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    Dr. Kyle Gillett: How to Optimize Your Hormones for Health & Vitality

    enApril 11, 2022

    Podcast Summary

    • Hormone Health Expert's Approach to Total WellnessDr. Gillette's balanced approach to hormone health and use of multiple tools and preventative medicine can benefit both males and females, shared for free on public platforms for greater accessibility and understanding.

      Dr. Kyle Gillette is an expert in hormone health, with a broad and in-depth knowledge on the topic. He provides full-spectrum medicine, with a balanced approach to total health across the lifespan. Dr. Gillette is a clear communicator with a deep love of understanding biology and medicine in ways that can benefit people. He uses various tools such as behavioral, nutritional, exercise-based, hormone replacement therapy and other supplementation to manage hormone health. His approach is very receptive to both male and female issues. Dr. Gillette's providing a wealth of knowledge on all things, hormones, and hormone-related health on zero cost to consumer platforms, making knowledge more approachable. A preventative approach towards medicine is a crucial component of overall health, and its significance is becoming evident in recent times.

    • Importance of Understanding Your Hormone Health and Lifestyle Interventions.Communicate with your doctor about concerns related to energy, focus, and athletic performance. Men and women have different challenges in accessing hormonal data, but lifestyle interventions such as diet, exercise, and stress optimization can help. Resistance training and caloric restriction can also improve hormone health. Start early and maintain interventions over time.

      Understanding your hormone health is important and can be approached by asking pertinent questions about your symptoms and family history. It is important to communicate with your doctor about concerns related to energy, focus, and athletic performance, even if you don't have a pathology. Men and women have different challenges related to accessing hormonal data. The six pillars of lifestyle interventions, including diet, exercise, stress optimization, sleep, environmental exposures, and supplements, are crucial for hormone health. Resistance training and caloric restriction can be particularly helpful for hormone health. Starting these interventions early and maintaining them over time is key to optimizing hormone health.

    • Achieving Optimal Health as a Household Unit with Focus on Six Key AreasPrioritize stress management, sleep, sunlight exposure, personalized nutrition, regular blood testing, and exercise (zone 2 cardio and resistance) for improved health. Don't forget to consider spiritual health as a crucial component for overall well-being.

      To achieve optimal health, it's important to work on it together as a household unit with a focus on six important areas including stress, sleep optimization, sunlight, spirit, diet, and exercise. Diet should be individualized based on genetics and biofeedback, and regular blood testing every three to six months is recommended. Exercise should include a minimum of 150 to 180 minutes of zone two cardio per week and resistance exercise for cardiovascular health, brain health, and musculoskeletal health. Spiritual health is also an important aspect to consider in achieving overall well-being, and should not be overlooked.

    • Caloric restriction, intermittent fasting, and overall healthCaloric restriction can benefit obese individuals but decrease testosterone levels in healthy individuals. Intermittent fasting may improve growth hormone and IGF-1 levels, but mental clarity and pleasure in eating are factors to consider. Understanding the difference between weight loss and overall health benefits is crucial. Exercise is another way to improve overall health.

      Caloric restriction can help obese and metabolic syndrome patients to improve their testosterone levels and overall health, but it can decrease testosterone levels in healthy individuals. Intermittent fasting can help improve growth hormone and IGF-1 levels but may not be necessary for weight loss. The mental clarity and increased pleasure in eating during the eating window is a factor that makes people try intermittent fasting. It is crucial to understand the difference between weight loss and overall health benefits when it comes to caloric restriction and exercise. Additionally, caloric restriction is not the only way to achieve intermittent fasting, and there are other methods to improve overall health like exercise.

    • Hormone Optimization and Its Impact on Sleep QualityHormone optimization can improve sleep quality by addressing growth hormone deficiency and utilizing progesterone and its derivatives as GABA agonists. Caution should be taken in considering the source of exogenous IGF-1.

      Hormone optimization can positively affect sleep. Growth hormone deficiency can impact sleep, while progesterone and its derivatives can function as a GABA agonist to improve sleep quality. IGF-1 has a longer duration of action compared to growth hormone and has a local action that improves body composition after exercise. While there is little evidence to suggest that increasing growth hormone levels from intermittent fasting or saunas can lead to cancer, it is important to consider the source of IGF-1, as exogenous IGF-1 does not necessarily improve body composition. Ultimately, sleep is crucial to mental and physical health, and hormone optimization can play a role in improving sleep quality.

    • The Impact of Testosterone on Sleep and HealthLow testosterone levels can negatively impact sleep in men, while testosterone replacement therapy can increase the risk of sleep apnea. It is also important to monitor testosterone levels in women to prevent certain health conditions.

      Low testosterone can lead to poor sleep in men. Testosterone replacement therapy (TRT) can increase the risk of sleep apnea, leading to poor sleep even in people with normal testosterone levels. Testosterone merely exacerbates existing features of people and does not change them as a person. Women have testosterone too, and it mostly comes from the Thika cells in the ovaries. Women have almost all significantly more testosterone than estrogen, and significantly more DHA than either. Knowing a woman's testosterone is important for pathology prevention, such as breast cancer and osteoporosis, but estrogen and progesterone levels are more important to know.

    • Understanding Natural Testosterone Production, DHT and Gene Transcription of Androgen ReceptorTestosterone production varies among individuals and can be genetically determined. DHT, a powerful androgen hormone, affects hair loss and is mediated by the androgen receptor. Gene transcription of the receptor affects the severity of male pattern baldness, and androgen insensitive insensitivity syndrome is caused by the gene from the mother being completely insensitive to androgens.

      Natural testosterone production varies greatly among individuals and can be genetically gifted, leading to controversies in sports competitions. DHT is a powerful androgen hormone in both men and women, and its effects are mediated by the androgen receptor. Male pattern baldness is related to gene transcription of the androgen receptor, and people with fewer CAG repeats have less severe hair loss. Elevated levels of DHT may not be causing more hair loss than 50 years ago, as people in the past were more sensitive to androgens. Androgen insensitive insensitivity syndrome (AIS) is related to men with the AR gene from their mother being completely insensitive to androgens.

