Logo
    Search

    Dr. Kyle Gillett: How to Optimize Your Hormones for Health & Vitality

    enApril 11, 2022

    Podcast Summary

    • Hormone Health Expert's Approach to Total WellnessDr. Gillette's balanced approach to hormone health and use of multiple tools and preventative medicine can benefit both males and females, shared for free on public platforms for greater accessibility and understanding.

      Dr. Kyle Gillette is an expert in hormone health, with a broad and in-depth knowledge on the topic. He provides full-spectrum medicine, with a balanced approach to total health across the lifespan. Dr. Gillette is a clear communicator with a deep love of understanding biology and medicine in ways that can benefit people. He uses various tools such as behavioral, nutritional, exercise-based, hormone replacement therapy and other supplementation to manage hormone health. His approach is very receptive to both male and female issues. Dr. Gillette's providing a wealth of knowledge on all things, hormones, and hormone-related health on zero cost to consumer platforms, making knowledge more approachable. A preventative approach towards medicine is a crucial component of overall health, and its significance is becoming evident in recent times.

    • Importance of Understanding Your Hormone Health and Lifestyle Interventions.Communicate with your doctor about concerns related to energy, focus, and athletic performance. Men and women have different challenges in accessing hormonal data, but lifestyle interventions such as diet, exercise, and stress optimization can help. Resistance training and caloric restriction can also improve hormone health. Start early and maintain interventions over time.

      Understanding your hormone health is important and can be approached by asking pertinent questions about your symptoms and family history. It is important to communicate with your doctor about concerns related to energy, focus, and athletic performance, even if you don't have a pathology. Men and women have different challenges related to accessing hormonal data. The six pillars of lifestyle interventions, including diet, exercise, stress optimization, sleep, environmental exposures, and supplements, are crucial for hormone health. Resistance training and caloric restriction can be particularly helpful for hormone health. Starting these interventions early and maintaining them over time is key to optimizing hormone health.

    • Achieving Optimal Health as a Household Unit with Focus on Six Key AreasPrioritize stress management, sleep, sunlight exposure, personalized nutrition, regular blood testing, and exercise (zone 2 cardio and resistance) for improved health. Don't forget to consider spiritual health as a crucial component for overall well-being.

      To achieve optimal health, it's important to work on it together as a household unit with a focus on six important areas including stress, sleep optimization, sunlight, spirit, diet, and exercise. Diet should be individualized based on genetics and biofeedback, and regular blood testing every three to six months is recommended. Exercise should include a minimum of 150 to 180 minutes of zone two cardio per week and resistance exercise for cardiovascular health, brain health, and musculoskeletal health. Spiritual health is also an important aspect to consider in achieving overall well-being, and should not be overlooked.

    • Caloric restriction, intermittent fasting, and overall healthCaloric restriction can benefit obese individuals but decrease testosterone levels in healthy individuals. Intermittent fasting may improve growth hormone and IGF-1 levels, but mental clarity and pleasure in eating are factors to consider. Understanding the difference between weight loss and overall health benefits is crucial. Exercise is another way to improve overall health.

      Caloric restriction can help obese and metabolic syndrome patients to improve their testosterone levels and overall health, but it can decrease testosterone levels in healthy individuals. Intermittent fasting can help improve growth hormone and IGF-1 levels but may not be necessary for weight loss. The mental clarity and increased pleasure in eating during the eating window is a factor that makes people try intermittent fasting. It is crucial to understand the difference between weight loss and overall health benefits when it comes to caloric restriction and exercise. Additionally, caloric restriction is not the only way to achieve intermittent fasting, and there are other methods to improve overall health like exercise.

    • Hormone Optimization and Its Impact on Sleep QualityHormone optimization can improve sleep quality by addressing growth hormone deficiency and utilizing progesterone and its derivatives as GABA agonists. Caution should be taken in considering the source of exogenous IGF-1.

      Hormone optimization can positively affect sleep. Growth hormone deficiency can impact sleep, while progesterone and its derivatives can function as a GABA agonist to improve sleep quality. IGF-1 has a longer duration of action compared to growth hormone and has a local action that improves body composition after exercise. While there is little evidence to suggest that increasing growth hormone levels from intermittent fasting or saunas can lead to cancer, it is important to consider the source of IGF-1, as exogenous IGF-1 does not necessarily improve body composition. Ultimately, sleep is crucial to mental and physical health, and hormone optimization can play a role in improving sleep quality.

    • The Impact of Testosterone on Sleep and HealthLow testosterone levels can negatively impact sleep in men, while testosterone replacement therapy can increase the risk of sleep apnea. It is also important to monitor testosterone levels in women to prevent certain health conditions.

      Low testosterone can lead to poor sleep in men. Testosterone replacement therapy (TRT) can increase the risk of sleep apnea, leading to poor sleep even in people with normal testosterone levels. Testosterone merely exacerbates existing features of people and does not change them as a person. Women have testosterone too, and it mostly comes from the Thika cells in the ovaries. Women have almost all significantly more testosterone than estrogen, and significantly more DHA than either. Knowing a woman's testosterone is important for pathology prevention, such as breast cancer and osteoporosis, but estrogen and progesterone levels are more important to know.

    • Understanding Natural Testosterone Production, DHT and Gene Transcription of Androgen ReceptorTestosterone production varies among individuals and can be genetically determined. DHT, a powerful androgen hormone, affects hair loss and is mediated by the androgen receptor. Gene transcription of the receptor affects the severity of male pattern baldness, and androgen insensitive insensitivity syndrome is caused by the gene from the mother being completely insensitive to androgens.

      Natural testosterone production varies greatly among individuals and can be genetically gifted, leading to controversies in sports competitions. DHT is a powerful androgen hormone in both men and women, and its effects are mediated by the androgen receptor. Male pattern baldness is related to gene transcription of the androgen receptor, and people with fewer CAG repeats have less severe hair loss. Elevated levels of DHT may not be causing more hair loss than 50 years ago, as people in the past were more sensitive to androgens. Androgen insensitive insensitivity syndrome (AIS) is related to men with the AR gene from their mother being completely insensitive to androgens.

    • Understanding DHT for Heart Health and Hair LossBalancing DHT levels is crucial for cardiovascular health and preventing male pattern baldness. Dietary changes and supplementation can help, but it's important to monitor levels and consult a doctor for personalized recommendations.

      DHT is important for cardiovascular health, including heart muscle growth and remodeling. While some level of DHT is necessary for optimal health, excess DHT can contribute to male pattern baldness and other health issues. Dietary changes and supplementation, such as turmeric and black pepper extracts, can inhibit the conversion of testosterone to DHT and therefore reduce DHT levels. However, individuals should avoid these supplements if their DHT levels are already low. Creatine, on the other hand, can increase the conversion of testosterone to DHT and may be beneficial for those with low DHT levels. DHT is also involved in libido, motivation, and drive. It's important to monitor DHT levels and consult a doctor for recommendations on how to optimize DHT levels for overall health.

    • Approaching Supplements and Medications with CautionConsult with your doctor before taking supplements or medications that inhibit ISO enzymes or progesterones. Be aware of potential side effects, but know that most effects are reversible. Be cautious when taking creatine as it may vary from person to person and potentially lead to hair loss.

      When experimenting with supplements or medication, it's important to approach it with caution and talk to your doctor. The effects of inhibiting five alpha reductase, which supplements like saw Palmetto and Finasteride do, can vary and have different impacts depending on the ISO enzymes they inhibit. Inhibiting certain progesterones can also cause side effects. However, most effects of these supplements and medications are reversible. Creatine monohydrate can potentially increase DHT, which can lead to hair loss, but it varies from person to person. If you notice more hair falling out while taking creatine, you can stop and the hair will grow back if the stem cell niches in the hair follicle are still there.

    • Options for Maintaining or Growing Hair and Addressing Polycystic Ovarian SyndromeWhile alpha reductase inhibitors may cause initial hair loss, they promote healthier follicles. For long-term hair maintenance, consider options like Dutasteride and Mesotherapy, but be aware of potential side effects. Additionally, early detection and treatment of PCOS can improve its management.

      Five alpha reductase inhibitors may cause a large amount of hair fall at first, but this sheds unhealthy cells and promotes growth of new and healthier follicles. Maintaining or growing hair can be done through options like Dutasteride and Mesotherapy, but it is important to consider the potential side effects of blocking DHT in the periphery, especially for women who can be sensitive to DHT. Polycystic ovarian syndrome (PCOS) is an underdiagnosed condition that causes infertility or subfertility, usually diagnosed in the thirties, and can be identified through the Rotterdam criteria. Early detection and treatment can help women with PCOS manage their symptoms.

    • Diagnosing and Treating PCOS: Beyond Polycystic OvariesManaging body composition, using supplements and medications, and addressing hormonal imbalances can alleviate symptoms and improve overall health in women with PCOS. Hormonal contraceptives can also affect perception of attractiveness.

      PCOS can be diagnosed without having polycystic ovaries, if there are symptoms of androgen excess, insulin resistance, oligomenorrhea, or infertility. Optimizing body composition, treating metabolic syndrome, and taking supplements like myo-inositol or ASTA tall can help with insulin sensitization and androgen inhibition. Women on oral contraceptives experience a shift in their perception of men's attractiveness due to blunting of hormone output. Men also perceive women on oral contraceptives differently. To reduce androgen receptor activity, women can take DeCarlo or Diane dull methane, along with considering anti-androgen medications like spironolactone.

