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    GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation

    Scientific discussions foster new discoveries by exchanging ideas and hybridizing concepts. Blocking Norepinephrine during sleep in PTSD can restore normal REM sleep and improve emotional resolution. Practices like yoga nidra can help individuals struggling with addiction and sleep deprivation.

    enMay 01, 2024

    About this Episode

    This is episode 5 of our 6-part special series on sleep with Dr. Matthew Walker, Ph.D., a professor of neuroscience and psychology at the University of California, Berkeley and the host of The Matt Walker Podcast. In this episode, we explain the connection between sleep and mood, emotional regulation and mental well-being.  We explain the role of rapid eye movement (REM) sleep in processing emotions and emotional memories and why sleep deprivation causes agitation, impulsivity and emotional reactivity.  We also discuss why sleep disruption is a hallmark feature of PTSD, anxiety, depression, suicidality, and other psychiatric conditions.  We explain protocols for improving REM sleep and other sleep phases in order to harness the therapeutic power of quality sleep to feel calmer and emotionally restored. This episode describes various actionable tools to improve sleep for those struggling with mental health or mood and those wanting to bolster their overall state and well-being.  The next episode in this special series explores dreams, including lucid dreaming, nightmares and dream interpretation. For show notes, including referenced articles and additional resources, please visit hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Eight Sleep: https://eightsleep.com/huberman LMNT: https://drinklmnt.com/huberman BetterHelp: https://betterhelp.com/huberman InsideTracker: https://insidetracker.com/huberman  Momentous: https://livemomentous.com/huberman Timestamps (00:00:00) Sleep & Mental Health (00:01:09) Sponsors: Eight Sleep, LMNT & BetterHelp (00:05:14) Emotions & Sleep, Amygdala (00:17:27) Emotional Memory & Sleep (00:25:48) “Overnight Therapy” & REM Sleep, Noradrenaline (00:29:13) Sponsor: AG1 (00:30:27) Sleep to “Remember & Forget”, Trauma; REM Sleep (00:38:27) Hinge Analogy; Motivation, Impulsivity & Addiction (00:47:08) Tool: Improve REM Sleep, Social Jet Lag, Alcohol & THC, Addiction (00:56:18) Sponsor: InsideTracker (00:57:23) Post-Traumatic Stress Disorder (PTSD) & REM Sleep (01:06:53) Noradrenaline & REM Sleep, PTSD & Prazosin (01:09:40) Addiction, Non-Sleep Deep Rest (NSDR); Liminal States (01:16:46) Anxiety & Sleep, Mood vs. Emotions (01:23:50) Deep Non-REM Sleep & Anxiety, Sleep Quality (01:28:51) Tool: Improve Deep Non-REM Sleep, Temperature; Alcohol (01:34:56) Suicidality & Sleep, Pattern Recognition; Nightmares (01:46:21) Depression, Anxiety & Time Context (01:51:24) Depression, Too Much Sleep?; REM Changes & Antidepressants (01:57:37) Sleep Deprivation & Depression (02:01:34) Tool: Circadian Misalignment & Mental Health, Chronotype (02:04:05) Tools: Daytime Light & Nighttime Darkness; “Junk Light” (02:13:04) Zero-Cost Support, Spotify & Apple Reviews, Sponsors, YouTube Feedback, Momentous, Social Media, Neural Network Newsletter Disclaimer

    🔑 Key Takeaways

    • Prioritize good sleep hygiene and mental health practices like controlling sleep environment temperature, reducing rumination, using science-based tools like 8 Sleep, LMNT electrolyte drink, and BetterHelp, to enhance emotional well-being and improve overall quality of life.
    • Research shows that sleep affects emotional regulation and mental health, with sleep deprivation increasing amygdala responsivity and amplifying brain activity for negative emotions.
    • Sleep deprivation weakens the connection between the amygdala and prefrontal cortex, leading to heightened emotional reactivity
    • Sleep deprivation increases emotional reactivity and sensitivity, while emotional memories may lose some emotional intensity over time.
    • REM sleep allows for emotional memory reprocessing without strong emotional reactions, enhancing emotional balance and recall
    • AG1 supplement enhances body's stress resilience and provides essential nutrients, acting as an insurance policy for overall health. It also helps in managing emotional responses to traumatic memories through the process of recall in a safe environment, similar to behavioral desensitization therapy.
    • REM sleep deprivation can cause emotional instability and mental health issues by disrupting the balance of the autonomic nervous system
    • Sleep deprivation makes individuals excessively reactive to both negative and positive emotional stimuli, increasing impulsivity and addictive potential. Prioritize good sleep hygiene and understanding individual sleep needs to optimize REM sleep and improve overall well-being.
    • Getting adequate REM sleep by sleeping an extra 15-20 minutes later into the morning, maintaining a consistent sleep schedule, and avoiding alcohol and THC can lead to improved mood, better mental health, and more memorable dreams.
    • THC use and sleep deprivation can negatively affect emotional wellbeing by suppressing REM sleep and increasing addiction sensitivity. Prioritize sleep, reduce THC use, and address trauma to maintain emotional balance.
    • PTSD's emotional memory processing failure leads to sleep disturbances, high noradrenaline, and repetitive nightmares. Prazosin, an alpha adrenergic antagonist, reduces noradrenaline and helps resolve symptoms.
    • Scientific discussions foster new discoveries by exchanging ideas and hybridizing concepts. Blocking Norepinephrine during sleep in PTSD can restore normal REM sleep and improve emotional resolution. Practices like yoga nidra can help individuals struggling with addiction and sleep deprivation.
    • Poor sleep quality can contribute to anxiety, and anxiety can disrupt sleep. Factors like QQRT of sleep influence this relationship. Using liminal states as a tool to improve sleep and reduce anxiety is an intriguing area for further research.
    • Anxiety can hinder sleep, and sleep deprivation can heighten anxiety. Both conditions can lead to anxiety disorders, with sleep disruptions predicting next-day anxiety increases.
    • Deep non-REM sleep quality plays a crucial role in managing anxiety by shifting the body from sympathetic to parasympathetic state, reducing heart rate, cortisol levels, and anxiety pressure. Regular sleep timing and physical activity enhance the electrical quality of deep sleep.
    • Exercise regularly, maintain a cool bedroom temperature, avoid excessive alcohol consumption before bed, and create a relaxing sleep environment for better sleep quality. Prioritize good sleep hygiene to reduce risk of suicidal thoughts and improve overall health.
    • Sleep disruptions can precede suicidal thoughts, attempts, and completion. Researchers are developing AI tools to detect changes in voice, sleep patterns, and other metrics to predict suicide risk and enable early intervention.
    • Negative thoughts and sleep disruptions, including nightmares, increase suicide risk during the hours of darkness. Depression, linked to both excessive sleep and sleep disruptions, disrupts sleep through past and future focus.
    • Anxiety involves excessive worry about the future disrupting the present, while depression can include a lack of optimism about the future and preoccupation with the past, affecting both present and future. Depression may also be linked to disrupted sleep, including difficulty staying asleep, shorter sleep duration, and even too much sleep.
    • Sleep deprivation can temporarily alleviate depression symptoms, but it's not a long-term solution. Understanding individual response to sleep deprivation and natural chronotype alignment is crucial for mental health management. Sleep is a valuable tool for mental health, but not all conditions are sleep disorders.
    • Matching sleep and wake times to your chronotype, getting natural light during the day, and ensuring a dark environment at night can significantly improve mental health, particularly in relation to depression.
    • Prioritize sleep hygiene, maintain a consistent schedule, avoid junk light before bed, and understand the link between sleep and mental health.
    • Subscribe to our free Neural Network newsletter for podcast summaries and PDFs on sleep, neuroplasticity, learning, and fitness protocols to improve sleep quality and overall well-being.

