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    Your Complex Brain

    Explore the myths, mysteries, and medical breakthroughs of the most complex and powerful organ in your body – your brain. Weaving together expert interviews with heartfelt, inspiring snapshots of the patients and family members in the middle of it all, Heather Sherman dives into the latest science on Alzheimer’s, Parkinson’s, epilepsy, stroke, concussion, spinal cord injury, brain cancer, chronic pain and other brain diseases and disorders. Along the way she uncovers surprising insights, sheds light on the latest research, and shares heroic, real life stories from the people on the front lines. Brought to you by Krembil Brain Institute at UHN, one of the largest and most comprehensive neurological centres in North America. Learn more about our mission at: http://www.uhn.ca/krembil
    en-usKrembil Brain Institute34 Episodes

    Episodes (34)

    Season 3 of the award-winning 'Your Complex Brain' podcast is back!

    Season 3 of the award-winning 'Your Complex Brain' podcast is back!

    We are once again bringing you inside UHN’s Krembil Brain Institute, one of North America's largest and most innovative neurological centres, to meet the scientists & physicians advancing discovery, the patients who inspire us, and the care teams who support them. 

    This season, we’re exploring some big new research in brain health, including: What young women need to know about preventing a stroke, Can loneliness re-wire your brain? And how YOU can reduce YOUR chances of Alzheimer’s. 

    We’ll also take you to the forefront of AI powered brain science, dive into the link between genetics and reading disabilities  and find out why getting a good night’s sleep is crucial for brain health.

    There are a million amazing things to know about your complex brain – and we couldn't be more excited to explore them with you. Season 3 launches March 19, with episodes every other Tuesday. Subscribe to Your Complex Brain so you don’t miss a thing.

    The Your Complex Brain production team is Heather Sherman, Jessica Schmidt, Dr. Amy Ma, Kim Perry, Sara Yuan, Meagan Anderi, Liz Chapman, and Lorna Gilfedder.

    The Krembil Brain Institute, part of University Health Network, in Toronto, is home to one of the world's largest and most comprehensive teams of physicians and scientists uniquely working hand-in-hand to prevent and confront problems of the brain and spine, such as Parkinson's, Alzheimer's, epilepsy, stroke, spinal cord injury, chronic pain, brain cancer or concussion, in their lifetime. Through state-of-the-art patient care and advanced research, we are working relentlessly toward finding new treatments and cures.

    Do you want to know more about the Krembil Brain Institute at UHN? Visit us at: uhn.ca/krembil

    To get in touch, email us at krembil@uhnresearch.ca or message us on social media:
    Instagram - @krembilresearch
    Twitter - @KBI_UHN
    Facebook - https://www.facebook.com/KrembilBrainInstitute

    Thanks for listening!

    Dr. Kathryn Curtis' 5-Minute breathing practice

    Dr. Kathryn Curtis' 5-Minute breathing practice

    Breathing exercises are simple techniques can help improve your overall well-being by promoting relaxation, reducing stress, and increasing mindfulness. Listen to this original 5-minute 'Breathing Space' practice created by Dr. Kathryn Curtis for listeners of Your Complex Brain.

    Dr. Kathryn Curtis is a clinical psychologist at the Comprehensive Integrated Pain Program at UHN, where she provides psychological services to individuals living with chronic pain. Dr. Curtis' research evaluates mind-body interventions, such as yoga and mindfulness, for populations experiencing chronic pain and mobility restrictions. She is a long-term student of eastern philosophy, meditation, and Vedic studies at Vidya Institute and integrating these eastern teachings into her clinical and research work is a passion of hers. In her spare time, Dr. Curtis enjoys spending time in nature with her family.

    The Your Complex Brain production team is Heather Sherman, Jessica Schmidt, Dr. Amy Ma, Kim Perry, Sara Yuan, Meagan Anderi, Liz Chapman, and Lorna Gilfedder.