    • Effects of Oral Contraceptives and Substance Use on Libido and FertilityOral contraceptives can alter hormones and reduce libido, but do not permanently damage fertility. Substance use, such as marijuana, alcohol, and barbiturates, can also have negative effects on testosterone levels.

      Oral contraceptives alter the peaks and troughs in libido and attractiveness, and reduce the associated increase in libido that normally occurs from the increase in androgen. Synthetic progestins have various pros and cons, and some can cause weak anti-androgen effects. Oral contraception may disrupt fertility past 6 to 12 months, but persistent elevated SHBG can be present for quite some time. However, it does not quicken the transition to infertility or cause permanent damage. Marijuana can decrease testosterone, while high alcohol and barbiturate intake can reduce testosterone.

    • The Effects of Marijuana, Alcohol, and Sleep Supplements on TestosteroneMarijuana, alcohol, and certain sleep supplements can decrease testosterone levels. It is important to talk with a doctor before considering testosterone replacement therapy as increasing testosterone without medical supervision can be harmful.

      Smoked marijuana may reduce testosterone or increase the conversion of testosterone to estrogen. Alcohol and potent GABA agonists like barbiturates, benzodiazepines, or non-benzo also decrease testosterone. The American heart association recommends moderate alcohol intake of one to two drinks a day for men and zero to one for women. Daily intake of sleep supplements containing GABA, Trazadone, or melatonin should be avoided. Magnesium and L-theanine can be exceptions. Testosterone levels are dropping, and people are considering taking testosterone, although it was previously considered steroid use. However, it's crucial to remember that increasing testosterone without a doctor's prescription can have dangerous side effects.

    • Maintaining Prostate Health and Decreasing Prostate Cancer RiskA healthy prostate involves avoiding things that harm it, such as infections and chronic constipation, while consuming a diet high in prebiotic fiber and probiotics. Regular checkups, decreasing inflammation and congestion, and monitoring PSA levels can reduce the risk of developing prostate cancer.

      Testosterone supplementation won't cause prostate cancer but it will grow an existing cancer. Prostate cancer is normal with aging, and it's only a matter of time until you develop it. Maintaining prostate health involves looking for things that can hurt it, such as infections, chronic constipation, and colitis, and preventing those with a diet rich in prebiotic fiber and probiotics to ensure regular bowel movements. Following PSA levels, having prostate MRIs, and decreasing inflammation and congestion of the prostate can decrease the chances of developing prostate cancer. Young males with higher testosterone levels don't have a higher risk of prostate cancer, but older males with cumulative damage and prostate cancer are normal with aging.

    • Maintaining Prostate Health through Prevention and Management TechniquesKeeping low levels of CRP, exercising pelvic floor muscles, taking Todalofil and Flomax medications, consuming enough insoluble fiber, and avoiding high estrogen levels are effective ways to prevent mutations, infections, and abnormal cell growth in the prostate.

      Maintaining low levels of CRP can help prevent mutations and atypical cell turnover in the prostate. Strengthening the pelvic floor is important for both men and women and can be aided by exercises and pelvic floor physical therapists. Taking low doses of Todalofil, such as Cialis, can help decrease congestion in the prostate and improve urinary system health. Flomax is another medication that can be used to improve urinary system health. Eating enough insoluble or non dietary fiber can prevent diverticulitis, colitis, and prostate infections. Avoiding high estrogen levels can also prevent atypical cells in the prostate.

    • Low dose Tadalafil and Testosterone Replacement Therapy for Prostate Health and Hair LossLow dose Tadalafil can benefit prostate health and potentially prevent hair loss, but may have negative effects on blood pressure. Testosterone replacement therapy should aim for a steady state to avoid overactivity of the androgen receptor gene and thick blood side effects.

      Low dose Tadalafil can be used to maintain or enhance prostate health, but it may carry negative effects such as lowering blood pressure. It can also potentially help prevent hair loss by increasing blood flow. Testosterone replacement therapy (TRT) is recommended only for hypogonadal patients whose benefits outweigh the side effects. TRT should aim for a steady state to avoid the overactivity of the androgen receptor gene and the side effects of thick blood. Different types of esters or topical testosterone can be used to get around these side effects. Steady-state TRT is not exactly the same as producing pulsatile testosterone release endogenously from our body.

    • Methods for Regulating Testosterone Levels and Controlling EstrogenInjections or lymph-absorbed capsules are better than topical applications for low SHBG. Longer Ester is needed for injectables. Aromatase inhibitors aren't recommended. Use lifestyle interventions, supplements, and regular monitoring for healthy estrogen levels.

      When it comes to regulating serum testosterone levels, injections are preferred over topical applications for people with low SHBG. Capsules that are absorbed through the lymph are also an option. A lower SHBG means a longer Ester is required for injectables. Aromatase inhibitors aren't recommended for most people as lifestyle interventions can often help with estrogen control. Supplements like calcium D glucarate and cruciferous vegetables can also assist with estrogen control. It's important to monitor estrogen levels regularly to ensure they're at a healthy level.

    • An Individualized Approach is Key to Optimizing TRTTestosterone replacement therapy should be personalized based on an individual's androgen receptor sensitivity, lifestyle factors, and preferences. Caution should be taken when using supplements and altering diet. Balanced testosterone to estrogen ratio is crucial for quality of life.

      When it comes to TRT, an individualized approach is crucial as everyone's androgen receptor sensitivity is different. Quality of life can be subjective and people are willing to give up different things. Supplements and practices can increase testosterone levels, but it's important to be cautious and only alter one thing at a time. Lifestyle factors like alcohol and high-fat meals can upregulate aromatase and increase estrogen levels, so it's important to be mindful. The ratio of testosterone to estrogen is a key factor in how one feels, and a true individualized approach is necessary to find the right dosage of TRT. Ingesting some amount of saturated fat may be useful as cholesterol serves as a precursor to testosterone and estrogen molecules.

    • The Importance of Healthy Trans Fats and Omega-3 for Hormone BalanceGetting healthy trans fats and omega-3 from ruminants or their food products can help balance testosterone to estrogen ratio. Vegans should consider supplementation or consuming plant-based diets rich in polyphenols to activate beta estrogen receptor.

      It's important to get healthy trans fats from ruminants or their food products, as well as proper amounts of omega-3 to maintain a healthy testosterone to estrogen ratio. Vegans may be at risk for not getting enough of these healthy fats and may need to supplement with other sources. Tongkat Ali, also known as long jack, has multiple mechanisms of action and can potentially reduce sex hormone binding globulin and free up testosterone, although its effects are not consistent. It's important to note that healthy trans fats are not necessary and can be found naturally occurring in ruminant cheese, milk, and butter. Plant-based diets rich in polyphenols may also activate the beta estrogen receptor.

    • The Benefits and Cycle of Tonga Ali and Dojokarate SupplementsTonga Ali can reduce hyperestrogenism and increase testosterone, while Dojokarate is a potential testosterone booster that needs further research for safety. Use Tonga Ali as post-cycle therapy, cycle off for safety purposes, and consider Indonesian sources for effectiveness.

      Tonga Ali can help reduce hyperestrogenism in women and increase testosterone in both men and women. A dosage of 400 milligrams taken once a day is effective and sources from Indonesian Tonga Bali is ideal. It can also be used for post-cycle therapy and to lower persistent SHBG levels after discontinuing birth control pills. While Tonga Ali may not need to be cycled off, it is recommended to cycle off for safety purposes. A reasonable cycle off would be 11 months on and one month off. Dojokarate is a potential testosterone booster that increases luteinizing hormone release and receptor sensitivity but needs further research to determine its safety as a long-term supplement.

    • Supplements for increasing LH and testosterone levels in recoverySupplements like Naltrexone, Tonga Ali, and boron may help regulate LH and testosterone levels in recovery, but consult with a physician and do blood work before taking. Cycling and recommended dosages are important, and those with high LH may not benefit from further increase.

      Naltrexone can potentially help increase LH in people recovering from opiates or alcohol, and Tonga Ali and boron supplements can help regulate SHBG and increase LH and testosterone levels. However, it is important to do blood work and consult a physician before taking supplements. Cycling supplements like Fiducia for three weeks on and one week off is likely safe, and boron can be taken at three to six milligrams once or twice a day. It's worth noting that although supplements are generally safer than medications, it is important to ensure the quality of supplements and follow recommended dosages. Additionally, people with already high LH may not benefit from increasing it further with supplements.

    • Understanding the uses and risks of HCG in fertility and hormone therapy.HCG can improve fertility and hormone function but may also have estrogenic effects and risks for women. Careful consideration and monitoring is necessary when using HCG for fertility or hormone therapy.

      HCG is a hormone that is similar to TSH and is commonly used for fertility treatment. It can suppress LH output, but also improve thyroid function. It can be used alone or in combination with testosterone therapy. HCG can also improve sensitivity in the genitals and is commonly used to treat post-finasteride syndrome. However, HCG may increase estrogen and there may be risks for women taking it on their ability to get pregnant. Overall, the potential benefits and risks of taking HCG should be carefully considered before use.

