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    Dr. Robert Sapolsky: Science of Stress, Testosterone & Free Will

    enAugust 30, 2021

    Podcast Summary

    • The Impact of Stress on Biology and PsychologyShort-term stress can provide mental stimulation, while chronic stress leads to negative health effects. Maintaining optimal stress levels through hydration and electrolyte balance can help optimize bodily and brain function. Being aware of the biological and psychological effects of stress can help us optimize our performance.

      Short-term stress can have beneficial effects, such as heightened mental acuity and focus, while chronic stress leads to negative health consequences. The optimal level of stress provides stimulation, and too little or too much stress leads to boredom or stress, respectively. The biology underlying valence is related to heart rate, breathing, muscle usage, and amygdala activation. Electrolytes and hydration play a key role in optimizing bodily function, including brain function. Understanding the impact of stress on our biology and psychology can help us leverage scientific mechanisms to be our best selves.

    • Understanding the Complex Relationship Between Testosterone and AggressionTestosterone does not cause aggression but can amplify preexisting patterns of behavior. It's more of a response than a cause and is influenced by social circumstances.

      Testosterone does not cause aggression, but rather lowers the threshold for aggression to occur more easily. It amplifies preexisting patterns of aggression and social learning. The amygdala is not suddenly stimulated by testosterone to promote fear and aggression, but rather increases the rate of neuronal firing and shortens after hyperpolarization. Testosterone levels may be correlated to status within a hierarchy, but individual differences do not matter much. Sexual and aggressive behavior can actually increase testosterone levels, which means that testosterone is more of a response than a cause. It is important to understand how social circumstances affect testosterone levels before making any conclusions about its effects on behavior.

    • The role of testosterone in sexual behavior and aggression is complex and multifaceted.While testosterone does impact the development of neural circuits responsible for initiating sexual behavior, prior history of behavior plays a role in continuing these behaviors even without testosterone. Additionally, the effects of hormones on the brain and other glands are difficult to define in a single sentence.

      Testosterone is not the sole cause of sexual behavior and aggression as the brain is not very sensitive to fluctuations in testosterone levels. Prior history of sexual behavior and aggression plays a role in continuing these behaviors even without testosterone. However, during fetal development, testosterone has a significant impact on the development of neural circuits responsible for initiating sexual behavior. The second to fourth digit ratio in hands is a predictor of subtle behavioral differences in adulthood based on prenatal testosterone exposure. Testosterone has a similar effect on both males and females, but at a much lower level in females. Therefore, one should not overemphasize the importance of androgens in females. Hormones have various effects on the brain and other glands, making it challenging to define them in a single sentence.

    • The Role of Testosterone in Human Health and BehaviorTestosterone affects neural circuits, aggression, and confidence, and can make people more likely to do behaviors needed to maintain their status. It can also influence economic gameplay and alter risk assessment. Testosterone replacement can increase energy, alertness, motivation, and rareness.

      Testosterone is a misunderstood molecule in human health that can influence neural circuits, libido, aggression, and confidence. Testosterone is secreted when one's status is being challenged and makes it more likely that you'll do the behaviors needed to hold onto your status. Testosterone can boost and elevate the status that is handed out in different ways, such as being generous and trustworthy in economic gameplay. Testosterone also makes people cocky and impulsive, altering risk assessment and playing a big role in miscalculations. Testosterone and dopamine are close cousins in the brain and are both involved in motivation and goal-directed behavior needed to get rewards. Testosterone replacement can increase energy, rareness, alertness, and motivation.

    • The Complex Roles of Hormones in the BodyTestosterone and estrogen have different effects on cognition and health, and natural levels must be maintained. Replacement therapy should only be considered after consulting with a physician, as it may have negative consequences. Caution is advised.

      Both testosterone and estrogen play a crucial role in the human body, and their effects depend on the context. Testosterone can have immediate activating effects on the body, but too much can negatively impact cognition and health. Meanwhile, estrogen can enhance cognition, protect against dementia and cardiovascular disease, and stimulate neurogenesis in the hippocampus. However, postmenopausal estrogen replacement therapy can have negative effects on health due to shifts in estrogen receptor patterns. Therefore, it is important to maintain physiological levels of hormones and to talk to a physician before considering replacement therapy. The effects of these hormones on the body are complex and context-dependent, and it's important to proceed with caution.