    📝 Podcast Summary

    Improve Mental Health through Better Sleep

    Sleep plays a crucial role in maintaining good mental health. During REM sleep, our brains process and remove the emotional content of memories, providing emotional restoration. Lack of REM sleep can negatively impact mental health. To improve REM sleep quality and quantity, consider using science-based tools such as controlling your sleeping environment temperature with a smart mattress cover like 8 Sleep. Additionally, reducing rumination and negative thoughts before sleep can be helpful. Other science-based tools mentioned include LMNT electrolyte drink for proper hydration and BetterHelp for professional online therapy sessions to improve mental health. Overall, prioritizing good sleep hygiene and mental health practices can significantly enhance our emotional well-being and overall quality of life.

    Sleep's Impact on Emotional Regulation and Mental Health

    Sleep plays a crucial role in emotional regulation and mental health. Over two decades of research have shown that there is no psychiatric condition in which sleep is normal. Sleep deprivation can lead to an increase in amygdala responsivity, which is the centerpiece region for generating emotional reactions. In a study, people who were sleep deprived showed a 60% increase in amygdala responsivity to negative emotional images compared to those who had a full night of sleep. This amplification in brain activity was observed across the entire emotional gradient, not just for aversive images. This research underscores the intimate bidirectional relationship between sleep health and mental health, emphasizing the importance of optimizing sleep for overall well-being.

    Sleep regulates emotional responses

    Sleep plays a crucial role in regulating our emotional responses. The study found that during a night of sleep deprivation, the connection between the amygdala and the medial prefrontal cortex, which acts as a control mechanism for emotional responses, is severed. This means that without sufficient sleep, the emotional response system becomes overactive with little regulatory control, leading to heightened emotional sensitivity and reactivity. The findings were replicated in a more realistic sleep restriction study. This research sheds light on why we may become more emotionally unstable and reactive when we don't get enough sleep. It's important to note that even minor sleep deprivation can have these effects. The prefrontal cortex, which is responsible for understanding context and inhibiting inappropriate brain activity, becomes less effective in the absence of sleep, making us more reflexive and less able to control our emotions.

    Sleep affects emotional responses

    Sleep plays a crucial role in regulating our emotional responses. When we're sleep-deprived, our emotional reactivity increases, and we become more sensitive to stimuli. This is due to reduced activity in the medial prefrontal cortex, which normally helps us regulate our emotions. As a result, our emotional threshold is lower, and we may react negatively to situations that would not bother us when we're well-rested. Additionally, emotional memories, which are prioritized in the brain due to their emotional content, can lose some of their emotional intensity over time. This dissociation between emotion and memory allows us to recall emotional events without experiencing the same level of emotional reaction as we did during the original experience.

    Emotional detoxification during REM sleep

    During REM sleep, the brain undergoes a unique process of emotional detoxification. This occurs due to the complete shutdown of noradrenaline, a brain chemical associated with emotional responsivity and stress. Simultaneously, acetylcholine, a neurotransmitter linked to memory and learning, ramps up in some brain regions. This combination allows for the reprocessing of emotional memories without the strong emotional reactions, essentially detoxifying the emotional rind off the memory. This theory, called overnight forgetting, suggests that sleep plays a crucial role in both forgetting and remembering emotional experiences. The more REM sleep one gets, the greater the emotional detoxification, leading to a more balanced recall of emotional memories.

    AG1 supplement supports body's resilience against stress and acts as insurance policy for essential nutrients

    AG1 supplementation provides essential nutrients and supports the body's resilience against stress. It acts as an insurance policy for getting enough vitamins, minerals, and other nutrients, while adaptogens and micronutrients help buffer against stress. If someone could only take one supplement, the speaker recommends AG1. The supplementation process is similar to behavioral desensitization therapy, where traumatic memories are recalled in a safe environment until the emotional load is removed. This is beneficial as emotions are important for memory prioritization during learning but not necessary long-term. REM sleep plays a role in both remembering and forgetting, and research suggests that it may help in reducing emotional reactivity. William Dement, a pioneer in sleep research, discovered the functions of REM and non-REM sleep in the 1960s. The speaker emphasizes the importance of holding onto memories while letting go of the emotional responses associated with them. This is particularly relevant for PTSD and other trauma-related conditions.