    The Krembil Brain Institute, part of University Health Network, in Toronto, is home to one of the world's largest and most comprehensive teams of physicians and scientists uniquely working hand-in-hand to prevent and confront problems of the brain and spine, such as Parkinson's, Alzheimer's, epilepsy, stroke, spinal cord injury, chronic pain, brain cancer or concussion, in their lifetime. Through state-of-the-art patient care and advanced research, we are working relentlessly toward finding new treatments and cures.

    Do you want to know more about the Krembil Brain Institute at UHN? Visit us at: uhn.ca/krembil

    To get in touch, email us at krembil@uhnresearch.ca or message us on social media:
    Instagram - @krembilresearch
    Twitter - @KBI_UHN
    Facebook - https://www.facebook.com/KrembilBrainInstitute

    Thanks for listening!

    Your Complex Brain
    en-usNovember 28, 2023

    Harry Forestell on his Deep Brain Stimulation surgery for Parkinson's

    Harry Forestell on his Deep Brain Stimulation surgery for Parkinson's

    Harry Forestell is a journalist with CBC Television. In 2013, he noticed a tremor in his right hand and was unsure what it was. It was later determined to be Parkinson's disease. He was referred to Dr. Tony Lang and the team at Toronto Western Hospital, a movement disorder clinic. They confirmed the diagnosis and began treatment. The symptoms of the disease began to worsen, and he was frustrated by the amount of focus and attention it took to walk normally. 

    His doctor suggested deep brain stimulation (DBS) as a potential treatment option. He was hesitant at first, but as the symptoms worsened, he decided to explore the option further. He spent a weekend in November going through a series of tasks to see if he would be a good candidate for DBS. He was delighted to pass and was excited about the prospect of another treatment option. He spent a month in Toronto having the procedure done and was impressed by how quickly and with little fuss the surgery was completed. 

    He was back at work and was able to return to his regular social life and work obligations. The impact of the DBS was immediate and very pleasing. His tremors and shakes abated, and he didn't have to experience dyskinesia anymore. He was able to return to work and even appear on camera, which was a huge bonus for him.

    The Your Complex Brain production team is Heather Sherman, Jessica Schmidt, Dr. Amy Ma, Kim Perry, Sara Yuan, Meagan Anderi, Liz Chapman, and Lorna Gilfedder.

    The Krembil Brain Institute, part of University Health Network, in Toronto, is home to one of the world's largest and most comprehensive teams of physicians and scientists uniquely working hand-in-hand to prevent and confront problems of the brain and spine, such as Parkinson's, Alzheimer's, epilepsy, stroke, spinal cord injury, chronic pain, brain cancer or concussion, in their lifetime. Through state-of-the-art patient care and advanced research, we are working relentlessly toward finding new treatments and cures.

    Do you want to know more about the Krembil Brain Institute at UHN? Visit us at: uhn.ca/krembil

    To get in touch, email us at krembil@uhnresearch.ca or message us on social media:
    Instagram - @krembilresearch
    Twitter - @KBI_UHN
    Facebook - https://www.facebook.com/KrembilBrainInstitute

    Thanks for listening!

    Your Complex Brain
    en-usNovember 14, 2023

    Why Fran Rider has donated her brain post-mortem to the Canadian Concussion Centre

    Why Fran Rider has donated her brain post-mortem to the Canadian Concussion Centre

    Fran Ryder is the president of the Ontario Women's Hockey Association and has been involved in women's hockey for many years. She has played and volunteered in various capacities in the sport. She has also been involved in research and initiatives related to spinal injuries and concussions in hockey, working closely with Dr. Charles Tator, a world-renowned neurosurgeon and researcher, on these initiatives. 

    Dr. Tator has been a mentor and inspiration to her. She has also been a champion of the importance of brain donations for research and has donated her brain to Dr. Tator's research. She is passionate about the sport and the importance of safety and prevention of injuries in addition to advocating for the recognition and treatment of concussions and other brain injuries in sports.

