neurology

On today’s episode: Microbes are the new stars of CSI: Miami, and Maura reaches into the mailbag and answers your burning questions! All that and more today on All Around Science...

RESOURCES

• Scientists identify “universal network” of microbes for decomposing flesh
• Why Do We See Visual Patterns When Rubbing Our Eyes? (explainplease.co.uk)
• Why do you see colors when you close or rub eyes | Ohio State Medical Center (osu.edu)
• Why do you see waves, colours and lights when you rub your eyes? (sciencenorway.no)
• Purkynĕ's description of pressure phosphenes and modern neurophysiological studies on the generation of phosphenes by eyeball deformation
• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8153716/#:~:text=INTRODUCTION,%2C%20sandstorms%2C%20or%20volcanic%20plumes. 
• https://www.sciencedirect.com/science/article/pii/S2095034920300453#:~:text=The%20studies%20indicate%20that%20the,is%20called%20Aeolian%20electric%20field.
• https://physics.aps.org/articles/v16/23
• https://www.science.org/content/article/static-electricity-strengthens-desert-dust-storms
• https://physicsworld.com/a/contact-electrification-explained-at-last/
• Vertigo While Sleeping: Tips and Treatment | Sleep Foundation

THEME MUSIC by Andrew Allen

https://twitter.com/KEYSwithSOUL
http://andrewallenmusic.com

HELLO ACTUAL PT NATION!!!!
Quick warning!!!! Audio has an 8 second lag at beginning and has poor quality intermittently due to Taylor's wifi...i know....i know.... how EMBARRASING! I was thinking the exact same thing! I mean how could he be so inconsiderate and not sacrifice for our beloved Actual PT Nation by getting higher quality wifi?! At the end of the day at least content is content...so hope you enjoy!!! 

On today’s episode: How much does light color affect your sleep cycle? And the 2024 calendar is already full of space missions all over the solar system! All that and more today on All Around Science...

RESOURCES

• Light color is less important for the internal clock than originally thought | University of Basel
• From the Moon’s south pole to an ice-covered ocean world, several exciting space missions are slated for launch in 2024

THEME MUSIC by Andrew Allen

https://twitter.com/KEYSwithSOUL
http://andrewallenmusic.com

Podcast summary of articles from the October 2023 edition of the Journal of Emergency Medicine from the American Academy of Emergency Medicine.  Topics include acute cholangitis, procedural sedation, urine drug screens, burns, and non-convolsive status epilepticus.  Guest speaker is Dr. Dustyn Whitesel.

Chronic pain can be incredibly challenging -- for patients, of course, and also for their physicians. On this episode of ANA investigates, Dr. Adeline Goss talks to Dr. Prasad Shirvalkar of UCSF about a new possible strategy for treating chronic pain: deep brain stimulation. Series 5, Episode 2

Featuring:

• Guest: Dr. Prasad Shirvalkar of UCSF
• Interviewer: Dr. Adeline Goss
• Disclosures: Dr. Shirvalkar disclosed that Medtronic Inc, donated devices for research, but no direct financial support

On today’s episode: Public trust in science is down… why is that? Sometimes the earth quakes. Why? All that and more today on All Around Science...

RESOURCES

• Our brains are not able to ‘rewire’ themselves, despite what most scientists believe, new study argues | University of Cambridge
• Study yields new insights into why some people get headaches from red wine
• Inhibition of ALDH2 by quercetin glucuronide suggests a new hypothesis to explain red wine headaches
• Acetaldehyde and Hangovers: The Role of Phenolic Compounds

THEME MUSIC by Andrew Allen
https://twitter.com/KEYSwithSOUL
http://andrewallenmusic.com

As leaders in neurology, it is vital for our health care system to recruit and to retain and diverse workforce. Institutional advocacy for international medical graduates (IMGs) can improve retention efforts for a department both for patient care as well as for growth into global and diversified research networks. In this episode, we will discuss the pathway for an IMG to train and work in the US and some of the issues that it is important to know about to help promote the career success and satisfaction of international physicians.

As the ANA's 2023 Annual Meeting comes to a close, we wanted to catch up with Frances Jensen Chair of the Department of Neurology at University of Pennsylvania and outgoing President of the ANA, and Rebecca Gottesman, Stroke Branch Chief of the National Institute of Neurological Disorders and Stroke and outgoing Chair of the Annual Meeting Planning Committee. Listen as these two leaders chat about the cutting-edge research, exciting sessions, and broader themes that have defined this year's meeting in Philadelphia.

On today’s episode: AI unlocked the world for a woman who hasn’t spoken for 18 years. How does caffeine work? And why doesn’t it seem to work for everyone? All that and more today on All Around Science...

LINKS:

SOURCES

• How Artificial Intelligence Gave a Paralyzed Woman Her Voice Back | UC San Francisco

• Sleep pressure; is this why we crash? 

