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    Dr. Craig Heller: Using Temperature To Optimize Performance, Brain & Body Health

    enOctober 04, 2021

    Podcast Summary

    • The Key to Mental and Physical Performance: Controlling Your Core Body TemperatureLearn how your body maintains homeostasis through thermal regulation and cool down effectively through specialized vascular compartments on your palms, soles, and upper face. Skip the ice bath and opt for a cold shower for better physiological and performance benefits.

      Learning to control your core body temperature can greatly increase both mental and physical performance, regardless of the environment that you're in. Dr. Craig Heller explains how thermal regulation works in the body to maintain homeostasis for healthy neurons and organ function. Contrary to popular belief, putting a cold pack on your head or neck is not the optimal way to cool down quickly and can actually lead to hyperthermia. Instead, specialized vascular compartments on the palms, soles, and upper face are the primary avenues for heat loss. While whole body immersion in cold water like an ice bath may provide a shock of adrenaline, it does not necessarily translate into any physiological or performance benefits compared to a cold shower.

    • Benefits of Taking a Cold Shower or Bath before ExerciseA quick cold shower or bath before working out regulates the body temperature, sustains performance, and can increase speed or distance, but should be used appropriately to achieve optimal results.

      Taking a cold shower or bath before aerobic activity helps increase the body's capacity to absorb excess heat. This helps sustain the performance and increase speed or distance of the workout. It only takes a few minutes to extract the heat from the body and the core temperature goes down, preventing heat loss. For anaerobic athletes like strength trainers, the temperature increase is local, and the body's core temperature does not rise as fast. Taking a cold shower or bath is beneficial for regulating body temperature and improving athletic performance, but its benefits depend on how one uses it. It could increase speed or distance, but some athletes use it to go faster, not necessarily further.

    • The Impact of Muscle Temperature on FatigueHigh muscle temperature can lead to fatigue and muscle failure, and traditional cooling methods may not be effective in preventing hyperthermia. Even non-targeted muscles can be influenced by the rise in temperature.

      Muscles produce heat during anaerobic activity and can reach hyperthermic limits, which can lead to muscle fatigue. The rise in temperature of the muscle is the most immediate factor that causes muscle fatigue. When the muscle temperature gets above 39 or 39 and five, it can shut off the enzyme required for fuel delivery and supply to the mitochondria, leading to muscular failure. Although muscles have fail-safe mechanisms to ensure hyperthermia doesn't occur, cooling off quadriceps by throwing a nice, cool towel on them isn't an effective strategy. Also, the biceps may not be the direct focal point, but they will still experience a fatigue curve influenced by the rise in temperature generated by lower body exercises.

    • The Science of Cooling the BodyWhile remedies like ice water or a neck towel may provide temporary relief from overheating, they do not fully cool the body. The thermoregulatory system of the body is complex and requires regulating temperature through the entire body surface.

      The skin, fascia, and muscles under the surface of our body act as insulators and prevent heat from escaping. Drinking ice water or using an ice pack on the back of the neck can provide temporary relief from overheating, but they do not have the full capacity to cool our body. Our thermoregulatory system works like a thermostat, and the pre optic interior hypothalamus in our brain serves as the thermostat, which requires input from our overall body surface to regulate temperature. Cooling the torso with an ice vest constricts heat loss portals and impairs heat loss rate. Putting a cold towel on the neck can protect the brain, but it could trick us into thinking that we have cooled off, whereas the brain could cook due to excessive hot blood flow from the body.

    • The Role of Temperature on Cognitive Capacity and Body FunctioningRising temperature can decrease cognitive capacity and lead to dangerous hyperthermic temperature. The body has portals that can be leveraged for performance, but it's important to recognize and prevent heat stroke during physical activity.

      Rising temperature decreases cognitive capacity and can lead to dangerous hyperthermic temperature. The brain receives thermal afferent information from the whole body and integrates the representation of body temperature. There are portals located in the hairless skin that can be leveraged for performance. These portals are in the pads of feet, upper part of the face for primates, portions of the ears for rabbits, inner surfaces for bears, and the tongue. When individuals transition into heat stroke, they feel exhausted, miserable and experience high heart rate. Heat stroke can occur during practice due to motivation to push.

    • The Science of Heat Loss in Mammals and Human PerformanceMale mammals use limited surface areas without fur to lose heat. Proper cooling of skin surfaces can improve human performance during exercise. Wearing thin protectors on hands and feet can maximize heat loss.

