longevity

Is aging a disease that can be cured? Neil deGrasse Tyson and cohosts Chuck Nice and Gary O’Reilly discover the field of epigenetics, the Information Theory of Aging, and curing blindness for mice with Professor of Genetics at Harvard Medical School, David Sinclair.

NOTE: StarTalk+ Patrons can listen to this entire episode commercial-free here: 
https://startalkmedia.com/show/is-aging-a-disease-epigenetics-with-david-sinclair/

Thanks to our Patrons Jason L, Daniel Holzmann, Anne P Vance, Unknown, Myles G Blanton, Paul A. Straus, and Gregory Dees for supporting us this week.

How do science competitions further innovation? Neil deGrasse Tyson sits down with Peter Diamandis, Founder of the XPRIZE Foundation, to discuss science innovation, incentive competitions, and the future of space, longevity, AI, and more.

NOTE: StarTalk+ Patrons can listen to this entire episode commercial-free here: 
https://startalkmedia.com/show/incentivizing-the-future-with-peter-diamandis/

Thanks to our Patrons Lauren Crist, Nick R, George Swain, Karsten de Braaf, Winifred Kessler, Lucille Bosco, and Tom Lindelius for supporting us this week.

Welcome to “The Ben & Marc Show”, featuring a16z’s co-founders Ben Horowitz and Marc Andreessen.  In this week’s episode, Marc and Ben are joined by special guest Tony Robbins to discuss the future of longevity.  

Tony Robbins is an entrepreneur, #1 NY Times bestselling author, philanthropist, and the nation’s #1 life & business strategist.  For over four and a half decades, Tony has empowered more than 50 million people from 100 countries around the world through his audio programs, educational videos, and live seminars. He’s also the author of six international bestsellers, including “Money: Master the Game” (2014), “Unshakable: Your Financial Freedom Playbook” (2017) and “Life Force: How New Breakthroughs in Precision Medicine Can Transform the Quality of Your Life and Those You Love” (2022).

Joined by a16z’s own Dr. Vijay Pande, PhD – General Partner since 2014, and founder and leader of a16z Bio + Health – the group discusses new breakthroughs in regenerative medicine, AI, biohacking, gene editing, mindset and confirms why this might be the best time to be alive. Enjoy!

Watch the full video version of this episode: https://youtu.be/V8h11baC_ok

Resources:

Marc on X: https://twitter.com/pmarca

Marc’s Substack: https://pmarca.substack.com/

Ben on X: https://twitter.com/bhorowitz

Dr. Vijay Pande on X: https://twitter.com/vijaypande

Learn more about Tony Robbins https://tonyrobbins.com

Tony’s Time to Rise Summit (Jan 25-27, 2024): https://timetorisesummit.com/join-now  

Pre-order Tony’s upcoming book “The Holy Grail of Investing” (Feb 2024): http://theholygrailofinvesting.com

Stay Updated: 

Find us on X: https://twitter.com/a16z

Find us on LinkedIn: https://www.linkedin.com/company/a16z

The views expressed here are those of the individual personnel quoted and are not the views of a16z or its affiliates. This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors and may not under any circumstances be relied upon when making a decision to invest in any a16z funds. PLEASE SEE MORE HERE: https://a16z.com/disclosures/

Could we eliminate the number one cause of death? Neil deGrasse Tyson and co-hosts Chuck Nice and Gary O’Reilly go to medical school to learn about heart health, the impacts of COVID, and the cardiovascular disease epidemic with physician Dr. Lipi Roy.

NOTE: StarTalk+ Patrons can listen to this entire episode commercial-free here: 
https://startalkmedia.com/show/beating-time-dodging-the-number-one-killer-with-dr-lipi-roy/

Thanks to our Patrons Kaleda Davis, Saúl Franco, Jake Egli, Josh Rolstad, Roxanne Landin, jamie brutnell, and Bailey Manasco for supporting us this week.

Photo Credit: Nephron, https://creativecommons.org/licenses/by-sa/3.0 target=_blank>CC BY-SA 3.0, via Wikimedia Commons

The Summit of Greatness is back! Buy your tickets today – summitofgreatness.com – 

Dr. Rhonda Patrick has a Ph.D. in biomedical science and has done extensive research on nutrition, aging, stress, and cancer. She trained as a postdoctoral fellow at Children’s Hospital Oakland Research Institute and has investigated the effects of micronutrient (vitamins and minerals) inadequacies on metabolism, inflammation, DNA damage, and aging and whether supplementation can reverse the damage. In addition, she also investigated the role of vitamin D in brain function, behavior, and other physiological functions.

Dr. Sten Ekberg, shares information that helps to take away the nutrition guess work. Dr. Ekberg is a former decathlon athlete who competed in the 1992 Summer Olympics for Sweden and was a Swedish decathlete National Record holder. Sten won the Swedish Championship in both decathlon and heptathlon. Ekberg currently resides in the United States where he works as a chiropractor and nutritionist at his office Wellness For Life in Cumming, Georgia. 