    REM sleep's role in emotional regulation and mental health

    REM sleep plays a crucial role in emotional regulation and mental health. The discovery of REM sleep stages in the same year as the DNA structure led researchers to investigate its importance. Depriving individuals of REM sleep resulted in signs of paranoia, hallucinations, and delusions, suggesting a link between REM sleep and sanity. The autonomic nervous system, which balances sympathetic and parasympathetic responses, can be thought of as a seesaw. Under normal conditions, the brain's hinge keeps the seesaw balanced. However, REM sleep deprivation can loosen the hinge, causing the seesaw to tilt towards sympathetic activation and potentially leading to increased stress and emotional instability. The exact nature of the hinge and how sleep regulates it is not fully understood, but ongoing research continues to explore this connection. Ultimately, a good night of sleep acts as a bridge between despair and hope, emphasizing the importance of prioritizing rest for emotional well-being.

    Sleep deprivation: Overreacting to emotions

    Sleep deprivation can lead to an erratic and extreme reaction from a neural perspective, with individuals being overly sensitive to both negative and positive emotional stimuli. Contrary to the hypothesis that sleep deprivation would result in a decrease in responsiveness to rewarding stimuli, individuals actually become excessively reactive to both negative and positive emotional domains. This maladaptive response can result in increased impulsivity and addictive potential. To improve sleep quality, it's essential to focus on not just the quantity of sleep but also the regularity and timing of sleep, as well as knowing one's chronotype. These factors were discussed in detail in previous episodes, specifically episodes 12, 3, and 4. By prioritizing good sleep hygiene and understanding individual sleep needs, individuals can optimize their REM sleep and improve overall well-being.

    Enhancing REM sleep for better mood and mental health

    Optimizing the quantity and quality of REM sleep can significantly impact mood and mental health. The speaker shares his personal experience of feeling depressed when not adhering to his chronotype and getting adequate REM sleep. To enhance REM sleep, the recommendation is to sleep an extra 15-20 minutes later into the morning, as REM sleep is predominantly found in the latter part of the night. Regularity in sleep schedule is also crucial to avoid social jet lag and its negative effects on the circadian rhythm. Additionally, avoid alcohol and THC as they abolish REM sleep. These simple changes can lead to more intense and memorable dreams, improved mood, and overall better mental health.

    Impact of THC and Sleep Deprivation on Emotional Wellbeing

    Both cannabis use, specifically THC, and sleep deprivation can negatively impact our emotional wellbeing and increase our vulnerability to addiction. The use of THC can suppress REM sleep, leading to a rebound effect when use is discontinued, resulting in intense dreams and emotional experiences. Sleep deprivation, on the other hand, can increase addiction sensitivity and make it harder to resist temptation. To maintain emotional balance and access positive emotions, it's essential to prioritize getting enough REM sleep and avoiding anything that inhibits it. Additionally, trauma, defined as an aversive event that changes the way our nervous system functions, can have a significant impact on our emotional wellbeing and should not be overlooked. Prioritizing sleep, reducing alcohol and cannabis use, and addressing any underlying trauma can help us be our best emotional selves.

    Sleep disturbances and heightened noradrenaline levels in PTSD

    Sleep disturbances, including repetitive nightmares, are a defining characteristic of Post Traumatic Stress Disorder (PTSD). PTSD is unique in that the emotional depotentiation process during sleep fails, leading to the persistence of emotionally charged memories. This failure results in heightened levels of noradrenaline during sleep and at rest in PTSD patients. The use of Prazosin, an alpha adrenergic antagonist, has been shown to help reduce noradrenaline levels, allowing for the emotional memory to be processed and leading to symptom resolution. This discovery has led to FDA approval of Prazosin for PTSD and repetitive nightmares. It's an example of successful scientific collaboration and the importance of combining theoretical models with clinical data.

    Exploring new treatments and ideas in scientific meetings and dialogues

    Scientific meetings, podcasts, and open dialogue among scientists are crucial for fostering new discoveries, as they facilitate the exchange of ideas and the hybridization of concepts. For instance, the discussion around blocking Norepinephrine during sleep, particularly in individuals with PTSD, sheds light on the importance of understanding the role of neurochemicals in sleep and memory processing. The notion is that during REM sleep, the ability to replay memories without the same neurochemical release allows for emotional resolution. However, in individuals with PTSD, the invasion of noradrenaline into REM sleep disrupts the process, potentially rendering it ineffective. Treatment with drugs like prazosin, which reduce sympathetic arousal, can help restore normal REM sleep and improve emotional resolution. Additionally, practices like yoga nidra, a form of non-sleep deep rest, can be beneficial for individuals struggling with addiction and sleep deprivation, especially during the morning hours when sleep can be fragile. Overall, the exchange of ideas and exploration of new treatments and practices can lead to significant advancements in our understanding of sleep, memory, and emotional processing.

    Sleep and Anxiety: A Complex Relationship

    The relationship between sleep and anxiety is complex, and poor sleep quality can contribute to anxiety, while anxiety can also disrupt sleep. The quality, quantity, regularity, and timing (QQRT) of sleep are important factors that influence this relationship. Someone may be getting enough hours of sleep, but if the quality is poor due to irregular or inconsistent sleep patterns, they may be more prone to anxiety. On the other hand, someone with anxiety may have difficulty falling or staying asleep, creating a vicious cycle. The idea of using liminal states as a tool to improve sleep and reduce anxiety is intriguing and could be an area for further research. These states, which can be reached through practices like meditation or relaxation techniques, may provide a bridge between wakefulness and sleep and help reduce stress and anxiety, making it easier to fall asleep and improve overall sleep quality.

    Anxiety's Impact on Sleep and Vice Versa

    There is a strong bidirectional relationship between anxiety and sleep. Anxiety can make it difficult to sleep, and conversely, sleep deprivation can increase anxiety. Anxiety disorders are common, and even people without anxiety disorders can experience significant increases in anxiety after sleep deprivation. In a study where participants with normal anxiety levels were sleep deprived, almost half of them reached the diagnostic threshold for an anxiety disorder the next day. Another study tracked individuals in their daily lives and found that small perturbations in sleep quality predicted increases or decreases in anxiety the next day. Contrary to initial assumptions, REM sleep is not the primary ingredient for reducing anxiety, but rather the quality of sleep plays a crucial role in offering an anxiolytic benefit.