      Male mammals have evolved special blood vessels in limited surface areas without fur to lose heat, which are shunts between the arteries and veins. These shunts enable the blood to bypass tiny capillaries and flow directly from arteries to veins. In the skin, these vessels are located below the epidermis and are absent in the backs of the hands. Gloves and thick socks impede heat loss and hinder performance during exercise. To maximize heat loss, it is recommended to wear thin protectors on hands and feet. Proper cooling of glamour skin surfaces can improve human performance during exercise. Cooling upper half of the face improves endurance and pouring water on the head can increase cognitive performance.

    • The Brain-Cooling Mechanism above the Beard Line and Its BenefitsCooling the brain through the non-hairy skin above the beard line can decrease inflammation and blood flow, benefiting athletes during anaerobic exercises and potentially offsetting physical damage. However, the mechanism still requires more investigation.

      Cooling the brain through the non-hairy skin above the beard line is one of the natural mechanisms for decreasing inflammation and blood flow. Athletes can benefit from cooling during anaerobic exercises like dips, increasing their capacity to do more reps by decreasing swelling. The blood vessels that cool the brain can also be used to offset physical damage, but it is still a controversial topic. Through the skull, the blood flows in a strange way, and these blood vessels are primarily thought to be ways that blood is leaving the brain. These discoveries need more investigation.

    • The Benefits of Hand Cooling for Athletes' WorkoutsCooling the palms for three minutes can enhance workout performance and reduce muscle soreness, allowing for more workouts. Cooling technology can be a game-changer for athletes looking to improve their workout performance and reduce recovery times.

      Cooling the palms of the hands for three minutes can significantly improve an athlete's workout performance. It can reduce the occurrence of delayed onset muscle soreness, allowing for more workouts between recovery periods. This was demonstrated through an athlete who doubled his work volume and tripled what he could do after standardizing intervals for resting and cooling. Cooling technology can enhance performance in various activities, including push-ups, bench presses, and endurance work. The technology is not yet portable, but was utilized by special ops soldiers who experienced its benefits. Overall, cooling technology can be a game-changer for athletes seeking to improve their workout performance and reduce recovery times.

    • CoolMitt technology improves endurance and mobility in various situationsTyroBio's CoolMitt technology enhances performance and is in beta testing with professional sports teams and the military. The wearable device fits under personal protective gear, making it useful for workers in high-temperature environments. Sign up for alerts on the company's website.

      Cooling technology developed by TyroBio, called CoolMitt, has been shown to improve endurance and mobility in a variety of situations, including multiple sclerosis patients playing golf, athletes in hot environments, and military special operators. The technology is currently in beta testing with professional sports teams and the military, but the company plans to eventually make it available to the general public. Although there have been many positive studies of the technology over the years, there hasn't been a clear pathway for getting it out to consumers. The development of wearable devices, which can fit under personal protective gear, has been particularly useful for military and medical workers facing high temperatures. While the technology is not currently available for purchase, interested individuals can sign up on the company's website to be alerted when the product becomes available.

    • CoolBot Technology: Enhancing Performance by Cooling the Body through the HandsThe CoolBot is a technology that cools the body temperature through the hands, enhancing performance. Even individuals can use a crude version with a frozen packet or juice can, taking care not to seal up heat loss or using water that is too cold.

      Cooling the body through the hands can enhance performance, and the CoolBot is a technology developed at Stanford University that cools the hand and, thus, the body temperature. Standardized on three minutes, the technology offers maximum benefit in the first two to three minutes. While the CoolBot is being used by sports teams and the military, an individual can use a crude version of the protocol with a packet of frozen peas or juice can, taking care not to seal up heat loss by long usage or using water that is too cold. Optimal results for an individual can be determined by testing. If the hand is cool to touch after switching peas, it indicates a successful heat loss.

    • Effective Cooling Methods for OverheatingTo cool down efficiently, use cooling methods like cold packs on the face, palms, and soles of the feet as they have larger surface areas for radiating heat. Cooling the radiating surfaces is more efficient than standard treatments.

      To cool down efficiently when overheated, it's better to put cooling methods like cold packs on the face, palms, and soles of the feet rather than on armpits, groin, or neck. This is because the efficiency of heat transfer between two objects increases with convection of the medium, and the areas mentioned have larger surface areas for radiating heat. Standard treatments recommended by medical organizations for hyperthermia are not as efficient as cooling the radiating surfaces. Also, putting cold packs with no convective stream of the cooling medium, like frozen peas, is not optimal as boundary layers decrease efficacy. Heat transfer involves convection, radiation, and convection.

