alzheimer's disease

Robert sits down with Dr. Kaveh Hoda to tell several hilarious fake doctor stories that wind up exposing the dark heart of the health insurance industry.

(2 Part Series)

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Hey podcast community, Dr. Mark here. My team and I are so excited to offer you a 7 Day Free trial of the Dr. Hyman+ subscription for Apple Podcast. For 7 days, you get access to all this and more entirely for free!  It's so easy to sign up. Just go click the Try Free button on the Doctor’s Farmacy Podcast page in Apple Podcast. 

In this teaser episode, you’ll hear a preview of our monthly Ask A Doctor Anything episode with Dr. Elizabeth Boham.

Want to hear the full episode? Subscribe now. With your 7 day free trial to Apple Podcast, you’ll gain access to audio versions of:

- Ad-Free Doctor’s Farmacy Podcast episodes

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- Bonus audio content exclusive to Dr. Hyman+

Trying to decide if the Dr. Hyman+ subscription for Apple Podcast is right for you?  Email my team at plus@drhyman.com with any questions you have.  

Please note, Dr. Hyman+ subscription for Apple Podcast does not include access to the Dr. Hyman+ site and only includes Dr. Hyman+ in audio content. 

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This Week in Startups is presented by:

Coda. A new doc that brings words, tables and teams together. All your valuable data, plans, objectives, and strategies in one place. Go to https://coda.io/twist to get a $1,000 credit!

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Today’s show:

CEO and Founder of Vistim Labs James Hamet joins Jason, as they discuss the current roadblocks with diagnosing dementia (1:18), before James breaks down how they use AI to detect signs of neurological disease (23:29). Then, Jason sits down with Kaitlin Malin at SALT iConnections New York, to discuss the keys to angel investing and AI (40:52).

Follow James: https://www.linkedin.com/in/jchamet/

Check Out Vistim Labs: https://vistimlabs.com/

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Time stamps:

(0:00) James joins Jason

(1:18) The faults with how we diagnose Dementia today

(6:46) Visitim Labs’ product

(9:25) Coda - Get a $1,000 startup credit at https://coda.io/twist

(10:46) Test trials and patient demographics

(12:53) Vistim’s go-to-market strategy

(18:24) Miro - Sign up for a free account at https://miro.com/startups

(20:32) James shares a video demoing Vistim Labs’ capabilities

(23:29) James’ previous startup, Neurable

(27:02) Catching Alzhimers’ early, habits that prevent neurological disease and the four horseman

(39:23) Veed - Sign up and engage your audience on any platform at https://www.veed.io

(40:52) Jason’s sits down with Kaitlin Malin at SALT iConnections New York

(46:03) Raising a 506-C fund’

(52:13) Jason’s keys to becoming a successful angel

(58:27) Jason’s thoughts on AI

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Read LAUNCH Fund 4 Deal Memo & Apply for Funding

Buy ANGEL

Great recent interviews: Brian Chesky, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland, PrayingForExits, Jenny Lefcourt

Check out Jason’s suite of newsletters: https://substack.com/@calacanis

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Follow Jason:

Twitter: https://twitter.com/jason

Instagram: https://www.instagram.com/jason

LinkedIn: https://www.linkedin.com/in/jasoncalacanis

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Follow TWiST:

Substack: https://twistartups.substack.com

Twitter: https://twitter.com/TWiStartups

YouTube: https://www.youtube.com/thisweekin

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Subscribe to the Founder University Podcast: https://www.founder.university/podcast

Why should we stop ageing? Today we talk about everything to with ageing, why it occurs, why there’s renewed interest in it and what we can do about it. Sue beautifully lays out the history of longevity research, the origins of this fascinating scientific discipline and what the latest research means for you.

We’re taking a short break on the podcast this week so we’re diving into the rich archives of The Doctor’s Kitchen Podcast to resurface one of my favourite conversations from 2 years ago.

Sue Armstrong is a writer and broadcaster specialising in science, health and development issues and author of one of my favourite books on longevity, “Borrowed Time – The science of how and why we age”.

Today we discuss how Sue's career got started as well as her experience reporting on Nelson Mandela’s release from prison as well as her time spent researching HIV.

We talk about:

The origins of ageing research

The different theories of why we age

Cellular senescence 

The ageing immune system

Calorie restriction and its pros and cons

And lots more

🎬 Watch the podcast on YouTube here

📱 Download The Doctor’s Kitchen app for free

You can download The Doctor’s Kitchen app for free to get access to all of our recipes, with specific suggestions tailored to your health needs and new recipes added every month. We’ve had some amazing feedback so far and we have new features being added all the time - check it out with a 14 day free trial too. On Android? Join the waitlist here!

Do check out this week’s “Eat, Listen, Read” newsletter, that you can subscribe to on our website - where I send you a recipe to cook as well as some mindfully curated media to help you have a healthier, happier week.