    • Hormones, environment and stress: The complex impacts on healthUnderstanding and managing stress is crucial for overall health, while environmental factors such as endocrine disruptors can also impact hormonal health. It's important to interpret stress correctly and mitigate it effectively to avoid harm.

      Understanding the complexities and effects of hormones, such as estrogen and testosterone, on health is challenging due to the various types and ratios that exist. Endocrine disruptors in the environment can impact sperm and hormone levels, but the extent and effects of these are still being studied. Stress mitigation can have significant impacts on health, but forcing oneself to mitigate stress can be just as harmful as severe stress itself. The interpretation of stress plays a critical role in its effects on the body, with ambiguous social interactions and other gray zones being major sources of stress for some individuals. Overall, the literature suggests that managing stress is necessary for maintaining overall health.

    • Managing Stress: The Importance of ContextA sense of control and predictability can be helpful in managing mild to moderate stressors, but may be harmful when facing major stressors such as terminal illness or refugee crisis. It is important to distinguish between helpful and damaging outlets for frustration, and to seek real social support. Managing stress is not simple and takes work to do it right.

      A sense of control and predictability makes stressors less stressful. However, this only works for mild to moderate stressors and for situations with a positive outcome. Arbitrary sense of control in the face of major stressors can lead to a false sense of self-deception. Outlets for frustration and social support are also protective factors against stress, but it is important to distinguish between damaging outlets and real social support. It is not simple to mitigate stress and it takes work to do it right. Stress management techniques of control and predictability can be far worse than neutral for people going through a real hell such as terminal illness, homelessness, or refugee crisis.

    • Taking Charge of Stress Management: Finding Your Own PathStress mitigation is a personal journey that requires self-initiative. Find a stress management technique you enjoy and make time for it daily. Prioritizing wellbeing and mindfulness can lead to positive outcomes and motivation for further action. Trust yourself to choose the best method for your unique physiology.

      Stress mitigation has no single solution. One must choose a method they enjoy, make time for it daily, and not trust anyone claiming a specific technique is scientifically proven. Entry points into the autonomic nervous system and stress system are numerous, and it's the one that an individual selects that will work best for them in terms of physiology. Making space for stress management and prioritizing one's wellbeing can have positive outcomes and activate motivation for further action. It's also crucial to be mindful of the effects that the perception of events has on brain circuitry and biological responses. Ultimately, stress mitigation requires self-initiative and action that works for the individual.

    • The Power of the Prefrontal Cortex in Our Perception and RealityOur prefrontal cortex plays a crucial role in our perception of the world and our ability to adapt to stressful situations, allowing us to navigate complex social contexts and morality. Its influence can be contradictory and vary from person to person.

      The prefrontal cortex is the thinking machinery that is the most interesting and powerful area of the brain. It is what powers the perception of things and can influence the reality of what is coming into our lives. The prefrontal cortex deals with social context, moral relativity, and situational ethics. It is responsible for cognitive flexibility, and we can tell ourselves that something is good for us even if we are not enjoying it. The individual differences in stress and stimulatory amounts are huge, and it accommodates the fact that not all people have the same stress tolerances. The prefrontal cortex is the area of the brain where we can draw contextual information for fear or love responses, and its varied influence can be mutually contradictory.

    • The Intersection of Human Psychology and Social MediaOur ability to participate in multiple hierarchies can be manipulated by social media, which affects our sense of self and use of primitive systems in modern-day psychology.

      Humans have the ability to select multiple hierarchies to participate in, which helps play psychological games and is important in excusing ourselves from bad things. Social media has expanded our prefrontal cortex and our sense of where we exist in multiple hierarchies into infinity, which interacts with our primitive systems and other aspects of biology. We tend to use the exact same blueprint, hormones and receptors to abstract stuff over space and time. We can do it by feeling inadequate compared to a movie character or a person driving an expensive car. Therefore, we can use the same primitive systems for modern-day problems and psychology.

    • Balancing Technology Use and Nature Time for Personal EmpowermentOur behaviors and choices are influenced by genetics, environment, and culture. But awareness of these factors empowers us to make positive changes. Prioritizing nature time and limiting technology use can enhance creativity.

