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    • Expanding Treatments for Rare Diseases: Insights from CEO Derick CooperRare diseases may affect a significant number of individuals when considered collectively, emphasizing the need for targeted treatments. Collaboration between different disciplines can lead to valuable insights and innovation.

      Derick Cooper, CEO of QOL Medical, specializes in producing treatments for rare diseases. His company focuses on understanding the genetic background of these diseases and developing therapies to counter them. Despite being classified as rare, these diseases are not actually uncommon when taken in their cumulative sense. This highlights the importance of addressing these conditions and developing treatments, as they affect a significant number of individuals. Cooper's expertise in immunological function has allowed him to draw parallels between how the immune system works and how cognitive systems work, providing valuable insights into both realms. This collaboration between business and biology showcases the potential for cross-disciplinary learning and innovation.

    • Understanding the Impact of Rare Diseases and the Interconnectedness of Different FieldsExploring niche fields and following one's interests can lead to a greater understanding of rare diseases and the broader context in which they exist, ultimately paving the way for successful ventures and fruitful careers.

      Rare diseases, although individually unique and small in terms of prevalence, collectively have a substantial impact on the total number of people affected. As we delve deeper into the genetic background of different diseases, we discover the implications they have for other diseases as well. This interconnectedness demonstrates the broader context in which rare diseases exist. Furthermore, exploring niche fields or specific areas of interest can lead to a greater understanding of the world at large. Just as scientists start as generalists before specializing intensely, they eventually develop a broader range of knowledge and connections between their field of study and other domains. This ability to follow one's interests, combined with a strong business acumen, can pave the way for successful ventures and fruitful careers.

    • The importance of skill sets and personality traits in different industries.Success in various industries depends on a combination of intelligence and personality traits, such as conscientiousness and openness, which greatly impact effectiveness and satisfaction.

      Different industries require different skill sets and personality traits for success. The baked foods industry, for example, is a cost-driven business that demands meticulous cost control and attention to detail. On the other hand, the pharmaceutical industry, with its focus on intellectual property and complex disease treatment, requires high levels of openness, creativity, and interest in intellectual matters. This demonstrates that success in complex endeavors relies on both intelligence and personality trait variance. Conscientiousness and detail-orientedness are crucial for managing costs and maintaining order, while openness and interest in ideas are essential for entrepreneurial endeavors and intellectual exploration. Understanding and leveraging these traits can greatly impact one's effectiveness and satisfaction in different industries.

    • Balancing Openness and Discipline in Decision-MakingFind a balance between being open to new ideas and maintaining discipline by prioritizing and allocating resources effectively, while also finding time for long-term strategic thinking.

      There needs to be a balance between being open to new ideas and maintaining discipline in decision-making. Highly open individuals may have a tendency to jump from one topic to another, triggering a flood of ideas. While this can lead to unique and innovative connections, it can also result in overwhelming chaos and inefficiency, especially when working with a team. To overcome this challenge, it is important to prioritize and allocate resources effectively. This involves identifying the best opportunities and giving them the necessary focus and investment, while letting go of less promising ideas. Additionally, managers need to resist the temptation to only focus on fixing problems and find time for long-term strategic thinking.

    • Fostering Success Through Effective Management StrategiesEffective leadership requires clear communication of goals, an understanding of individual motivations, and recognition of diverse skill sets within the organization. Practicing humility and self-awareness contribute to organizational success.

      When it comes to managing employees, it is important to focus on the high-performing individuals who can bring exponential benefits to the organization. However, it is equally important to build a functional organization with people in different roles and understand how the entire hierarchy functions. Chaos within the organization can be a signal that goals are not clear or there is a fear of not achieving them. It is crucial for leaders to communicate goals effectively and understand what motivates their employees to change direction. Additionally, intelligence and competence may vary across different specialized areas, so it is essential to recognize and appreciate the diverse skill sets within the organization. Ultimately, understanding oneself and practicing epistemic humility can contribute to effective leadership and organizational success.

    • Understanding Knowledge Boundaries and Diversity for Effective Organizational FunctioningRecognizing and filling knowledge gaps, understanding different perspectives, and aligning personality traits and skills with roles can lead to successful management and thriving organizations.