    • Understanding DHT for Heart Health and Hair LossBalancing DHT levels is crucial for cardiovascular health and preventing male pattern baldness. Dietary changes and supplementation can help, but it's important to monitor levels and consult a doctor for personalized recommendations.

      DHT is important for cardiovascular health, including heart muscle growth and remodeling. While some level of DHT is necessary for optimal health, excess DHT can contribute to male pattern baldness and other health issues. Dietary changes and supplementation, such as turmeric and black pepper extracts, can inhibit the conversion of testosterone to DHT and therefore reduce DHT levels. However, individuals should avoid these supplements if their DHT levels are already low. Creatine, on the other hand, can increase the conversion of testosterone to DHT and may be beneficial for those with low DHT levels. DHT is also involved in libido, motivation, and drive. It's important to monitor DHT levels and consult a doctor for recommendations on how to optimize DHT levels for overall health.

    • Approaching Supplements and Medications with CautionConsult with your doctor before taking supplements or medications that inhibit ISO enzymes or progesterones. Be aware of potential side effects, but know that most effects are reversible. Be cautious when taking creatine as it may vary from person to person and potentially lead to hair loss.

      When experimenting with supplements or medication, it's important to approach it with caution and talk to your doctor. The effects of inhibiting five alpha reductase, which supplements like saw Palmetto and Finasteride do, can vary and have different impacts depending on the ISO enzymes they inhibit. Inhibiting certain progesterones can also cause side effects. However, most effects of these supplements and medications are reversible. Creatine monohydrate can potentially increase DHT, which can lead to hair loss, but it varies from person to person. If you notice more hair falling out while taking creatine, you can stop and the hair will grow back if the stem cell niches in the hair follicle are still there.

    • Options for Maintaining or Growing Hair and Addressing Polycystic Ovarian SyndromeWhile alpha reductase inhibitors may cause initial hair loss, they promote healthier follicles. For long-term hair maintenance, consider options like Dutasteride and Mesotherapy, but be aware of potential side effects. Additionally, early detection and treatment of PCOS can improve its management.

      Five alpha reductase inhibitors may cause a large amount of hair fall at first, but this sheds unhealthy cells and promotes growth of new and healthier follicles. Maintaining or growing hair can be done through options like Dutasteride and Mesotherapy, but it is important to consider the potential side effects of blocking DHT in the periphery, especially for women who can be sensitive to DHT. Polycystic ovarian syndrome (PCOS) is an underdiagnosed condition that causes infertility or subfertility, usually diagnosed in the thirties, and can be identified through the Rotterdam criteria. Early detection and treatment can help women with PCOS manage their symptoms.

    • Diagnosing and Treating PCOS: Beyond Polycystic OvariesManaging body composition, using supplements and medications, and addressing hormonal imbalances can alleviate symptoms and improve overall health in women with PCOS. Hormonal contraceptives can also affect perception of attractiveness.

      PCOS can be diagnosed without having polycystic ovaries, if there are symptoms of androgen excess, insulin resistance, oligomenorrhea, or infertility. Optimizing body composition, treating metabolic syndrome, and taking supplements like myo-inositol or ASTA tall can help with insulin sensitization and androgen inhibition. Women on oral contraceptives experience a shift in their perception of men's attractiveness due to blunting of hormone output. Men also perceive women on oral contraceptives differently. To reduce androgen receptor activity, women can take DeCarlo or Diane dull methane, along with considering anti-androgen medications like spironolactone.

    • Effects of Oral Contraceptives and Substance Use on Libido and FertilityOral contraceptives can alter hormones and reduce libido, but do not permanently damage fertility. Substance use, such as marijuana, alcohol, and barbiturates, can also have negative effects on testosterone levels.

      Oral contraceptives alter the peaks and troughs in libido and attractiveness, and reduce the associated increase in libido that normally occurs from the increase in androgen. Synthetic progestins have various pros and cons, and some can cause weak anti-androgen effects. Oral contraception may disrupt fertility past 6 to 12 months, but persistent elevated SHBG can be present for quite some time. However, it does not quicken the transition to infertility or cause permanent damage. Marijuana can decrease testosterone, while high alcohol and barbiturate intake can reduce testosterone.

    • The Effects of Marijuana, Alcohol, and Sleep Supplements on TestosteroneMarijuana, alcohol, and certain sleep supplements can decrease testosterone levels. It is important to talk with a doctor before considering testosterone replacement therapy as increasing testosterone without medical supervision can be harmful.

      Smoked marijuana may reduce testosterone or increase the conversion of testosterone to estrogen. Alcohol and potent GABA agonists like barbiturates, benzodiazepines, or non-benzo also decrease testosterone. The American heart association recommends moderate alcohol intake of one to two drinks a day for men and zero to one for women. Daily intake of sleep supplements containing GABA, Trazadone, or melatonin should be avoided. Magnesium and L-theanine can be exceptions. Testosterone levels are dropping, and people are considering taking testosterone, although it was previously considered steroid use. However, it's crucial to remember that increasing testosterone without a doctor's prescription can have dangerous side effects.

    • Maintaining Prostate Health and Decreasing Prostate Cancer RiskA healthy prostate involves avoiding things that harm it, such as infections and chronic constipation, while consuming a diet high in prebiotic fiber and probiotics. Regular checkups, decreasing inflammation and congestion, and monitoring PSA levels can reduce the risk of developing prostate cancer.

      Testosterone supplementation won't cause prostate cancer but it will grow an existing cancer. Prostate cancer is normal with aging, and it's only a matter of time until you develop it. Maintaining prostate health involves looking for things that can hurt it, such as infections, chronic constipation, and colitis, and preventing those with a diet rich in prebiotic fiber and probiotics to ensure regular bowel movements. Following PSA levels, having prostate MRIs, and decreasing inflammation and congestion of the prostate can decrease the chances of developing prostate cancer. Young males with higher testosterone levels don't have a higher risk of prostate cancer, but older males with cumulative damage and prostate cancer are normal with aging.

    • Maintaining Prostate Health through Prevention and Management TechniquesKeeping low levels of CRP, exercising pelvic floor muscles, taking Todalofil and Flomax medications, consuming enough insoluble fiber, and avoiding high estrogen levels are effective ways to prevent mutations, infections, and abnormal cell growth in the prostate.