    The Your Complex Brain production team is Heather Sherman, Jessica Schmidt, Dr. Amy Ma, Kim Perry, Sara Yuan, Meagan Anderi, Liz Chapman, and Lorna Gilfedder.

    The Krembil Brain Institute, part of University Health Network, in Toronto, is home to one of the world's largest and most comprehensive teams of physicians and scientists uniquely working hand-in-hand to prevent and confront problems of the brain and spine, such as Parkinson's, Alzheimer's, epilepsy, stroke, spinal cord injury, chronic pain, brain cancer or concussion, in their lifetime. Through state-of-the-art patient care and advanced research, we are working relentlessly toward finding new treatments and cures.

    Do you want to know more about the Krembil Brain Institute at UHN? Visit us at: uhn.ca/krembil

    To get in touch, email us at krembil@uhnresearch.ca or message us on social media:
    Instagram - @krembilresearch
    Twitter - @KBI_UHN
    Facebook - https://www.facebook.com/KrembilBrainInstitute

    Thanks for listening!

    Your Complex Brain
    en-usOctober 31, 2023

    Natalie Ladly on parenting a child with special needs & the importance of supporting research

    Natalie Ladly on parenting a child with special needs & the importance of supporting research

    Natalie Ladly is the president and fundraising chair for CDKL5 Canada. She lives in Heathcoate, a town outside of Collingwood, Ontario, with her husband Eric and their three children: Brynn, Reece, and Cullen. Brynn has CDD, a rare disease that prevents the brain from developing normally. She was diagnosed with the disease at nine months old, and since then, Natalie has been dedicated to raising awareness and funds for research. 

    Natalie is also a member of the CDKL5 Canada board, which gives her a sense of purpose and the ability to make a difference. Natalie is grateful for the support of Dr. Eubanks, a scientist who is dedicated to researching CDD and making a real impact in the lives of those affected by the disease. She believes that collaboration between the scientific community and patient advocacy groups is crucial for rare diseases, as it allows for a more holistic approach to treatment and care. Overall, Brynn's journey with CDD has taught Natalie to take things one day at a time and to cherish the silver linings in life.

    The Your Complex Brain production team is Heather Sherman, Jessica Schmidt, Dr. Amy Ma, Kim Perry, Sara Yuan, Meagan Anderi, Liz Chapman, and Lorna Gilfedder.

    The Krembil Brain Institute, part of University Health Network, in Toronto, is home to one of the world's largest and most comprehensive teams of physicians and scientists uniquely working hand-in-hand to prevent and confront problems of the brain and spine, such as Parkinson's, Alzheimer's, epilepsy, stroke, spinal cord injury, chronic pain, brain cancer or concussion, in their lifetime. Through state-of-the-art patient care and advanced research, we are working relentlessly toward finding new treatments and cures.

    Do you want to know more about the Krembil Brain Institute at UHN? Visit us at: uhn.ca/krembil

    To get in touch, email us at krembil@uhnresearch.ca or message us on social media:
    Instagram - @krembilresearch
    Twitter - @KBI_UHN
    Facebook - https://www.facebook.com/KrembilBrainInstitute

    Thanks for listening!

    Your Complex Brain
    en-usOctober 17, 2023

    Why Jack Conway is participating in a VR research trial to improve his vision after a brain tumour

    Why Jack Conway is participating in a VR research trial to improve his vision after a brain tumour

    Jack Conway, a 19-year-old from Toronto, Canada, is a huge fan of video games and roller coasters. His family includes his mom, Kim, his dad, Steve, and his older brother, Brian. Jack plays a variety of video games, from Call of Duty to Minecraft, and he loves roller coasters. 

    He also has a vision impairment due to a brain tumor he had when he was a baby. He was one of the first children in the world to receive a certain treatment for the tumor, and he spent a lot of time at SickKids hospital. School can be challenging for him because of his vision, but he tries not to let it get the better of him.