    • Use of Heated Limbs to Warm up Hypothermic IndividualsWhen dealing with hypothermia, heat up extremities and torso using heated limbs. This method pulls blood into the limb, effectively warming it and the whole body in a science-backed solution for quick and effective warming. Also, warm liquids should be provided, but not too hot.

      When dealing with hypothermic individuals, it is important to heat up their extremities as well as their torso to prevent further heat loss. The use of one heated appendage, such as an arm, can effectively warm up the whole body by pulling more blood into the limb and effectively heating it. This method has been successful in preventing shivering and normalizing core temperature in a short amount of time. This is a science-backed solution that could be used in hospitals, military settings, athletes, and civilians doing other types of work to quickly and effectively warm up hypothermic individuals. It is also important to note that warm liquids could be given to someone who is hypothermic, but not too hot.

    • Palmer Cooling and Warming Up for DogsPalmer cooling uses a dog's instinctual behavior to cool them down by targeting the AVS found in their paws and palms. Warming up is also important for flexibility, not just raising body temperature. Core body temperature can be measured through a salvage seal or tympanic temperature.

      Palmer cooling, a technique used to cool down overheated dogs, was made possible due to the discovery of special blood vessels called arterial venous anastomosis (AVS). AVS is a connection between arteries and veins found only in the hands and feet. This technique works because dogs instinctively know to stand in bodies of water to cool themselves off and have the advantage that their paws and palms are essentially the same things. Warming up before exercise is essential to avoid joint damage and increase flexibility. Interestingly, the major contribution of warming up is not to raise the temperature but to increase flexibility. The best way to measure core body temperature is a salvage seal, but tympanic (ear) temperature is also reliable.

    • Improving Sports Performance through Cooling Workouts and Proper GearDecreasing heat loss and proper ventilation in helmets and gloves, along with cooling workouts, can enhance performance without the negative effects of anabolic steroids. It's crucial to prioritize safe and natural methods for improving athletic performance.

      Improving performance can be done by decreasing heat loss and ensuring proper ventilation in helmets and gloves during sports activities. Cooling workouts can also lead to a true conditioning effect as it increases the number of contractual elements in muscles and causes them to get bigger, resulting in a performance-enhancing effect. This can occur even without the cooling workout. Anabolic steroids, which are commonly used to improve recovery time and ability to synthesize protein, have negative effects and are banned in many sports organizations. It is important to note that while there is no research comparing Palmer cooling to anabolic steroids, there is plenty of research available on the latter.

    • Steroid Use in Bodybuilding and Sports PerformanceSteroids only show a marginal increase in bench press performance, while paying attention to nutrition, sleep, and other factors such as temperature has a more significant impact. Military special operators and black bears are interesting groups to study for their ability to perform under unpredictable conditions.

      Steroids are not an effective tool for bodybuilding and sports performance, with independent studies showing only a 1% per week increase in bench press performance with or without steroids. Alternative parameters like temperature may have a more significant impact on performance while paying attention to nutrition and sleep is essential. Military special operators are an interesting group because they are trained to perform under unpredictable and variable conditions. Shivering increases metabolism but exercise can take metabolism up to 10 times, and it can happen without being exposed to cold. Black bears do hibernate, and researchers can implant them with EEG, EKG, and temperature sensors to study their hibernation patterns.

    • Brown Fat and Hibernation: How Animals Stay WarmBrown fat helps animals produce heat during hibernation, and humans also have brown fat that can be stimulated by ice packs, but caution should be exercised to avoid shivering and activation of brown fat.

      Bears maintain their body temperature while hibernating by shivering if the temperature drops below 33-34 degrees Celsius, while smaller animals like ground squirrels can drop their body temperature to one or two degrees Celsius above the environment. Brown fat is a tissue that helps animals produce heat during hibernation by storing energy and having lots of mitochondria and blood supply. Humans also have brown fat, which is distributed along with other fat tissue, and can be stimulated by ice packs; however, putting ice packs on the upper back may not be the best way to stimulate brown fat activation as it can affect the vertebral arteries and cause shivering and activation of brown fat.

    • Brown fat, brain freeze, and fidgeting: How temperature affects the body's functions.The amount of brown fat in one's body varies, while cold temperatures activate the sympathetic nervous system causing brain freeze. Fidgeting burns significant calories, and preliminary data suggests heat devices alleviate migraines.