      Maintaining low levels of CRP can help prevent mutations and atypical cell turnover in the prostate. Strengthening the pelvic floor is important for both men and women and can be aided by exercises and pelvic floor physical therapists. Taking low doses of Todalofil, such as Cialis, can help decrease congestion in the prostate and improve urinary system health. Flomax is another medication that can be used to improve urinary system health. Eating enough insoluble or non dietary fiber can prevent diverticulitis, colitis, and prostate infections. Avoiding high estrogen levels can also prevent atypical cells in the prostate.

    • Low dose Tadalafil and Testosterone Replacement Therapy for Prostate Health and Hair LossLow dose Tadalafil can benefit prostate health and potentially prevent hair loss, but may have negative effects on blood pressure. Testosterone replacement therapy should aim for a steady state to avoid overactivity of the androgen receptor gene and thick blood side effects.

      Low dose Tadalafil can be used to maintain or enhance prostate health, but it may carry negative effects such as lowering blood pressure. It can also potentially help prevent hair loss by increasing blood flow. Testosterone replacement therapy (TRT) is recommended only for hypogonadal patients whose benefits outweigh the side effects. TRT should aim for a steady state to avoid the overactivity of the androgen receptor gene and the side effects of thick blood. Different types of esters or topical testosterone can be used to get around these side effects. Steady-state TRT is not exactly the same as producing pulsatile testosterone release endogenously from our body.

    • Methods for Regulating Testosterone Levels and Controlling EstrogenInjections or lymph-absorbed capsules are better than topical applications for low SHBG. Longer Ester is needed for injectables. Aromatase inhibitors aren't recommended. Use lifestyle interventions, supplements, and regular monitoring for healthy estrogen levels.

      When it comes to regulating serum testosterone levels, injections are preferred over topical applications for people with low SHBG. Capsules that are absorbed through the lymph are also an option. A lower SHBG means a longer Ester is required for injectables. Aromatase inhibitors aren't recommended for most people as lifestyle interventions can often help with estrogen control. Supplements like calcium D glucarate and cruciferous vegetables can also assist with estrogen control. It's important to monitor estrogen levels regularly to ensure they're at a healthy level.

    • An Individualized Approach is Key to Optimizing TRTTestosterone replacement therapy should be personalized based on an individual's androgen receptor sensitivity, lifestyle factors, and preferences. Caution should be taken when using supplements and altering diet. Balanced testosterone to estrogen ratio is crucial for quality of life.

      When it comes to TRT, an individualized approach is crucial as everyone's androgen receptor sensitivity is different. Quality of life can be subjective and people are willing to give up different things. Supplements and practices can increase testosterone levels, but it's important to be cautious and only alter one thing at a time. Lifestyle factors like alcohol and high-fat meals can upregulate aromatase and increase estrogen levels, so it's important to be mindful. The ratio of testosterone to estrogen is a key factor in how one feels, and a true individualized approach is necessary to find the right dosage of TRT. Ingesting some amount of saturated fat may be useful as cholesterol serves as a precursor to testosterone and estrogen molecules.

    • The Importance of Healthy Trans Fats and Omega-3 for Hormone BalanceGetting healthy trans fats and omega-3 from ruminants or their food products can help balance testosterone to estrogen ratio. Vegans should consider supplementation or consuming plant-based diets rich in polyphenols to activate beta estrogen receptor.

      It's important to get healthy trans fats from ruminants or their food products, as well as proper amounts of omega-3 to maintain a healthy testosterone to estrogen ratio. Vegans may be at risk for not getting enough of these healthy fats and may need to supplement with other sources. Tongkat Ali, also known as long jack, has multiple mechanisms of action and can potentially reduce sex hormone binding globulin and free up testosterone, although its effects are not consistent. It's important to note that healthy trans fats are not necessary and can be found naturally occurring in ruminant cheese, milk, and butter. Plant-based diets rich in polyphenols may also activate the beta estrogen receptor.

    • The Benefits and Cycle of Tonga Ali and Dojokarate SupplementsTonga Ali can reduce hyperestrogenism and increase testosterone, while Dojokarate is a potential testosterone booster that needs further research for safety. Use Tonga Ali as post-cycle therapy, cycle off for safety purposes, and consider Indonesian sources for effectiveness.

      Tonga Ali can help reduce hyperestrogenism in women and increase testosterone in both men and women. A dosage of 400 milligrams taken once a day is effective and sources from Indonesian Tonga Bali is ideal. It can also be used for post-cycle therapy and to lower persistent SHBG levels after discontinuing birth control pills. While Tonga Ali may not need to be cycled off, it is recommended to cycle off for safety purposes. A reasonable cycle off would be 11 months on and one month off. Dojokarate is a potential testosterone booster that increases luteinizing hormone release and receptor sensitivity but needs further research to determine its safety as a long-term supplement.

    • Supplements for increasing LH and testosterone levels in recoverySupplements like Naltrexone, Tonga Ali, and boron may help regulate LH and testosterone levels in recovery, but consult with a physician and do blood work before taking. Cycling and recommended dosages are important, and those with high LH may not benefit from further increase.

      Naltrexone can potentially help increase LH in people recovering from opiates or alcohol, and Tonga Ali and boron supplements can help regulate SHBG and increase LH and testosterone levels. However, it is important to do blood work and consult a physician before taking supplements. Cycling supplements like Fiducia for three weeks on and one week off is likely safe, and boron can be taken at three to six milligrams once or twice a day. It's worth noting that although supplements are generally safer than medications, it is important to ensure the quality of supplements and follow recommended dosages. Additionally, people with already high LH may not benefit from increasing it further with supplements.

    • Understanding the uses and risks of HCG in fertility and hormone therapy.HCG can improve fertility and hormone function but may also have estrogenic effects and risks for women. Careful consideration and monitoring is necessary when using HCG for fertility or hormone therapy.

      HCG is a hormone that is similar to TSH and is commonly used for fertility treatment. It can suppress LH output, but also improve thyroid function. It can be used alone or in combination with testosterone therapy. HCG can also improve sensitivity in the genitals and is commonly used to treat post-finasteride syndrome. However, HCG may increase estrogen and there may be risks for women taking it on their ability to get pregnant. Overall, the potential benefits and risks of taking HCG should be carefully considered before use.