      Understanding the boundaries of what you know and what you don't know is crucial for effective functioning within an organization. By filling in knowledge gaps and aligning different skillsets appropriately, the organization can thrive. Another key component is recognizing that people perceive the world differently, and it's important to have some understanding of their reference frame to effectively communicate. True diversity lies in diversity of temperament, with different skills associated with each temperament dimension. Knowing these differences can help in motivating individuals and assigning them to suitable roles. It is also beneficial to appreciate the advantages and disadvantages of different personality traits, such as being agreeable or disagreeable. By aligning personality and competence with the job, good management can be achieved.

    • Unpacking Personality: Insights for Better Interactions and RelationshipsUnderstanding personality dimensions and aligning perspectives can improve communication, cooperation, and relationships, not only in personal interactions but also in professional fields like investment banking.

      Understanding the complexity of personality can greatly benefit our interactions and relationships. By analyzing personality through five dimensions and ten different aspects, we can uncover our strengths and weaknesses, as well as gain insight into others' perspectives. This knowledge becomes especially important when communicating with individuals who possess different personality traits than our own. It allows us to navigate potential misunderstandings and friction, fostering better understanding and cooperation. Additionally, the idea of aligning perspectives extends beyond personality analysis. In fields like investment banking, exposure to a variety of competent individuals and concepts at a young age offers immense educational value. This exposure allows for the development of crucial skills and a deeper understanding of financial and operational concepts.

    • Factors Influencing the Success of CompaniesSuccess in business depends on various factors, including effective management, market timing, and marketing strategies. Relying on hard data, rather than intuition, is crucial to evaluate growth potential. Effective communication is vital within an organization for success.

      The success of a company is not solely determined by its creative ideas or products. There are various factors that contribute to a company's success, such as the management team, timing in the market, marketing strategies, and more. This complexity makes it difficult to accurately predict which companies will perform well. Investment bankers, for example, aim for a high return on their investments because many companies that appear promising ultimately fail. To evaluate the growth potential of companies, it is crucial to rely on hard data rather than intuition. Additionally, effective communication and understanding within an organization are vital for its success, as excessive layers of operation can hinder the flow of valuable information.

    • The Chaos of Large Organizations: Fiefdoms and Loss of DirectionMaintaining efficiency becomes challenging as organizations grow larger, leading to chaos and a loss of organizational goals. Jordan Peterson suggests that groups of around 200 individuals are manageable, and profitability should be driven by benefiting others.

      The chaos and lack of understanding within organizations can lead to the growth of fiefdoms and a loss of direction. As group sizes become larger and more people report to a single person, it becomes increasingly difficult to keep track of interactions and maintain efficiency. This can result in a recipe for chaos and a loss of organizational goals. Jordan Peterson suggests that human beings tend to operate best in groups of around 200 individuals, beyond which the organization becomes unmanageable. Additionally, the focus on profitability is not just about financial success, but also a measure of running an efficient organization that positively impacts people's lives. It is possible to find meaning in profit when it is driven by the desire to benefit others. However, skeptics argue that underlying motivations may be driven by power and money rather than genuine concern for others.

    • The Power of Motivation and Ethical Exchanges in Achieving GoalsFinding satisfaction in achieving goals and creating something valuable is driven by dopamine-related fulfillment and the implicit ethic of capitalism, promoting excellence and reciprocity in social interactions and exchanges.

      The motivation to help others is often a genuine desire for a job well done and a functioning organization. Competent and successful individuals find deep satisfaction in achieving goals and creating something valuable. This satisfaction is likely dopamine-related and stems from the fulfillment of doing something meaningful. Furthermore, capitalism, when understood as voluntary exchange, carries an implicit ethic that promotes excellence. The exchange of goods, ideas, and interactions within a social community fosters ethics that emerge from iterated exchanges. Goals that are sustained must serve the purposes of this exchange and meet certain constraints for social acceptance. Ultimately, the pursuit of goals and the adherence to an implicit ethic highlight the importance of reciprocity and maintaining equal quality in interactions and exchanges.

    • Building Reputation & Storing Treasure: The Power of Goodwill and IntegrityEffective communication, clear goals, and guiding teams towards shared objectives are essential in propagating goodwill, integrity, and ultimately building a strong reputation.