• Why Caffeine Affects People Differently | Discover

• Why does coffee make me tired? | Medical News Today

THEME MUSIC by Andrew Allen
https://twitter.com/KEYSwithSOUL
http://andrewallenmusic.com

On today’s episode: Do we hear silence? Simon and Garfunkel may have been on to something. And we finally close the book on the four fundamental forces by talking about gravity. All that and more today on All Around Science...

LINKS:

SOURCES

• The perception of silence
• The Perception of Silence
• From Event Representation to Linguistic Meaning
• The one-is-more illusion: Sets of discrete objects appear less extended than equivalent continuous entities in both space and time
• Gravitational Waves Detected 100 Years After Einstein's Prediction | LIGO Caltech
• What is Gravity? | Wondrium Perspectives | YouTube

THEME MUSIC by Andrew Allen
https://twitter.com/KEYSwithSOUL
http://andrewallenmusic.com

Lysosomal storage diseases are progressive, inherited disorders of metabolism, many with devastating effects on the nervous system. Some of these diseases, like Infantile-Onset Pompe disease, can be treated to some degree in childhood by giving back the missing enzyme - a strategy called enzyme replacement therapy, or ERT. But a recent study reported in the New England Journal of Medicine goes a step farther -- by giving enzyme replacement therapy to a fetus with Pompe disease, for the first time, in an attempt to treat the disease before it does any serious damage. The paper’s first author is Dr. Jennifer Cohen, a Pediatric Medical Genetics Physician-Scientist at Duke University Health System. During this episode, she’ll walk us through the potential benefits of in-utero enzyme replacement therapy and other cutting-edge approaches to treating genetic neurologic conditions. A relatively new field called fetal therapy. Dr. Cohen was interviewed by Dr. Adeline Goss, the host of ANA Investigates. Series 4, Episode 10

Featuring:

• Guest: Dr. Jennifer Cohen, Duke University Health System
• Interviewer: Dr. Adeline Goss, Highland Hospital
• Disclosures: Dr. Cohen is a consultant with Bayer.

Measurement of clinical performance, driven by the requirements of the Centers for Medicare and Medicaid Services, accrediting bodies like The Joint Commission, and benchmarking companies like Vizient, is ubiquitous in academic neurology. Forward-thinking department chairs have an opportunity to design and implement highly effective, sustainable quality improvement programs by emphasizing faculty training, recognition, and collaboration.

A recent study in JAMA Neurology found an association between contaminated water at a military base in the 1970s-80s and the risk of Parkinson’s disease in military service members. What do we know about Parkinson’s and environmental toxins? Series 4, Episode 9

Featuring:

• Guest: Dr. Ray Dorsey, University of Rochester
• Interviewer: Dr. Sara Stern-Nezer, UC Irvine
• Disclosures: This episode does not award CME credit.

On today’s episode: Soon you might be able get your blood pressure by pinching your smartphone. Psilocybin and other psychedelics might be a major advancement in treating some mental illnesses. All that and more today on All Around Science...

LINKS:

SOURCES

• Ultra low-cost smartphone attachment measures blood pressure at home
• Ethical principles of traditional Indigenous medicine to guide western psychedelic research and practice
• Neurotransmitter Receptors and Their Effects
• Psychedelics and Neuroplasticity: A Systematic Review Unraveling the Biological Underpinnings of Psychedelics
• The Impact of Studying Brain Plasticity
• Quality of Acute Psychedelic Experience Predicts Therapeutic Efficacy of Psilocybin for Treatment-Resistant Depression
• Psychedelic-inspired drugs could relieve depression without causing hallucinations
• Therapeutic use of psilocybin: Practical considerations for dosing and administration

THEME MUSIC by Andrew Allen
https://twitter.com/KEYSwithSOUL
http://andrewallenmusic.com

On today’s episode: It’s happening… Scientists are starting to be able to read our minds! We might owe the existence of life to quasars. All that and more today on All Around Science...

LINKS:

• Evidence of conscious-like activity in the dying brain | Michigan Medicine
• The potential for a plastic recycling facility to release microplastic pollution and possible filtration remediation effectiveness
• Recycling in the U.S. Is Broken. How Do We Fix It?
• How Big Oil Misled The Public Into Believing Plastic Would Be Recycled

THEME MUSIC by Andrew Allen
https://twitter.com/KEYSwithSOUL
http://andrewallenmusic.com

Recently on the podcast we’ve been talking about neurotechnology -- devices that interface with the brain to treat disease, for example by restoring speech function in people with locked-in syndrome, or motor function in people with paralyzed limbs. But listen to the media, and you’ll also hear buzz about neurotechnology for healthy people... Series 4, Episode 7

Featuring:

• Guest: Philip Sabes, PhD, UCSF
• Interviewer: Rohini Samudralwar, MD, UPENN
• Disclosures: This episode is non-CME.