    • Maintaining the Delicate Balance between Dopamine and ProlactinThe delicate balance between dopamine and prolactin is crucial to avoid a hyperdopaminergic state and overflow of dopamine, which can cause severe side effects. Proper diagnosis of pituitary tumors is essential to manage hormonal imbalances caused by the tumors.

      The delicate balance between dopamine and prolactin needs to be maintained as dopamine agonists can lead to hyperdopaminergic state and overflow of dopamine, leading to the crash of dopamine waves. Prolactin gene or estrogen upregulates PRL gene, increasing prolactin synthesis and inhibiting the release of testosterone. Pituitary tumors are common and can be caused by high contact sports, head blows, or even concussion. Microadenomas can be non-producing, causing fatigue and high prolactin feeling. Augmenting dopamine through prescription drugs can lead to hitting many transmitter systems, and it's important to maintain a delicate dance between sympathetic and parasympathetic drive even across minutes.

    • Boosting Dopamine and Energy to Improve MotivationImproving low motivation and energy can be accomplished through steps such as eliminating prolactin-increasing factors and taking supplements like dopamine agonists, vitamin B6, and L-carnitine, while also prioritizing lifestyle factors such as exercise and sleep.

      Low drive and motivation may be caused by low levels of dopamine, which can be increased through various interventions such as taking dopamine agonists, vitamin B6, and vitamin E. However, it is important to start with the least powerful interventions such as eliminating things that could be increasing prolactin. L-carnitine can also be beneficial for enhancing sperm quality, egg quality, and rates of conception as it acts as the shuttle that helps get the fuel into the motor in a cell. Overall, lifestyle factors such as diet, exercise, sleep quality, and supplementation can significantly affect the body's energy production and fuel utilization.

    • Tips for Taking L-Carnitine for Fertility and Androgen Receptor UpregulationL-Carnitine can be taken in capsule or injectable form, but a high dose is needed for fertility benefits. Garlic or Alison can mitigate potential side effects and regular blood tests can provide important health information.

      L-carnitine can be taken in capsule or injectable form, but only a small amount is bioavailable. For fertility and androgen receptor upregulation, the recommended dose is one gram per day, which would require taking approximately 15-20 capsules. L-carnitine can be found in some foods, but it is not very bioavailable. Injecting L-carnitine is 100% bioavailable, but it burns if injected subcutaneously. One possible side effect of taking L-carnitine is an increase in TMAO. Incorporating 600 milligrams of garlic or Alison into the daily diet can mitigate this effect. Regular blood tests can provide important information about hormone levels, metabolic markers, and lipids. While insurance may not cover these tests, they are becoming more affordable through options like FSAs, HSAs, and care credit.

    • The Importance of Building Positive Relationships and Maintaining Hormonal BalanceBuilding and maintaining positive relationships requires a balance of time apart and time together, planning for good times, avoiding hyperprolactin phases. Hormonal crosstalk and dopamine fluctuations play important roles. Optimization of hormones is critical for both relationship success and individual well-being.

      Building positive relationships and maintaining hormonal balance is important for overall well-being. Time apart and time together, planning ahead for good times, and avoiding hyperprolactin phases can help stabilize relationships. Hormonal crosstalk and pheromonal communication plays an important role in both new and long-term relationships. Dopamine is associated with novelty and excitement, and its levels fluctuate over time during a relationship. Relationships go through crises and planning ahead can help stabilize them. Hormone optimization both for the sake of a relationship and because of the relationship is important, and it is bi-directional. It is suggested that spending 100% of time together can be detrimental to a relationship, and time apart can renew excitement.

    • Understanding the Hormonal Changes in RelationshipsHormones like dopamine, prolactin, and oxytocin play important roles in shaping perception and behavior in relationships. Being aware of these changes can make it easier to navigate through the different stages and maintain the spark in relationships.

      Relationships go through different stages, including the dopamine-fueled initial phase and the changing dynamics during pregnancy and infancy. Hormones like dopamine, prolactin, and oxytocin play a significant role in shaping perception and behavior. Separation and affiliation bonds can serve as a dopamine reservoir for couples to maintain the spark in their relationships. Prolactin is essential for nesting instinct, breastfeeding, infant maturity, and respiratory health. Cold exposure may not correct hypogonadism, but it can acutely help with warming testes and increasing testosterone levels. Understanding the changes and being aware of the side effects in relationships and hormonal changes can make it easier to navigate through them.

    • Peptides, Saunas, and Reproductive Health: Things to Watch Out ForPeptides are not equal in safety, and professional guidance is necessary. Avoid hot tubs and heated water if you have infertility or low sperm count, and consider cold showers and ice baths for women to increase beta adrenergic receptor activity. Be cautious to avoid frostbite in the future.

      Peptides are gaining popularity, but they are heterogeneous with varying degrees of safety. Insulin is a peptide that is safe when prescribed by doctors. Some peptides are FDA approved, like Tessa Moreland for lipo dystrophy. However, usage of other peptides should be approached with caution and only with professional guidance. Saunas raise the temperature of the testes, which is the enemy of sperm production. For those with infertility or low sperm count, hot tubs and heated water should be avoided. Women can benefit from cold showers and ice baths as it can increase the activity of beta adrenergic receptors. The primary concern is not estrogen output. People need to be careful not to get frostbite in the future.

    • Understanding Peptide Therapy and Potential RisksPeptide therapy can offer benefits such as promoting lean body mass and healing injuries, but it's important to consult a doctor before use and be aware of potential risks such as increased cancer risk.

      Using growth hormone releasing hormone peptides like Sermorelin prescribed by doctors may have risks such as increased cancer risk. However, these peptides can be used in injuries and for other benefits like decreasing body fat and increasing lean body mass without taking growth hormone. Other peptides like BPC 1, 5, 7 have gastroprotective benefits and can increase vascular endothelial growth factor, but should be avoided by people with cancer risk. It is essential to consult a doctor before taking any of these peptides and understand their mechanism of action and potential risks.

    • The Benefits and Risks of Peptides and Malana TanPeptides like BPC 1, 5, 7 and copper peptide GFK have healing properties, but must be obtained from a reputable source. Malana tan has FDA-approved uses, but recreational use can cause harm. Consult with a physician and ask about individualized treatment. Sometimes, less is more.

      Peptides like BPC 1, 5, 7 can help increase blood flow to the injured area and aid in recovering from injuries but it's important to work with a physician and get it from a good compounding pharmacy. Non-prescription forms often contain lipopolysaccharide (LPs) which can cause inflammation. Malana tan has several FDA approved indications but it's important to avoid its recreational use for tanning purposes as it can cause serious damages like Priya prism. It's essential to ask questions to your doctor regarding the dosing regimen and individualized treatment. Copper peptide like GFK can help regenerate the liver and nervous system. Sometimes, the best dosage of something to take is zero.

    • Peptide PT 1 41 and Hormone Health OptimizationPeptide PT 1 41 can aid in boosting libido for women with hypoactive sexual disorder but long-term use may increase alpha melanocyte stimulating hormone levels. Optimizing hormone health requires a holistic approach involving diet, exercise, stress management, rest, sunlight exposure, and spirituality.

      Peptide PT 1 41 helps women with hypoactive sexual disorder to boost their libido, and it is also relatively safe and approved for men. However, long-term administration may increase alpha melanocyte stimulating hormone, so people with a family history of melanoma or potentially having it should be careful. Besides, the peptide is also approved for lipo dystrophy and a rare genetic condition in childhood. Optimizing hormone health requires managing six critical factors, namely diet, exercise, appropriate caloric restriction, managing stress, sleep, and sunlight, as well as nurturing spiritual health as part of the holistic approach to health and wellness. Patients need to bring physical, mental, and spiritual health together, as they are interconnected and essential for overall health and quality of life.

    • Embracing Personal Spirituality in the Absence of Religious PracticesA person's spiritual journey is personal and should not be pressured. Being open to diverse beliefs and practices can foster positive physician-patient relationships and stimulate critical thinking. Neuroscience is exploring the basis of spiritual experiences in the brain.

      People who identify as atheists or agnostics may not have prescriptive religious practices, but can still explore spirituality and find what they truly believe in. As a physician, Dr. Kyle Gillett believes that everyone's spiritual journey is personal and should not be pressured. Neuroscience is currently asking questions about the grounding of spiritual experiences in the brain. The most commonly used drug, caffeine, may not have a significant effect on hormones unless it affects sleep. Being open to different beliefs and practices, regardless of one's own background, can lead to excellent physician-patient rapport and stimulate thinking, which is the ultimate goal of this podcast.