    Improving deep non-REM sleep quality for anxiety management

    The quality of deep non-REM sleep plays a crucial role in managing anxiety. Contrary to previous beliefs, it's not just the quantity or regularity of sleep that matters, but also the electrical quality. During deep non-REM sleep, the brain and body undergo a shift from the sympathetic (fight or flight) to the parasympathetic (rest and digest) state. This helps reduce heart rate, cortisol levels, and anxiety pressure. Regularity in sleep timing is essential for the continuity and quality of deep sleep, while physical activity, particularly exercise, enhances the electrical quality. These findings suggest that focusing on improving the quality of deep non-REM sleep could be a strategic tool for managing anxiety without relying on medication.

    Promoting better sleep through habits and environment

    Optimizing sleep quality involves both doing certain things and avoiding others. Regular exercise and a cool bedroom temperature are two things that can promote better sleep. On the other hand, excessive alcohol consumption in the evening can fragment sleep and reduce deep sleep, particularly in the first few hours. Additionally, while the relationship between sleep deprivation and suicide is not well understood, there is evidence that a lack of sleep can increase suicidal ideation, attempts, and completion. It's important to prioritize good sleep hygiene and seek professional help if you're struggling with anxiety or suicidal thoughts. Other low-cost techniques for improving sleep include taking a warm bath or shower before bed and creating a cool, dark sleep environment. Remember, every little bit helps when it comes to improving your sleep and overall health.

    Sleep disruptions as potential suicide risk biomarkers

    Sleep disruptions could serve as biomarkers for potential suicide risk. The relationship between sleep disturbances and suicide goes beyond mere coincidence in time. Sleep disruptions have been observed to precede suicidal thoughts, attempts, and even completion. Researchers are exploring the idea of using sleep patterns as predictors of suicide risk, with AI tools being developed to detect changes in voice, sleep patterns, and other metrics. These tools could help individuals who are prone to suicide but may not realize it, enabling early intervention and support. The specific pattern of sleep abnormalities is being studied to identify the most predictive signs. Additionally, it has been noted that suicide ideation and attempts often occur during the late middle of the night, which could be linked to the circadian rhythm or the solitude of the night. This information underscores the importance of addressing sleep disturbances as a potential indicator of suicide risk and the potential of AI and biomarkers in suicide prevention.

    The connection between sleep, mental health, and suicide risk

    The relationship between sleep and mental health, particularly suicide risk, is complex. Negative thoughts and sleep disruptions, including nightmares, are more pronounced during the hours of darkness, increasing the risk of suicide ideation, attempts, and completions. Lack of sleep also increases the likelihood of entering a suicidal state. Interestingly, the content of dreams, specifically nightmares, has emerged as a more predictive factor than sleep itself. Depression, often associated with excessive sleep, can also disrupt sleep, creating a bidirectional relationship. Depression is conceptualized as a disorder of both the future and the past, with both abnormal prospection and retrospection disrupting sleep. It's important to note that major depressive episodes are common, and some individuals experience recurring episodes. The feeling of losing something, often described in past tense, is a common thought pattern in depression. The past focus in this context underscores the importance of understanding the role of sleep and dream content in mental health.

    Anxiety vs Depression: Distinguishing Features and Sleep Differences

    Anxiety and depression, two common mental health conditions, can be distinguished by their relationship to time. Anxiety is often characterized by excessive worry about the future, disrupting the present. In contrast, depression can involve a lack of optimism about the future and preoccupation with the past, impairing the sense of both present and future. Regarding sleep, people with depression often experience disrupted sleep, including difficulty staying asleep and shorter sleep duration. However, some studies suggest that depression may also be associated with too much sleep, or hypersomnia. This paradox may be due to people with depression spending more time in bed, reflecting their lack of motivation to engage with the world. Another intriguing finding is the altered REM sleep patterns in depression, with the first REM sleep period occurring earlier than usual. While some theories suggest this may be adaptive, others propose it could be maladaptive. Overall, the complex relationship between anxiety, depression, and sleep warrants further investigation.

    Sleep's Impact on Depression and Mental Health

    Sleep plays a significant role in mental health, particularly in the context of depression. Some antidepressants alter REM sleep, and there's ongoing debate about their efficacy. Depriving a depressed person of sleep can lead to resolution of depression symptoms, but it's not a sustainable solution. This effect might be due to sleep deprivation increasing reward sensitivity, helping depressed individuals move closer to a normal reward-based reactivity. However, as soon as they start sleeping again, the antidepressant benefit disappears. Furthermore, understanding an individual's response to sleep deprivation and their natural chronotype alignment is crucial for mental health management. Sleep is a low-cost, accessible option to help stabilize mental health, but it's essential to remember that not all psychiatric conditions are sleep disorders.

    Optimizing light exposure for mental health

    Maintaining a healthy circadian rhythm by matching your sleep and wake times to your chronotype, and optimizing your exposure to light and darkness throughout the day and night, can significantly improve mental health, particularly in relation to depression. A recent study published in Nature Mental Health supports this, finding a near linear relationship between the amount of light during the day and reduction in depression symptoms, as well as the importance of darkness at night. This means getting as much natural light as possible during the day and ensuring a dark environment at night can help improve mental health, even if daytime light exposure is not optimal. This is in line with conventional sleep optimization advice, which emphasizes the importance of darkness at night to help regulate sleep. By considering artificial light sources as "empty calories" at night and prioritizing natural light during the day, individuals can create an environment that supports overall feelings of well-being, improved sleep, and increased daytime wakefulness.