      Building a reputation and storing up treasure in heaven are both rooted in the concept of propagating goodwill and integrity across time. Just as sharing successful hunting experiences in ancient times created a mutual banking system, investing in the minds and perceptions of others today can lead to a network of support and reciprocity. This notion of reputational integrity is emphasized in the gospels, where Christ condemns those who manipulate reputation for personal gain. In a practical sense, effective communication within organizations involves setting clear overarching goals and cascading them into specific actions for different functions. By understanding how communication propagates within an organization, leaders can motivate and guide their teams towards achieving shared objectives.

    • The Importance of Setting Clear and Specific Goals for Success and IdentitySetting clear goals not only provides direction and purpose but also helps to avoid failure, prioritize tasks, reduce anxiety and ambiguity, create order, and increase effectiveness in achieving desired outcomes.

      Setting clear and specific goals is crucial for success and identity. It not only provides a sense of direction and purpose, but also helps to avoid failure and prioritize tasks. Clear goals help to translate high-level objectives into actionable steps, ensuring that everyone understands what needs to be done. Moreover, clear goals reduce anxiety and ambiguity, allowing for better management of chaos. By narrowing focus and establishing boundaries, goals create order and increase effectiveness. Just like a lion communicates which zebra to focus on, setting goals helps to target efforts and achieve desired outcomes. Goals are the foundation of identity and provide emotional fulfillment as progress is made towards their attainment.

    • The Similarities between Prey Animals and the Immune SystemBoth prey animals and the immune system use a strategy of randomness and adaptability to protect themselves and eliminate threats.

      Prey animals, such as zebras and quails, use a strategy of disorientation to protect themselves from predators. By running around randomly and creating chaos, they make it difficult for predators like lions and raccoons to single them out. This behavior is not limited to land animals but is also observed in bees when they swarm and sting bears that try to steal their honey. Understanding these survival tactics can provide insight into the functioning of the immune system. The immune system also employs a similar strategy of randomness and adaptability when targeting pathogens. It produces millions of different antibodies that grasp onto pathogens, allowing the body to identify and eliminate them. This sequence of general to specific analysis helps the immune system map and respond to bacterial cells effectively.

    • The immune system's antibody production process as a metaphor for mapping a coastline.The immune system gradually refines antibodies to specifically target bacteria, demonstrating that understanding enough information and achieving the desired outcome is more important than capturing every detail.

      The immune system has a fascinating process of generating antibodies to fight off bacteria. The antibodies start with a vague grasp on the bacteria, but as they get copied and refined, they become more specific and effective in targeting the bacteria. It's like mapping a coastline using blocks of different sizes. The immune system starts with low-resolution blocks and gradually progresses to smaller, more precise blocks, mapping out the bacteria accurately. The immune system doesn't need to map every single detail; it just needs to understand enough to stop the bacteria. This process aligns with the philosophy of knowledge, where something is considered right if it helps achieve the desired outcome.

    • The General to Specific Pattern in Biological and Cognitive ProcessesOur immune system and human thought follow a similar pattern of progressing from broader concepts to more specific ones, highlighting the importance of hierarchy and understanding in both biology and cognition.

      The immune system and human thought share a similar pattern of operating from the general to the specific. Just as the immune system identifies bacterial cells at multiple levels of analysis, human thought progresses from broad concepts to more specific ones. This hierarchy of understanding is observed in children as they learn the hierarchy of objects. Additionally, in linguistic history, shorter words map onto more fundamental concepts, similar to how shorter words like "cat" and "dog" are considered base level words. Furthermore, archetypes and stories play a crucial role in problem-solving, as they provide general-purpose problem-solving tools with broad application. When a story resonates deeply, it indicates that it fits into our memory's evolved framework, highlighting its importance for our overall functionality. This pattern of seeking patterns and searching for similarity at the appropriate level of analysis is also seen in scientific research as knowledge from one domain can often translate to another. Overall, these observations suggest that there is a consistent pattern of moving from the general to the specific in both biological and cognitive processes.

    • The Importance of Stories, Clarity, and Commitment in Our LivesStories can guide us towards meaningful lives, but translating them to our own experiences may be complex. By prioritizing and committing to our goals, we can find clarity and move towards a fulfilling life.

