TWiN reveals how oligodendrocytes enhance axonal energy metabolism by transcellular delivery of a protein, SIRT2, that deacetylates mitochondrial proteins.
Hosts: Vincent Racaniello, Timothy Cheung, and Vivianne Morrison
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Download TWiN 028 (77 MB .mp3, 64 min)
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Music is by Ronald Jenkees
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TWiN discusses the finding that rewiring retinal projections to the auditory thalamus in ferrets leads to visually responsive cells that are typical of cells in the visual cortex.
Hosts: Ori Lieberman, Jason Shepherd, Timothy Cheung, and Vivianne Morrison
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Music is by Ronald Jenkees
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Become a patron of TWiN!
Music is by Ronald Jenkees
Send your neuroscience questions and comments to twin@microbe.tv
TWiN answers listener questions on sex in neuroscience studies, rotating memories in the brain, odorant receptors in the brain, and neutrophils that promote neuron survival.
Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung
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Music is by Ronald Jenkees
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Ioana and Robert join TWiN to discuss their work demonstrating that rodents acquire maternal behavior by social transmission from an experienced mother to a virgin female how to care for a litter via endogenous oxytocin.
Hosts: Vincent Racaniello and Timothy Cheung
Guests: Ioana Carcea and Robert Froemke
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Music is by Ronald Jenkees
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Bruce Carter joins TWiN to discuss the peripheral nervous system: the development of nerves that convey sensory information like touch from the tips of your toes to the brain, and Schwann cells, which are necessary for ensuring that those sensory signals are sustained as they travel long distances to the brain.
Hosts: Vincent Racaniello, Timothy Cheung, and Vivianne Morrison
Guest: Bruce Carter
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Music is by Ronald Jenkees
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TWiN explains how anti-DNA antibodies present in lupus patients bind to GluN2A-containing NMDA receptors, act as positive allosteric modulators, and impair spatial memory.
Hosts: Vincent Racaniello, Ori Lieberman, Jason Shepherd, Timothy Cheung, and Vivianne Morrison
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Music is by Ronald Jenkees
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TWiN explores a study of hallucination-like perception in mice which supports the idea that hallucinations arise as faulty perceptual inferences due to elevated dopamine in the striatum.
Hosts: Vincent Racaniello, Ori Lieberman, and Timothy Cheung
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Music is by Ronald Jenkees
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While perceptual constancy requires the brain to maintain a stable representation of sensory input, TWiN explores a study showing that odor-evoked responses in the olfactory cortex drift over periods of days to weeks.
Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison
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Music is by Ronald Jenkees
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On this episode, Vivianne gives a primer on glial cells, with the goal of thinking about the central nervous system holistically and appreciating the different cell types that contribute to its function.
Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison
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Music is by Ronald Jenkees
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Mauro Costa-Mattioli joins TWiN to discuss how his laboratory dissects the contribution of host genetics and the microbiome in complex neurodevelopment disorders such as autism spectrum disorders.
Hosts: Vincent Racaniello, Ori Lieberman, Jason Shepherd, Timothy Cheung, and Vivianne Morrison
Guest: Mauro Costa-Mattioli
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Music is by Ronald Jenkees
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Michael Nitabach joins TWiN to discuss the finding that the nematode C. elegans, which do not have eyes, can discriminate between colors to guide foraging decisions and move them away from harmful bacteria that produce a blue-pigment toxin.
Hosts: Vincent Racaniello, Ori Lieberman, Jason Shepherd, Timothy Cheung, and Vivianne Morrison
Guest: Michael Nitabach
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Music is by Ronald Jenkees
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Stefano joins TWiN to discuss his work on understanding genomic decoding of neuronal depolarization by stimulus-specific transcriptional regulators.
Hosts: Ori Lieberman, Jason Shepherd, and Timothy Cheung
Guest: Stefano Brigidi
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Music is by Ronald Jenkees
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Helen joins TWiN to discuss her work on understanding how the maternal microbiome modulates fetal neurodevelopment in mice.
Hosts: Ori Lieberman, Andres Bendesky, Jason Shepherd, and Vincent Racaniello
Guest: Helen Vuong
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Music is by Ronald Jenkees
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Ori, Jason, and Vincent discuss the use of antibodies to neutralize amyloid-β seeds before their deposition becomes detectable in transgenic mice, and the finding that the preclinical phase of Alzheimer‘s disease may be a late manifestation of earlier pathogenic seed formation.
Hosts: Ori Lieberman, Jason Shepherd, and Vincent Racaniello
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Music is by Ronald Jenkees
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Ori, Jason, Erin, and Vincent dissect a study that utilizes single-cell RNA sequencing to reveal the genes that underlie remote memory storage in the medial prefrontal cortex of the mouse.
Hosts: Ori Lieberman, Erin Calipari, Jason Shepherd, and Vincent Racaniello
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Music is by Ronald Jenkees
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Ori, Jason, and Vincent reveal identification of an orphan receptor that modifies short-term memory in mice, and a mouse model of COVID-19 that includes anosmia or loss of smell.
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Music is by Ronald Jenkees
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Maria joins TWiN to explain how single-cell transcriptomics is being used to reveal the evolution of the brain, at a cost of about $1 per neuron.
Hosts: Ori Lieberman, Andres Bendesky, and Vincent Racaniello
Guest: Maria Tosches
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Links for this episode
Music is by Ronald Jenkees
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TWiN explains how a cytokine produced by neurons activates microglia which modify the extracellular matrix and remodel synapses, leading to memory consolidation.
Hosts: Ori Lieberman, Andres Bendesky, Erin Calipari, Jason Shepherd and Vincent Racaniello
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Music is by Ronald Jenkees
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Columbia University Chief Neurology Resident Genna Waldman joins TWiN to explains how her department prepared for COVID-19, and the neurological symptoms associated with the disease.
Hosts: Ori Lieberman, Andres Bendesky, Jason Shepherd and Vincent Racaniello
Guest: Genna Waldman
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Intro music is by Ronald Jenkees
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