    Recent Episodes from Huberman Lab

    Dr. Stacy Sims: Female-Specific Exercise & Nutrition for Health, Performance & Longevity

    Dr. Stacy Sims: Female-Specific Exercise & Nutrition for Health, Performance & Longevity
    In this episode, my guest is Dr. Stacy Sims, Ph.D., an exercise physiologist, nutrition scientist, and expert in female-specific nutrition and training for health, performance, and longevity. We discuss which exercise and nutrition protocols are ideal for women based on their age and particular goals. We discuss whether women should train fasted, when and what to eat pre- and post-training, and how the menstrual cycle impacts training and nutrition needs. We also explain how to use a combination of resistance, high-intensity, and sprint interval training to effectively improve body composition, hormones, and cardiometabolic health, offset cognitive decline, and promote longevity.  We also discuss supplements and caffeine, the unique sleep needs of women based on age, whether women should use deliberate cold exposure, and how saunas can improve symptoms of hot flashes and benefit athletic performance. Dr. Sims challenges common misconceptions about women’s health and fitness and explains why certain types of cardio, caloric restriction, and low-protein diets can be harmful to women’s metabolic health. Listeners will learn a wealth of actionable information on how to improve their training and nutrition to enhance their health and how to age with greater ability, mobility, and vitality. Access the full show notes for this episode at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Maui Nui Venison: https://mauinuivenison.com/huberman  Eight Sleep: https://eightsleep.com/huberman   Waking Up: https://wakingup.com/huberman  Timestamps 00:00:00 Dr. Stacy Sims 00:02:24 Sponsors: Maui Nui, Eight Sleep & Waking Up 00:07:03 Intermittent Fasting, Exercise & Women 00:12:50 Cortisol & Circadian Rhythm, Caffeine & Training 00:17:25 Reps in Reserve, Rate of Perceived Exertion (RPE); Age & Women 00:21:06 Pre-Training Meal & Brain, Kisspeptin 00:26:45 Post-Training Meal & Recovery Window 00:29:59 Sponsor: AG1 00:31:48 Hormones, Calories & Women 00:34:24 Women, Strength Improvements & Resistance Training 00:39:10 Tool: Women & Training Goals by Age Range 00:44:16 Women, Perimenopause, Training & Longevity 00:47:14 Women & Training for Longevity, Cardio, Zone 2 00:51:42 Tools: How to Start Resistance Training, Machines; Polarized Training 00:58:23 Perform with Dr. Andy Galpin Podcast 00:59:10 Menstrual Cycle & Training, Tool: Tracking & Individual Variability 01:04:31 Tool: 10-Minute Rule; High-Intensity Training & Menstrual Cycle 01:08:36 “Train Hard & Eat Well”; Appetite, Nutrition & Menstrual Cycle 01:12:22 Oral Contraception, Hormones, Athletic Performance; IUD 01:20:57 Evaluating Menstrual Blood, PCOS; Hormones & Female Athletes 01:26:31 Iron, Fatigue; Blood Testing & Menstrual Cycle 01:29:33 Caffeine & Perimenopause; Nicotine, Schisandra 01:34:24 Deliberate Cold Exposure & Women, Endometriosis; Tool: Sauna & Hot Flashes 01:42:19 Tools: “Sims’ Protocol”: Post-Training Sauna & Performance; “Track Stack” 01:49:37 Women, Hormones & Sleep, Perimenopause & Sleep Hygiene 01:52:54 Supplements: Creatine, Water Weight, Hair Loss; Vitamin D3 01:57:21 Protein Powder; Adaptogens & Timing 02:00:11 Pregnancy & Training; Cold & Hot Exposure 02:06:19 Tool: Women in 50s & Older, Training & Nutrition for Longevity 02:09:38 Tool: Women in 20s-40s & Training, Lactate 02:12:18 Tool: What is High-Intensity Training?, Cardiovascular Sets & Recovery 02:17:22 Training for Longevity, Cellular & Metabolic Changes 02:19:30 Nutrition, 80/20 Rule 02:23:30 Listening to Self 02:26:00 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter  Disclaimer & Disclosures
    Huberman Lab
    enJuly 22, 2024

    Dr. Stuart McGill: Build a Strong, Pain-Proof Back

    Dr. Stuart McGill: Build a Strong, Pain-Proof Back
    In this episode, my guest is Dr. Stuart McGill, Ph.D., a distinguished professor emeritus of spine biomechanics at the University of Waterloo and a world expert on spine anatomy and physiology, back pain, and rehabilitation. We discuss the most common sources of back pain, how back pain can be assessed (including self-assessment techniques), and how to design a personalized recovery plan to reduce back pain. We discuss how to train for lifelong fitness, reduce injury risk, and protect your back and joints based on your age and personal goals. We also discuss how to prevent back pain, build core stability, and explain how “McGill’s Big 3” exercises protect and strengthen the back. Dr. McGill, who is exceptionally fit in his late 60s, describes his low-time investment, personal training routine, and the specific exercises he uses for mobility, strength, and cardiovascular fitness. We also discuss controversial issues in the back pain and rehabilitation field, including how pain originates, the biopsychosocial model of pain, and treatments such as platelet-rich plasma (PRP). This episode provides clear, actionable tools to strengthen, prevent, and remedy back pain and injury so you can be pain-free while enjoying sports, exercise, and daily activities at any age. Access the full show notes for this episode at hubermanlab.com. Watch the clip on back pain relief and spine anatomy that accompanies this episode. Demonstration of The McGill Method Thank you to our sponsors AG1: https://drinkag1.com/huberman Helix Sleep: https://helixsleep.com/huberman BetterHelp: https://betterhelp.com/huberman Waking Up: https://wakingup.com/huberman LMNT: https://drinklmnt.com/huberman Timestamps 00:00:00 Dr. Stuart McGill 00:02:33 Sponsors: Helix Sleep, BetterHelp & Waking Up 00:06:23 What Causes Back Pain?; Genetics, Dog Breed Analogy 00:12:55 Tool: Skeleton & Body Type; Spine Flexibility & Discs 00:20:25 Flexibility & Exercises; Discs & Collagen 00:25:43 Sponsor: AG1 00:27:32 Stress & Tipping Point; Athletic Tradeoffs, Triathletes 00:36:17 Back Pain, Goals & Training Program 00:45:57 Spine Hygiene, Back Pain, Powerlifting 00:53:33 Genetics & Running 00:59:34 Sponsor: LMNT 01:00:46 Rehabilitation & Reducing Volume; Injury 01:07:42 Tool: Training for Lifelong Fitness, Injury & Joints 01:17:40 Pain Types, Biopsychosocial Model of Pain 01:26:15 Coaching, Explosivity & Endurance 01:32:43 Virtual Surgery & Rest, Pain Recovery 01:41:25 Tool: McGill’s Big 3; Building Back Strength & Stability 01:46:39 Inversion Tables & Spine Deloading, Disc Bulge, Tool: Lumbar Support 01:51:09 Tool: Daily Walking; Sitting 01:55:33 Deadlift & Bone Density, Glute-Ham Raise 02:06:20 Training & Age, Osteoporosis, Tool: Deadlift Alternatives 02:16:47 Tools: Biblical Training Week; Spine Stability & McGill’s Big 3; Shrinking & Age 02:24:16 Platelet-Rich Plasma (PRP); Disc Damage 02:27:56 Tools: Biblical Training Week & Strength Exercises, Neck Strength 02:35:24 Tools: Sword Play, Distal Limb Loading, Training for Symmetry 02:42:38 Tools: Biblical Training Week, Mobility & Cardiovascular Exercises, Athletic Panel 02:49:22 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures
    Huberman Lab
    enJuly 15, 2024

    Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

    Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks
    In this episode, my guest is Dr. Matthew Hill, Ph.D., a professor of cell biology and anatomy at the Hotchkiss Brain Institute at the University of Calgary and an expert on the biology of cannabis. We discuss how cannabis affects the brain to produce its psychoactive effects (feeling “high”), including altered time perception, focus, memory, appetite, and stress. We discuss how THC vs. cannabidiol (CBD) affects the brain, the effects of different routes of cannabis administration (e.g., smoking, vaping, edibles), high-potency THC, and whether cannabis is addictive. We discuss if there is a link between cannabis use and the development of psychosis, anxiety, bipolar depression, or schizophrenia.  We discuss whether CBD has clinical benefits in regulating stress, promoting sleep, and treating certain diseases. We also discuss if there are real and consistent differences in the biological effects of different cannabis strains, if cannabis impacts hormones, and the uses of cannabis for the management of pain, stress, Post-traumatic stress disorder (PTSD), anxiety, and nausea. Listeners of this episode will get an up-to-date understanding of what is currently known about how cannabis affects the brain and body, including both its potential benefits and risks. Access the full show notes for this episode at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Eight Sleep: https://www.eightsleep.com/huberman LMNT: https://drinklmnt.com/huberman BetterHelp: https://betterhelp.com/huberman InsideTracker: https://insidetracker.com/huberman Timestamps 00:00:00 Dr. Matthew Hill 00:00:00 Sponsors: Eight Sleep, LMNT & BetterHelp 00:07:16 Cannabis, THC, Cannabidiol (CBD), Terpenes 00:12:08 Psychoactive Effects, Cannabis “High”; Time Perception 00:16:55 Cannabis & Brain, CB1 Receptor, Endocannabinoids 00:26:19 Endocannabinoids Types: Anandamide, 2-AG 00:33:46 “Munchies”, Cannabis & Appetite 00:42:17 Sponsor: AG1 00:44:06 THC & Anandamide, Pharmacology 00:52:37 THC & CB1 Receptors, Intoxication & Appetite 00:58:57 Cannabis & Focus, Memory 01:04:09 Routes of Administration, Concentration, Cannabis Research 01:15:12 Self-Regulation, Inhalation & THC, Tolerance; THC Concentrates 01:22:25 Sponsor: InsideTracker 01:23:36 Addiction & Cannabis, Cannabis Use Disorder 01:31:30 Cannabis Legalization & Use, Edibles & ER Visits 01:36:48 Oral Consumption, Edibles, Dosing & Time Course 01:41:12 Drug Testing & Cannabis, Exercise 01:46:04 Cannabis & Hormones, Gynecomastia, Sperm Quality 01:54:37 Cannabis & Pregnancy; Selling Recreational Cannabis 02:04:07 Vaping 02:07:05 Psychosis, Anxiety & Cannabis 02:17:17 Cannabis, Psychosis, Schizophrenia & Genetics 02:30:45 Cannabis Use & Schizophrenia, Manic Bipolar, THC Potency, Nicotine 02:40:37 Schizophrenia, Cannabis Legalization 02:45:06 Cannabis Strains, Indica, Sativa, Subjective Effects & Expectancy Bias 02:57:00 CBD, Pediatric Epilepsy, Adenosine 03:07:22 Entourage Effect; Placebo Effect, CBD & Doses 03:19:12 Cannabis Health Risks, Cardiovascular Risk, Schizophrenia  03:27:08 Cyclic Vomiting Syndrome & Hot Shower 03:31:30 Cannabis Benefits: Pain, Stress, Anxiety, Post-Traumatic Stress Disorder (PTSD) 03:40:18 Cannabis & Anxiety, Anandamide & Stress Response 03:45:55 Scientific Discussion, Clarification & Advancement 03:49:47 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter Disclaimer
    Huberman Lab
    enJuly 08, 2024