🥗 Join the newsletter and 7 day meal plan

📷 Follow on Instagram

🐦 Tweet me

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For most people lucky enough to live a long life, aging comes with some cognitive decline. But memory loss isn’t inevitable. Some people -- “SuperAgers” -- have memory abilities that remain intact into their 80s, 90s and even beyond. Emily Rogalski, PhD, head of the SuperAger study at Northwestern University, talks about what sets these SuperAgers apart, how their brains differ from the brains of people who age in a more typical way, and what might we learn from studying SuperAgers that could, potentially, help the rest of us to age better.

In part 1 of this 3 part series, Matthew Walker, professor of neuroscience at UC Berkeley and expert on sleep, describes the different stages and cycles of sleep, including what he calls the 4 pillars of sleep, and how they contribute to memory consolidation and numerous important pathways to mental health. We also get into the dangers of chronic sleep deprivation, such as the development of dementia, and the more acute dangers of sleep deprivation like fatal car crashes which are most often caused by drowsy driving. We also discuss the different and important roles of REM vs. non-REM sleep, and the impact that bad sleep habits can have specifically on those sleep stages. 

We discuss:

• Matthew’s background and interest in sleep [6:03];

• Sleep and Alzheimer’s disease, and the 4 pillars of sleep [12:18];

• Stages of sleep, sleep cycles, and brain waves [41:18];

• Memory and sleep, and the risk of insufficient REM sleep [55:48];

• Evolutionary reasons to sleep [1:02:03];

• The early riser vs. the night owl, and tips for overcoming jet lag [1:10:18];

• Is there one type or stage of sleep that is most important? [1:17:33];

• The dangers of drowsy driving [1:28:48];

• The timeliness of Matthew’s book, and how the conversation of sleep has changed over the past several years [1:35:18]; and

• More.

Learn more at www.PeterAttiaMD.com
Connect with Peter on Facebook | Twitter | Instagram.

In this episode, Francisco Gonzalez-Lima, a Professor of Neuroscience and Pharmacology & Toxicology, explains the vascular hypothesis of Alzheimer’s disease which says the central problem is a progressive neuronal energy crisis of impaired blood flow to the brain and impaired mitochondrial respiration. He walks us through the ways we can intervene in this process and also shares details of the exciting future of Alzheimer’s treatment and prevention.

We discuss:

• Background and interest in the brain [5:15];
• The unique nature of the human brain [9:15];
• Why we’ve made so little progress in Alzheimer’s research [23:00];
• The amyloid beta hypothesis [28:30];
• Hypometabolism in the brain leading to cognitive decline [39:30];
• Early signs of AD, and deciphering between age-related decline versus something pathologic [47:45];
• The vascular hypothesis of Alzheimer’s disease [54:00];
• The relationship between mitochondria, cytochrome c oxidase, and Alzheimer’s disease [1:08:00];
• Chronic inhibition of cytochrome c oxidase leads to chronic neurodegenerative disease [1:22:45];
• Major risk factors for AD, head trauma, and other forms of dementia [1:33:45];
• Methylene blue for treating and preventing neurodegeneration [1:38:15];
• Current standard of care for AD, and the reasons for a lack of advancement [2:01:45];
• Near infrared light as a targeted treatment for cognitive decline [2:05:30];
• The ketogenic diet as a treatment and preventative measure [2:13:15];
• Exciting future research coming from Francisco [2:23:00];
• Methylene blue for traumatic brain injuries [2:25:15]; and
• More.

Learn more at www.PeterAttiaMD.com

Connect with Peter on Facebook | Twitter | Instagram.

On this episode, I invite fellow doctor and friend Dr Ayan Panja, General Practitioner, super generalist, lifestyle medicine enthusiast and co-founder of Lobe Medical to talk about eating for our mind - with specific regard to neurodegenerative disease.

We talk through:

• What we mean by the concept of Eating for your brain
• How food is such an important consideration in brain health
• What we discuss with patients in regard to cognitive decline
• How many listeners in their 30-40s might be thinking that this topic is only relevant for an older generation - but actually, looking after your brain is a lifelong process
• The impact of stress, sleep and exercise on your brain
• What neurogenesis is
• The burden of Dementia and Alzheimer’s Disease
• The factors that have been proven to reduce the effects of disease

If I was to suggest one recipe from my cookbook The Doctor's Kitchen that pretty much sums up our conversation - it would be the Elegant Flavanol Porridge - it has whole oats in it and also includes berries and cacao - which is a lovely chocolate spice that adds a wealth of aroma to your foods.

You can find Dr Ayan at the social medial links below and at Lobe Medical - where you can find out more about his amazing project, teaching GP's and other practitioners how to improve their lifestyle medical consultations.

Follow Dr Panja on Twitter @Dr_Ayan and Instagram @drayanpanja.

The Doctor's Kitchen cookbook is out now. Order your copy here.

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