      The activation of brown fat is a sympathetic nervous system response, and any lowering of core temperature will let the thermostat say you're too cold and turn on sympathetic. Different people have different amounts of brown fat, and newborns have more brown fat than adults. The brain freeze from eating something cold like an ice cream cone or drinking a cold beverage is caused by vasomotor change, which is an increase in blood pressure. There is preliminary data that suggests using a heat device can help reduce migraines, but it's anecdotal and doesn't have a decent dataset. Fidgeters burn off a large amount of calories (800-2500 calories per day) by way of shaking their knee or moving around a lot.

    • The Connection Between Muscle Activity and Energy ConsumptionSmall movements like tapping your foot can produce a lot of heat. Energy drinks may hinder muscular performance and affect the adenosine system. Keeping the temperature cool while sleeping can improve muscle oxygenation. Muscle hypoxia releases adenosine, increasing blood flow to muscles.

      Muscle activity increases energy consumption and heat production, and even small movements like tapping your foot can result in four times the amount of energy being lost as heat. While energy drinks and pre-workout drinks may contain thermogenic compounds to increase body temperature, they may also hinder muscular performance by inhibiting the adenosine system that supports the oxygenation of muscle. The effects of these drinks may vary depending on their cocktail of compounds and glucose sources. Additionally, keeping the room cool and dark while sleeping is advised, and there may be other useful tips for better sleep that people don't hear much about. Muscle hypoxia releases adenosine, which causes blood vessels to dilate, increasing blood flow to the muscles.

    • Tips for Better Sleep Hygiene with Cognitive Behavioral TherapyEstablish a consistent sleep schedule, avoid screens before bedtime, relax before sleeping, regulate temperature with a cooler environment and try sleeping with a limb out to help regulate body temperature. Wearing socks for toe-sensitive spots can enhance thermal comfort.

      Cognitive behavioral therapy is more emphasized than pharmacology in the sleep medicine community to increase sleep hygiene. Rules such as having regular bedtime and wake time, avoiding screens before bedtime, doing relaxing activities, and keeping the sleep environment cooler for thermoregulation are recommended. Sleeping with one leg or hand out in cool environments can help regulate body temperature passively. Temperature-sensitive spots in the body are the toes, making wearing socks helpful for thermal comfort in cooler environments. However, socks may not be necessary if it is too warm. Finally, a rational and science-grounded explanation is given for why it's better to sleep in a cool room.