    He has done a vision study using virtual reality goggles, and it has improved his vision and quality of life. He is excited about the potential for technology to restore vision and is happy to have been accepted into all six college programs he applied for.

    The Your Complex Brain production team is Heather Sherman, Jessica Schmidt, Dr. Amy Ma, Kim Perry, Sara Yuan, Meagan Anderi, Liz Chapman, and Lorna Gilfedder.

    The Krembil Brain Institute, part of University Health Network, in Toronto, is home to one of the world's largest and most comprehensive teams of physicians and scientists uniquely working hand-in-hand to prevent and confront problems of the brain and spine, such as Parkinson's, Alzheimer's, epilepsy, stroke, spinal cord injury, chronic pain, brain cancer or concussion, in their lifetime. Through state-of-the-art patient care and advanced research, we are working relentlessly toward finding new treatments and cures.

    Do you want to know more about the Krembil Brain Institute at UHN? Visit us at: uhn.ca/krembil

    To get in touch, email us at krembil@uhnresearch.ca or message us on social media:
    Instagram - @krembilresearch
    Twitter - @KBI_UHN
    Facebook - https://www.facebook.com/KrembilBrainInstitute

    Thanks for listening!

    Your Complex Brain
    en-usOctober 03, 2023

    Lindsay Bongard-Batori on losing her mom Barbara to Alzheimer's

    Lindsay Bongard-Batori on losing her mom Barbara to Alzheimer's

    Lindsay's mother Barbara had Alzheimer's disease. Lindsay, her brothers, and her father noticed changes in her mid-sixties. They started noticing her repeating herself and she stopped coming to the pool with them when they went to visit her and their dad in Florida. She also forgot where she parked her car and had to ask for help. Her memory was not what it used to be and she started to withdraw from social events.

    Lindsay and her brothers decided they needed to talk to her doctor about these memory issues. They decided as a family that it was time to look into homes for her. They did not want to wait until it was an emergency and they had to put her into a home. They found a home that was dedicated to people with dementia and they were able to get her a room there. It was a very hard decision for Lindsay and her family. They had to depend on each other to take care of her. 

    Lindsay visited her every day and she felt like she was doing this for herself as well. It was very hard for Lindsay to see her mother like this. She missed being able to call her and tell her about her life. She wished her mother could see her kids grow up and experience life without her.

    The Your Complex Brain production team is Heather Sherman, Jessica Schmidt, Dr. Amy Ma, Kim Perry, Sara Yuan, Meagan Anderi, Liz Chapman, and Lorna Gilfedder.

    The Krembil Brain Institute, part of University Health Network, in Toronto, is home to one of the world's largest and most comprehensive teams of physicians and scientists uniquely working hand-in-hand to prevent and confront problems of the brain and spine, such as Parkinson's, Alzheimer's, epilepsy, stroke, spinal cord injury, chronic pain, brain cancer or concussion, in their lifetime. Through state-of-the-art patient care and advanced research, we are working relentlessly toward finding new treatments and cures.

    Do you want to know more about the Krembil Brain Institute at UHN? Visit us at: uhn.ca/krembil

    To get in touch, email us at krembil@uhnresearch.ca or message us on social media:
    Instagram - @krembilresearch
    Twitter - @KBI_UHN
    Facebook - https://www.facebook.com/KrembilBrainInstitute

    Thanks for listening!

    Your Complex Brain
    en-usSeptember 19, 2023

    What Lara Pingue wants you to know about living with chronic pain

    What Lara Pingue wants you to know about living with chronic pain

    Lara Pingue shares her story about living with chronic back pain and the challenges of getting a diagnosis and finding effective treatment. She describes the initial onset of her pain and the various treatments she tried, including physical therapy, chiropractic care, and prescription medications. 

    She also discusses the impact of the pain on her daily life and the frustration of not being able to find a lasting solution. Eventually, she decided to pursue surgery and was able to get a referral from her doctor. The surgery was not without complications, but it did provide some relief from her pain. 