    How to Improve Skin Health & Appearance

    How to Improve Skin Health & Appearance
    In this episode, I discuss skin health appearance and why both are important indicators of the health status of your immune system, gut microbiome, and other organ systems. I explain why sunlight is essential for skin and hormone health and how excessive sunlight can accelerate skin aging and cause certain skin cancers. I discuss the different types of sunscreens (physical, chemical, and mineral-based) and potential health concerns of the chemicals found in some (but not all) sunscreens. I also discuss the importance of getting your skin (and not just moles) checked for pre-cancerous and cancer growths, the role of nutrition and lifestyle factors that improve skin health and appearance, and how to improve your skin by reducing local and systemic inflammation and supporting your microbiome.  I explain what works to improve your skin's youthfulness and appearance, including reducing wrinkles, sagging, and pore size. I review the data on ingesting (or topically applied) collagen, vitamin C, niacinamide, hyaluronic acid, and retinol, and what is known about the use of peptides (e.g., BPC-157, copper peptides) and red and far-red light phototherapies for improving skin health and appearance. I also discuss the causes of acne, rosacea, and psoriasis and explain nutritional, skin care, and prescription-based approaches to treating these common skin conditions. This episode ought to help everyone better understand the biology of the skin and help them make the best possible decisions for their skin health, care, and appearance according to age, goals, and current skin conditions. Access the full show notes, including referenced articles, books, people mentioned, and additional resources at hubermanlab.com. Andrew's New Book Protocols: An Operating Manual for the Human Body: https://protocolsbook.com Thank you to our sponsors AG1: https://drinkag1.com/huberman Joovv: https://joovv.com/huberman BetterHelp: https://betterhelp.com/huberman  ROKA: https://roka.com/huberman  LMNT: https://drinklmnt.com/huberman  Timestamps 00:00:00 Skin Health 00:02:59 Sponsors: Joovv, BetterHelp & ROKA  00:07:18 Skin Biology, Skin Layers 00:12:40 Sun Exposure, UV Light & Skin Cancers; Sunscreen 00:19:51 Aging, Sun Exposure, Skin Cancers, Physical Barriers 00:27:24 Sunburn & Skin Cancers 00:30:09 Sponsor: AG1 00:31:58 Vitamin D, Sun Exposure & Sunscreen 00:36:50 Organic (Chemical) Sunscreen & Inorganic (Mineral-Based) Sunscreen 00:49:20 Skin Cancers, Moles, Laser Resurfacing 00:53:59 Sponsor: LMNT 00:55:34 Sun Exposure, Melanoma & Life Expectancy 01:03:13 Tool: Youthful Skin, Collagen & Vitamin C 01:12:55 Peptides, BPC-157, Copper 01:20:58 Tool: Niacinamide (Nicotinamide), Youthful Skin, Dark Spots, Hyaluronic Acid 01:26:25 Tool: Retinol (Retin-A, Tretinoin, Retinyl Esters), Youthful Skin 01:33:07 Tool: Phototherapy, Youthful Skin, Treating Skin Conditions 01:41:10 Tool: Nutrition for Skin Health, Anti-Inflammatory Diets 01:47:54 Highly Processed Foods, Advanced Glycation End Products & Skin Health 01:52:08 Tools: Reduce Inflammation: Gut Microbiome, Sleep, Alcohol, Smoking, Stress 01:58:58 Acne, Hormones & Insulin; Tool: Low Glycemic Diet, Dairy 02:07:26 Tools: Face Cleansing & Acne; Scarring & Popping Pimples 02:13:29 Tool: Treating Rosacea, Alcohol, Skin Care, Nutrition 02:18:31 Stubborn Rosacea, Over Cleansing, Pulsed Dye Laser 02:21:04 Psoriasis Treatment, Immune System & Prescriptions 02:25:24 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter Disclaimer
    Huberman Lab
    enJuly 01, 2024

    Dr. Gabrielle Lyon: How to Exercise & Eat for Optimal Health & Longevity

    Dr. Gabrielle Lyon: How to Exercise & Eat for Optimal Health & Longevity
    In this episode, my guest is Dr. Gabrielle Lyon, D.O., a board-certified physician who did her clinical and research training at Washington University in geriatrics and nutrition. She is also an expert in how diet and exercise impact muscle and whole-body health and longevity. Dr. Lyon is a bestselling author and public educator. We discuss how healthy skeletal muscle promotes longevity, brain health, disease prevention, ideal body composition, and the health of other organs and bodily systems. She makes specific nutritional recommendations for optimal health: what to eat, how much to eat, the timing of meals, the essential need for adequate quality protein (including animal and plant-based options), supplementation, and how our dietary requirements change with age. She explains why specific types of resistance training are essential to build and maintain muscle and overall metabolic health. She also describes how to include resistance training as part of your exercise regimen — regardless of age or sex.  She also provides specific mindset tools to encourage sustained adherence to healthy eating and exercise practices. Women and men of all ages will benefit from Dr. Lyon’s practical, evidence-based protocols to improve muscle and whole-body appearance, function, and health. Access the full show notes, including referenced articles, books, people mentioned, and additional resources at hubermanlab.com. Andrew's New Book Protocols: An Operating Manual for the Human Body: https://protocolsbook.com Thank you to our sponsors AG1: https://drinkag1.com/huberman Maui Nui Venison: https://mauinuivenison.com/huberman  Levels: https://levels.link/huberman  Helix Sleep: https://helixsleep.com/huberman InsideTracker: https://insidetracker.com/huberman  Timestamps 00:00:00 Protocols Book; Dr. Gabrielle Lyon 00:03:23 Sponsors: Maui Nui, Levels & Helix Sleep 00:07:40 Skeletal Muscle & Longevity 00:11:25 “Under-muscled”, Leucine & Muscle Health 00:15:55 Muscle Health 00:19:45 Tool: Carbohydrate Consumption & Activity, Glycogen 00:25:14 Tools: Nutrition for Healthy Skeletal Muscle, First Meal 00:31:57 Sponsor: AG1 00:33:46 Quality Protein, Animal & Plant-Based Proteins 00:37:36 Dietary Protein Recommendations, Meal Threshold 00:41:19 Muscle Health & Aging 00:46:02 Supplements & Creatine; Dietary Protein 00:50:07 Tool: Dietary Protein Recommendation; Gout & Cancer Risk 00:52:43 Effects of Dietary Protein & Exercise on Body Composition 01:03:06 Thermic Effects, Protein  01:05:02 Sponsor: InsideTracker 01:06:14 Protein & Satiety, Insulin & Glucose 01:12:04 Tool: Older Adults, Resistance Training & Dietary Protein 01:17:48 Dietary Protein, mTOR & Cancer Risk 01:21:36 Muscle Span & Aging, Sedentary Behaviors 01:24:00 Mixed Meals, Protein Quality, Fiber 01:29:21 Inactivity & Insulin Resistance, Inflammation 01:38:43 Exercise & Myokines, Brain Health & BDNF 01:44:11 Tool: Resistance Training Protocols, Hypertrophy, “High Ground” 01:52:51 High Ground Exercises; Tendon Strength; Training Duration, Blue Zones 01:58:19 Movement, Exercise & Older Adults 02:04:25 Tool: Protein Timing & Resistance Training; VO2 Max, Aging, Blood Work 02:11:13 Supplements: Creatine, Urolithin A, Whey Protein, Fish Oil, Collagen 02:20:18 Fasting, Older Adults; Tool: Meal Timing 02:25:18 Animal Proteins & Dairy; Organ Meats, Vegan; Magnesium, Zinc 02:30:59 Medications & Muscle Health 02:32:49 Obesity & GLP-1 Analogs, Ozempic, Mounjaro, Skeletal Muscle 02:40:48 Benefits of Skeletal Muscle & Aging 02:42:16 Tools: Nutrition & Resistance Training for Muscle Health 02:45:44 Mindset Tools: Standards vs. Goals; Vulnerability Points 02:52:00 Mindset Tools: Neutrality; Health & Worth 03:01:14 Zero-Cost Support, Spotify & Apple Follow & Reviews, YouTube Feedback, Social Media, Neural Network Newsletter, Protocols Book Disclaimer
    Huberman Lab
    enJune 24, 2024