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    In this episode, my guest is Dr. Gabrielle Lyon, D.O., a board-certified physician who did her clinical and research training at Washington University in geriatrics and nutrition. She is also an expert in how diet and exercise impact muscle and whole-body health and longevity. Dr. Lyon is a bestselling author and public educator. We discuss how healthy skeletal muscle promotes longevity, brain health, disease prevention, ideal body composition, and the health of other organs and bodily systems. She makes specific nutritional recommendations for optimal health: what to eat, how much to eat, the timing of meals, the essential need for adequate quality protein (including animal and plant-based options), supplementation, and how our dietary requirements change with age. She explains why specific types of resistance training are essential to build and maintain muscle and overall metabolic health. She also describes how to include resistance training as part of your exercise regimen — regardless of age or sex.  She also provides specific mindset tools to encourage sustained adherence to healthy eating and exercise practices. Women and men of all ages will benefit from Dr. Lyon’s practical, evidence-based protocols to improve muscle and whole-body appearance, function, and health. Access the full show notes, including referenced articles, books, people mentioned, and additional resources at hubermanlab.com. Andrew's New Book Protocols: An Operating Manual for the Human Body: https://protocolsbook.com Thank you to our sponsors AG1: https://drinkag1.com/huberman Maui Nui Venison: https://mauinuivenison.com/huberman  Levels: https://levels.link/huberman  Helix Sleep: https://helixsleep.com/huberman InsideTracker: https://insidetracker.com/huberman  Timestamps 00:00:00 Protocols Book; Dr. Gabrielle Lyon 00:03:23 Sponsors: Maui Nui, Levels & Helix Sleep 00:07:40 Skeletal Muscle & Longevity 00:11:25 “Under-muscled”, Leucine & Muscle Health 00:15:55 Muscle Health 00:19:45 Tool: Carbohydrate Consumption & Activity, Glycogen 00:25:14 Tools: Nutrition for Healthy Skeletal Muscle, First Meal 00:31:57 Sponsor: AG1 00:33:46 Quality Protein, Animal & Plant-Based Proteins 00:37:36 Dietary Protein Recommendations, Meal Threshold 00:41:19 Muscle Health & Aging 00:46:02 Supplements & Creatine; Dietary Protein 00:50:07 Tool: Dietary Protein Recommendation; Gout & Cancer Risk 00:52:43 Effects of Dietary Protein & Exercise on Body Composition 01:03:06 Thermic Effects, Protein  01:05:02 Sponsor: InsideTracker 01:06:14 Protein & Satiety, Insulin & Glucose 01:12:04 Tool: Older Adults, Resistance Training & Dietary Protein 01:17:48 Dietary Protein, mTOR & Cancer Risk 01:21:36 Muscle Span & Aging, Sedentary Behaviors 01:24:00 Mixed Meals, Protein Quality, Fiber 01:29:21 Inactivity & Insulin Resistance, Inflammation 01:38:43 Exercise & Myokines, Brain Health & BDNF 01:44:11 Tool: Resistance Training Protocols, Hypertrophy, “High Ground” 01:52:51 High Ground Exercises; Tendon Strength; Training Duration, Blue Zones 01:58:19 Movement, Exercise & Older Adults 02:04:25 Tool: Protein Timing & Resistance Training; VO2 Max, Aging, Blood Work 02:11:13 Supplements: Creatine, Urolithin A, Whey Protein, Fish Oil, Collagen 02:20:18 Fasting, Older Adults; Tool: Meal Timing 02:25:18 Animal Proteins & Dairy; Organ Meats, Vegan; Magnesium, Zinc 02:30:59 Medications & Muscle Health 02:32:49 Obesity & GLP-1 Analogs, Ozempic, Mounjaro, Skeletal Muscle 02:40:48 Benefits of Skeletal Muscle & Aging 02:42:16 Tools: Nutrition & Resistance Training for Muscle Health 02:45:44 Mindset Tools: Standards vs. Goals; Vulnerability Points 02:52:00 Mindset Tools: Neutrality; Health & Worth 03:01:14 Zero-Cost Support, Spotify & Apple Follow & Reviews, YouTube Feedback, Social Media, Neural Network Newsletter, Protocols Book Disclaimer
    Huberman Lab
    enJune 24, 2024

    Perform with Dr. Andy Galpin: Why Muscle Matters & How to Build It

    Perform with Dr. Andy Galpin: Why Muscle Matters & How to Build It
    I'm honored to share Episode 2 of the first season of Perform with Dr. Andy Galpin. Dr. Andy Galpin is a tenured full professor at California State University, Fullerton, where he co-directs the Center for Sport Performance and leads the Biochemistry and Molecular Exercise Physiology Laboratory. Andy is both a friend and a colleague, and I'm delighted to have assisted in the creation of this podcast. I'm certain you'll both enjoy and learn from it. Season 1 features 10 episodes, airing every Wednesday for 10 weeks. Dr. Galpin will cover everything from building strength, the importance of strength for long-term health, the science of breathing, the benefits of sleep extension, genetic testing for personalized training, and nutrition for injury recovery. While we have Episode 2 of Perform with Dr. Andy Galpin here, please be sure to subscribe and follow Perform with Dr. Andy Galpin on your preferred platform. Show notes for this episode can be found at performpodcast.com. Timestamps 00:00:00 Introduction from Dr. Andrew Huberman 00:01:06 Skeletal Muscle 00:04:06 Sponsors: Absolute Rest & Momentous 00:07:20 Quantity & Quality; Organ System; Health & Performance 00:12:58 Plasticity, “Look Good, Feel Good, Play Good”; Muscle Types 00:15:46 What is Muscle?, Muscle Fibers, Tendon 00:21:37 Muscle Fiber Number, Hyperplasia, Anabolic Steroids, Age 00:24:03 Myonuclei & Adaptability 00:26:27 Muscle Fiber Types, Variable Muscle Functions 00:32:24 Fiber Type & Lifestyle Factors 00:34:54 Sponsors: David Protein & AG1 00:37:37 Age & Muscle Loss, Slow vs. Fast-Twitch Fibers; Motor Units 00:46:36 Muscle Size vs. Muscle Strength, Quantity vs. Quality 00:50:56 Investigate: Muscle Quantity, Fat-Free Mass Index (FFMI) 00:56:21 FFMI, Elite Athletes, Muscle Mass 01:00:59 Muscle Asymmetry; Too Much Muscle Possible? 01:03:49 Interpret: Muscle Mass, FFMI Calculations & Percentiles 01:09:28 Tool: Intervene - Increase Muscle Mass, 72-Hour Rule 01:15:27 Sponsors: Maui Nui & Renaissance Periodization 01:17:51 Investigate: Muscle Quality & 4 Movement Principles 01:23:34 Muscle Quality & 3 Performance Principles  01:26:42 Interpret: Muscle Speed, Age 01:32:45 Muscle Power, Vertical Jump, Broad Jump 01:36:17 Muscle Strength, Powerlifting Elite, Bench Press, Leg Press, Grip Strength 01:44:05 Increasing Strength, Improve Health & Longevity 01:46:44 Tool: Intervene - Improve Muscle Quality, 4 Training Principles, 3-to-5 Rule 01:53:56 Zero-Cost Support, YouTube, Spotify & Apple Subscribe & Reviews, Sponsors, YouTube Feedback, Social Media 01:56:10 Conclusion from Dr. Andrew Huberman Disclaimer
    Huberman Lab
    enJune 19, 2024