      Stories, like the religious ones, have levels of generality and specificity. They can be applied to our own lives, but translating them may be complex. However, they serve as a valuable starting place. As we move from the general to the specific, the boundary between order and chaos changes, and the target becomes clearer. Just like how bees rank flower beds based on the frequency of bees returning from them, we too can rank and prioritize our goals. Bees communicate the value of a flower bed through a dance and their sacrificial action, indicating its worth. Similarly, the time and effort someone puts into convincing us of something shows their commitment and estimation of the goal's value. These insights remind us of the importance of stories, clarity, and commitment in our pursuit of meaningful lives.

    • Bees' Communication Dance: A Hierarchical System of DirectionBees use advanced communication through their dance to guide each other to valuable flower beds, showcasing hierarchical organization and suggesting the presence of similar value-seeking behaviors in humans.

      Bees have an incredibly sophisticated communication system to direct one another to valuable flower beds. Through their dance, bees convey the distance and direction of the flower bed, with each second of the dance representing about a thousand meters. This dance creates a hierarchy as more and more bees join in, providing more precise information about the flower bed's location. This system of communication relies on the bees' sacrifice of energy in flying and their ability to detect the smell of valuable nectar. However, it is also possible for bees to lie in their dance, signaling for treasure that doesn't exist. This demonstrates the existence of hierarchies in nature and suggests that human beings can find value in similar ways.

    • Pursuing Your Calling and Conscience: The Keys to a Fulfilling LifeEmbrace curiosity, learning, and adaptability while following your calling and maintaining a clear conscience to achieve a harmonious balance between order and chaos in life.

      Pursuing your calling and attending to your conscience can lead to a fulfilling and successful life. The conversation between Derick Cooper and Jordan Peterson highlights the importance of curiosity, learning, and adaptability. Derick's deep interest in the biopharmaceutical company stemmed from the dynamic environment and academic challenge it offered. Jordan explains that following one's calling and maintaining a clear conscience can create a harmonious balance between order and chaos. As you embark on an adventure, like a bee searching for flowers, you may not have a perfectly defined goal, but taking that first step into chaos can lead you in the right direction. It is through gaining knowledge and setting boundaries that you can find the right path and increase flexibility in pursuing future goals.

    • The Power of Multidimensional Education and KnowledgeExpanding our education and knowledge across multiple domains enhances problem-solving abilities, ethical decision-making, functional societies, and effective communication. It is similar to the immune system, guiding us through the complexities of life.

      A multidimensional education and knowledge of multiple domains can lead to greater meta knowledge and pattern recognition. Specialization in a single area can result in blindness and a lack of understanding of how different functions and behaviors may interact across domains. By expanding our education and increasing the dimensionality of our knowledge, we can have a better starting point for solving problems and making ethical decisions. A shared language of value and a common understanding of foundational stories and principles can contribute to a functional society and effective communication. This multidimensionality is akin to the elements of the immune system, providing us with a starting place and a doorway into the maze of life.

    • Navigating the balance between order and chaos in life.Embracing chaos is essential for all organisms to find and maintain value in their lives, and this ability extends to both biological life and human consciousness.

      All living things possess the ability to navigate the tension between order and chaos. This is because the physical world itself is inherently chaotic, with elements that can randomly change and become something completely different. Biology, therefore, must have the capacity to navigate this complex environment. Different species have developed their own unique strategies to direct their behavior and prioritize what is valuable to them. This boundary-setting mechanism allows them to adapt and survive in their respective ecosystems. Furthermore, this ability to mediate between order and chaos is not limited to biological life, but also extends to consciousness and the pursuit of value in human beings. Ultimately, it is essential for all organisms to embrace chaos in order to find and maintain value in their lives.

    • The Dichotomy of Perception and BehaviorOur perception of the world is influenced by conflicting messages of unlimited potential and oppressive hierarchies, leading to a prey response in young people. Recognizing the nuances and finding balance is crucial.

      Our perception of the world is influenced by a dichotomy. On one hand, we are taught that we can be anything and do anything we want, with no constraints. On the other hand, there exists a hyper-oppressive, patriarchal hierarchy that hinders our success. This contradictory message leads to a prey response in young people, as they are taught that they are not capable of being successful. It is important to recognize that there are two aspects at play here. The predatory side encourages goal-seeking and becoming a better person, while the prey side promotes victimization. Both extremes can deteriorate and lead to negative behaviors. It is crucial to understand the nuances and not categorize all predatory behavior as narcissistic psychopathy. We should be mindful that treasure hunting behavior, for example, is not necessarily predatory. Overall, it is important to strike a balance and recognize the complexity in our perceptions and behaviors.