Dr. Mark Hyman is a practicing family physician and an internationally recognized advocate in the field of Functional Medicine and a fourteen-time New York Times best-selling author. He is the host of one of the leading health podcasts, The Doctor’s Farmacy. 

Thomas DeLauer is a Nutritionist and Expert in Diet, Cognitive Nutrition and Performance. He is motivated by a guiding ethos of integrated optimization: if you perform better, so does the world. Thomas reaches more than 15 million viewers monthly (on average) through his Youtube channel, where he translates experience and learning from his own health transformation utilizing intermittent fasting and other forms of nutrition into actionable steps for his dedicated community of 2.85 million subscribers.

In this episode you will learn,

• How our gut health directly helps our immune system function
• The four essential foods for longevity
• Why meat-eaters need to avoid confounding factors like smoking if they want to stay healthy
• How your chronological age doesn’t tell the full aging story
• Why to avoid processed food, especially carbohydrates

For more information go to www.lewishowes.com/1465

Dr. Rhonda Patrick’s Full Episode: https://lewishowes.com/podcast/a-scientific-guide-to-living-longer-feeling-happier-and-eating-healthier-with-dr-rhonda-patrick/

Dr. Sten Ekberg’s Full Episode: https://link.chtbl.com/1345-pod

Dr. Mark Hyman’s Full Episode: https://link.chtbl.com/1375-pod

Thomas DeLauer’s Full Episode: https://link.chtbl.com/1389-pod

What’s the maximum human lifespan? Neil deGrasse Tyson and co-hosts Chuck Nice and Gary O’Reilly explore how to extend your longevity, the history of medicine, and how we can live better with author of Outlive: The Science & Art of Longevity, Dr. Peter Attia.

NOTE: StarTalk+ Patrons can listen to this entire episode commercial-free here: https://startalkmedia.com/show/medicine-3-0-extending-human-lifespan-with-dr-peter-attia/ 

Thanks to our Patrons Charles Macko, Richard S Buller, Jane Boltz, Chris Bickford, and Alan Gratz for supporting us this week.

Photo Credit: Sarka Na kopci, CC BY-SA 4.0, via Wikimedia Commons

Would you want to live forever? On this episode, Neil deGrasse Tyson and author, inventor, and futurist Ray Kurzweil discuss immortality, longevity escape velocity, the singularity, and the future of technology. What will life be like in 10 years? 

NOTE: StarTalk+ Patrons can listen to this entire episode commercial-free here: https://startalkmedia.com/show/could-we-someday-live-forever-with-ray-kurzweil/

Thanks to our Patrons Johan Svensson, Galen J., Kellen Bolander, Sunshine, and Brian White for supporting us this week.

Photo Credit: Jon Manning, CC0, via Wikimedia Commons

Welcome to the first episode of Bio Eats World, a brand new podcast all about how biology is technology. Bio is breaking out of the lab and clinic and into our daily lives -- on the verge of revolutionizing our world in ways we are only just beginning to imagine.

In this episode, we talk all about the science of aging. Once a fringe field, aging research is now entering a new phase with the first clinical trials of aging-related drugs. As the entire field shifts into this moment of translation, what have we learned? What are the basic approaches to developing aging-related drugs? How is studying aging helping us understand diseases like cancer and Alzheimer’s -- and increasing the amount of time we are healthy -- today? 

In this conversation, Laura Deming, founder of The Longevity Fund; Kristen Fortney, co-founder of BioAge, a clinical-stage company focused on finding drugs to extend healthspan; Vijay Pande, general partner at a16z; and host Hanne Winarsky discuss the entire arc of aging science from one genetic tweak in a tiny worm to changing a whole paradigm of healthcare delivery.

Be sure to subscribe to 'Bio Eats World' if you want to keep getting it (and please feel free to rate it as well). To learn more about the expanding a16z Podcast network, please visit a16z.com/podnetwork.

CAR T therapy is a groundbreaking medicine that uses engineered T cells to attack cancer. But CAR T cells (that is, chimeric antigen receptor T cells) can be programmed to recognize a huge range of target proteins and cell types. So what other types of cells should we train CAR Ts to recognize and destroy to improve human health?

On this episode of the a16z Journal Club, a16z General Partner Jorge Conde, bio deal team partner Andy Tran, and Lauren Richardson discuss new research published in Nature in which the authors engineer CAR T cells to recognize and kill senescent cells. Cellular senescence is a process where cells stop dividing (sort of go to sleep), and in many cases this can be protective, like its role in tumor suppression, but if too many cells become senescent of if they are not removed, they can trigger inflammation and cause disease, like in atherosclerosis and type 2 diabetes. Critically, senescent cells build up as we age and contribute to a whole host of age-related conditions. In this episode we cover how the authors created these senescence killing (aka senolytic) CAR T cells, the diseases that could be treated with senolytic CAR Ts, the hurdles to getting them into the clinic, and how they could potentially be used to treat aging and possibly improve longevity.