      Our social networks, including social media, can influence how we feel about ourselves. Choosing to limit exposure to technology and spending time in nature without distractions can enhance creativity and insight. The concept of free will is debated, with some arguing that our behaviors and choices are the result of intertwined genetic, environmental, and cultural factors. However, recognizing these influences can empower individuals to make positive changes in their lives. While change is possible, it is important to understand the complex factors that contribute to our behavior and choices.

    • Change is Possible with Knowledge and CircumstancesDespite our limited control over our actions, knowledge and circumstances can still be powerful tools for growth and change, leading to a more optimistic and motivated outlook towards being better human beings.

      Change is possible despite our mechanistic neurobiology, as we can be changed by circumstances, and knowledge itself can be a powerful tool to reshape our brain circuits. Understanding that change is possible can lead to a more optimistic and motivated outlook, enabling us to strive towards being better human beings. The concept of free will is complex and controversial, but science suggests that our control over our actions is much less than we think. Despite this, knowledge can still be a powerful tool for growth and change, and we should embrace it as such. So, don't give up on trying to change because you think you can't. Circumstances can change, and so can we.

    • The Illusion of Free Will and its ConsequencesDr. Sapolsky's argument for limited free will challenges traditional beliefs, but acknowledging this reality can lead to a more compassionate and just society, as past examples have shown.

      Dr. Robert Sapolsky argues that there is much less free will than people typically think, and that the belief in free will can be problematic in areas where it doesn't make sense. While it may be challenging to function with the belief that free will is an illusion, we have subtracted agency from realms of blame before, such as the historical belief that witches caused hailstorms. Sapolsky cautions that grappling with the concept of no free will will be a difficult process, but it is possible, and it has led to a more humane society in the past. His upcoming book, Determined for the Science of Life without Free Will, explores this topic further.

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    I'm honored to share Episode 2 of the first season of Perform with Dr. Andy Galpin. Dr. Andy Galpin is a tenured full professor at California State University, Fullerton, where he co-directs the Center for Sport Performance and leads the Biochemistry and Molecular Exercise Physiology Laboratory. Andy is both a friend and a colleague, and I'm delighted to have assisted in the creation of this podcast. I'm certain you'll both enjoy and learn from it. Season 1 features 10 episodes, airing every Wednesday for 10 weeks. Dr. Galpin will cover everything from building strength, the importance of strength for long-term health, the science of breathing, the benefits of sleep extension, genetic testing for personalized training, and nutrition for injury recovery. While we have Episode 2 of Perform with Dr. Andy Galpin here, please be sure to subscribe and follow Perform with Dr. Andy Galpin on your preferred platform. Show notes for this episode can be found at performpodcast.com. Timestamps 00:00:00 Introduction from Dr. Andrew Huberman 00:01:06 Skeletal Muscle 00:04:06 Sponsors: Absolute Rest & Momentous 00:07:20 Quantity & Quality; Organ System; Health & Performance 00:12:58 Plasticity, “Look Good, Feel Good, Play Good”; Muscle Types 00:15:46 What is Muscle?, Muscle Fibers, Tendon 00:21:37 Muscle Fiber Number, Hyperplasia, Anabolic Steroids, Age 00:24:03 Myonuclei & Adaptability 00:26:27 Muscle Fiber Types, Variable Muscle Functions 00:32:24 Fiber Type & Lifestyle Factors 00:34:54 Sponsors: David Protein & AG1 00:37:37 Age & Muscle Loss, Slow vs. Fast-Twitch Fibers; Motor Units 00:46:36 Muscle Size vs. Muscle Strength, Quantity vs. Quality 00:50:56 Investigate: Muscle Quantity, Fat-Free Mass Index (FFMI) 00:56:21 FFMI, Elite Athletes, Muscle Mass 01:00:59 Muscle Asymmetry; Too Much Muscle Possible? 01:03:49 Interpret: Muscle Mass, FFMI Calculations & Percentiles 01:09:28 Tool: Intervene - Increase Muscle Mass, 72-Hour Rule 01:15:27 Sponsors: Maui Nui & Renaissance Periodization 01:17:51 Investigate: Muscle Quality & 4 Movement Principles 01:23:34 Muscle Quality & 3 Performance Principles  01:26:42 Interpret: Muscle Speed, Age 01:32:45 Muscle Power, Vertical Jump, Broad Jump 01:36:17 Muscle Strength, Powerlifting Elite, Bench Press, Leg Press, Grip Strength 01:44:05 Increasing Strength, Improve Health & Longevity 01:46:44 Tool: Intervene - Improve Muscle Quality, 4 Training Principles, 3-to-5 Rule 01:53:56 Zero-Cost Support, YouTube, Spotify & Apple Subscribe & Reviews, Sponsors, YouTube Feedback, Social Media 01:56:10 Conclusion from Dr. Andrew Huberman Disclaimer
    Huberman Lab
    enJune 19, 2024