    • Maintaining the Delicate Balance between Dopamine and ProlactinThe delicate balance between dopamine and prolactin is crucial to avoid a hyperdopaminergic state and overflow of dopamine, which can cause severe side effects. Proper diagnosis of pituitary tumors is essential to manage hormonal imbalances caused by the tumors.

      The delicate balance between dopamine and prolactin needs to be maintained as dopamine agonists can lead to hyperdopaminergic state and overflow of dopamine, leading to the crash of dopamine waves. Prolactin gene or estrogen upregulates PRL gene, increasing prolactin synthesis and inhibiting the release of testosterone. Pituitary tumors are common and can be caused by high contact sports, head blows, or even concussion. Microadenomas can be non-producing, causing fatigue and high prolactin feeling. Augmenting dopamine through prescription drugs can lead to hitting many transmitter systems, and it's important to maintain a delicate dance between sympathetic and parasympathetic drive even across minutes.

    • Boosting Dopamine and Energy to Improve MotivationImproving low motivation and energy can be accomplished through steps such as eliminating prolactin-increasing factors and taking supplements like dopamine agonists, vitamin B6, and L-carnitine, while also prioritizing lifestyle factors such as exercise and sleep.

      Low drive and motivation may be caused by low levels of dopamine, which can be increased through various interventions such as taking dopamine agonists, vitamin B6, and vitamin E. However, it is important to start with the least powerful interventions such as eliminating things that could be increasing prolactin. L-carnitine can also be beneficial for enhancing sperm quality, egg quality, and rates of conception as it acts as the shuttle that helps get the fuel into the motor in a cell. Overall, lifestyle factors such as diet, exercise, sleep quality, and supplementation can significantly affect the body's energy production and fuel utilization.

    • Tips for Taking L-Carnitine for Fertility and Androgen Receptor UpregulationL-Carnitine can be taken in capsule or injectable form, but a high dose is needed for fertility benefits. Garlic or Alison can mitigate potential side effects and regular blood tests can provide important health information.

      L-carnitine can be taken in capsule or injectable form, but only a small amount is bioavailable. For fertility and androgen receptor upregulation, the recommended dose is one gram per day, which would require taking approximately 15-20 capsules. L-carnitine can be found in some foods, but it is not very bioavailable. Injecting L-carnitine is 100% bioavailable, but it burns if injected subcutaneously. One possible side effect of taking L-carnitine is an increase in TMAO. Incorporating 600 milligrams of garlic or Alison into the daily diet can mitigate this effect. Regular blood tests can provide important information about hormone levels, metabolic markers, and lipids. While insurance may not cover these tests, they are becoming more affordable through options like FSAs, HSAs, and care credit.

    • The Importance of Building Positive Relationships and Maintaining Hormonal BalanceBuilding and maintaining positive relationships requires a balance of time apart and time together, planning for good times, avoiding hyperprolactin phases. Hormonal crosstalk and dopamine fluctuations play important roles. Optimization of hormones is critical for both relationship success and individual well-being.

      Building positive relationships and maintaining hormonal balance is important for overall well-being. Time apart and time together, planning ahead for good times, and avoiding hyperprolactin phases can help stabilize relationships. Hormonal crosstalk and pheromonal communication plays an important role in both new and long-term relationships. Dopamine is associated with novelty and excitement, and its levels fluctuate over time during a relationship. Relationships go through crises and planning ahead can help stabilize them. Hormone optimization both for the sake of a relationship and because of the relationship is important, and it is bi-directional. It is suggested that spending 100% of time together can be detrimental to a relationship, and time apart can renew excitement.

    • Understanding the Hormonal Changes in RelationshipsHormones like dopamine, prolactin, and oxytocin play important roles in shaping perception and behavior in relationships. Being aware of these changes can make it easier to navigate through the different stages and maintain the spark in relationships.

      Relationships go through different stages, including the dopamine-fueled initial phase and the changing dynamics during pregnancy and infancy. Hormones like dopamine, prolactin, and oxytocin play a significant role in shaping perception and behavior. Separation and affiliation bonds can serve as a dopamine reservoir for couples to maintain the spark in their relationships. Prolactin is essential for nesting instinct, breastfeeding, infant maturity, and respiratory health. Cold exposure may not correct hypogonadism, but it can acutely help with warming testes and increasing testosterone levels. Understanding the changes and being aware of the side effects in relationships and hormonal changes can make it easier to navigate through them.

    • Peptides, Saunas, and Reproductive Health: Things to Watch Out ForPeptides are not equal in safety, and professional guidance is necessary. Avoid hot tubs and heated water if you have infertility or low sperm count, and consider cold showers and ice baths for women to increase beta adrenergic receptor activity. Be cautious to avoid frostbite in the future.

      Peptides are gaining popularity, but they are heterogeneous with varying degrees of safety. Insulin is a peptide that is safe when prescribed by doctors. Some peptides are FDA approved, like Tessa Moreland for lipo dystrophy. However, usage of other peptides should be approached with caution and only with professional guidance. Saunas raise the temperature of the testes, which is the enemy of sperm production. For those with infertility or low sperm count, hot tubs and heated water should be avoided. Women can benefit from cold showers and ice baths as it can increase the activity of beta adrenergic receptors. The primary concern is not estrogen output. People need to be careful not to get frostbite in the future.

    • Understanding Peptide Therapy and Potential RisksPeptide therapy can offer benefits such as promoting lean body mass and healing injuries, but it's important to consult a doctor before use and be aware of potential risks such as increased cancer risk.

      Using growth hormone releasing hormone peptides like Sermorelin prescribed by doctors may have risks such as increased cancer risk. However, these peptides can be used in injuries and for other benefits like decreasing body fat and increasing lean body mass without taking growth hormone. Other peptides like BPC 1, 5, 7 have gastroprotective benefits and can increase vascular endothelial growth factor, but should be avoided by people with cancer risk. It is essential to consult a doctor before taking any of these peptides and understand their mechanism of action and potential risks.

