alzheimer

Neuroscientist Lisa Moscone discusses the evolutionary reasons behind menopausal brain transformations, emphasizing resilience and complexity. This episode covers brain function shifts, the grandmother hypothesis, and the impact of hormone therapy on brain pruning. Along with Dr. Mindy, Lisa stresses the importance of research on menopause's mental health implications and advocates for personalized menopausal toolkits. They also highlight the benefits of a plant-forward diet, fibre for hormonal balance, and the influence of estrogen on brain health.

To view full show notes, more information on our guests, resources mentioned in the episode, discount codes, transcripts, and more, visit https://drmindypelz.com/ep234

Dr. Mosconi holds a PhD degree in Neuroscience and Nuclear Medicine from the University of Florence, Italy. A world-renowned neuroscientist, she ranks in the top 1% of scientists of the past 20 years by official metrics. Recognized by The Times as one of the 17 most influential living female scientists and honored in ELLE 100: Women That Are Changing The World, Dr. Mosconi has been acclaimed as “the Mona Lisa of Neuroscience” by ELLE International. 

Check out our fasting membership at resetacademy.drmindypelz.com.

Please note our medical disclaimer.

View the Show Notes Page for This Episode

Become a Member to Receive Exclusive Content

Sign Up to Receive Peter’s Weekly Newsletter

John Kastelein is a renowned expert in lipoprotein metabolism and atherosclerotic cardiovascular disease (ASCVD) research. In this discussion, John delves deep into familial hypercholesterolemia (FH), a genetic disorder characterized by high levels of LDL cholesterol in the blood that increases the risk of developing heart disease. He covers its definition, genetic underpinnings, and clinical identification. He then explores the therapeutic options available for the prevention and treatment of cardiovascular disease, including the captivating history of CETP inhibitors. He explains the past shortcomings of previous CETP inhibitors before underscoring the compelling potential of the latest iterations, not only for cardiovascular disease but also for conditions like Alzheimer's disease and type 2 diabetes. Moreover, he unveils the intricate role of APOE, shedding light on why the APOE4 isoform codes for a protein that significantly increases the risk of Alzheimer's disease and cardiovascular disease. Concluding the discussion, John shares a profound sense of optimism, envisioning the possibility of targeted therapeutic interventions for high-risk patients in the near future.

We discuss:

• Familial hypercholesterolemia (FH): a genetic condition [4:30];
• Differentiating between phenotype and genotype when it comes to FH [9:45];
• The pathophysiology related to mutations of FH [15:30];
• Clinical presentations, physical manifestations, and diagnosis of FH [22:00];
• Why a small fraction of people with FH do not develop premature ASCVD [34:15];
• Treatment and prevention for those with FH [39:45];
• Addressing the assertion by some that elevated LDL is not casual in cardiovascular disease [52:45];
• The history of CETP inhibitors, and the role of the CETP protein [55:45];
• The thrifty gene hypothesis and why genes underlying FH may have been preserved [1:09:00];
• The compelling potential of the latest CETP inhibitor (obicetrapib) [1:13:00];
• Promising results from phase 3 trials exploring obicetrapib [1:27:45];
• Why the APOE4 allele increases the risk of Alzheimer’s disease, and the connection to blood lipids [1:41:30];
• The role of APOE in cardiovascular disease [1:51:45];
• Takeaways and looking ahead [1:57:00]; and
• More.

Connect With Peter on Twitter, Instagram, Facebook and YouTube

View the Show Notes Page for This Episode

Become a Member to Receive Exclusive Content

Sign Up to Receive Peter’s Weekly Newsletter

Rhonda Patrick, Ph.D., is a scientist with expertise in the areas of aging, cancer, and nutrition who translates complex scientific topics into actionable insights on her podcast, Found My Fitness. In this episode, Rhonda provides her latest thinking as it relates to Alzheimer's disease including the possibility of a vascular hypothesis as well as the factors that can impact disease risk such as type 2 diabetes, blood pressure, omega supplementation, exercise, sauna, and more. She also touches on cancer risk including the relationship between cancer and exercise as well as the link between alcohol consumption and cancer. Additionally, Rhonda explains her new focus on exercise and protein consumption as well as how her perspective has shifted as it pertains to fasting and time-restricted feeding.