    The Importance of Sleep for Mental Health and Emotional Well-Being

    The quality, quantity, regularity, and timing of sleep are crucial factors for both mental health and emotional well-being. Exposure to natural sunlight during the day is ideal, but if not possible, bright artificial light is the next best alternative. However, binging on junk light at night can negatively impact sleep and mental health. Junk light refers to empty photons that can disrupt the body's natural circadian rhythm. It's essential to prioritize sleep hygiene and avoid using electronic devices before bedtime. Sleep plays a significant role in regulating emotions and mood, and poor sleep quality can lead to anxiety, depression, and other mental health issues. By understanding the importance of sleep and implementing good sleep habits, we can improve our overall well-being and emotional resilience. Remember, the goal is to prioritize quantity and quality of sleep, maintain a consistent sleep schedule, and avoid disrupting our circadian rhythm with excessive exposure to artificial light, especially at night.

    Stay informed about the latest sleep research

    Key takeaway from our discussion with Dr. Matthew Walker is the importance of prioritizing good sleep hygiene and understanding the science behind sleep for optimal health. To help you stay informed about the latest research in this area, we offer a free Neural Network newsletter. Subscribing to this newsletter provides you with podcast summaries and brief PDFs on various topics, including neuroplasticity, learning, sleep, and fitness protocols. You can access these resources by visiting hubermanlab.com, subscribing to the newsletter, and supplying your email address. Rest assured, your email will not be shared with anyone. By staying informed and implementing the science-backed practices discussed, you can significantly improve your sleep quality and overall well-being. So, join us in our pursuit of knowledge and subscribe to the Neural Network newsletter today.

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    Dr. Casey Means: Transform Your Health by Improving Metabolism, Hormone & Blood Sugar Regulation

    Dr. Casey Means: Transform Your Health by Improving Metabolism, Hormone & Blood Sugar Regulation
    In this episode, my guest is Dr. Casey Means, M.D., a physician trained at Stanford University School of Medicine, an expert on metabolic health and the author of the book, "Good Energy." We discuss how to leverage nutrition, exercise and environmental factors to enhance your metabolic health by improving mitochondrial function, hormone and blood sugar regulation.  We also explore how fasting, deliberate cold exposure and spending time in nature can impact metabolic health, how to control food cravings and how to assess your metabolic health using blood testing, continuous glucose monitors and other tools.  Metabolic dysfunction is a leading cause of chronic disease, obesity and reduced lifespan around the world. Conversely, improving your mitochondrial and metabolic health can positively affect your health span and longevity. Listeners of this episode will learn low- and zero-cost tools to improve their metabolic health, physical and mental well-being, body composition and target the root cause of various common diseases. For show notes, including referenced articles and additional resources, please visit hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Maui Nui Venison: https://mauinuivenison.com/huberman  Eight Sleep: https://eightsleep.com/huberman  AeroPress: https://aeropress.com/huberman  InsideTracker: https://insidetracker.com/huberman  Momentous: https://livemomentous.com/huberman Timestamps 00:00:00 Dr. Casey Means 00:02:18 Sponsors: Maui Nui, Eight Sleep & AeroPress 00:06:32 Metabolism, Metabolic Dysfunction, Medicinal Blindspot 00:14:17 Trifecta of Bad Energy 00:24:02 Western Living, United States, Specialization & Medicine 00:27:57 Insulin Resistance, Tool: Mitochondrial Capacity & Exercise 00:33:33 Sponsor: AG1 00:35:03 Tools: Walking & Glucose; Frequent Movement 00:44:25 Tools: Exercises to Improve Mitochondrial Capacity; Desk Treadmill 00:51:18 Soleus Push-Ups & Fidgeting, Non-Exercise Activity Thermogenesis (NEAT) 00:57:14 Sponsor: InsideTracker 00:58:21 Tool: Blood Test Biomarkers, Vital Signs & Mitochondrial Function 01:11:16 Navigate Medical System & Blood Tests, Consumer Lab Testing 01:16:46 Tool: Environmental Factors; Food, Life as a Process 01:21:58 Tool: Ultra-Processed vs. Real Food, Obesity, Soil & Micronutrients 01:32:03 Ultra-Processed Foods: Brain & Cellular Confusion 01:39:10 Tools: Control Cravings, GLP-1 Production, Microbiome Support 01:51:42 Ozempic, GLP-1 Analogs; Root Cause & Medicine 02:00:54 Tool: Deliberate Cold & Heat Exposure, Brown Fat 02:07:27 Tool: Intermittent Fasting & Metabolic Flexibility; Insulin Sensitivity 02:17:03 Tool: Continuous Glucose Monitors (CGMs) & Awareness, Glucose Spikes 02:24:34 Tool: CGMs, Glycemic Variability, Dawn Effect, Individuality 02:33:10 Sleep; Continuous Monitoring & Biomarkers 02:37:39 Mindset & Safety, Stress & Cell Danger Response 02:44:04 Tool: Being in Nature, Sunlight, Fear 02:54:44 Zero-Cost Support, Spotify & Apple Reviews, Sponsors, YouTube Feedback, Social Media, Neural Network Newsletter Disclaimer

    GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation

    GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation
    This is episode 5 of our 6-part special series on sleep with Dr. Matthew Walker, Ph.D., a professor of neuroscience and psychology at the University of California, Berkeley and the host of The Matt Walker Podcast. In this episode, we explain the connection between sleep and mood, emotional regulation and mental well-being.  We explain the role of rapid eye movement (REM) sleep in processing emotions and emotional memories and why sleep deprivation causes agitation, impulsivity and emotional reactivity.  We also discuss why sleep disruption is a hallmark feature of PTSD, anxiety, depression, suicidality, and other psychiatric conditions.  We explain protocols for improving REM sleep and other sleep phases in order to harness the therapeutic power of quality sleep to feel calmer and emotionally restored. This episode describes various actionable tools to improve sleep for those struggling with mental health or mood and those wanting to bolster their overall state and well-being.  The next episode in this special series explores dreams, including lucid dreaming, nightmares and dream interpretation. For show notes, including referenced articles and additional resources, please visit hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Eight Sleep: https://eightsleep.com/huberman LMNT: https://drinklmnt.com/huberman BetterHelp: https://betterhelp.com/huberman InsideTracker: https://insidetracker.com/huberman  Momentous: https://livemomentous.com/huberman Timestamps (00:00:00) Sleep & Mental Health (00:01:09) Sponsors: Eight Sleep, LMNT & BetterHelp (00:05:14) Emotions & Sleep, Amygdala (00:17:27) Emotional Memory & Sleep (00:25:48) “Overnight Therapy” & REM Sleep, Noradrenaline (00:29:13) Sponsor: AG1 (00:30:27) Sleep to “Remember & Forget”, Trauma; REM Sleep (00:38:27) Hinge Analogy; Motivation, Impulsivity & Addiction (00:47:08) Tool: Improve REM Sleep, Social Jet Lag, Alcohol & THC, Addiction (00:56:18) Sponsor: InsideTracker (00:57:23) Post-Traumatic Stress Disorder (PTSD) & REM Sleep (01:06:53) Noradrenaline & REM Sleep, PTSD & Prazosin (01:09:40) Addiction, Non-Sleep Deep Rest (NSDR); Liminal States (01:16:46) Anxiety & Sleep, Mood vs. Emotions (01:23:50) Deep Non-REM Sleep & Anxiety, Sleep Quality (01:28:51) Tool: Improve Deep Non-REM Sleep, Temperature; Alcohol (01:34:56) Suicidality & Sleep, Pattern Recognition; Nightmares (01:46:21) Depression, Anxiety & Time Context (01:51:24) Depression, Too Much Sleep?; REM Changes & Antidepressants (01:57:37) Sleep Deprivation & Depression (02:01:34) Tool: Circadian Misalignment & Mental Health, Chronotype (02:04:05) Tools: Daytime Light & Nighttime Darkness; “Junk Light” (02:13:04) Zero-Cost Support, Spotify & Apple Reviews, Sponsors, YouTube Feedback, Momentous, Social Media, Neural Network Newsletter Disclaimer

    AMA #17: Making Time for Fitness, Top Sleep Tools & Best Learning Strategies

    AMA #17: Making Time for Fitness, Top Sleep Tools & Best Learning Strategies
    Welcome to a preview of the 17th Ask Me Anything (AMA) episode, part of Huberman Lab Premium. Huberman Lab Premium was launched for two main reasons. First, it was launched in order to raise support for the main Huberman Lab podcast — which will continue to come out every Monday at zero-cost. Second, it was launched as a means to raise funds for important scientific research. A significant portion of proceeds from the Huberman Lab Premium subscription will fund human research (not animal models) selected by Dr. Huberman, with a dollar-for-dollar match from the Tiny Foundation. Read our Annual Letter 2023. If you're an existing Premium member, you can login to access the full episode. If you're not a member, you can join Huberman Lab Premium to enjoy exclusive content, including monthly Ask Me Anything (AMA) episodes, AMA transcripts, podcast episode transcripts, early access to live events and help advance human scientific research. Resources Foundational Fitness Protocol Timestamps (00:00:00) Introduction to AMA #17 (00:00:14) Exciting Announcement (00:02:16) Diving Into the Foundational Fitness Protocol (00:09:37) Flexibility in Your Fitness Routine (00:17:12) Optimizing Workout Times & Prioritizing Health (00:23:31) Closing Thoughts & Huberman Lab Premium Benefits In the full AMA episode, we discuss: Periodization & the Philosophy of Fitness Unlocking the Secrets of Sleep: Insights & Tools Chronotypes and Personalized Sleep Strategies The QQRT Formula: Quantity, Quality, Regularity & Timing of Sleep Exploring Naps & Non-Sleep Deep Rest (NSDR) Effective Learning & Note-Taking Strategies The Power of Teaching & Self-Testing in Learning Title Card Photo Credit: Mike Blabac Disclaimer

    Protocols to Strengthen & Pain Proof Your Back

    Protocols to Strengthen & Pain Proof Your Back
    In this episode, I explain how to strengthen and build a stable, pain-free back and how to reduce or eliminate existing back pain. I explain the anatomy and physiology of the spinal cord and vertebrae, intervertebral disks and nerve pathways, and the abdominal and back muscles that together can be leveraged to stabilize the back.  Then, I describe protocols: “McGill’s Big 3” exercises, a highly effective psoas stretch, abdominal stabilization, breathing techniques, and protocols to reinforce essential supports for the back, including the neck, pelvis, feet, and toes.  I also explain how you can reduce and potentially eliminate back pain and sciatica using a specific type of bar hang, “cobra push-ups,” medial-glute strengthening exercises, and more.  Back pain greatly impedes one’s ability to enjoy daily activities; this episode provides zero-cost, minimal time-investment protocols to improve your back strength and stability and allow you to move through life pain-free and with ease and mobility.  For show notes, including referenced articles and additional resources, please visit hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman AeroPress: https://aeropress.com/huberman Joovv: https://joovv.com/huberman Waking Up: https://wakingup.com/huberman Plunge: https://plunge.com/huberman Momentous: https://livemomentous.com/huberman Timestamps (00:00:00) Back Health (00:03:47) Sponsors: AeroPress, Joovv & Waking Up (00:07:57) Back Anatomy: Spine, Vertebrae, Spinal Cord (00:12:07) Spinal Cord & Nerves; Herniated Discs (00:19:50) Build Strong Pain-Free Back; Bulging Discs (00:24:26) Back Pain & Professional Evaluation; Tool: Spine Self-Assessment  (00:34:58) Sponsor: AG1 (00:36:29) Tool: McGill Big 3 Exercises, Curl-Up (00:44:40) Tool: McGill Big 3 Exercises, Side Plank (00:53:13) Tool: McGill Big 3 Exercises, Bird Dog; Back Pain (01:04:10) Sponsor: Plunge (01:05:37) Tool: Back Pain & Oreo Analogy, Bar Hang (01:10:34) Time & Back Pain; Tool: Reversing Disc Herniation, Cobra Push-Ups  (01:21:28) Sciatica, Referred Pain, Herniated Disc (01:24:21) Tool: Improve Spine Stability, Strengthen Neck (01:29:23) Tools: Strengthen Feet, Toe Spreading (01:34:35) Tools: Belly Breathing; Stagger Stance (01:42:03) Tools: Relieve Low Back Pain, Medial Glute Activation; Rolled Towel (01:50:59) Tool: Psoas Stretching (01:57:00) Tool: Back Awareness; Strengthen & Pain-Proof Back (02:05:49) Zero-Cost Support, Spotify & Apple Reviews, Sponsors, YouTube Feedback, Momentous, Social Media, Neural Network Newsletter Disclaimer