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    For Ayaan Hirsi Ali:

     

    On X https://twitter.com/Ayaan?ref_src=twsrc%5Egoogle%7Ctwcamp%5Eserp%7Ctwgr%5Eauthor

     

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    • Basecamp’s policy on email and expectations for a quick response, and why Jason believes in sleeping on big decisions [14:30];

    • How Jason implements “true” work-life balance in his life and at Basecamp [19:15];

    • Does work and life have to be separated in order to have balance? [32:00];

    • How Jason makes time the fixed component to avoid the compulsion to keep pushing forward on a project perpetually [34:15];

    • Jason’s tip for physicians who may be facing burnout [45:00];

    • Signs of “burnout” if you do the same thing for work and pleasure, and tips to avoid and manage that feeling [49:45];

    • Is a 40-hour work week the correct amount? [53:45];

    • How to evaluate a company’s culture when looking for a job with the right work environment [59:00];

    • Jason’s take on salaries and alternate incentives like equity, profit sharing, etc. [1:06:45];

    • What traits does Jason look for when hiring new employees? [1:13:45];

    • Does Jason believe in process-oriented work or outcome-driven work, and Basecamp’s unique process for completing projects [1:16:15];

    • How does Jason handle a project that results in a failure? [1:20:00];

    • Advice for people in situations where they don’t have full control of their time and work demands [1:23:50];

    • How much of success should be attributed to skill versus luck? [1:29:30];

    • The importance of writing skills, and tip to improve your writing [1:43:15];

    • Lessons learned from parenting, and Peter’s top priority when it comes to raising kids [1:52:15];

    • An important skill: the ability to say “no” to things [2:01:15]; and

    • More.

    Learn more: https://peterattiamd.com/

    Show notes page for this episode: https://peterattiamd.com/jasonfriedama

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    035. Know Pain with Mike Stewart

    035. Know Pain with Mike Stewart

    Persistent pain can be a challenge, but also enjoyable to treat. In this episode of the Physio Edge podcast, Mike Stewart and I focus on specific examples and case studies of patients with complex or persistent pain, how you may approach persistent pain patients, explain their pain, use metaphors and explanations so they understand it, and help guide them through the recovery process. 

    Mike and I get into the details on:

    • Why Physios need a deep understanding of pain science
    • How does the “bio” part come into bio-pscyho-social
    • How can we identify if the patient needs pain education, further investigations, a biological approach eg specific exercise
    • How can you incorporate pain science into the treatment of patients with acute pain
    • Mike’s top tips when working with persistent pain
    • Specific case studies of patients with persistent and complex back pain, and how Mike has worked with these patients, including their presentation, beliefs, Mike’s language used in their session, activity modification and results achieved with these patients
    • How to develop our teaching skills to achieve the best results with our patients

    Links of Interest

    Mike Stewart

    Know Pain

    Courses with Mike Stewart

    Mike Stewart on Twitter

    Virtual conferences with Physio Edge and Clinical Edge

    Clinical Edge discounts for Undergraduate Physio students available by emailing verification of your student status to info at clinicaledge.com.au

    Clinical Edge online education

    Free video on Metatarsal head padding with Nick Torrance

    Free video on soft metatarsal domes for acute metatarsalgia

    Free video on firmer metatarsal domes for metatarsalgia

    Facebook

    David on Twitter

     

    Recording a Promo for the Pod

    Recording a Promo for the Pod
    Joe and David begrudgingly record a Promo for their own podcast. A glimpse behind the curtains of the PR machine at Chatabix HQ. Follow Chatabix on Twitter & Instagram: twitter.com/chatabix1 www.instagram.com/chatabixpodcast/ Patreon for early access to our eps: https://www.patreon.com/chatabix Crunchy fresh tees and hoodies: https://chatabixshop.com/ Hosted on Acast. See acast.com/privacy for more information. Learn more about your ad choices. Visit podcastchoices.com/adchoices