    Dr. Zachary Knight: The Science of Hunger & Medications to Combat Obesity

    Dr. Zachary Knight: The Science of Hunger & Medications to Combat Obesity
    In this episode, my guest is Dr. Zachary Knight, Ph.D., a professor of physiology at the University of California, San Francisco (UCSF), and Howard Hughes Medical Institute (HHMI) investigator. We discuss how the brain controls our sense of hunger, satiety, and thirst. He explains how dopamine levels impact our cravings and eating behavior (amount, food choices, etc) and how we develop and can change our food preferences and adjust how much we need to eat to feel satisfied. We discuss factors that have led to the recent rise in obesity, such as interactions between our genes and the environment and the role of processed foods and food combinations. We also discuss the new class of medications developed for the treatment of obesity and diabetes, including the GLP-1 agonists semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro). We discuss how these medications work to promote weight loss, the source of their side effects, and the newer compounds soon to overcome some of those side effects, such as muscle loss. Dr. Knight provides an exceptionally clear explanation for our sense of hunger, thirst, and food cravings that translates to practical knowledge to help listeners better understand their relationship to food, food choices, and meal size to improve their diet and overall health. For show notes, including referenced articles and additional resources, please visit hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman  BetterHelp: https://betterhelp.com/huberman Eight Sleep: https://eightsleep.com/huberman Waking Up: https://wakingup.com/huberman LMNT: https://drinklmnt.com/huberman Timestamps 00:00:00 Dr. Zachary Knight 00:02:38 Sponsors: BetterHelp, Helix Sleep & Waking Up 00:07:07 Hunger & Timescales 00:11:28 Body Fat, Leptin, Hunger 00:17:51 Leptin Resistance & Obesity 00:20:52 Hunger, Food Foraging & Feeding Behaviors, AgRP Neurons 00:30:26 Sponsor: AG1 00:32:15 Body Weight & Obesity, Genes & POMC Neurons 00:39:54 Obesity, Genetics & Environmental Factors 00:46:05 Whole Foods, Ultra-Processed Foods & Palatability 00:49:32 Increasing Whole Food Consumption, Sensory Specific Satiety & Learning 00:58:55 Calories vs. Macronutrients, Protein & Salt 01:02:23 Sponsor: LMNT 01:03:58 Challenges of Weight Loss: Hunger & Energy Expenditure 01:09:50 GLP-1 Drug Development, Semaglutide, Ozempic, Wegovy 01:19:03 GLP-1 Drugs: Muscle Loss, Appetite Reduction, Nausea 01:23:24 Pharmacologic & Physiologic Effects; GLP-1 Drugs, Additional Positive Effects 01:30:14 GLP-1-Plus Development, Tirzepatide, Mounjaro, AMG 133 01:34:49 Alpha-MSH & Pharmacology 01:40:41 Dopamine, Eating & Context 01:46:01 Dopamine & Learning, Water Content & Food 01:53:23 Salt, Water & Thirst 02:03:27 Hunger vs. Thirst 02:05:46 Dieting, Nutrition & Mindset 02:09:39 Tools: Improving Diet & Limiting Food Intake 02:14:15 Anti-Obesity Drug Development 02:17:03 Zero-Cost Support, Spotify & Apple Follow & Reviews, YouTube Feedback, Social Media, Neural Network Newsletter Disclaimer
    Huberman Lab
    enJune 17, 2024

    Perform with Dr. Andy Galpin: How & Why to Strengthen Your Heart & Cardiovascular Fitness