    GUEST SERIES | Dr. Matt Walker: Using Sleep to Improve Learning, Creativity & Memory

    GUEST SERIES | Dr. Matt Walker: Using Sleep to Improve Learning, Creativity & Memory
    This is episode 4 of a 6-part special series on sleep with Dr. Matthew Walker, Ph.D., a professor of neuroscience and psychology at the University of California, Berkeley, and author of the best-selling book "Why We Sleep." In this episode, we discuss the relationship between sleep, learning and creativity.  We explain why and how sleep before and after a learning bout can improve memory and performance for both cognitive tasks and physical skills. We also discuss how to use time learning and sleep, how to use naps, non-sleep deep rest states, and caffeine to optimize learning, and the mechanisms for sleep and memory consolidation.  We also explain the critical role that sleep plays in creativity and one's ability to discover novel solutions to challenges and problems.  This episode is filled with actionable information on using sleep to enhance skill learning and improve memory and creativity.  The next episode in this guest series explains how sleep benefits emotional regulation and mental health.  For show notes, including referenced articles and additional resources, please visit hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Helix Sleep: https://helixsleep.com/huberman  WHOOP: https://join.whoop.com/huberman  Waking Up: https://wakingup.com/huberman  InsideTracker: https://insidetracker.com/huberman  Momentous: https://livemomentous.com/huberman Timestamps (00:00:00) Sleep & Learning (00:00:59) Sponsors: Helix Sleep, Whoop & Waking Up (00:05:48) Learning, Memory & Sleep (00:09:32) Memory & Sleep, “All-Nighters”, Hippocampus (00:13:46) Naps & Learning Capacity (00:16:59) Early School Start Times, Performance & Accidents (00:26:38) Medical Residency & Sleep Deprivation (00:29:35) Sponsor: AG1 (00:30:49) Tool: Sleep Before Learning; Cramming Effect (00:35:09) Tools: Caffeine; Timing Peak Learning; “Second Wind” (00:44:25) Memory Consolidation in Sleep (00:55:07) Sleepwalking & Talking; REM-Sleep Behavioral Disorder (01:00:16) REM Sleep Paralysis, Alcohol, Stress (01:07:41) Sponsor: InsideTracker (01:08:46) Skills, Motor Learning & Sleep (01:17:03) Tool: Timing Sleep & Learning, Skill Enhancement (01:20:00) Naps; Specificity & Memory Consolidation, Sleep Spindles (01:27:21) Sleep, Motor Learning & Athletes; Automaticity (01:34:10) Can Learning Improve Sleep? (01:39:13) Tool: Exercise to Improve Sleep; Performance, Injury & Motivation (01:44:38) Pillars of Health; Dieting & Sleep Deprivation (01:49:35) Performance & Poor Sleep, Belief Effects, “Orthosomnia” (01:57:03) “Overnight Alchemy”, Sleep & Novel Memory Linking (02:05:58) Sleep & Creativity (02:11:09) Tools: Waking & Technology; Naps; “Sleep on a Problem” (02:20:51) Creative Insight & Sleep (02:26:18) Zero-Cost Support, Spotify & Apple Reviews, Sponsors, YouTube Feedback, Momentous, Social Media, Neural Network Newsletter Disclaimer

    Dr. Bonnie Halpern-Felsher: Vaping, Alcohol Use & Other Risky Youth Behaviors

    Dr. Bonnie Halpern-Felsher: Vaping, Alcohol Use & Other Risky Youth Behaviors
    In this episode, my guest is Dr. Bonnie Halpern-Felsher, PhD, FSAHM. She is a professor of pediatrics and adolescent medicine and a developmental psychologist at Stanford University School of Medicine. Dr. Halpern-Felsher is a world expert in adolescent decision-making and risk-taking behaviors. She explains the huge increase in vaping (e-cigarettes) by young people. She explains why vaping nicotine and cannabis is particularly dangerous to the developing brain. We discuss the rise in vaping addiction, the unique social pressures and social media influences faced by youth that make quitting challenging, and interventions to aid them in quitting or reducing use. We also discuss the role of technology and social media. And, the use of alcohol, nicotine pouches, fentanyl, and other risky behaviors that adolescents face now. This episode should interest parents, teachers, coaches, teens, and families. It covers the current youth substance use landscape and also covers resources and ways to quit these addictive behaviors.  For show notes, including referenced articles and additional resources, please visit hubermanlab.com. Use Ask Huberman Lab, our new AI-powered platform, for a summary, clips, and insights from this episode. Thank you to our sponsors AG1: https://drinkag1.com/huberman Eight Sleep: https://eightsleep.com/huberman  Mateina: https://drinkmateina.com/huberman  LMNT: https://drinklmnt.com/huberman  Waking Up: https://wakingup.com/huberman Momentous: https://livemomentous.com/huberman Timestamps (00:00:00) Dr. Bonnie Halpern-Felsher (00:01:40) Sponsors: Eight Sleep, Mateina & LMNT  (00:05:38) Adolescence (00:09:19) Household Conflict, Parents; Smart Phones (00:12:35) Smart Phones & Social Media (00:18:25) Vaping, E-Cigarettes, Nicotine & Cannabis (00:23:46) Adolescent Nicotine Use: Marketing, Flavors (00:30:41) Sponsor: AG1 (00:32:13) Nicotine Initiation, Freebase vs. Salt-Based Nicotine, Concentration (00:41:35) Addiction & Withdrawal; E-Cigarette Access (00:48:48) Vaping Health Hazards, Aldehydes, Flavors (00:56:32) Sponsor: Waking Up (00:57:48) “Just Say No”, Adolescent Defiance (01:04:21) Cannabis & Potency, Blunts, E-Cigarette Combinations (01:10:30) Psychosis, THC & Adolescence (01:14:11) Quitting Nicotine & Cannabis; Physical & Social Withdrawal Symptoms (01:23:05) Social Pressures, Quitting Vaping, Environment Concerns (01:30:08) Teen Activities, Social Media, Autonomy (01:36:28) Risky Behaviors, Alcohol, Driving, Sexual Behavior (01:43:27) International E-Cigarette Use, Regulation (01:46:10) Nicotine Pouches, Health Risks; Tolerance (01:53:25) Tools: Vaping Interventions, Decision Making, Harm Reduction (02:02:37) Fentanyl, Drug Testing, Recreational Drug Use (02:13:45) Tool: Organic Conversations & Risky Behavior (02:17:20) Long-Term Goals & Teens; Vaping, Pornography & Teens (02:24:08) Mental Health Crisis & Substance Use (02:29:11) Zero-Cost Support, Spotify & Apple Reviews, Sponsors, YouTube Feedback, Momentous, Social Media, Neural Network Newsletter Disclaimer