    Perform with Dr. Andy Galpin: Why Muscle Matters & How to Build It

    Perform with Dr. Andy Galpin: Why Muscle Matters & How to Build It
    I'm honored to share Episode 2 of the first season of Perform with Dr. Andy Galpin. Dr. Andy Galpin is a tenured full professor at California State University, Fullerton, where he co-directs the Center for Sport Performance and leads the Biochemistry and Molecular Exercise Physiology Laboratory. Andy is both a friend and a colleague, and I'm delighted to have assisted in the creation of this podcast. I'm certain you'll both enjoy and learn from it. Season 1 features 10 episodes, airing every Wednesday for 10 weeks. Dr. Galpin will cover everything from building strength, the importance of strength for long-term health, the science of breathing, the benefits of sleep extension, genetic testing for personalized training, and nutrition for injury recovery. While we have Episode 2 of Perform with Dr. Andy Galpin here, please be sure to subscribe and follow Perform with Dr. Andy Galpin on your preferred platform. Show notes for this episode can be found at performpodcast.com. Timestamps 00:00:00 Introduction from Dr. Andrew Huberman 00:01:06 Skeletal Muscle 00:04:06 Sponsors: Absolute Rest & Momentous 00:07:20 Quantity & Quality; Organ System; Health & Performance 00:12:58 Plasticity, “Look Good, Feel Good, Play Good”; Muscle Types 00:15:46 What is Muscle?, Muscle Fibers, Tendon 00:21:37 Muscle Fiber Number, Hyperplasia, Anabolic Steroids, Age 00:24:03 Myonuclei & Adaptability 00:26:27 Muscle Fiber Types, Variable Muscle Functions 00:32:24 Fiber Type & Lifestyle Factors 00:34:54 Sponsors: David Protein & AG1 00:37:37 Age & Muscle Loss, Slow vs. Fast-Twitch Fibers; Motor Units 00:46:36 Muscle Size vs. Muscle Strength, Quantity vs. Quality 00:50:56 Investigate: Muscle Quantity, Fat-Free Mass Index (FFMI) 00:56:21 FFMI, Elite Athletes, Muscle Mass 01:00:59 Muscle Asymmetry; Too Much Muscle Possible? 01:03:49 Interpret: Muscle Mass, FFMI Calculations & Percentiles 01:09:28 Tool: Intervene - Increase Muscle Mass, 72-Hour Rule 01:15:27 Sponsors: Maui Nui & Renaissance Periodization 01:17:51 Investigate: Muscle Quality & 4 Movement Principles 01:23:34 Muscle Quality & 3 Performance Principles  01:26:42 Interpret: Muscle Speed, Age 01:32:45 Muscle Power, Vertical Jump, Broad Jump 01:36:17 Muscle Strength, Powerlifting Elite, Bench Press, Leg Press, Grip Strength 01:44:05 Increasing Strength, Improve Health & Longevity 01:46:44 Tool: Intervene - Improve Muscle Quality, 4 Training Principles, 3-to-5 Rule 01:53:56 Zero-Cost Support, YouTube, Spotify & Apple Subscribe & Reviews, Sponsors, YouTube Feedback, Social Media 01:56:10 Conclusion from Dr. Andrew Huberman Disclaimer
    Huberman Lab
    enJune 19, 2024

    Dr. Zachary Knight: The Science of Hunger & Medications to Combat Obesity

    Dr. Zachary Knight: The Science of Hunger & Medications to Combat Obesity
    In this episode, my guest is Dr. Zachary Knight, Ph.D., a professor of physiology at the University of California, San Francisco (UCSF), and Howard Hughes Medical Institute (HHMI) investigator. We discuss how the brain controls our sense of hunger, satiety, and thirst. He explains how dopamine levels impact our cravings and eating behavior (amount, food choices, etc) and how we develop and can change our food preferences and adjust how much we need to eat to feel satisfied. We discuss factors that have led to the recent rise in obesity, such as interactions between our genes and the environment and the role of processed foods and food combinations. We also discuss the new class of medications developed for the treatment of obesity and diabetes, including the GLP-1 agonists semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro). We discuss how these medications work to promote weight loss, the source of their side effects, and the newer compounds soon to overcome some of those side effects, such as muscle loss. Dr. Knight provides an exceptionally clear explanation for our sense of hunger, thirst, and food cravings that translates to practical knowledge to help listeners better understand their relationship to food, food choices, and meal size to improve their diet and overall health. For show notes, including referenced articles and additional resources, please visit hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman  BetterHelp: https://betterhelp.com/huberman Eight Sleep: https://eightsleep.com/huberman Waking Up: https://wakingup.com/huberman LMNT: https://drinklmnt.com/huberman Timestamps 00:00:00 Dr. Zachary Knight 00:02:38 Sponsors: BetterHelp, Helix Sleep & Waking Up 00:07:07 Hunger & Timescales 00:11:28 Body Fat, Leptin, Hunger 00:17:51 Leptin Resistance & Obesity 00:20:52 Hunger, Food Foraging & Feeding Behaviors, AgRP Neurons 00:30:26 Sponsor: AG1 00:32:15 Body Weight & Obesity, Genes & POMC Neurons 00:39:54 Obesity, Genetics & Environmental Factors 00:46:05 Whole Foods, Ultra-Processed Foods & Palatability 00:49:32 Increasing Whole Food Consumption, Sensory Specific Satiety & Learning 00:58:55 Calories vs. Macronutrients, Protein & Salt 01:02:23 Sponsor: LMNT 01:03:58 Challenges of Weight Loss: Hunger & Energy Expenditure 01:09:50 GLP-1 Drug Development, Semaglutide, Ozempic, Wegovy 01:19:03 GLP-1 Drugs: Muscle Loss, Appetite Reduction, Nausea 01:23:24 Pharmacologic & Physiologic Effects; GLP-1 Drugs, Additional Positive Effects 01:30:14 GLP-1-Plus Development, Tirzepatide, Mounjaro, AMG 133 01:34:49 Alpha-MSH & Pharmacology 01:40:41 Dopamine, Eating & Context 01:46:01 Dopamine & Learning, Water Content & Food 01:53:23 Salt, Water & Thirst 02:03:27 Hunger vs. Thirst 02:05:46 Dieting, Nutrition & Mindset 02:09:39 Tools: Improving Diet & Limiting Food Intake 02:14:15 Anti-Obesity Drug Development 02:17:03 Zero-Cost Support, Spotify & Apple Follow & Reviews, YouTube Feedback, Social Media, Neural Network Newsletter Disclaimer
    Huberman Lab
    enJune 17, 2024

    Perform with Dr. Andy Galpin: How & Why to Strengthen Your Heart & Cardiovascular Fitness

    Perform with Dr. Andy Galpin: How & Why to Strengthen Your Heart & Cardiovascular Fitness
    I'm honored to share the first episode of the new podcast, Perform with Dr. Andy Galpin. Dr. Andy Galpin is a tenured full professor at California State University, Fullerton, where he co-directs the Center for Sport Performance and leads the Biochemistry and Molecular Exercise Physiology Laboratory. Andy is both a friend and a colleague, and I’m delighted to have assisted in the creation of this podcast. I'm certain you'll both enjoy and learn from it. Season 1 features 10 episodes, airing every Wednesday for 10 weeks. Dr. Galpin will cover everything from building strength, the importance of strength for long-term health, the science of breathing, the benefits of sleep extension, genetic testing for personalized training, and nutrition for injury recovery. While we have Episode 1 of Perform with Dr. Andy Galpin here, please be sure to subscribe and follow Perform with Dr. Andy Galpin on your preferred platform. Show notes for this episode can be found at performpodcast.com. Timestamps 00:00:00 Introduction from Dr. Andrew Huberman 00:01:07 Heart 00:03:55 Sponsors: Vitality Blueprint & Rhone 00:07:27 Muscle Types 00:09:54 VO2 max, Health & Mortality 00:15:49 Overall Health, Cardiorespiratory Fitness & All-Cause Mortality 00:25:23 Sponsor: AG1 00:26:54 Disease, Health & Mortality 00:30:02 Cardiac Muscle & Heart 00:38:29 Cardiac Muscle vs. Skeletal Muscle, Cardiac Advantages 00:43:53 Pacemakers & Heart Rate, Vagus Nerve 00:50:35 Why Doesn’t the Heart Get Sore? 00:54:32 Heart & Exercise, Stroke Volume, Ejection Fraction, Cardiac Output 00:59:21 Heart Rate Variability 01:02:41 Sponsors: Momentous & LMNT 01:06:54 Why Do You Breathe?: Oxygen, Carbon Dioxide & Respiratory Rate 01:13:37 Respiratory Rate & Stress 01:15:08 Tool: The “Three I’s”, Investigate: Heart Rate, Respiratory Rate, VO2 Max 01:19:53 Tool: Interpretation, Resting Heart Rate & Ranges 01:23:16 Tool: Interpretation: VO2 Max & Ranges 01:30:45 Athletes & Highest VO2 Max Scores 01:35:53 Elite Athletes & Context for VO2 Max Scores 01:41:42 Tool: Intervention, VO2 Max, Varying Exercise Intensities, SAID Principle 01:48:20 Tool: Varying Exercise Intensity; Intervals & Continuous Training; Frequency 01:58:18 Zero-Cost Support, YouTube, Spotify & Apple Subscribe & Reviews, Sponsors, YouTube Feedback, Social Media 01:59:55 Conclusion from Dr. Andrew Huberman Disclaimer
    Huberman Lab
    enJune 12, 2024