    Dr. Zachary Knight: The Science of Hunger & Medications to Combat Obesity

    Dr. Zachary Knight: The Science of Hunger & Medications to Combat Obesity
    In this episode, my guest is Dr. Zachary Knight, Ph.D., a professor of physiology at the University of California, San Francisco (UCSF), and Howard Hughes Medical Institute (HHMI) investigator. We discuss how the brain controls our sense of hunger, satiety, and thirst. He explains how dopamine levels impact our cravings and eating behavior (amount, food choices, etc) and how we develop and can change our food preferences and adjust how much we need to eat to feel satisfied. We discuss factors that have led to the recent rise in obesity, such as interactions between our genes and the environment and the role of processed foods and food combinations. We also discuss the new class of medications developed for the treatment of obesity and diabetes, including the GLP-1 agonists semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro). We discuss how these medications work to promote weight loss, the source of their side effects, and the newer compounds soon to overcome some of those side effects, such as muscle loss. Dr. Knight provides an exceptionally clear explanation for our sense of hunger, thirst, and food cravings that translates to practical knowledge to help listeners better understand their relationship to food, food choices, and meal size to improve their diet and overall health. For show notes, including referenced articles and additional resources, please visit hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman  BetterHelp: https://betterhelp.com/huberman Eight Sleep: https://eightsleep.com/huberman Waking Up: https://wakingup.com/huberman LMNT: https://drinklmnt.com/huberman Timestamps 00:00:00 Dr. Zachary Knight 00:02:38 Sponsors: BetterHelp, Helix Sleep & Waking Up 00:07:07 Hunger & Timescales 00:11:28 Body Fat, Leptin, Hunger 00:17:51 Leptin Resistance & Obesity 00:20:52 Hunger, Food Foraging & Feeding Behaviors, AgRP Neurons 00:30:26 Sponsor: AG1 00:32:15 Body Weight & Obesity, Genes & POMC Neurons 00:39:54 Obesity, Genetics & Environmental Factors 00:46:05 Whole Foods, Ultra-Processed Foods & Palatability 00:49:32 Increasing Whole Food Consumption, Sensory Specific Satiety & Learning 00:58:55 Calories vs. Macronutrients, Protein & Salt 01:02:23 Sponsor: LMNT 01:03:58 Challenges of Weight Loss: Hunger & Energy Expenditure 01:09:50 GLP-1 Drug Development, Semaglutide, Ozempic, Wegovy 01:19:03 GLP-1 Drugs: Muscle Loss, Appetite Reduction, Nausea 01:23:24 Pharmacologic & Physiologic Effects; GLP-1 Drugs, Additional Positive Effects 01:30:14 GLP-1-Plus Development, Tirzepatide, Mounjaro, AMG 133 01:34:49 Alpha-MSH & Pharmacology 01:40:41 Dopamine, Eating & Context 01:46:01 Dopamine & Learning, Water Content & Food 01:53:23 Salt, Water & Thirst 02:03:27 Hunger vs. Thirst 02:05:46 Dieting, Nutrition & Mindset 02:09:39 Tools: Improving Diet & Limiting Food Intake 02:14:15 Anti-Obesity Drug Development 02:17:03 Zero-Cost Support, Spotify & Apple Follow & Reviews, YouTube Feedback, Social Media, Neural Network Newsletter Disclaimer
    Huberman Lab
    enJune 17, 2024

