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    #258 - AMA #48: Blood pressure—how to measure, manage, and treat high blood pressure

    enJune 12, 2023

    Podcast Summary

    • Accurately Measuring Blood Pressure at Home for Better Health.Measure your blood pressure accurately with a cuff at home to prevent cardiovascular disease, dementia & hypertension. Exercise, weight loss, nutrition & medication can reduce high blood pressure.

      High blood pressure is one of the leading causes of atherosclerosis and cardiovascular disease. People may have high blood pressure without realizing it, so it's important to measure it accurately at home with a cuff. Weight loss, exercise, nutrition, and medication can all help to reduce blood pressure. Knowing your blood pressure is important not only for preventing cardiovascular disease but also for preventing dementia. Anyone with elevated blood pressure should address it. The accuracy and repeatability of measurements are crucial in determining a diagnosis of high blood pressure. Although blood pressure measurement in the doctor's office may not be accurate, getting a cuff and measuring it at home is a reliable option.

    • Understanding Blood Pressure and How to Manage ItBlood pressure is a major risk factor for cardiovascular disease and can be controlled through lifestyle changes like exercise, diet, and stress management. Medications can also help. Regular monitoring is crucial.

      Blood pressure is an important topic and a major risk factor for cardiovascular disease alongside smoking and APOB. The heart pumps and creates pressure in the arteries during systole and diastole. To control blood pressure, you can adopt lifestyle changes like exercise, monitor your diet, and avoid stress. Medications can also help lower blood pressure. The focus of this AMA is to explain what blood pressure is, why it is crucial, what it affects, how to check it, and what lifestyle and medical options are available to manage it.

    • Understanding Blood Pressure and How it Affects the BodyBlood pressure is the force of blood against the arteries, with two readings representing systole and diastole. The heart receives blood supply during diastole, while other organs receive their supply during systole.

      Blood pressure is the force exerted by blood on the walls of arteries. During systole, the higher number of blood pressure is the pressure exerted by the blood during contraction of the left ventricle, while the lower number is the pressure when the left ventricle is relaxed and blood is flowing back through the atria. During diastole, the heart muscle relaxes, and the ventricles fill with blood. The heart itself receives its blood supply during diastole, while the other organs receive their blood supply during systole. The body's ability to function effortlessly and do things that we don't think about daily is amazing.

    • Understanding Blood Pressure and Hypertension LevelsMaintaining a healthy blood pressure level is crucial for overall cardiovascular health. Regular monitoring and treatment can help prevent hypertension and reduce the risk of ASCBD events, especially for those with high cardiovascular risk.

      Blood pressure is a crucial part of cardiovascular health. The systolic and diastolic numbers, both less than 120 and 80 respectively, represent normal blood pressure. Elevated blood pressure is between 120 and 129 systolically, whereas stage one hypertension includes systolic numbers between 130 to 139, or diastolic numbers between 80 and 89. Stage two hypertension is greater than or equal to 140 systolic or diastolic greater than or equal to 90. These guidelines come from the Sprint trial which looked at aggressive blood pressure control and its benefit. Monitoring blood pressure is particularly important for those with advanced cardiovascular risk, but those without type 2 diabetes, due to the risk for ASCBD events.

    • High-Intensity Blood Pressure Treatment can reduce mortalityRigorous blood pressure assessments and high-intensity treatment can significantly reduce cardiovascular risks and overall mortality. This study demonstrates the significant benefits of high-intensity treatment in reducing the compounding risk factor that is blood pressure.

      A blood pressure study showed that high-intensity treatment resulted in reduced cardiovascular mortality by 25%. The study measured blood pressure three times using a specific protocol and took the average of those readings. The intervention was stopped early due to the significant benefits in the high-intensity group. The study also saw a reduction in all-cause mortality, not just cardiovascular mortality, by 27%. This was unexpected and included reductions in accidental death, suicide, and homicide. The absolute risk differences may seem small, but they are significant as blood pressure is a compounding risk factor. The study highlights the importance of rigorous blood pressure assessments and high-intensity treatment for reducing cardiovascular risks and improving overall health outcomes.

    • Aggressive Blood Pressure Management to Prevent Endothelial DisruptionLowering blood pressure to less than 120 is highly recommended for effective prevention of endothelial disruption. Early intervention is essential, even for those in the normal category, as small differences in blood pressure can lead to major problems over time.