    • The Benefits and Risks of Peptides and Malana TanPeptides like BPC 1, 5, 7 and copper peptide GFK have healing properties, but must be obtained from a reputable source. Malana tan has FDA-approved uses, but recreational use can cause harm. Consult with a physician and ask about individualized treatment. Sometimes, less is more.

      Peptides like BPC 1, 5, 7 can help increase blood flow to the injured area and aid in recovering from injuries but it's important to work with a physician and get it from a good compounding pharmacy. Non-prescription forms often contain lipopolysaccharide (LPs) which can cause inflammation. Malana tan has several FDA approved indications but it's important to avoid its recreational use for tanning purposes as it can cause serious damages like Priya prism. It's essential to ask questions to your doctor regarding the dosing regimen and individualized treatment. Copper peptide like GFK can help regenerate the liver and nervous system. Sometimes, the best dosage of something to take is zero.

    • Peptide PT 1 41 and Hormone Health OptimizationPeptide PT 1 41 can aid in boosting libido for women with hypoactive sexual disorder but long-term use may increase alpha melanocyte stimulating hormone levels. Optimizing hormone health requires a holistic approach involving diet, exercise, stress management, rest, sunlight exposure, and spirituality.

      Peptide PT 1 41 helps women with hypoactive sexual disorder to boost their libido, and it is also relatively safe and approved for men. However, long-term administration may increase alpha melanocyte stimulating hormone, so people with a family history of melanoma or potentially having it should be careful. Besides, the peptide is also approved for lipo dystrophy and a rare genetic condition in childhood. Optimizing hormone health requires managing six critical factors, namely diet, exercise, appropriate caloric restriction, managing stress, sleep, and sunlight, as well as nurturing spiritual health as part of the holistic approach to health and wellness. Patients need to bring physical, mental, and spiritual health together, as they are interconnected and essential for overall health and quality of life.

    • Embracing Personal Spirituality in the Absence of Religious PracticesA person's spiritual journey is personal and should not be pressured. Being open to diverse beliefs and practices can foster positive physician-patient relationships and stimulate critical thinking. Neuroscience is exploring the basis of spiritual experiences in the brain.

      People who identify as atheists or agnostics may not have prescriptive religious practices, but can still explore spirituality and find what they truly believe in. As a physician, Dr. Kyle Gillett believes that everyone's spiritual journey is personal and should not be pressured. Neuroscience is currently asking questions about the grounding of spiritual experiences in the brain. The most commonly used drug, caffeine, may not have a significant effect on hormones unless it affects sleep. Being open to different beliefs and practices, regardless of one's own background, can lead to excellent physician-patient rapport and stimulate thinking, which is the ultimate goal of this podcast.

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    In this episode, my guest is Dr. Mary Claire Haver, M.D., a board-certified OB/GYN and an expert on women’s health and menopause. We discuss the biology and symptoms of perimenopause and menopause and their effects on body composition, cardiometabolic health, mental health, and longevity. She explains the lifestyle factors, including nutrition, resistance training, sleep, and supplements, that can better prepare women for and improve symptoms of both perimenopause and menopause. We also discuss hormone replacement therapy (HRT) and whether HRT impacts the incidence of breast cancer or can affect cardiovascular health. We also discuss contraception, cellulite, polycystic ovary syndrome (PCOS), and how to reduce the risk of osteoporosis. This episode is rich in actionable information related to what is known about menopause and perimenopause and the stages before, allowing women of all ages to best navigate these life stages. For show notes, including referenced articles and additional resources, please visit hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman  AeroPress: https://aeropress.com/huberman  Eight Sleep: https://eightsleep.com/huberman  BetterHelp: https://betterhelp.com/huberman  InsideTracker: https://insidetracker.com/huberman  Timestamps 00:00:00 Dr. Mary Claire Haver 00:02:04 Sponsors: AeroPress, Eight Sleep & BetterHelp 00:06:26 Menopause, Age of Onset 00:09:50 Perimenopause, Hormones & “Zone of Chaos” 00:14:42 Perimenopause, Estrogen & Mental Health 00:20:04 Perimenopause Symptoms; Tool: Lifestyle Factors & Ovarian Health 00:25:26 Early Menopause, Premature Ovarian Failure; Estrogen Therapy 00:29:42 Sponsor: AG1 00:31:31 Contraception, Transdermal, IUDs; Menopause Onset, Freezing Eggs 00:38:18 Women’s Health: Misconceptions & Research 00:45:01 Tool: Diet, Preparing for Peri-/Menopause; Visceral Fat 00:48:31 Tools: Body Composition, Muscle & Menopause, Protein Intake 00:51:42 Menopause: Genetics, Symptoms; Tools: Waist-to-Hip Ratio; Gut Microbiome 00:58:22 Galveston vs. Mediterranean Diet, Fasting, Tool: Building Muscle 01:05:18 Sponsor: InsideTracker 01:06:29 Hot Flashes; Estrogen Hormone Replacement Therapy (HRT), Breast Cancer Risk & Cognition 01:15:36 Estrogen HRT, Cardiovascular Disease, Blood Clotting; “Meno-posse” 01:24:00 Estrogen & Testosterone: Starting HRT & Ranges 01:30:36 Other Hormones, Thyroid & DHEA; Local Treatment, Urinary Symptoms 01:37:57 OB/GYN Medical Education & Menopause 01:41:30 Supplements, Fiber, Tools: Osteoporosis “Prevention Pack” 01:46:53 Collagen, Cellulite, Bone Density 01:51:42 HRT, Vertigo, Tinnitus, Dry Eye; Conditions Precluding HRT  01:55:27 Polycystic Ovary Syndrome (PCOS) & Treatment; GLP-1, Addictive Behaviors 02:01:55 Post-menopause & HRT, Sustained HRT Usage 02:04:58 Mental Health, Perimenopause vs. Menopause; Sleep Disruptions, Alcohol 02:09:09 Male Support; Rekindle Libido 02:12:46 HRT Rash Side-Effect; Acupuncture; Visceral Fat 02:16:24 Zero-Cost Support, Spotify & Apple Reviews, YouTube Feedback, Sponsors, Social Media, Neural Network Newsletter Disclaimer
    Huberman Lab
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    Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis

    Dr. Diego Bohórquez: The Science of Your Gut Sense & the Gut-Brain Axis
    In this episode, my guest is Dr. Diego Bohórquez, PhD, professor of medicine and neurobiology at Duke University and a pioneering researcher into how we use our ‘gut sense.’ He describes how your gut communicates to your brain and the rest of your body through hormones and neural connections to shape your thoughts, emotions, and behaviors. He explains how your gut senses a range of features such as temperature, pH, the macro- and micronutrients in our foods, and much more and signals that information to the brain to affect our food preferences, aversions, and cravings. Dr. Bohórquez describes his early life in the Amazon jungle and how exposure to traditional agriculture inspired his unique expertise combining nutrition, gastrointestinal physiology, and neuroscience. We discuss how the gut and brain integrate sensory cues, leading to our intuitive “gut sense” about food, people, and situations. This episode provides a scientific perspective into your gut sense to help you make better food choices and, indeed, to support better decision-making in all of life. For show notes, including referenced articles and additional resources, please visit hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Joovv: https://joovv.com/huberman LMNT: https://drinklmnt.com/huberman Helix Sleep: https://helixsleep.com/huberman InsideTracker: https://insidetracker.com/huberman Timestamps 00:00:00 Dr. Diego Bohórquez 00:02:37 Sponsors: Joovv, LMNT & Helix Sleep; YouTube, Spotify & Apple Subscribe 00:06:49 Gut-Brain Axis 00:11:35 Gut Sensing, Hormones 00:15:26 Green Fluorescent Protein; Neuropod Cells & Environment Sensing 00:26:57 Brain & Gut Connection, Experimental Tools & Rabies Virus 00:35:28 Sponsor: AG1 00:37:00 Neuropod Cells & Nutrient Sensing 00:43:55 Gastric Bypass Surgery, Cravings & Food Choice 00:51:14 Optogenetics; Sugar Preference & Neuropod Cells 01:00:29 Gut-Brain Disorders, Irritable Bowel Syndrome 01:03:03 Sponsor: InsideTracker 01:04:04 Gut & Behavior; Gastric Bypass, Cravings & Alcohol 01:07:38 GLP-1, Ozempic, Neuropod Cells 01:11:46 Food Preference & Gut-Brain Axis, Protein 01:21:35 Protein & Sugar, Agriculture & ‘Three Sisters’ 01:25:16 Childhood, Military School; Academics, Nutrition & Nervous System 01:36:15 Plant Wisdom, Agriculture, Indigenous People 01:41:48 Evolution of Food Choices; Learning from Plants 01:48:15 Plant-Based Medicines; Amazonia, Guayusa Ritual & Chonta Palm 01:56:58 Yerba Mate, Chocolate, Guayusa 02:00:22 Brain, Gut & Sensory Integration; Variability 02:06:01 Electrical Patterns in Gut & Brain, “Hangry” 02:12:43 Gut Intuition, Food & Bonding; Subconscious & Superstition 02:22:00 Vagus Nerve & Learning, Humming 02:26:46 Digestive System & Memory; Body Sensing 02:32:51 Listening to the Body, Meditation 02:40:12 Zero-Cost Support, Spotify & Apple Reviews, YouTube Feedback, Sponsors, Social Media, Neural Network Newsletter Disclaimer
    Huberman Lab
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    Dr. Gary Steinberg: How to Improve Brain Health & Offset Neurodegeneration

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    Huberman Lab
    enMay 20, 2024

    LIVE EVENT Q&A: Dr. Andrew Huberman at the ICC Sydney Theatre

    LIVE EVENT Q&A: Dr. Andrew Huberman at the ICC Sydney Theatre
    Recently I had the pleasure of hosting a live event in Sydney, Australia. This event was part of a lecture series called The Brain Body Contract. My favorite part of the evening was the question and answer period, where I had the opportunity to answer questions from the attendees of each event. Included here is the Q&A from our event at the ICC Sydney Theatre. Sign up to get notified about future events: https://www.hubermanlab.com/events Thank you to our sponsors AG1: https://drinkag1.com/huberman Eight Sleep: https://eightsleep.com/huberman Timestamps 00:00 Introduction 00:15 Live Event Recap: The Brain Body Contract 00:32 Sponsors: AG1 & Eight Sleep 03:30 Q&A Session Begins: Napping and Sleep Quality 06:34 The Power of the Placebo Effect 11:31 Entering Rest and Digest State: Techniques and Tools 15:35 Muscle Growth, Learning & the Brain 20:13 Hallucinogens: Personal Experiences & Clinical Insights 27:28 The Misunderstood Effects of MDMA 27:42 Exploring the Potential of MDMA in Clinical Settings 29:25 The Complex World of Psychedelics & Mental Health 30:07 Ketamine: From Misconception to Medical Use 31:53 The Fascinating Science of DMT 33:11 Supporting Science: Funding & Future Directions 34:48 The Gut-Brain Axis: A Key to Overall Health 40:41 Sleep Patterns and Chronotypes: Personalizing Rest 42:50 Addressing ADHD & Focus in the Modern World 49:27 Closing Remarks & Gratitude Disclaimer
    Huberman Lab
    enMay 17, 2024