    Dr. Jonathan Haidt: How Smartphones & Social Media Impact Mental Health & the Realistic Solutions

    Dr. Jonathan Haidt: How Smartphones & Social Media Impact Mental Health & the Realistic Solutions
    In this episode, my guest is Dr. Jonathan Haidt, Ph.D., professor of social psychology at New York University and bestselling author on how technology and culture impact the psychology and health of kids, teens, and adults. We discuss the dramatic rise of suicide, depression, and anxiety as a result of replacing a play-based childhood with smartphones, social media, and video games. He explains how a screen-filled childhood leads to challenges in psychological development that negatively impact learning, resilience, identity, cooperation, and conflict resolution — all of which are crucial skills for future adult relationships and career success. We also discuss how phones and social media impact boys and girls differently and the underlying neurobiological mechanisms of how smartphones alter basic brain plasticity and function.  Dr. Haidt explains his four recommendations for healthier smartphone use in kids, and we discuss how to restore childhood independence and play in the current generation.  This is an important topic for everyone, young or old, parents and teachers, students and families, to be aware of in order to understand the potential mental health toll of smartphone use and to apply tools to foster skill-building and reestablish healthy norms for our kids. For show notes, including referenced articles and additional resources, please visit hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman  Helix Sleep: https://helixsleep.com/huberman AeroPress: https://aeropress.com/huberman Joovv: https://joovv.com/huberman LMNT: https://drinklmnt.com/huberman Timestamps 00:00:00 Dr. Jonathan Haidt 00:02:01 Sponsors: Helix Sleep, AeroPress & Joovv 00:06:23 Great Rewiring of Childhood: Technology, Smartphones & Social Media 00:12:48 Mental Health Trends: Boys, Girls & Smartphones 00:16:26 Smartphone Usage, Play-Based to Phone-Based Childhood 00:20:40 The Tragedy of Losing Play-Based Childhood 00:28:13 Sponsor: AG1 00:30:02 Girls vs. Boys, Interests & Trapping Kids 00:37:31 “Effectance,” Systems & Relationships, Animals 00:41:47 Boys Sexual Development, Dopamine Reinforcement & Pornography 00:49:19 Boys, Courtship, Chivalry & Technology; Gen Z Development 00:55:24 Play & Low-Stakes Mistakes, Video Games & Social Media, Conflict Resolution 00:59:48 Sponsor: LMNT 01:01:23 Social Media, Trolls, Performance 01:06:47 Dynamic Subordination, Hierarchy, Boys 01:10:15 Girls & Perfectionism, Social Media & Performance 01:14:00 Phone-Based Childhood & Brain Development, Critical Periods 01:21:15 Puberty & Sensitive Periods, Culture & Identity 01:23:55 Brain Development & Puberty; Identity; Social Media, Learning & Reward 01:33:37 Tool: 4 Recommendations for Smartphone Use in Kids 01:41:48 Changing Childhood Norms, Policies & Legislature 01:49:13 Summer Camp, Team Sports, Religion, Music 01:54:36 Boredom, Addiction & Smartphones; Tool: “Awe Walks” 02:03:14 Casino Analogy & Ceding Childhood; Social Media Content 02:09:33 Adult Behavior; Tool: Meals & Phones 02:11:45 Regaining Childhood Independence; Tool: Family Groups & Phones 02:16:09 Screens & Future Optimism, Collective Action, KOSA Bill 02:24:52 Zero-Cost Support, Spotify & Apple Reviews, YouTube Feedback, Social Media, Neural Network Newsletter Disclaimer
    Huberman Lab
    enJune 10, 2024

    LIVE EVENT Q&A: Dr. Andrew Huberman at the Brisbane Convention & Exhibition Centre

    LIVE EVENT Q&A: Dr. Andrew Huberman at the Brisbane Convention & Exhibition Centre
    Recently I had the pleasure of hosting a live event in Brisbane, Australia. This event was part of a lecture series called The Brain Body Contract. My favorite part of the evening was the question and answer period, where I had the opportunity to answer questions from the attendees of each event. Included here is the Q&A from our event at the Brisbane Convention & Exhibition Centre. Sign up to get notified about future events: https://www.hubermanlab.com/events Thank you to our sponsors AG1: https://drinkag1.com/huberman Eight Sleep: https://eightsleep.com/huberman Resources Mentioned Huberman Lab Non-Sleep Deep Rest Protocols Huberman Lab Guest Series with Dr. Matt Walker Huberman Lab Guest Series with Dr. Paul Conti Huberman Lab Guest Series with Dr. Andy Galpin Dr. Becky Kennedy: Protocols for Excellent Parenting & Improving Relationships of All Kinds Perform with Dr. Andy Galpin Timestamps 00:00 Introduction 00:31 Sponsors: AG1 & Eight Sleep 03:48 Nicotine Discussion 07:42 ADHD Management: Tools & Medications 12:43 Sleep Deprivation & Recovery 18:54 Understanding & Addressing Burnout 22:12 Daily Nutrition & Eating Habits 24:40 Understanding Food & Neural Pathways 26:21 The Benefits of Elimination Diets 27:21 Intermittent Fasting & Personal Diet Choices 28:23 Top Health & Fitness Recommendations 30:50 The Value of Non-Sleep Deep Rest (NSDR) 33:08 Testosterone Replacement Therapy Insights 38:02 Breathing Techniques for Stress & Focus 41:46 Morning Sunlight & Circadian Rhythms 43:18 Parenting Tips for a Healthy Start 49:03 Final Thoughts & Gratitude Disclaimer
    Huberman Lab
    enJune 07, 2024

    Related Episodes

    Dr. Sara Gottfried: How to Optimize Female Hormone Health for Vitality & Longevity

    Dr. Sara Gottfried: How to Optimize Female Hormone Health for Vitality & Longevity
    My guest is Sara Gottfried, M.D., a Harvard-trained, board-certified gynecologist and clinical assistant professor of integrative medicine & nutritional sciences at Thomas Jefferson University. Dr. Gottfried specializes in hormone health, vitality and longevity using precision/personalized approaches. We discuss female hormone health, puberty, perimenopause, and menopause, hormone testing, the microbiome, stress related hormone challenges, their causes, and various treatments. We also discuss fertility, birth control and tools for improving microbiome health, treating PCOS, insulin management, and the best nutrition, supplementation, and exercise programs for women. While the episode focuses mainly on female hormones, males will also  benefit from our discussion because it includes  actionable tools suggested for managing stress, bolstering the gut microbiome, and immunity—all of which stand to improve overall health, vitality and longevity in males and females. For the full show notes, visit hubermanlab.com. Thank you to our sponsors AG1: https://athleticgreens.com/huberman LMNT: https://drinklmnt.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman Timestamps (00:00:00) Dr. Sara Gottfried (00:04:07) Sponsor: LMNT (00:07:50) Women, Family History, Heredity & Environment (00:11:00) Puberty, Stress, Menstrual Cycles, Intrauterine Devices (IUDs) (00:17:26) Tool: Sex Hormones, Microbiome, Estrobolome & Disease; Biomarker Testing (00:25:11) Nutritional Testing; Vegetables, Microbiome & Disease (00:27:33) Sponsor: AG1 (00:32:22) Microbiome, Prebiotics & Probiotics, Inflammation (00:36:08) Microbiome Testing, Magnesium, Constipation & Thyroid (00:42:25) Female Colonoscopy; Network Effect & Modern Medicine, Stress Factors (00:45:13) Constipation, Stress & Trauma, Autonomic Balance (00:55:35) Constipation Relief, Stress, Breathwork & Meditation (01:02:58) Systemic & Societal Stress Unique to Females (01:09:23) Testing & Future Behavior (01:11:55) Polycystic Ovary Syndrome (PCOS) & Cardiometabolic Disease; Stress  (01:22:57) PCOS, Insulin, Glucose Monitoring and Management; Data Access (01:29:48) Behaviors for Vitality; Exercise & Body Phenotype; Cortisol (01:36:40) Cortisol Supplements: Ashwagandha, Rhodiola, Fish Oil, Phosphatidylserine (01:42:36) Cortisol, Anxiety & Immune System; Adrenal Function, Resilience (01:48:07) Tool: Omega-3 Fatty Acids, Inflammation, Specialized Pro-Resolving Mediators (01:54:20) Oral Contraceptives, Benefits & Risks; Ovarian Cancer; Testosterone (02:06:50) Fertility, Follicular & Anti-Mullerian Hormone (AMH) Assessments (02:10:29) Menopause & Hormone Replacement Therapy; Women’s Health Initiative (02:15:30) Perimenopause, Cerebral Hypometabolism, Metabolism & Estrogen (02:21:49) Intermittent Fasting, Ketogenic Diet, Metabolic Flexibility  (02:23:29) Stool Testing (02:25:32) Coronary Artery Calcium (CAC) Test, ACE Score & Disease  (02:31:56) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Social Media, Neural Network Newsletter, Momentous Title Card Photo Credit: Mike Blabac Disclaimer