    Perform with Dr. Andy Galpin: How & Why to Strengthen Your Heart & Cardiovascular Fitness
    I'm honored to share the first episode of the new podcast, Perform with Dr. Andy Galpin. Dr. Andy Galpin is a tenured full professor at California State University, Fullerton, where he co-directs the Center for Sport Performance and leads the Biochemistry and Molecular Exercise Physiology Laboratory. Andy is both a friend and a colleague, and I’m delighted to have assisted in the creation of this podcast. I'm certain you'll both enjoy and learn from it. Season 1 features 10 episodes, airing every Wednesday for 10 weeks. Dr. Galpin will cover everything from building strength, the importance of strength for long-term health, the science of breathing, the benefits of sleep extension, genetic testing for personalized training, and nutrition for injury recovery. While we have Episode 1 of Perform with Dr. Andy Galpin here, please be sure to subscribe and follow Perform with Dr. Andy Galpin on your preferred platform. Show notes for this episode can be found at performpodcast.com. Timestamps 00:00:00 Introduction from Dr. Andrew Huberman 00:01:07 Heart 00:03:55 Sponsors: Vitality Blueprint & Rhone 00:07:27 Muscle Types 00:09:54 VO2 max, Health & Mortality 00:15:49 Overall Health, Cardiorespiratory Fitness & All-Cause Mortality 00:25:23 Sponsor: AG1 00:26:54 Disease, Health & Mortality 00:30:02 Cardiac Muscle & Heart 00:38:29 Cardiac Muscle vs. Skeletal Muscle, Cardiac Advantages 00:43:53 Pacemakers & Heart Rate, Vagus Nerve 00:50:35 Why Doesn’t the Heart Get Sore? 00:54:32 Heart & Exercise, Stroke Volume, Ejection Fraction, Cardiac Output 00:59:21 Heart Rate Variability 01:02:41 Sponsors: Momentous & LMNT 01:06:54 Why Do You Breathe?: Oxygen, Carbon Dioxide & Respiratory Rate 01:13:37 Respiratory Rate & Stress 01:15:08 Tool: The “Three I’s”, Investigate: Heart Rate, Respiratory Rate, VO2 Max 01:19:53 Tool: Interpretation, Resting Heart Rate & Ranges 01:23:16 Tool: Interpretation: VO2 Max & Ranges 01:30:45 Athletes & Highest VO2 Max Scores 01:35:53 Elite Athletes & Context for VO2 Max Scores 01:41:42 Tool: Intervention, VO2 Max, Varying Exercise Intensities, SAID Principle 01:48:20 Tool: Varying Exercise Intensity; Intervals & Continuous Training; Frequency 01:58:18 Zero-Cost Support, YouTube, Spotify & Apple Subscribe & Reviews, Sponsors, YouTube Feedback, Social Media 01:59:55 Conclusion from Dr. Andrew Huberman Disclaimer
    Huberman Lab
    enJune 12, 2024

    Dr. Jonathan Haidt: How Smartphones & Social Media Impact Mental Health & the Realistic Solutions