    Dr. James Hollis: How to Find Your True Purpose & Create Your Best Life

    Dr. James Hollis: How to Find Your True Purpose & Create Your Best Life
    In this episode, my guest is Dr. James Hollis, Ph.D., a Jungian psychoanalyst, renowned educator and author on finding and pursuing one’s unique purpose. Dr. Hollis is also an expert in the psychology of relationships and healing from trauma. We discuss how early family dynamics and social context create patterns of both adaptive and maladaptive behavior and internal narratives that, when examined, lead to better choices and a deeply fulfilling existence. We discuss discovering your unique self-identity and purpose through specific practices of reflection, meditation and conversations with others. We also discuss self-perception and the evolution of roles within marriages, parent-child relationships, and work. Throughout the episode, Dr. Hollis provides both basic knowledge and practical tools to help us assess ourselves and better understand who we are and what we really want in careers, relationships of all kinds, and society. For show notes, including referenced articles and additional resources, please visit hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Mateína: https://drinkmateina.com/huberman Joovv: https://joovv.com/huberman BetterHelp: https://betterhelp.com/huberman Waking Up: https://wakingup.com/huberman Momentous: https://livemomentous.com/huberman Timestamps 00:00:00 Dr. James Hollis 00:02:14 Sponsors: Mateina, Joovv & BetterHelp 00:05:57 Self, Ego, Sense of Self 00:13:59 Unconscious Patterns, Blind Spots, Dreams; Psyche & Meaning 00:21:56 Second Half of Life, Purpose, Depression 00:25:37 Sponsor: AG1 00:27:08 Tool: Daily Reflection; Crisis 00:31:47 Families & Children, Permission & Burdens 00:37:27 Complex Identification, Self-Perception; Social Media & Borderline 00:41:55 Daily Stimulus Response, Listening to the Soul 00:45:40 Exiting Stimulus-Response, Loneliness, Burnout 00:51:19 Meditation & Perception, Reflection 00:54:58 Sponsor: Waking Up 00:56:15 Recognizing the “Shadow” & Adulthood 01:02:48 Socialization; Family & Life Journey 01:09:04 Relationships & “Otherness”, Standing Your Ground 01:15:51 Marriage, “Starter Marriages” & Evolution; Parenting 01:19:37 Shadow Issues, Success & External Reward, Personal Growth 01:27:59 Men, Alcohol, “Stoic Man”, Loneliness, Fear & Longing 01:37:33 Women & Men, Focused vs. Diffuse Awareness; Male Rite of Passage 01:44:31 Sacrifice, Relationships; Facing Fears 01:48:20 Therapy, “Abyss of the Self”, Repeating Patterns & Stories 01:55:17 Women, Career & Family, Partner Support; Redefining Roles 02:01:40 Pathology & Diagnosis, Internet 02:07:05 Life, Suffering & Accountability, “Swamplands” & Task 02:11:32 Abuse & Recovery of Self, Patience, Powerlessness 02:14:11 Living a Larger Life; “Shut Up, Suit Up, Show Up” 02:17:49 Life Stages; Despair & Integrity Conflict 02:25:00 Death, Ego, Mortality & Meaning 02:38:07 Zero-Cost Support, Spotify & Apple Reviews, Sponsors, YouTube Feedback, Social Media, Neural Network Newsletter Disclaimer
    Huberman Lab
    enMay 13, 2024

    GUEST SERIES | Dr. Matt Walker: The Science of Dreams, Nightmares & Lucid Dreaming

    GUEST SERIES | Dr. Matt Walker: The Science of Dreams, Nightmares & Lucid Dreaming
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    Dr. Casey Means: Transform Your Health by Improving Metabolism, Hormone & Blood Sugar Regulation

    Dr. Casey Means: Transform Your Health by Improving Metabolism, Hormone & Blood Sugar Regulation
    In this episode, my guest is Dr. Casey Means, M.D., a physician trained at Stanford University School of Medicine, an expert on metabolic health and the author of the book, "Good Energy." We discuss how to leverage nutrition, exercise and environmental factors to enhance your metabolic health by improving mitochondrial function, hormone and blood sugar regulation.  We also explore how fasting, deliberate cold exposure and spending time in nature can impact metabolic health, how to control food cravings and how to assess your metabolic health using blood testing, continuous glucose monitors and other tools.  Metabolic dysfunction is a leading cause of chronic disease, obesity and reduced lifespan around the world. Conversely, improving your mitochondrial and metabolic health can positively affect your health span and longevity. Listeners of this episode will learn low- and zero-cost tools to improve their metabolic health, physical and mental well-being, body composition and target the root cause of various common diseases. For show notes, including referenced articles and additional resources, please visit hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Maui Nui Venison: https://mauinuivenison.com/huberman  Eight Sleep: https://eightsleep.com/huberman  AeroPress: https://aeropress.com/huberman  InsideTracker: https://insidetracker.com/huberman  Momentous: https://livemomentous.com/huberman Timestamps 00:00:00 Dr. Casey Means 00:02:18 Sponsors: Maui Nui, Eight Sleep & AeroPress 00:06:32 Metabolism, Metabolic Dysfunction, Medicinal Blindspot 00:14:17 Trifecta of Bad Energy 00:24:02 Western Living, United States, Specialization & Medicine 00:27:57 Insulin Resistance, Tool: Mitochondrial Capacity & Exercise 00:33:33 Sponsor: AG1 00:35:03 Tools: Walking & Glucose; Frequent Movement 00:44:25 Tools: Exercises to Improve Mitochondrial Capacity; Desk Treadmill 00:51:18 Soleus Push-Ups & Fidgeting, Non-Exercise Activity Thermogenesis (NEAT) 00:57:14 Sponsor: InsideTracker 00:58:21 Tool: Blood Test Biomarkers, Vital Signs & Mitochondrial Function 01:11:16 Navigate Medical System & Blood Tests, Consumer Lab Testing 01:16:46 Tool: Environmental Factors; Food, Life as a Process 01:21:58 Tool: Ultra-Processed vs. Real Food, Obesity, Soil & Micronutrients 01:32:03 Ultra-Processed Foods: Brain & Cellular Confusion 01:39:10 Tools: Control Cravings, GLP-1 Production, Microbiome Support 01:51:42 Ozempic, GLP-1 Analogs; Root Cause & Medicine 02:00:54 Tool: Deliberate Cold & Heat Exposure, Brown Fat 02:07:27 Tool: Intermittent Fasting & Metabolic Flexibility; Insulin Sensitivity 02:17:03 Tool: Continuous Glucose Monitors (CGMs) & Awareness, Glucose Spikes 02:24:34 Tool: CGMs, Glycemic Variability, Dawn Effect, Individuality 02:33:10 Sleep; Continuous Monitoring & Biomarkers 02:37:39 Mindset & Safety, Stress & Cell Danger Response 02:44:04 Tool: Being in Nature, Sunlight, Fear 02:54:44 Zero-Cost Support, Spotify & Apple Reviews, Sponsors, YouTube Feedback, Social Media, Neural Network Newsletter Disclaimer

    GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation

    GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation
    This is episode 5 of our 6-part special series on sleep with Dr. Matthew Walker, Ph.D., a professor of neuroscience and psychology at the University of California, Berkeley and the host of The Matt Walker Podcast. In this episode, we explain the connection between sleep and mood, emotional regulation and mental well-being.  We explain the role of rapid eye movement (REM) sleep in processing emotions and emotional memories and why sleep deprivation causes agitation, impulsivity and emotional reactivity.  We also discuss why sleep disruption is a hallmark feature of PTSD, anxiety, depression, suicidality, and other psychiatric conditions.  We explain protocols for improving REM sleep and other sleep phases in order to harness the therapeutic power of quality sleep to feel calmer and emotionally restored. This episode describes various actionable tools to improve sleep for those struggling with mental health or mood and those wanting to bolster their overall state and well-being.  The next episode in this special series explores dreams, including lucid dreaming, nightmares and dream interpretation. For show notes, including referenced articles and additional resources, please visit hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Eight Sleep: https://eightsleep.com/huberman LMNT: https://drinklmnt.com/huberman BetterHelp: https://betterhelp.com/huberman InsideTracker: https://insidetracker.com/huberman  Momentous: https://livemomentous.com/huberman Timestamps (00:00:00) Sleep & Mental Health (00:01:09) Sponsors: Eight Sleep, LMNT & BetterHelp (00:05:14) Emotions & Sleep, Amygdala (00:17:27) Emotional Memory & Sleep (00:25:48) “Overnight Therapy” & REM Sleep, Noradrenaline (00:29:13) Sponsor: AG1 (00:30:27) Sleep to “Remember & Forget”, Trauma; REM Sleep (00:38:27) Hinge Analogy; Motivation, Impulsivity & Addiction (00:47:08) Tool: Improve REM Sleep, Social Jet Lag, Alcohol & THC, Addiction (00:56:18) Sponsor: InsideTracker (00:57:23) Post-Traumatic Stress Disorder (PTSD) & REM Sleep (01:06:53) Noradrenaline & REM Sleep, PTSD & Prazosin (01:09:40) Addiction, Non-Sleep Deep Rest (NSDR); Liminal States (01:16:46) Anxiety & Sleep, Mood vs. Emotions (01:23:50) Deep Non-REM Sleep & Anxiety, Sleep Quality (01:28:51) Tool: Improve Deep Non-REM Sleep, Temperature; Alcohol (01:34:56) Suicidality & Sleep, Pattern Recognition; Nightmares (01:46:21) Depression, Anxiety & Time Context (01:51:24) Depression, Too Much Sleep?; REM Changes & Antidepressants (01:57:37) Sleep Deprivation & Depression (02:01:34) Tool: Circadian Misalignment & Mental Health, Chronotype (02:04:05) Tools: Daytime Light & Nighttime Darkness; “Junk Light” (02:13:04) Zero-Cost Support, Spotify & Apple Reviews, Sponsors, YouTube Feedback, Momentous, Social Media, Neural Network Newsletter Disclaimer

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    Intermittent Fasting vs. Caloric Restriction & Ketones!

    Hi friends!

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    This episode is all about Intermittent Fasting vs. Caloric Restriction & Ketones!

    Follow @optimalproteinpodcast on Instagram to see visuals and posts mentioned on this podcast.

    Link to join the facebook group for the podcast: https://www.facebook.com/groups/2017506024952802/

    Follow Vanessa on instagram to see her meals, recipes, informative posts and much more! Click here @ketogenicgirl

    Try the Higher Protein Keto Meal Plans & Coaching: https://www.ketogenicgirl.com

    Special thank you to our podcast sponsor:

    Magnesium Breakthrough by BiOptimizers

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    Prior to beginning a ketogenic diet you should undergo a health screening with your physician to confirm that a ketogenic diet is suitable for you and to rule out any conditions and contraindications that may pose risks or are incompatible with a ketogenic diet, including by way of example: conditions affecting the kidneys, liver or pancreas; muscular dystrophy; pregnancy; breast-feeding; being underweight; eating disorders; any health condition that requires a special diet [other conditions or contraindications]; hypoglycemia; or type 1 diabetes. A ketogenic diet may or may not be appropriate if you have type 2 diabetes, so you must consult with your physician if you have this condition. Anyone under the age of 18 should consult with their physician and their parents or legal guardian before beginning such a diet. Use of Ketogenic Girl videos are subject to the Ketogenicgirl.com Terms of Use and Medical Disclaimer. All rights reserved. If you do not agree with these terms, do not listen to, or view any Ketogenic Girl podcasts or videos.

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    Follow @optimalproteinpodcast on Instagram to see visuals and posts mentioned on this podcast.

    Follow Vanessa on instagram to see her meals, recipes, informative posts and much more! Click here @ketogenicgirl

    Link to join the facebook group for the podcast: https://www.facebook.com/groups/2017506024952802/

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    Special thank you to our sponsor:

    Magnesium Breakthrough by Bioptimizers

    Make Magnesium Breakthrough part of your daily routine this year, so you can get the vitality you need to conquer your dreams.

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    This podcast content does not constitute an attempt to practice medicine and does not establish a doctor-patient relationship. Please consult a qualified healthcare provider for medical advice and personal health questions.

    Prior to beginning a new diet you should undergo a health screening with your physician to confirm that a new diet is suitable for you and to out any conditions and contraindications that may pose risks or are incompatible with a new diet, including by way of example: conditions affecting the kidneys, liver or pancreas; muscular dystrophy; pregnancy; breast-feeding; being underweight; eating disorders; any health condition that requires a special diet [other conditions or contraindications]; hypoglycemia; or type 1 diabetes. A new diet may or may not be appropriate if you have type 2 diabetes, so you must consult with your physician if you have this condition. Anyone under the age of 18 should consult with their physician and their parents or legal guardian before beginning such a diet. Use of Ketogenic Girl videos are subject to the Ketogenicgirl.com Terms of Use and Medical Disclaimer. All rights reserved. If you do not agree with these terms, do not listen to, or view any Ketogenic Girl podcasts or videos.