On today’s episode: Ancient Egyptians have handed archaeologists new evidence of a gruesome ceremonial practice. Migraines. They’re a lot more than a headache. All that and more today on All Around Science...

LINKS:

• Gruesome cache of severed hands is evidence of trophy-taking in ancient Egypt
• First osteological evidence of severed hands in Ancient Egypt
• What is a migraine? A Mayo Clinic expert explains
• A Phase-by-Phase Review of Migraine Pathophysiology
• [VIDEO] What Causes Migraine Disease? 5 Factors in Migraine Neurobiology
• Where Migraines Start: The Trigeminal Nerve
• The Phases of Migraine
• Dysfunction of the Nervous System Can Cause Migraine

THEME MUSIC by Andrew Allen
https://twitter.com/KEYSwithSOUL
http://andrewallenmusic.com

A major challenge in academic neurology departments is supporting basic and translational research.  As clinical revenue becomes increasingly important to the financial health of Neurology Departments, supporting non-clinical activities such as teaching and research has become increasingly difficult.

This is especially problematic for physician scientists, many of which require several years of both salary and research support.

So how can you build research in your Department?

Bob Wold is from Clusterbusters Inc. He joins us on this episode of Adventures Through The Mind podcast to present cluster headaches, one of the most painful conditions known to humankind—their patterns, symptoms, and pathophysiology; as well as the treatments presently available, with a specific deep dive into psychedelic tryptamines as the most effective treatment discovered thus far and how those with clusters use those tryptamines.

...

For links to Bob and Clusterbusters', full show notes, and a link to watch this episode in video, head to bit.ly/ATTMind173

*** FULL TOPICS BREAKDOWN BELOW**

SUPPORT THE PODCAST

• Patreon: https://patreon.com/jameswjesso
• Paypal Donation: https://www.paypal.com/biz/fund?id=383635S3BKJVS
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*** Extra BIG thanks to my patrons on Patreon for helping keep this podcast alive!

Especially my $23+ patrons, Andreas D, Ian C, Alex F, Eliz C, Joe A, Nanci BF, & Heartwood Mushrooms —— 

*****

Episode Breakdown

• (0:00) Opening
• (3:13) Episode Overture
• (6:42) Patreon Thanks
• (7:58) Interview begins
• (8:44) What are Cluster Headaches: patterns, symptoms, and physiology
• (16:52) Cluster cycles | headaches returning every year at the same time
• (20:09) Physiological causes and triggers
• (24:40) The strain of clusters on family and relationships | The life-saving benefits of community
• (29:24) Suicidality amongst survivors of cluster headaches
• (33:24) Pathophysiology of clusters: trigeminal nerve and the hypothalamus
• (36:34) The treatment landscape | medications and high-flow oxygen
• (43:49) Lack of funding compromising research on cluster headaches
• (48:55) The treatment landscape: opiates(e.g. heroin), caffeine, and aerobic exercises
• (58:57) The history of psychedelic tryptamines for cluster headaches
• (1:05:33) Psychedelic tryptamines are the most effective treatment for cluster headaches
• (1:0911) Psychedelic tryptamines for clusters: dosage, efficacy, and protocol
• (1:16:24) Why psychedelic tryptamines help cluster headaches
• (1:19:10) LSA vs LSD vs Psilocybin for treatment efficacy
• (1:23:10) Growing your own psychedelic medicine is revolutionary
• (1:28:57) Advocation and education on psychedelic tryptamines for cluster survivors
• (1:32:39) Novel psychedelics tryptamines for cluster headaches
• (1:35:54) Conflicts between the DEA and research into new psychedelic treatments
• (1:42:36) Clusterbusters: who they are, what they do, and how you can connect with them
• (1:45:22) Outro

*****

SUPPORT THE PODCAST

• Patreon: https://patreon.com/jameswjesso
• Paypal Donation: https://www.paypal.com/biz/fund?id=383635S3BKJVS
• Merchandise:  https://www.jameswjesso.com/shop/
• More Options: https://www.jameswjesso.com/support
• Newsletter:  https://www.jameswjesso.com/newsletter
• Telgram Channel:  https://t.me/jameswjesso

OR you can buy a copy of one of my books!

• Decomposing The Shadow: Lessons From The Psilocybin Mushroom – https://www.jameswjesso.com/decomposing-the-shadow/
• The True Light Of Darkness — https://www.jameswjesso.com/true-light-darkness/

On today’s episode: Pull out your map, we’re taking a trip into an insect brain! It’s part 2 of our reading science chat… speed reading! All that and more today on All Around Science...

LINKS:

• [ARTICLE] Scientists complete first map of an insect brain | Hub

THEME MUSIC by Andrew Allen
https://twitter.com/KEYSwithSOUL
http://andrewallenmusic.com