    Perform with Dr. Andy Galpin: How & Why to Strengthen Your Heart & Cardiovascular Fitness

    Perform with Dr. Andy Galpin: How & Why to Strengthen Your Heart & Cardiovascular Fitness
    I'm honored to share the first episode of the new podcast, Perform with Dr. Andy Galpin. Dr. Andy Galpin is a tenured full professor at California State University, Fullerton, where he co-directs the Center for Sport Performance and leads the Biochemistry and Molecular Exercise Physiology Laboratory. Andy is both a friend and a colleague, and I’m delighted to have assisted in the creation of this podcast. I'm certain you'll both enjoy and learn from it. Season 1 features 10 episodes, airing every Wednesday for 10 weeks. Dr. Galpin will cover everything from building strength, the importance of strength for long-term health, the science of breathing, the benefits of sleep extension, genetic testing for personalized training, and nutrition for injury recovery. While we have Episode 1 of Perform with Dr. Andy Galpin here, please be sure to subscribe and follow Perform with Dr. Andy Galpin on your preferred platform. Show notes for this episode can be found at performpodcast.com. Timestamps 00:00:00 Introduction from Dr. Andrew Huberman 00:01:07 Heart 00:03:55 Sponsors: Vitality Blueprint & Rhone 00:07:27 Muscle Types 00:09:54 VO2 max, Health & Mortality 00:15:49 Overall Health, Cardiorespiratory Fitness & All-Cause Mortality 00:25:23 Sponsor: AG1 00:26:54 Disease, Health & Mortality 00:30:02 Cardiac Muscle & Heart 00:38:29 Cardiac Muscle vs. Skeletal Muscle, Cardiac Advantages 00:43:53 Pacemakers & Heart Rate, Vagus Nerve 00:50:35 Why Doesn’t the Heart Get Sore? 00:54:32 Heart & Exercise, Stroke Volume, Ejection Fraction, Cardiac Output 00:59:21 Heart Rate Variability 01:02:41 Sponsors: Momentous & LMNT 01:06:54 Why Do You Breathe?: Oxygen, Carbon Dioxide & Respiratory Rate 01:13:37 Respiratory Rate & Stress 01:15:08 Tool: The “Three I’s”, Investigate: Heart Rate, Respiratory Rate, VO2 Max 01:19:53 Tool: Interpretation, Resting Heart Rate & Ranges 01:23:16 Tool: Interpretation: VO2 Max & Ranges 01:30:45 Athletes & Highest VO2 Max Scores 01:35:53 Elite Athletes & Context for VO2 Max Scores 01:41:42 Tool: Intervention, VO2 Max, Varying Exercise Intensities, SAID Principle 01:48:20 Tool: Varying Exercise Intensity; Intervals & Continuous Training; Frequency 01:58:18 Zero-Cost Support, YouTube, Spotify & Apple Subscribe & Reviews, Sponsors, YouTube Feedback, Social Media 01:59:55 Conclusion from Dr. Andrew Huberman Disclaimer
    Huberman Lab
    enJune 12, 2024

    Dr. Jonathan Haidt: How Smartphones & Social Media Impact Mental Health & the Realistic Solutions