    Since then, she has focused on managing her pain through a combination of movement and over-the-counter pain medication. She emphasizes the importance of believing people with chronic pain and destigmatizing treatment for it.

    The Your Complex Brain production team is Heather Sherman, Jessica Schmidt, Dr. Amy Ma, Kim Perry, Sara Yuan, Meagan Anderi, Liz Chapman, and Lorna Gilfedder.

    The Krembil Brain Institute, part of University Health Network, in Toronto, is home to one of the world's largest and most comprehensive teams of physicians and scientists uniquely working hand-in-hand to prevent and confront problems of the brain and spine, such as Parkinson's, Alzheimer's, epilepsy, stroke, spinal cord injury, chronic pain, brain cancer or concussion, in their lifetime. Through state-of-the-art patient care and advanced research, we are working relentlessly toward finding new treatments and cures.

    Do you want to know more about the Krembil Brain Institute at UHN? Visit us at: uhn.ca/krembil

    To get in touch, email us at krembil@uhnresearch.ca or message us on social media:
    Instagram - @krembilresearch
    Twitter - @KBI_UHN
    Facebook - https://www.facebook.com/KrembilBrainInstitute

    Thanks for listening!

    Your Complex Brain
    en-usSeptember 05, 2023

    How Nikki Ashworth's epilepsy diagnosis changed her life

    How Nikki Ashworth's epilepsy diagnosis changed her life

    As a child, Nikki experienced seizures that she did not realize were seizures. She would feel "other" and disconnected from the world. Her earliest seizure memory is from when she was six years old, triggered by looking out the window of her parent's house. She would sometimes go to the window to see if she would have a seizure.

    Today, her seizures are still the same as when she was a child. They last about a minute and are triggered by being outside. They start with a warming sensation in her lower abdomen and a feeling of over-familiarity. Then, she gets a radiating heat and nausea, which makes her cough. She then feels like she is being taken up a roller coaster and dropped. She can calculate how many seconds she has left in the seizure based on where the heat is in her body. After the seizure, she is fatigued but not confused. 

    She accepts the differences in her body and does not let them affect her daily life. She is grateful to not have to deal with the struggles that other people with epilepsy face. Having focal aware seizures has allowed her to learn more about herself and her brain.

    The Your Complex Brain production team is Heather Sherman, Jessica Schmidt, Dr. Amy Ma, Kim Perry, Sara Yuan, Meagan Anderi, Liz Chapman, and Lorna Gilfedder.

    The Krembil Brain Institute, part of University Health Network, in Toronto, is home to one of the world's largest and most comprehensive teams of physicians and scientists uniquely working hand-in-hand to prevent and confront problems of the brain and spine, such as Parkinson's, Alzheimer's, epilepsy, stroke, spinal cord injury, chronic pain, brain cancer or concussion, in their lifetime. Through state-of-the-art patient care and advanced research, we are working relentlessly toward finding new treatments and cures.

    Do you want to know more about the Krembil Brain Institute at UHN? Visit us at: uhn.ca/krembil

    To get in touch, email us at krembil@uhnresearch.ca or message us on social media:
    Instagram - @krembilresearch
    Twitter - @KBI_UHN
    Facebook - https://www.facebook.com/KrembilBrainInstitute

    Thanks for listening!

    Your Complex Brain
    en-usAugust 22, 2023

    Farrah Schwartz's take on stress and the importance of prioritizing your mental health

    Farrah Schwartz's take on stress and the importance of prioritizing your mental health

    Farrah Schwartz is the manager of Patient Education and Engagement at UHN. Her work entails assisting patients in actively participating in their care and improving organizational processes. The Patient Education and Engagement program provides resources, training, and coaching to help Team UHN engage patients in their care. They are also working on patient engagement within organizational improvement and partnering with equity-seeking groups to ensure that health information is inclusive and non-stigmatizing.