“Senolytic CAR T cells reverse senescence-associated pathologies” in Nature (June 2020) by Corina Amor, Judith Feucht, Josef Leibold, Yu-Jui Ho, Changyu Zhu, Direna Alonso-Curbelo, Jorge Mansilla-Soto, Jacob A. Boyer, Xiang Li, Theodoros Giavridis, Amanda Kulick, Shauna Houlihan, Ellinor Peerschke, Scott L. Friedman, Vladimir Ponomarev, Alessandra Piersigilli, Michel Sadelain & Scott W. Lowe

a16z bio Journal Club (part of the a16z Podcast), curates and covers recent advances from the scientific literature -- what papers we’re reading, and why they matter from our perspective at the intersection of biology & technology. You can find all these episodes at a16z.com/journalclub.

“A leaky gut is the cause of all disease.”

QUESTIONS

What are specific ways to heal your heart without surgery? (7:20)

What’s the difference between a good virus and a bad virus? (18:03)

What are the foods that heal leaky gut and defend against viruses? (28:50)

Why is peanut butter such a bad thing? (37:25)

What boosts the immune system? (59:43)

Is it possible to have such a strong immune system that you can reject any virus? (1:06:40)

How important are probiotics right now? (1:09:35)

YOU WILL LEARN

Why fixing the heart medically can only help your health so much (1:06)

Why we need germs and bacteria to stay healthy (13:45)

The benefits of time-restricted feeding (20:25)

What causes aging (23:17)

How mental illness comes from the gut (43:30)

Why food labels can’t be trusted (49:20)

The importance of human connection for your heart during a time of social distancing (1:12:55)

How bacteria choose who you are attracted to (1:15:01)

LINKS MENTIONED

The Plant Paradox

Dr. Gundry Podcast

David Kessler

Terry Wahls

The Longevity Paradox

Dr. Amen podcast with Dr. Gundry

Vibrant America

GundryMD.com

If you enjoyed this episode, show notes and more at http://www.lewishowes.com/935 and follow at instagram.com/lewishowes

Aging is a disease.

Everyone gets old. But did you ever think of the symptoms of aging as a disease that can be cured?

I'd heard about Dr. David Sinclair and his ground-breaking longevity research, and I knew he would be a fascinating person to interview about this idea.

We ended up going really deep into the science of why we age, how to reverse it, and what is actually in our control.

David told stories he'd never shared before, and I kept asking questions because I was so interested in what he was telling me.

David Sinclair is a professor in the Department of Genetics and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School. He is an inventor on 35 patents and has received more than 35 awards and honors. In 2014, he was on Time Magazine’s list of the “100 Most Influential People in the World,” and listed as Time's Top 50 in healthcare in 2018.

In this conversation, we discussed all of my top questions on why we age, how much of it is reversible, and all of the ways I've heard to increase your longevity and health.

David is a wealth of wisdom on all these topics, and he also shared some of the hardest times of his life, including watching his mother die of lung cancer and why that impacted his work so much.

If you are committed to improving your health and living a long and healthy life, this conversation is a must-listen in Episode 904.

• Is it possible to reverse death? (7:42)
• What are the main ways to turn on the longevity genes? (9:30)
• How do you say no to all the food offers around you? (17:30)
• How did you get fascinated by longevity and anti-aging? (19:15)
• How did you recover from a major career setback? (37:06)
• What was the biggest lesson you learned from a year of being homeless? (49:28)
• How important are heat and cold therapy to anti-aging? (59:38)
• What is the ideal way to use fasting to improve your health? (1:05:42)
• How old do you think you’ll be able to live? (1:14:15)
• How much does inflammation play into the longevity of your life? (1:20:44)

• How our body’s built-in defenses against aging work (1:12)
• Why 3 meals a day is too much food for most people (10:09)
• The main benefits of a plant-based diet for longevity (13:13)
• Why it’s important to remember that there will always be another meal (15:10)
• Why death is so shocking to us even though it happens all the time (21:01)
• The molecule that has been proven to protect against a variety of diseases (29:34)
• The story that David has never told of how he was homeless after college (44:45)
• How cells lose their ability to stay young (55:32)
• Lewis’ experience doing a cold-exposure intensive in Poland with Wim Hof (1:08:45)
• Plus much more...

If you enjoyed this episode, check out the video, show notes and more at http://www.lewishowes.com/904 and follow at instagram.com/lewishowes

DIE YOUNG AT AN OLD AGE.
How many fad diets have you tried?
There’s a reason that they don’t work.
Health and diet are not one-size-fits-all. We all have a special set of genes that tell us what foods we need.
But it’s more than your genes.
Doctor’s will ask you if you have a history of a disease in your family. That’s because you not only share the same genetic make-up, you probably eat the same way.
It’s a combination of the two that will determine your health.
On today’s episode of The School of Greatness, I talk about the secret to longevity with one of the world’s top health experts: Dr. Steven Grundy.