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    About this Episode

    Rabid demand for weight-loss drugs like Ozempic and Wegovy is altering US society and transforming the healthcare industry. Rapid Response host Bob Safian guides us through the upheaval and lessons, talking with CEO Zach Reitano of Ro, a telehealth platform that has ridden the wave to a $7 billion valuation. Reitano shares why he chose obesity-treatment as his company’s “hero product,” the impact of weight-loss drugs on industries beyond health-care, and why the potential of GLP-1s like Ozempic mirrors that of AI.

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    🔑 Key Takeaways

    • Grammarly, an AI-powered writing assistant, helps professionals create clearer, more direct, and concise documents, saving time and ensuring data security. Grammarly is committed to responsible AI and data security.
    • Telemedicine can provide scalable solutions to a large population by identifying and addressing unmet needs in healthcare, as shown by the success of GLP1 drugs and telehealth company Row in the obesity treatment market.
    • During a nationwide medication shortage, our company prioritized patient access over advertising, issued refunds and credits, made over 40,000 calls to find supply, and added less effective alternatives to ensure continuous treatment. Personal connection to the issue emphasized the importance of treating obesity as a disease, not a matter of willpower.
    • Identifying a transformative product or solution can significantly impact a company and lead to great success, even amidst doubts and risks.
    • Founders of Ro made tough decisions, pivoted when necessary, and learned from mistakes to consolidate under one brand, focusing on obesity and GLP-1s, leading to significant investment and re-acceleration.
    • Weight loss can lead to changes in eating habits, social implications, and impact various industries. It's more complex than just personal health.
    • Roman Health's obesity ads featuring patients of eligible BMI and portraying them in positions of power challenged societal norms and resonated with individuals seeking treatment, emphasizing the importance of prioritizing patient needs and experiences to reduce stigma and shame.
    • New treatments for weight-related conditions like Osempic are crucial for improving health, but high prices limit access. Efforts to increase coverage and competition, along with research into new uses and cheaper delivery methods, could make these treatments more accessible and sustainable.
    • Weight loss drugs have the potential to improve overall health and extend life spans beyond just weight loss. Accessibility and responsible use are important. The pipeline for new discoveries is tremendous, with significant progress expected in the coming years, and potential impacts on various industries.

    📝 Podcast Summary

    Using Grammarly for efficient and secure content creation

    Grammarly, an AI-powered writing assistant, is a valuable tool for professionals looking to streamline their content creation process while maintaining data security. Tucker Legersky, a researcher on Masters of Scale, shared his experience of using Grammarly to make his documents clearer, more direct, and more concise, saving him a significant amount of time. He also praised Grammarly's commitment to responsible AI and data security. Marsha Mukutenianna, a producer on Masters of Scale, recommended TED Tech, a tech podcast that explores the latest innovations in tech and their potential impact on society. In the news segment, Bob Safian discussed the boom in weight loss drugs and their far-reaching effects on various industries and sectors. The use of these drugs, such as ozempic and wagovi, is leading to significant conversations around health, economics, and culture. The rapid response to these developments is comparable to the response to AI, and the cascading impacts are expected to be more far-reaching than we can currently imagine.

    Identifying and addressing unmet needs in healthcare

    The combination of GLP1 drugs like Ozempic and Mugavia, which satisfy unprecedented criteria of eligibility, effectiveness, patient desire, provider support, and scalability, has led to an explosive demand in the market. Telehealth company Row, which pivoted from erectile dysfunction to obesity treatments, capitalized on this trend by launching its body program in January 2023, just as a national shortage of Vlogovii disrupted patient access to consistent dosing. The company responded by significantly reducing its advertising efforts due to high demand. This case illustrates the importance of identifying and addressing unmet needs in healthcare, and the potential for telemedicine to provide scalable solutions to a large population.

    Prioritizing patient access during medication shortage

    During a nationwide medication shortage for obesity treatments, our company prioritized ensuring continuous access to medication for patients over advertising and fueling demand. We issued refunds and credits, made over 40,000 phone calls to find supply, and added less effective alternatives to the formula. When a new medication became available at the end of 2023, we resumed advertising and onboarding patients with confidence in their ability to access treatment. The company's response was driven by a personal connection to the issue, as the founder's father, a physician, struggled with obesity despite his dedication to helping others. This experience highlighted the importance of understanding obesity as a disease, not a matter of willpower or self-discipline.