    LIVE EVENT Q&A: Dr. Andrew Huberman at the Sydney Opera House

    LIVE EVENT Q&A: Dr. Andrew Huberman at the Sydney Opera House
    Recently I had the pleasure of hosting a live event in Sydney, Australia. This event was part of a lecture series called The Brain Body Contract. My favorite part of the evening was the question and answer period, where I had the opportunity to answer questions from the attendees of each event. Included here is the Q&A from our event at the Sydney Opera House. Sign up to get notified about future events: https://www.hubermanlab.com/events Thank you to our sponsors AG1: https://drinkag1.com/huberman Eight Sleep: https://eightsleep.com/huberman Timestamps (00:00:00) Introduction (00:00:15) Live Event Recap: The Brain Body Contract (00:00:36) Sponsor: AG1 & Eight Sleep (00:02:50) The Power of Mindset on Stress (00:05:23) David Goggins: A Case Study in Resilience (00:09:59) Exploring Time Perception & Frame Rate (00:18:20) Jet Lag Protocol: Adjusting to New Time Zones (00:26:44) The Science of Neuroplasticity (00:26:49) The Transformative Power of Psychedelics (00:29:26) Exploring Psilocybin & MDMA: Personal Experiences & Insights (00:36:12) The Science of Sleep: How Temperature Affects It (00:39:38) Understanding Stress Response & Habituation (00:41:20) Personal Anecdotes (00:47:00) Finding Your Passion: Advice for the Youth (00:51:20) Closing Thoughts & Gratitude Disclaimer

    GUEST SERIES | Dr. Matt Walker: How to Structure Your Sleep, Use Naps & Time Caffeine

    GUEST SERIES | Dr. Matt Walker: How to Structure Your Sleep, Use Naps & Time Caffeine
    This is episode 3 of a 6-part special series on sleep with Dr. Matthew Walker, Ph.D., a professor of neuroscience and psychology at the University of California, Berkeley, and leading public educator about the role of sleep in health, disease and performance.  We explain how our sleep architecture changes as we age. We also cover how childhood development and aging affect sleep biology and needs. We also discuss whether polyphasic sleep (multiple short sleep periods) is beneficial.  Then, we discuss naps, including their positive benefits, individual variability, those who should not nap, and alternative rest states like non-sleep deep rest. Dr. Walker shares protocols to optimize nap duration, timing and effectiveness. We also explore the effects of caffeine on sleep and other health aspects, as well as the optimal timing for caffeine intake. This episode describes many actionable science-based tools for optimizing sleep, naps and caffeine use for better health and performance. The next episode in this special series explores the relationship between sleep, memory, and creativity. For show notes, including referenced articles and additional resources, please visit hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman BetterHelp: https://betterhelp.com/huberman LMNT: https://drinklmnt.com/huberman Waking Up: https://wakingup.com/huberman Eight Sleep: https://eightsleep.com/huberman Momentous: https://livemomentous.com/huberman Timestamps (00:00:00) Sleep Structure (00:01:29) Sponsors: BetterHelp, LMNT & Waking Up (00:05:42) Sleep Phases & Lifespan (00:11:58) Sleep Stages & Lifespan, Sleep Paralysis & Animals (00:20:19) Adults & Biphasic Sleep, Modern Society (00:25:14) Chronotype, Circadian Rhythms & Biological Flexibility (00:29:07) Genetics & Chronotype (00:31:42) Sponsor: AG1 (00:32:55) Biphasic Sleep, Adults; Body Position & Sleepiness (00:40:09) Naps, Positive Benefits, Nighttime Insomnia (00:49:38) Tool: Optimal Nap: Duration & Timing; Grogginess (00:58:15) Nap Capacity, “Liminal” States & NSDR (01:07:37) NASA Nap Culture, Power Naps (01:11:49) Sponsor: Eight Sleep (01:12:50) Tools: Nap Timing, “Fragile” Nighttime Sleep; On-Off-On Protocol (01:18:57) Avoiding Naps: Insomnia, Aging & Sleep Quality Decline (01:28:20) Caffeine, “Nappuccino”; Hot Drinks (01:38:28) Adenosine Clearance, Sleep  (01:43:10) Tool: Delaying Caffeine, Afternoon Crash, Sleep Quality (01:49:06) Caffeine, Health, Antioxidants; Caffeine Tolerance & Alcohol (01:56:54) Tool: Nap “Enhancements”, Caffeine, Light & Face Washing (02:04:33) Polyphasic Sleep, Adverse Effects (02:12:43) Sleep Deprivation & Car Crashes; Polyphasic Sleep (02:16:49) Zero-Cost Support, Spotify & Apple Reviews, Sponsors, YouTube Feedback, Momentous, Social Media, Neural Network Newsletter Disclaimer