for a $50K startup loan in less than 2 minutes.

*

Today’s show:

Zest's Jake Gutstein joins Jason to discuss his journey in creating the cooking app Zest (1:37). The two dive into how the Zest team formed (10:29), finding the right tools for your startup (25:24), Jake's experience in the Launch Accelerator program (33:27), and more!

*

Timestamps:

(0:00) Zest’s Jake Gutstein joins Jason

(1:37) What prompted the creation of Zest and the initial concept and MVP for Zest

(9:22) Vanta - Get $1000 off your SOC 2 at https://vanta.com/twist

(10:29) The product development, initial testing, and finding a technical co-founder

(17:21) The decision to go full-time with Zest, the process of raising initial funding, and the importance of overcoming ambiguity and uncertainty

(20:54) MEV - Get $30,000 off your first three months at http://mev.com/twist

(22:05) Demo of Zest’s product

(25:24) Finding the right tools and mentors and the value propositions of Zest discovered through user research

(32:35) Paintbrush - Visit http://getpaintbrush.com to see if you qualify for a $50K startup loan in less than 2 minutes

(33:27) Product launch, approach to fundraising, and experience with the Launch Accelerator program

(46:48) Future plans and goals for Zest

*

Check out the Launch Accelerator: https://launchaccelerator.co

*

Check out Founder University: https://www.founder.university

*

Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp

*

Mentioned on the show:

https://www.respondent.io

https://therewiredgroup.com

https://twitter.com/bmoesta

https://twitter.com/nealsales

https://twitter.com/jasonfried

https://twitter.com/dhh

https://www.youtube.com/watch?v=7LK6lKCKMQM

*

Follow Jake:

X: https://twitter.com/GutsteinJake LinkedIn: https://www.linkedin.com/in/jacob-gutstein Check out: https://zestapp.co

*

Follow Jason:

X: ⁠https://twitter.com/jason⁠

Instagram: ⁠https://www.instagram.com/jason⁠

LinkedIn: ⁠https://www.linkedin.com/in/jasoncalacanis

*

Thank you to our partners:

(9:22) Vanta - Get $1000 off your SOC 2 at https://vanta.com/twist

(20:54) MEV - Get $30,000 off your first three months at http://mev.com/twist

(32:35) Paintbrush - Visit http://getpaintbrush.com to see if you qualify for a $50K startup loan in less than 2 minutes

*

Great 2023 interviews: Steve Huffman, Brian Chesky, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland

*

Check out Jason’s suite of newsletters: https://substack.com/@calacanis

*

Follow TWiST:

Substack: https://twistartups.substack.com

Twitter: https://twitter.com/TWiStartups

YouTube: https://www.youtube.com/thisweekin

Instagram: https://www.instagram.com/thisweekinstartups

TikTok: https://www.tiktok.com/@thisweekinstartups

*

Subscribe to the Founder University Podcast: https://www.founder.university/podcast

Developing stories you need to know just in time for your drive home. Get the facts first on Morning Wire.

Hillsdale: Enroll for FREE today at https://www.hillsdale.edu/wire
ZBiotics: The drink before drinking with ZBiotics. Get 15% off your order with promo code WIRE at http://www.ZBiotics.com/Wire

Ukraine’s President is back in the U.S. asking for aid, the House votes today to approve an impeachment inquiry, and Harvard’s board allows Claudine Gay to keep her job as president. Get the facts first with Morning Wire.

American Home Shield: Save $50 when you join American Home Shield. Visit http://www.ahs.com/MorningWire

ZipRecruiter: "Try ZipRecruiter for FREE: https://www.ziprecruiter.com/Wire"

Ukraine’s president, Volodymyr Zelensky, is making a rare trip to Washington this week, pleading his case for American military aid, something which has long been a lifeline for his country but is now increasingly in doubt.

Julian Barnes, who covers international security for The Times, explains what has brought Ukraine to the most perilous point since the war began nearly two years ago.

Guest: Julian E. Barnes, a correspondent covering the U.S. intelligence agencies and international security for The New York Times.

Background reading: 

• The U.S. and Ukraine are searching for a new strategy after a failed counteroffensive.
• The Ukrainian leader will be appealing for more military support from the United States as an emboldened Russia steps up its attacks on his country.

For more information on today’s episode, visit nytimes.com/thedaily. Transcripts of each episode will be made available by the next workday.

Rob Kalin founded Etsy for people like him: makers and hobbyists. In 2005, he was kicking around New York trying to find buyers for his hand-made furniture, when he noticed that other craftspeople had the same need. So he and a few friends built a website where makers could sell a wide range of goods. Rob named it after an Italian phrase he heard in a Fellini film, and within three years, Etsy passed $10 million in sales. But as a young founder, Rob struggled to manage the rapidly-growing company; and in 2011, after being fired without warning, he returned to a quieter life as a maker and small-businessman. Meanwhile, Etsy has become one of the most popular online marketplaces in the world, with $2.5 billion in revenue.

This episode was produced by Kerry Thompson with music by Ramtin Arablouei.

Edited by Neva Grant, with research from Sam Paulson.

Our engineers were Gilly Moon and Maggie Luther.

You can follow HIBT on Twitter & Instagram, and email us at hibt@id.wondery.com.

This episode is brought to you in part by Canva, the easy-to-use online design platform for presentations, social posts, videos, websites, and more. Start designing today at Canva – the home for every brand.