    Discovering a hero product

    Identifying a transformative product or solution, even in the face of doubts and uncertainty, can significantly impact a company and its brand. The speaker's father's experience with weight loss using an obesity drug inspired the speaker to shift their company's focus, despite initial skepticism and risks. This "hero product" served as the initial tip of the spear, introducing the company and its promise to customers, and ultimately leading to product-market fit. The speaker's earlier product, which was related to ED, also served as a hero product in the beginning. Building a brand involves a combination of art and science, and finding a hero product is a crucial step in the process. Despite the challenges and doubts, believing in the potential impact of a product and trusting the team to execute can lead to great success.

    Pivoting and Consolidating for Success

    Building a successful company involves making tough decisions, pivoting when necessary, and learning from mistakes. The founders of Ro initially launched their company under the brand Roman, focusing on erectile dysfunction, but knew they wanted to treat patients of all ages and genders. They experimented with various brands for different health issues but eventually decided to consolidate under one brand. Their hero product was intended to be obesity, leading to a significant investment. However, they also had to restructure the company by letting go of some employees and shutting down revenue-generating products. These changes, along with bringing everything under one brand, contributed to Ro's re-acceleration. The founders see these drugs, particularly GLP-1s, as the healthcare equivalent of AI, as they will have a profound impact on the healthcare system, reducing the need for surgeries, procedures, and medical devices. Building a company is a humbling experience with constant hurdles and rejections, requiring both high conviction and the ability to adapt.

    The far-reaching consequences of weight loss

    The impact of weight loss, whether through drugs or lifestyle changes, can have far-reaching consequences beyond just personal health. The discussion highlighted how people's eating habits change when they lose weight, leading to an increase in fish, poultry, and vegetables consumption, and a decrease in ice cream intake. Furthermore, there are unexpected social implications, such as an increase in both marriages and divorces after significant weight loss. The discussion also touched upon the stigma around obesity and the responsibility of companies like Roe to ensure their weight loss drugs are only prescribed to those who truly need them. The cascading impact of weight loss drugs, such as Wagovi and Ozempic, goes beyond just healthcare and can affect various industries and societal norms. The speaker also emphasized the limitations of Body Mass Index (BMI) as a measure of obesity and the need for a more nuanced approach. Overall, the conversation underscored the complexity and multifaceted nature of weight loss and its implications.

    Challenging societal norms with patient-centric obesity ads

    Addressing the stigma surrounding obesity and weight loss requires a patient-centric approach that prioritizes validation, normalization, and unapologetic representation. Roman Health, a healthcare company, has demonstrated this philosophy through its marketing efforts for its obesity treatment program. By featuring patients of eligible BMI in ads and portraying them in positions of power, Roman challenged societal norms and sparked controversy. However, these ads resonated with individuals seeking treatment, reflecting the importance of focusing on those who need help, regardless of external criticism. The company's guiding principle remains unapologetic patient centricity, which also applies to other personal health issues like erectile dysfunction. By prioritizing patient needs and experiences, Roman aims to reduce the shame and stigma associated with these conditions. The ongoing shift towards body neutrality in the body positivity movement further emphasizes the importance of reducing the role of physical appearance in emotional and mental health.

    Affordable treatments for weight-related conditions

    Access to affordable and effective treatments for conditions related to excess weight and adipose tissue, such as Osempic, is crucial for improving people's lives and health. Currently, the cost of these treatments can be a significant burden for many, with prices ranging from $25 to $900 a month depending on insurance coverage. However, there are efforts underway to increase coverage and competition, which could lead to lower prices and more accessible treatments. Additionally, research is expanding the potential uses of these treatments beyond obesity to include conditions like heart disease, chronic kidney disease, and sleep apnea. The pipeline for new treatments is also promising, with once-a-year oral versions of GLP1 being studied, which would be significantly less expensive than current injectables given multiple times a week. Overall, these developments have the potential to make these treatments more sustainable and accessible for those who need them.

    Exploring the potential impact of weight loss drugs

    The current excitement around weight loss drugs is just the beginning, as our understanding of cardiometabolic health and the potential impact of these treatments on various industries and aspects of society is still in its infancy. The potential benefits extend beyond just weight loss, with the potential to improve overall health and life spans. However, it's important that these treatments are made accessible and used responsibly. The pipeline for new discoveries and inventions in this field is tremendous, and we can expect to see significant progress in the coming years. The potential impact on industries such as grocery, restaurant, travel, and healthcare is also significant and worth exploring. Overall, the conversation around weight loss drugs is just getting started, and it's an exciting time to be a part of it.

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