We discuss:

• Alzheimer’s disease: Rhonda’s evolved thinking on neurodegenerative diseases [2:30];
• The breakdown of the blood-brain barrier in neurodegenerative disease [8:45];
• An explanation for the observation that type 2 diabetes increases risk of Alzheimer’s disease [15:45];
• The role of omega-3 fatty acids (EPA and DHA) in brain health and prevention of neurodegeneration [19:45];
• Comparing the preventable nature of type 2 diabetes, atherosclerosis, cancer, and dementia [32:15];
• Blood pressure: an important modifiable lifestyle factor that can affect Alzheimer's disease risk [35:15];
• Rhonda’s outlook on “precision medicine” as it pertains to one’s genetic predispositions [38:45];
• Possible mechanisms by which exercise reduces the risk of Alzheimer’s disease [45:45];
• Building your aerobic pyramid: neurobiological effects of exercise, benefits of lactate peaks, and more [53:45];
• Maximizing mitochondrial biogenesis: alternative training approaches and strategies [58:45];
• Possible brain benefits of sauna, and Rhonda’s personal protocol [1:09:30];
• The relationship between cardiorespiratory fitness and dementia risk [1:15:30];
• How exercise may reduce the risk of cancer [1:20:30];
• The overarching impact of exercise on health, and the importance of focusing the factors that matter most [1:33:15];
• Impact of alcohol consumption on breast cancer risk and overall health [1:37:15];
• Exercise as an intervention for poor sleep habits [1:42:30];
• The longevity benefits of consuming adequate protein and strength training to preserve muscle mass and strength [1:46:30];
• How to get enough of the right kind of protein in your diet [2:05:15];
• Fasting: weighing the risk vs. reward [2:12:15];
• How Rhonda’s views have shifted on diet and exercise [2:15:30];
• How to follow Rhonda’s work and more about the benefits of lactate for the brain [2:21:00]; and
• More.

Connect With Peter on Twitter, Instagram, Facebook and YouTube

View the Show Notes Page for This Episode

Become a Member to Receive Exclusive Content

Sign Up to Receive Peter’s Weekly Newsletter

In this “Ask Me Anything” (AMA) episode, Peter goes into depth on the topic of brain health, starting with how Alzheimer's disease is diagnosed, the significance of blood-based biomarkers in diagnosis, and what the various APOE gene variants mean in terms of a person's risk of developing Alzheimer's disease. Next, Peter discusses the various strategies for preventing Alzheimer's disease and neurodegeneration. He touches briefly on exercise as a potent tool, but focuses more on lesser-known factors that could impact brain health, such as nutrition supplementation, lipid management, brain games, sauna, oral health, hearing loss, and more.

If you’re not a subscriber and are listening on a podcast player, you’ll only be able to hear a preview of the AMA. If you’re a subscriber, you can now listen to this full episode on your private RSS feed or our website at the AMA #46 show notes page. If you are not a subscriber, you can learn more about the subscriber benefits here.

We discuss:

• Diagnosing Alzheimer's disease [2:45];
• Biomarkers for Alzheimer’s disease, the C2N test, and other tools for diagnosis [7:30];
• Genetic component of Alzheimer’s disease: genes that confer risk [12:45];
• Understanding your APOE status and why it’s important to know [17:15];
• The prevalence of Alzheimer’s disease and other forms of dementia, and who is at higher risk [21:15];
• Can the risk of Alzheimer’s disease be decreased with behavioral changes? [24:15];
• Overview of modifiable behaviors that potentially play a role in risk reduction of neurodegeneration [30:15];
• Things that clearly impact brain health: smoking, alcohol, sleep, head injuries, blood pressure, and more [34:15];
• How nutrition impacts brain health: common diets, metabolic health, energy balance, and more [46:15];
• Comparing common diets: data showing the association between the incidence of Alzheimer’s disease and specific diets [59:45];
• Supplements: EPA and DHA, vitamin D, and B vitamins [1:13:00];
• Supplements: theracurmin, cocoa flavonols, and magnesium L-threonate [1:25:15];
• Impact of exercise on brain health, minimum effective dose, and the most important types of exercise [1:33:00];
• Challenging the mind with brain games—does it impact neurodegeneration? [1:43:00];
• The data on sauna and brain health [1:49:45];
• Oral health and its association with brain health [1:52:45];
• How reducing lipids can improve brain health and prevent neurodegeneration [1:55:30];
• The potential impact of hearing loss on brain health and neurodegeneration [2:04:30]; and
• More.

Connect With Peter on Twitter, Instagram, Facebook and YouTube

Hey podcast community, Dr. Mark here. My team and I are so excited to offer you a 7 Day Free trial of the Dr. Hyman+ subscription for Apple Podcast. For 7 days, you get access to all this and more entirely for free!  It's so easy to sign up. Just go click the Try Free button on the Doctor’s Farmacy Podcast page in Apple Podcast. 

In this teaser episode, you’ll hear a preview of our latest Dr. Hyman+ Functional Medicine Deep Dive on the roles of genetics and lifestyle factors in the development of Alzheimer’s disease with Dr. Cindy Geyer. 

