disease prevention

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Dr. Eric Topol is the Founder and Director of the Scripps Research Translational Institute, Professor of Molecular Medicine, and Executive Vice-President of Scripps Research. He has published over 1,200 peer-reviewed articles with more than 330,000 citations, was elected to the National Academy of Medicine, and is one of the top 10 most cited researchers in medicine. His principal scientific focus has been on individualized medicine using genomic, digital, and AI tools.

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In this episode we discuss (audio version / Apple Subscriber version):

• The first phase of AI’s application in medicine (7:19 / 5:40)
• How medicine will incorporate AI over the next few years (9:59 / 8:19)
• Retinal imaging (16:45 / 15:05)
• Expert-informed AI (20:02 / 18:23)
• The impending and biggest shake-up in the history of medicine (22:18 / 20:38)
• How AI can improve issues of medical error (26:08 / 24:29)
• Using AI to personalize medicine and prevent disease (33:01 / 29:11)
• The obesity crisis and toxic food environment (41:04 / 37:14)
• How AI can help restore the patient-doctor relationship (46:53 / 43:03)
• Using AI as a guide for medical self care (50:34 / 46:44)
• Reimagining research in the era of AI-enabled medicine (56:58 / 53:07)

Dr. Topol’s Substack, Ground Truths.

Deep Medicine: How Artificial Intelligence Can Make Healthcare Human Again

Hosted on Acast. See acast.com/privacy for more information.

Dr. Shawn Baker is a physician, athlete, author of "The Carnivore Diet," host of "The Dr. Shawn Baker Podcast," and co-founder of online medical clinic Revero. 
https://carnivore.diet/shawn-baker-links/

View the Show Notes Page for This Episode

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In this “Ask Me Anything” (AMA) episode, Peter dives deep into the critical topic of metabolic disease. He first sheds light on how poor metabolic health drives up the risk of developing other chronic diseases such as cardiovascular disease, cancer, neurodegenerative disease, and overall mortality. He explores the array of metrics and tests used to assess metabolic health, underscoring his preferred methodologies utilized with patients. Finally, Peter provides an overview of the factors one can manipulate in order to improve metabolic health.

If you’re not a subscriber and are listening on a podcast player, you’ll only be able to hear a preview of the AMA. If you’re a subscriber, you can now listen to this full episode on your private RSS feed or our website at the AMA #51 show notes page. If you are not a subscriber, you can learn more about the subscriber benefits here.

We discuss:

• Importance of metabolic health and a primer on metabolic disease [1:30];
• How poor metabolic health increases one’s risk for other chronic diseases [6:00];
• How useful is body weight and BMI for estimating metabolic health? [9:45];
• Overview of various tests and metrics used to understand metabolic health [12:15];
• Traditional biomarkers and how Peter’s point of view may differ from the guidelines [15:00];
• Lactate: insights into metabolic health through fasting and resting lactate levels [17:00];
• Zone 2 output: an important functional test of metabolic health [20:00];
• Cardiopulmonary exercise testing (CPET) [25:45];
• Visceral adipose tissue (VAT): what is VAT and how does it impact health? [27:00];
• Oral glucose tolerance test (OGTT): how it works and why it is such an important metric for assessing metabolic health [32:15];
• The utility of a continuous glucose monitor (CGM) [40:45];
• Liver function and NAFLD [42:15];
• Sleep as an intervention [46:00];
• Exercise as an intervention [53:15];
• Diet and nutrition [59:00];
• How reducing stress can improve metabolic health [1:05:15]; and
• More.

Connect With Peter on Twitter, Instagram, Facebook and YouTube

If you are heading somewhere tropical this summer, or just want to protect yourself from bites in your own back garden, then which mosquito repellents can you trust?

Greg Foot gets up close and personal with a box full of hungry mosquitoes to find out.

Is it all about DEET or are there alternatives which are just as effective? What about citronella? And how well do bracelets, patches and candles perform?

And if you do get bitten, what is the best treatment for a mosquito bite?

Greg assesses the scientific evidence with Professor James Logan from the London School of Hygiene and Tropical Medicine and Dr Jane Wilcock, an indepedent researcher and GP.

If you’ve seen an ad, trend or fad relating to another consumer product and wonder if there’s any evidence to back up a claim, drop us an email to sliced.bread@bbc.co.uk or you can send a voice note to our WhatsApp number: 07543 306807

PRESENTER: Greg Foot PRODUCER: Jon Douglas

In the last several years, intermittent fasting — only eating for a short window each day — has gotten a lot of attention, particularly for the way it can facilitate weight loss. But as my guest will explain, going longer than a few hours or even a full day without eating also has some striking, potentially even life-changing benefits too, and may be able to heal a variety of health issues. 

Steve Hendricks is the author of The Oldest Cure in the World: Adventures in the Art and Science of Fasting. He spends the first part of this conversation offering a thumbnail sketch of the history of extended fasting as a medical treatment. From there, we get into what emerging modern science is showing as to how prolonged fasts lasting days or even weeks can prevent and even cure a variety of diseases, from type 2 diabetes to rheumatoid arthritis. We then talk about fasting's effect on cancer, and how it may address mental health issues by offering a metabolic reset. If you're an intermittent faster, you'll be interested to hear why it is you should ideally schedule your eating window for earlier rather than later in the day. We end our conversation with how to get started with extended fasting.

Resources Related to the Episode

• AoM Article: The Spiritual Disciplines — Fasting
• AoM Article: How Intermittent Fasting Can Help You Lose Fat, Gain Muscle, and Get Healthier
• AoM Podcast #328: The Pros and Cons of Intermittent Fasting
• AoM Podcast #624: The Crazy, Forgotten Story of America’s First Fitness Influencer
• Henry S. Tanner
• Minnesota Starvation Experiment 
• Professor Valter Longo
• AoM Podcast #852: The Brain Energy Theory of Mental Illness

Connect With Steve Hendricks

• Steve's Website, including his answers to FAQs on fasting

The COVID-19 pandemic is a grim reminder that infectious diseases have been a danger throughout human history–so much so that the threat of infection has actually helped shape human evolution. Disgust, wariness of strangers, cultural norms around food and cleanliness–all of these behaviors may have evolved at least in part to keep us safe from infectious disease. Researchers call this suite of protective mechanisms the behavioral immune system. University of British Columbia psychologist Mark Schaller, PhD, who coined that phrase, discusses the origins of the behavioral immune system and how behaviors that evolved to protect us from diseases may not be suitable for the threats we face today.

We’d love to know what you think of Speaking of Psychology, what you would change about it, and what you’d like to hear more of. Please take our listener survey, visit www.apa.org/podcastsurvey.

Links

Mark Schaller, PhD

Music

Minimalist Piano w/ Cello by tyops via Freesound.org

Freesound.org

"Endless Thread" presents "Infectious: The Strange Past and Surprising Present of Vaccines – and Anti-Vaxxers."