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

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View the Show Notes Page for This Episode

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In this episode of The Drive, Peter welcomes guests David Sabatini and Matt Kaeberlein, two world-leading experts on rapamycin and mTOR. David and Matt begin by telling the fascinating story of the discovery of rapamycin and its brief history as a pharmacological agent in humans. They then unravel the function of mTOR, a central regulator of numerous biological processes, and they discuss the pathways through which rapamycin exerts its potential benefits on lifespan. They touch upon initial studies that suggested rapamycin may have geroprotective effects and the ongoing research that continues to shed light on this unique molecule. Furthermore, they discuss the elusive details surrounding the frequency and dosing of rapamycin use in humans, and Peter emphasizes his reservations about indiscriminately prescribing rapamycin as a longevity drug for patients.

We discuss:

• David and Matt’s expertise in mTOR and rapamycin [3:00];
• The discovery of rapamycin and its first use in humans as an immunosuppressant [13:15];
• The emergence of rapamycin as a molecule with the potential to prolong lifespan [19:30];
• The groundbreaking rapamycin study on mouse lifespan extension and the open questions about the timing and frequency of dosing [26:00];
• Explaining mTOR and the biology behind rapamycin’s effects [35:30];
• Differences in how rapamycin inhibits mTOR complex 1 (MTORC1) versus mTOR complex 2 (MTORC2) [45:15];
• Reconciling the biochemical mechanism of rapamycin with its longevity benefit [49:15];
• Important discoveries about the interplay of amino acids (leucine in particular) and mTOR [54:15];
• Reconciling rapamycin-mediated mTOR inhibition with mTOR's significance in building and maintaining muscle [1:01:30];
• Unanswered questions around the tissue specificity of rapamycin [1:08:30];
• What we know about rapamycin’s ability to cross the blood-brain barrier and its potential impacts on brain health and neurodegeneration [1:13:45];
• Rapamycin may act as an immune modulator in addition to immunosuppressive effects [1:21:30];
• Might rapamycin induce changes in T cell methylation patterns, potentially reversing biological aging? [1:34:15];
• Rapamycin side effects and impacts on mental health: fascinating results of Matt’s survey on off-label rapamycin use [1:42:00];
• The impact of taking rapamycin in people who contracted COVID-19: more insights from Matt’s survey [1:51:15];
• What David would like to study with mTOR inhibitors [1:54:45];
• Joan Mannick’s studies of RTB101 and other ATP-competitive inhibitors of mTOR [2:00:30];
• The impact of mTOR inhibition on autophagy and inflammation and a discussion of biomarkers [2:10:00];
• The Dog Aging Project: what we’ve learned and what’s to come from testing rapamycin in companion dogs [2:17:30];
• Preliminary results of primate studies with rapamycin [2:24:45];
• Dosing of rapamycin [2:27:45];
• The effect of rapamycin on fertility [2:36:45];
• The outlook for future research of rapamycin and the development of rapalogs [2:39:00]; and
• More.

Connect With Peter on Twitter, Instagram, Facebook and YouTube

GCSE and A Level results are out, and the proportion of top grades have dipped since the pandemic years. It's an opportunity for the government and the opposition to talk about their ambitions for education. Are they both failing to do so?

Anoosh Chakelian, Rachel Cunliffe and Freddie Hayward discuss the Tory education record, from Michael Gove’s reforming agenda to unprecedented churn at the top of the Department for Education. And, they ask, what would Labour do differently?

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Show me the (taxpayers) money...

What does the RTÉ scandal tell us about Ireland? Joe and Dion explain why this was always about more than Ryan Tubridy’s salary. The Late Late Show’s decline from the glory days of Gay Byrne shows how RTÉ has been captured and why it can’t be a public service broadcaster and an advertising agency at the same time.

Free State with Joe Brolly and Dion Fanning is a Gold Hat Production in association with SwanMcG.

For more on Free State: https://freestatepodcast.com/

To get in touch with the podcast: info@freestatepodcast.com

Twitter: @dionfanning @JoeBrolly1993 @freestateirl

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Today on the podcast, we have a new format for you! Jason will hear four pitches from Founder University participants and choose ONE startup to invest $25K in! (1:45)

(0:00) Jason kicks off the show and explains the pitch format!

(1:45) Jason brings on Presh and Kelly to explain the fundamentals of Founder University and introduces today's pitches!

(13:44) ⁠Squarespace - Use code TWIST to save 10% off your first purchase of a website or domain at https://Squarespace.com/TWIST

(16:18) George Lam pitches Fantastic Funding

(21:18) Naman Dwivedi pitches Promptify

(25:59) Pilot - Go to https://pilot.com/twist for 20% off your first 6 months

(27:30) Phil Boucher pitches OpenSpot

(34:00) Matt Edminster pitches Renegade Labs

(39:22) ⁠Fennel - Join the waitlist and get your first month free at http://fennel.com/twist

(40:35) Kelly and Presh's pick for best return for LPs

(45:33) The live audience votes!

(50:22) What Founder University meant to these Founders

(53:39) Jason makes his decision on who will receive $25K

Check out the startups!:

https://fantasticfunding.com

https://www.promptify.ai

https://www.findopenspot.com

https://www.renegadelabs.io

FOLLOW Jason: https://linktr.ee/calacanis

FOLLOW Presh: https://twitter.com/preshdkumar

FOLLOW Kelly: https://twitter.com/KSchricks