    Dr. Peter Attia: Exercise, Nutrition, Hormones for Vitality & Longevity

    Dr. Peter Attia: Exercise, Nutrition, Hormones for Vitality & Longevity
    My guest this episode is Dr. Peter Attia, M.D., who trained at Stanford University School of Medicine, Johns Hopkins Hospital and the National Institutes of Health (NIH). Dr. Attia is host of The Drive podcast and is a world expert on behavioral approaches, nutritional interventions, supplementation and pharmacological techniques to improve lifespan, healthspan and athletic performance. We discuss how best to evaluate your health status using routine blood work, body scans and regular tests of physical strength and endurance. Dr. Attia explains what he uses with his patients to “back-cast” their health goals as a way to design their exercise and nutritional programs. We also discuss hormone modulation and replacement therapy for both men and women. We explain how cholesterol and related factors contribute to cardiovascular disease risk and how to monitor and mitigate that risk. Dr. Attia details various supplementation, nutrition, exercise and prescription approaches useful to people in every decade of life to improve vitality, reduce their risk of disease and increase the number of years sustaining peak cognitive and physical health.  For the full show notes, visit hubermanlab.com. Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman LMNT: https://drinklmnt.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman Timestamps (00:00:00) Assessing Health Status & Improving Vitality  (00:03:07) Sponsors: AG1, LMNT (00:07:29) Lifespan: Bloodwork & Biomarkers Testing, The “4 Horseman of Disease”  (00:11:51) Healthspan: Functional Testing, Cognitive & Emotional States  (00:13:59) Blood Testing: Best Frequency  (00:16:01) DEXA Scan: Lean Mass & Fat, Bone Mineral Density & Osteoporosis  (00:22:33) Bone Mineral Density & Age-Related Decline, Strength Training, Corticosteroids  (00:29:24) Osteopenia & Osteoporosis Diagnosis, Strength Training (00:29:52) Sponsor: AG1 (00:32:16) Back-casting: Defining Your “Marginal Decade”  (00:38:31) All-Cause Mortality: Smoking, Strength, VO2 max  (00:44:43) Attia’s Rule of Supplementation, “Centenarian Decathlete” Physical Goals (00:49:24) Importance of Exercise, Brain Health, MET hours  (00:55:23) Nicotine & Cognitive Focus (01:03:12) Menstruation, PMS & Menopause  (01:10:10) Hormone Replacement Therapy, Menopause & Breast Cancer Risk (01:22:06) Estrogen, Progesterone & Testosterone Therapies in Women (01:26:35) Hormone Replacement Therapy in Men, SHBG & Testosterone, Insulin (01:37:23) Clomid, Pituitary, Testosterone & Cholesterol, Anastrozole, HCG (01:47:46) Fadogia Agrestis, Supplements, Rapamycin  (01:52:06) Testosterone Replacement Therapy & Fertility  (01:59:26) Total Testosterone vs. Free Testosterone (02:02:51) Cholesterol & Dietary Cholesterol, Saturated Fat, LDL & HDL, Apolipoprotein B (02:17:42) Apolipoprotein B, Diet, Statins & Other Cholesterol Prescriptions  (02:25:15) Cardiovascular Disease, Age & Disease Risk  (02:28:53) Peptides, Stem Cells, BPC157, PRP (Platelet-Rich Plasma), Injury Rehabilitation  (02:37:40) Metabolomics & Exercise  (02:40:44) GLP-1 & Weight Loss  (02:47:06) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous Supplements, Instagram, Twitter, Neural Network Newsletter, Huberman Lab Clips Title Card Photo Credit: Mike Blabac Disclaimer

    Intermittent Fasting vs. Caloric Restriction & Ketones!

    Intermittent Fasting vs. Caloric Restriction & Ketones!

    Hi friends!

    Introducing the brand new TONE Device! Struggling to lose weight or reach your fitness goals? The TONE is a new breath acetone meter which lets you know if your body is burning fat! 

    All TONE devices are NOW SHIPPING Worldwide!!

    Order the Black & Gold TONE HERE

    Order the Black & Rose Gold TONE HERE

    This episode is all about Intermittent Fasting vs. Caloric Restriction & Ketones!

    Follow @optimalproteinpodcast on Instagram to see visuals and posts mentioned on this podcast.

    Link to join the facebook group for the podcast: https://www.facebook.com/groups/2017506024952802/

    Follow Vanessa on instagram to see her meals, recipes, informative posts and much more! Click here @ketogenicgirl

    Try the Higher Protein Keto Meal Plans & Coaching: https://www.ketogenicgirl.com

    Special thank you to our podcast sponsor:

    Magnesium Breakthrough by BiOptimizers

    For an exclusive offer for my listeners go to magbreakthrough.com/fastketo and use the code FASTKETO during checkout to save 10 percent and get free shipping.

    So VISIT www.magbreakthrough.com/fastketo  and use the code FASTKETO for 10% off plus free shipping!

    -

    Prior to beginning a ketogenic diet you should undergo a health screening with your physician to confirm that a ketogenic diet is suitable for you and to rule out any conditions and contraindications that may pose risks or are incompatible with a ketogenic diet, including by way of example: conditions affecting the kidneys, liver or pancreas; muscular dystrophy; pregnancy; breast-feeding; being underweight; eating disorders; any health condition that requires a special diet [other conditions or contraindications]; hypoglycemia; or type 1 diabetes. A ketogenic diet may or may not be appropriate if you have type 2 diabetes, so you must consult with your physician if you have this condition. Anyone under the age of 18 should consult with their physician and their parents or legal guardian before beginning such a diet. Use of Ketogenic Girl videos are subject to the Ketogenicgirl.com Terms of Use and Medical Disclaimer. All rights reserved. If you do not agree with these terms, do not listen to, or view any Ketogenic Girl podcasts or videos.

    How To Fix Your Fatburn! Dr. Cate Shanahan

    How To Fix Your Fatburn! Dr. Cate Shanahan

    The BRAND NEW 2nd Generation Tone Devices are launching soon! Pre-order HERE & get $40 OFF with the code VIPLAUNCHGEN2

    Dr. Cate Shanahan is the leading authority on nutrition and human metabolism. A board-certified Family Physician with over 20 years of clinical experience, and NY Times bestselling author of The FatBurn Fix, Deep Nutrition and Food Rules. https://drcate.com/

    Everyone is loving the taste of Tone Protein! Scientifically optimized to support Muscle Protein Synthesis. Click Here to Check it out!

    Get $50 OFF The Tone LUX Red Light Therapy Panels when combined with a pre-order for the new Tone LUX Crystal Mask - use the code TONELUXSAVE50 - Click HERE To Shop!

    -

    Follow @optimalproteinpodcast on Instagram to see visuals and posts mentioned on this podcast.

    Follow Vanessa on instagram to see her meals, recipes, informative posts and much more! Click here @ketogenicgirl

    Link to join the facebook group for the podcast: https://www.facebook.com/groups/2017506024952802/

    -

    Special thank you to our sponsor:

    Magnesium Breakthrough by Bioptimizers

    Make Magnesium Breakthrough part of your daily routine this year, so you can get the vitality you need to conquer your dreams.

    Go to www.bioptimizers.com/vanessa now and enter promo code VANESSA to get 10% off any order.

    -

    This podcast content does not constitute an attempt to practice medicine and does not establish a doctor-patient relationship. Please consult a qualified healthcare provider for medical advice and personal health questions.

    Prior to beginning a new diet you should undergo a health screening with your physician to confirm that a new diet is suitable for you and to out any conditions and contraindications that may pose risks or are incompatible with a new diet, including by way of example: conditions affecting the kidneys, liver or pancreas; muscular dystrophy; pregnancy; breast-feeding; being underweight; eating disorders; any health condition that requires a special diet [other conditions or contraindications]; hypoglycemia; or type 1 diabetes. A new diet may or may not be appropriate if you have type 2 diabetes, so you must consult with your physician if you have this condition. Anyone under the age of 18 should consult with their physician and their parents or legal guardian before beginning such a diet. Use of Ketogenic Girl videos are subject to the Ketogenicgirl.com Terms of Use and Medical Disclaimer. All rights reserved. If you do not agree with these terms, do not listen to, or view any Ketogenic Girl podcasts or videos.