    Dr. Jonathan Haidt: How Smartphones & Social Media Impact Mental Health & the Realistic Solutions
    In this episode, my guest is Dr. Jonathan Haidt, Ph.D., professor of social psychology at New York University and bestselling author on how technology and culture impact the psychology and health of kids, teens, and adults. We discuss the dramatic rise of suicide, depression, and anxiety as a result of replacing a play-based childhood with smartphones, social media, and video games. He explains how a screen-filled childhood leads to challenges in psychological development that negatively impact learning, resilience, identity, cooperation, and conflict resolution — all of which are crucial skills for future adult relationships and career success. We also discuss how phones and social media impact boys and girls differently and the underlying neurobiological mechanisms of how smartphones alter basic brain plasticity and function.  Dr. Haidt explains his four recommendations for healthier smartphone use in kids, and we discuss how to restore childhood independence and play in the current generation.  This is an important topic for everyone, young or old, parents and teachers, students and families, to be aware of in order to understand the potential mental health toll of smartphone use and to apply tools to foster skill-building and reestablish healthy norms for our kids. For show notes, including referenced articles and additional resources, please visit hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman  Helix Sleep: https://helixsleep.com/huberman AeroPress: https://aeropress.com/huberman Joovv: https://joovv.com/huberman LMNT: https://drinklmnt.com/huberman Timestamps 00:00:00 Dr. Jonathan Haidt 00:02:01 Sponsors: Helix Sleep, AeroPress & Joovv 00:06:23 Great Rewiring of Childhood: Technology, Smartphones & Social Media 00:12:48 Mental Health Trends: Boys, Girls & Smartphones 00:16:26 Smartphone Usage, Play-Based to Phone-Based Childhood 00:20:40 The Tragedy of Losing Play-Based Childhood 00:28:13 Sponsor: AG1 00:30:02 Girls vs. Boys, Interests & Trapping Kids 00:37:31 “Effectance,” Systems & Relationships, Animals 00:41:47 Boys Sexual Development, Dopamine Reinforcement & Pornography 00:49:19 Boys, Courtship, Chivalry & Technology; Gen Z Development 00:55:24 Play & Low-Stakes Mistakes, Video Games & Social Media, Conflict Resolution 00:59:48 Sponsor: LMNT 01:01:23 Social Media, Trolls, Performance 01:06:47 Dynamic Subordination, Hierarchy, Boys 01:10:15 Girls & Perfectionism, Social Media & Performance 01:14:00 Phone-Based Childhood & Brain Development, Critical Periods 01:21:15 Puberty & Sensitive Periods, Culture & Identity 01:23:55 Brain Development & Puberty; Identity; Social Media, Learning & Reward 01:33:37 Tool: 4 Recommendations for Smartphone Use in Kids 01:41:48 Changing Childhood Norms, Policies & Legislature 01:49:13 Summer Camp, Team Sports, Religion, Music 01:54:36 Boredom, Addiction & Smartphones; Tool: “Awe Walks” 02:03:14 Casino Analogy & Ceding Childhood; Social Media Content 02:09:33 Adult Behavior; Tool: Meals & Phones 02:11:45 Regaining Childhood Independence; Tool: Family Groups & Phones 02:16:09 Screens & Future Optimism, Collective Action, KOSA Bill 02:24:52 Zero-Cost Support, Spotify & Apple Reviews, YouTube Feedback, Social Media, Neural Network Newsletter Disclaimer
    Huberman Lab
    enJune 10, 2024

    LIVE EVENT Q&A: Dr. Andrew Huberman at the Brisbane Convention & Exhibition Centre

    LIVE EVENT Q&A: Dr. Andrew Huberman at the Brisbane Convention & Exhibition Centre
    Recently I had the pleasure of hosting a live event in Brisbane, Australia. This event was part of a lecture series called The Brain Body Contract. My favorite part of the evening was the question and answer period, where I had the opportunity to answer questions from the attendees of each event. Included here is the Q&A from our event at the Brisbane Convention & Exhibition Centre. Sign up to get notified about future events: https://www.hubermanlab.com/events Thank you to our sponsors AG1: https://drinkag1.com/huberman Eight Sleep: https://eightsleep.com/huberman Resources Mentioned Huberman Lab Non-Sleep Deep Rest Protocols Huberman Lab Guest Series with Dr. Matt Walker Huberman Lab Guest Series with Dr. Paul Conti Huberman Lab Guest Series with Dr. Andy Galpin Dr. Becky Kennedy: Protocols for Excellent Parenting & Improving Relationships of All Kinds Perform with Dr. Andy Galpin Timestamps 00:00 Introduction 00:31 Sponsors: AG1 & Eight Sleep 03:48 Nicotine Discussion 07:42 ADHD Management: Tools & Medications 12:43 Sleep Deprivation & Recovery 18:54 Understanding & Addressing Burnout 22:12 Daily Nutrition & Eating Habits 24:40 Understanding Food & Neural Pathways 26:21 The Benefits of Elimination Diets 27:21 Intermittent Fasting & Personal Diet Choices 28:23 Top Health & Fitness Recommendations 30:50 The Value of Non-Sleep Deep Rest (NSDR) 33:08 Testosterone Replacement Therapy Insights 38:02 Breathing Techniques for Stress & Focus 41:46 Morning Sunlight & Circadian Rhythms 43:18 Parenting Tips for a Healthy Start 49:03 Final Thoughts & Gratitude Disclaimer
    Huberman Lab
    enJune 07, 2024

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