Want to hear the full episode? Subscribe now. With your 7 day free trial to Apple Podcast, you’ll gain access to audio versions of:

- Ad-Free Doctor’s Farmacy Podcast episodes

- Exclusive monthly Functional Medicine Deep Dives

- Monthly Ask Mark Anything Episodes 

- Bonus audio content exclusive to Dr. Hyman+

Trying to decide if the Dr. Hyman+ subscription for Apple Podcast is right for you?  Email my team at plus@drhyman.com with any questions you have.  

Please note, Dr. Hyman+ subscription for Apple Podcast does not include access to the Dr. Hyman+ site and only includes Dr. Hyman+ in audio content.

Hosted on Acast. See acast.com/privacy for more information.

This episode is brought to you by InsideTracker, Athletic Greens, and Paleovalley.

Until recently, the most popular approach to treating Alzheimer’s has been to focus on managing the symptoms in the brain. Now brain experts and neurologists know that a better, more effective approach to helping Alzheimer’s patients requires a full-body assessment with all-encompassing, highly individualized treatment that includes improving the microbiome, a healthy diet, plenty of exercise, hormonal balance, adequate sleep, and more.

In today’s episode, I talk with Dr. Richard Isaacson, Dhru Purohit, and Dr. Dale Bredesen about why Alzheimer’s is not just a disease of the brain, but one of the entire body.

Dr. Richard Isaacson serves as Director of the Center for Brain Health and Director of the Alzheimer’s Prevention Clinic (APC) at Florida Atlantic University’s Schmidt College of Medicine. He previously served as Director of the APC at the Weill Cornell Memory Disorders Program, Assistant Dean of Faculty Development, and associate professor of neurology at Weill Cornell Medicine & NewYork-Presbyterian. He remains an adjunct associate professor of neurology in the Department of Neurology at Weill Cornell. Prior to that, he served as associate professor of clinical neurology, Vice-Chair of Education, and Education Director of the McKnight Brain Institute in the Department of Neurology at the University of Miami Miller School of Medicine.

Dhru Purohit is a podcast host, serial entrepreneur, and investor in the health and wellness industry. His podcast, The Dhru Purohit Podcast, is a top 50 global health podcast with over 30 million unique downloads. His interviews focus on the inner workings of the brain and the body and feature the brightest minds in wellness, medicine, and mindset.

Dr. Dale Bredesen is internationally recognized as an expert in the mechanisms of neurodegenerative diseases such as Alzheimer's disease and is the author of the New York Times bestsellers The End of Alzheimer's, The End of Alzheimer's Program, and his latest book, The First Survivors of Alzheimer's: How Patients Recovered Life and Hope in Their Own Words.

This episode is brought to you by InsideTracker, Athletic Greens, and Paleovalley. 

InsideTracker is a personalized health and wellness platform like no other. Right now they’re offering my community 20% off at insidetracker.com/drhyman.

Right now when you purchase AG1 from Athletic Greens, you will receive 10 FREE travel packs with your first purchase by visiting athleticgreens.com/hyman.

Paleovalley is offering my listeners 15% off their entire first order. Just go to paleovalley.com/hyman to check out all their clean Paleo products and take advantage of this deal.

Full-length episodes of these interviews can be found here:

Dr. Richard Isaacson

Dhru Purohit

Dr. Dale Bredesen

Hosted on Acast. See acast.com/privacy for more information.

Hey podcast community, Dr. Mark here. My team and I are so excited to offer you a 7 Day Free trial of the Dr. Hyman+ subscription for Apple Podcast. For 7 days, you get access to all this and more entirely for free!  It's so easy to sign up. Just go click the Try Free button on the Doctor’s Farmacy Podcast page in Apple Podcast. 

In this teaser episode, you’ll hear a preview of our monthly Ask Mark Anything episode.

Want to hear the full episode? Subscribe now. With your 7 day free trial to Apple Podcast, you’ll gain access to audio versions of:

- Ad-Free Doctor’s Farmacy Podcast episodes

- Exclusive monthly Functional Medicine Deep Dives

- Monthly Ask Mark Anything Episodes 

- Bonus audio content exclusive to Dr. Hyman+

Trying to decide if the Dr. Hyman+ subscription for Apple Podcast is right for you?  Email my team at plus@drhyman.com with any questions you have.  

Please note, Dr. Hyman+ subscription for Apple Podcast does not include access to the Dr. Hyman+ site and only includes Dr. Hyman+ in audio content. 

Mentioned in this episode

A Harvard Psychiatrist Rethinks Mental Health As A Metabolic Disease with Dr. Christopher Palmer

Hosted on Acast. See acast.com/privacy for more information.

This week's Addicted to Fitness describes how one certain type of exercise can reduce chances of cognitive decline as you age. Nick and Shannon discuss a recent study that suggests that completing regular cardio workouts can actually grow the parts of your brain responsible for cognitive function. Follow the newly created podcast profile on Instagram @TheATFPodcast. Give it a listen and let us know what you think by leaving a rating & review in Apple Podcasts.