      Lowering blood pressure aggressively to a systolic pressure less than 120 compared to standard of care, which was previously considered 130 to 140, is tolerable and highly recommended. The study demonstrated its efficacy in a short period of time and reinforces the importance of aggressive blood pressure management to prevent endothelial disruption. The compounding effect of high blood pressure over a lifetime is significant, making early intervention critical. Lower is always better when it comes to blood pressure management, even if someone is in the normal category but creeping towards the elevated category. It is essential to take care of it earlier, as even small differences in blood pressure can lead to major problems over time.

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    • The significance of klotho levels: studies linking lower levels to increased mortality and the broader implications for organ health and disease prevention [1:47:15];
    • Measuring klotho levels and determining an individual’s KL-VS status [1:52:15];
    • The promising potential of klotho for Alzheimer’s disease treatment, and the importance of philanthropy for funding research [1:58:00]; and
    • More.

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    The Peter Attia Drive
    enMay 27, 2024

    #302 - Confronting a metabolic epidemic: understanding liver health and how to prevent, diagnose, and manage liver disease | Julia Wattacheril, M.D., M.P.H.

    #302 - Confronting a metabolic epidemic: understanding liver health and how to prevent, diagnose, and manage liver disease | Julia Wattacheril, M.D., M.P.H.

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    Julia Wattacheril is a physician scientist and director of the Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD) program at Columbia University Irving Medical Center. In this episode, Julia delves deep into the complex world of liver health, beginning with a foundational overview of liver physiology. She provides an in-depth look at how alcohol impacts liver function, breaking down the metabolism of ethanol and its detrimental effects. Julia then shifts the focus to understanding liver function tests and optimal enzyme levels, providing a detailed explanation of AST and ALT and elucidating why fluctuations in these levels may or may not be concerning. She provides a primer on the four major stages of liver disease, discussing risk and emphasizing the importance of early diagnosis. Julia highlights the role of liver disease in increasing the risk of cancer and cardiovascular disease and covers in detail the various strategies for diagnosing, treating, and preventing the progression of liver disease.

    We discuss:

    • Julia’s training, the importance of liver health, and the challenges and innovations of hepatology [3:15];
    • The complex and crucial functionality of the liver, its four most essential functions, and more [8:45];
    • Liver injuries: historical and evolving understanding of causal factors, and the progression to liver diseases and cancer [13:15];
    • How the liver metabolizes nutrients and what happens in the presence of excess calories or alcohol [24:45];
    • Methods of diagnosing liver disease and how insights guide treatment and management strategies [33:30];
    • The poisonous nature of ethanol to the liver [40:30];
    • Varied responses to alcohol, damaging effects of alcohol beyond the liver, and the process of advising patients on their alcohol consumption [47:15];
    • Understanding liver enzymes AST and ALT—interpreting levels, lifestyle factors that affect them, and diagnostic approaches [58:30];
    • Interpreting liver function tests for fatty liver disease, and the challenges of diagnosing liver pathologies, particularly in children versus adults [1:13:15];
    • Comprehensive liver health assessments via imaging and various diagnostic tools to prevent overlooking potential liver pathologies [1:18:45];
    • Potential impact of recreational drugs, statins, and other medications on liver function test results [1:26:45];
    • Shifting nomenclature from NAFLD to MASLD to reflect accuracy in the underlying pathophysiology and understanding of liver diseases [1:30:30];
    • Pathophysiology of MASLD, the need for proactive screening, and the significance of liver fat percentage as an indicator of metabolic health [1:36:30];
    • The importance of screening for rare conditions alongside common metabolic diseases associated with fatty liver accumulation [1:42:45];
    • Practical strategies for managing MAFLD [1:45:30];
    • The impact of fructose consumption on liver health and the challenges of disentangling its effects from other factors like obesity and insulin resistance [1:52:45];
    • The potential of GLP-1 agonists for the treatment of MASLD [1:57:45];
    • How the four stages of liver disease have evolved [2:00:30];
    • Increased cancer and heart disease risk associated with early-stage MAFLD [2:05:15];
    • Emerging drugs and therapies for addressing fat accumulation and fibrosis related to MAFLD [2:12:15];
    • Peter’s major takeaways [2:18:45]; and
    • More.

    Connect With Peter on TwitterInstagramFacebook and YouTube

    The Peter Attia Drive
    enMay 20, 2024

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