    Dr. Jonathan Haidt: How Smartphones & Social Media Impact Mental Health & the Realistic Solutions
    In this episode, my guest is Dr. Jonathan Haidt, Ph.D., professor of social psychology at New York University and bestselling author on how technology and culture impact the psychology and health of kids, teens, and adults. We discuss the dramatic rise of suicide, depression, and anxiety as a result of replacing a play-based childhood with smartphones, social media, and video games. He explains how a screen-filled childhood leads to challenges in psychological development that negatively impact learning, resilience, identity, cooperation, and conflict resolution — all of which are crucial skills for future adult relationships and career success. We also discuss how phones and social media impact boys and girls differently and the underlying neurobiological mechanisms of how smartphones alter basic brain plasticity and function.  Dr. Haidt explains his four recommendations for healthier smartphone use in kids, and we discuss how to restore childhood independence and play in the current generation.  This is an important topic for everyone, young or old, parents and teachers, students and families, to be aware of in order to understand the potential mental health toll of smartphone use and to apply tools to foster skill-building and reestablish healthy norms for our kids. For show notes, including referenced articles and additional resources, please visit hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman  Helix Sleep: https://helixsleep.com/huberman AeroPress: https://aeropress.com/huberman Joovv: https://joovv.com/huberman LMNT: https://drinklmnt.com/huberman Timestamps 00:00:00 Dr. Jonathan Haidt 00:02:01 Sponsors: Helix Sleep, AeroPress & Joovv 00:06:23 Great Rewiring of Childhood: Technology, Smartphones & Social Media 00:12:48 Mental Health Trends: Boys, Girls & Smartphones 00:16:26 Smartphone Usage, Play-Based to Phone-Based Childhood 00:20:40 The Tragedy of Losing Play-Based Childhood 00:28:13 Sponsor: AG1 00:30:02 Girls vs. Boys, Interests & Trapping Kids 00:37:31 “Effectance,” Systems & Relationships, Animals 00:41:47 Boys Sexual Development, Dopamine Reinforcement & Pornography 00:49:19 Boys, Courtship, Chivalry & Technology; Gen Z Development 00:55:24 Play & Low-Stakes Mistakes, Video Games & Social Media, Conflict Resolution 00:59:48 Sponsor: LMNT 01:01:23 Social Media, Trolls, Performance 01:06:47 Dynamic Subordination, Hierarchy, Boys 01:10:15 Girls & Perfectionism, Social Media & Performance 01:14:00 Phone-Based Childhood & Brain Development, Critical Periods 01:21:15 Puberty & Sensitive Periods, Culture & Identity 01:23:55 Brain Development & Puberty; Identity; Social Media, Learning & Reward 01:33:37 Tool: 4 Recommendations for Smartphone Use in Kids 01:41:48 Changing Childhood Norms, Policies & Legislature 01:49:13 Summer Camp, Team Sports, Religion, Music 01:54:36 Boredom, Addiction & Smartphones; Tool: “Awe Walks” 02:03:14 Casino Analogy & Ceding Childhood; Social Media Content 02:09:33 Adult Behavior; Tool: Meals & Phones 02:11:45 Regaining Childhood Independence; Tool: Family Groups & Phones 02:16:09 Screens & Future Optimism, Collective Action, KOSA Bill 02:24:52 Zero-Cost Support, Spotify & Apple Reviews, YouTube Feedback, Social Media, Neural Network Newsletter Disclaimer
    Huberman Lab
    enJune 10, 2024

    LIVE EVENT Q&A: Dr. Andrew Huberman at the Brisbane Convention & Exhibition Centre

    LIVE EVENT Q&A: Dr. Andrew Huberman at the Brisbane Convention & Exhibition Centre
    Recently I had the pleasure of hosting a live event in Brisbane, Australia. This event was part of a lecture series called The Brain Body Contract. My favorite part of the evening was the question and answer period, where I had the opportunity to answer questions from the attendees of each event. Included here is the Q&A from our event at the Brisbane Convention & Exhibition Centre. Sign up to get notified about future events: https://www.hubermanlab.com/events Thank you to our sponsors AG1: https://drinkag1.com/huberman Eight Sleep: https://eightsleep.com/huberman Resources Mentioned Huberman Lab Non-Sleep Deep Rest Protocols Huberman Lab Guest Series with Dr. Matt Walker Huberman Lab Guest Series with Dr. Paul Conti Huberman Lab Guest Series with Dr. Andy Galpin Dr. Becky Kennedy: Protocols for Excellent Parenting & Improving Relationships of All Kinds Perform with Dr. Andy Galpin Timestamps 00:00 Introduction 00:31 Sponsors: AG1 & Eight Sleep 03:48 Nicotine Discussion 07:42 ADHD Management: Tools & Medications 12:43 Sleep Deprivation & Recovery 18:54 Understanding & Addressing Burnout 22:12 Daily Nutrition & Eating Habits 24:40 Understanding Food & Neural Pathways 26:21 The Benefits of Elimination Diets 27:21 Intermittent Fasting & Personal Diet Choices 28:23 Top Health & Fitness Recommendations 30:50 The Value of Non-Sleep Deep Rest (NSDR) 33:08 Testosterone Replacement Therapy Insights 38:02 Breathing Techniques for Stress & Focus 41:46 Morning Sunlight & Circadian Rhythms 43:18 Parenting Tips for a Healthy Start 49:03 Final Thoughts & Gratitude Disclaimer
    Huberman Lab
    enJune 07, 2024

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