    Farrah has experienced stress throughout her life, including during the pandemic. She had a laser focus on her work and was able to channel her stress into something productive. Stress comes in many forms, and it is important to recognize and manage it. 

    Farrah recommends tuning into your mood, practicing self-compassion, and finding gratitude in small things. She has learned that it is not possible to do everything and that it is important to set realistic expectations.

    The Your Complex Brain production team is Heather Sherman, Jessica Schmidt, Dr. Amy Ma, Kim Perry, Sara Yuan, Meagan Anderi, Liz Chapman, and Lorna Gilfedder.

    The Krembil Brain Institute, part of University Health Network, in Toronto, is home to one of the world's largest and most comprehensive teams of physicians and scientists uniquely working hand-in-hand to prevent and confront problems of the brain and spine, such as Parkinson's, Alzheimer's, epilepsy, stroke, spinal cord injury, chronic pain, brain cancer or concussion, in their lifetime. Through state-of-the-art patient care and advanced research, we are working relentlessly toward finding new treatments and cures.

    Do you want to know more about the Krembil Brain Institute at UHN? Visit us at: uhn.ca/krembil

    To get in touch, email us at krembil@uhnresearch.ca or message us on social media:
    Instagram - @krembilresearch
    Twitter - @KBI_UHN
    Facebook - https://www.facebook.com/KrembilBrainInstitute

    Thanks for listening!

    Your Complex Brain
    en-usAugust 08, 2023

    Season 2 Recap

    Season 2 Recap

    In the second season of Your Complex Brain, join us on a thrilling journey as we delve into the boundless realm of neuroscience, brain health, and ground-breaking research and its impact on our lives. Through thought-provoking discussions, expert interviews, and captivating patient stories, we unravel the mysteries of our brain.

    The Your Complex Brain production team is Heather Sherman, Jessica Schmidt, Dr. Amy Ma, Kim Perry, Sara Yuan, Meagan Anderi, Liz Chapman, and Lorna Gilfedder.

    The Krembil Brain Institute, part of University Health Network, in Toronto, is home to one of the world's largest and most comprehensive teams of physicians and scientists uniquely working hand-in-hand to prevent and confront problems of the brain and spine, such as Parkinson's, Alzheimer's, epilepsy, stroke, spinal cord injury, chronic pain, brain cancer or concussion, in their lifetime. Through state-of-the-art patient care and advanced research, we are working relentlessly toward finding new treatments and cures.

    Do you want to know more about the Krembil Brain Institute at UHN? Visit us at: uhn.ca/krembil

    To get in touch, email us at krembil@uhnresearch.ca or message us on social media:
    Instagram - @krembilresearch
    Twitter - @KBI_UHN
    Facebook - https://www.facebook.com/KrembilBrainInstitute

    Thanks for listening!

    Your Complex Brain
    en-usAugust 03, 2023

    Top 5 Science-Based Tips to Keep Your Brain Fit & Healthy

    Top 5 Science-Based Tips to Keep Your Brain Fit & Healthy

    From new Alzheimer’s drugs, to novel treatments for brain cancer, to chronic pain, many of us feel overwhelmed by the sheer volume of health news in the media and confused about what to believe - and how it applies to our own health.

    In this special episode of Your Complex Brain - our last of the season - we bring back five of our featured UHN brain experts to weigh in on the top, science-based, evidence-backed tips for keeping your brain fit and healthy as you age (and some of their answers may surprise you!)

    Host Heather Sherman also introduces the Your Complex Brain production team and asks what they each do to keep their brains happy and healthy.

    Featuring:
    Drs. Andrea Furlan, Jaideep Bains, Mary Pat McAndrews, Donald Weaver and Aleksandra Pikula. 

    Additional resources (5-6):
    Dr. Andrea Furlan’s YouTube Channel
    Dr. Jaideep Bains’ public talk – ‘Is My Stress Your Stress?’
    Dr. Mary Pat McAndrews’ discussing her science journey & why she studies memory
    Dr. Donald Weaver’s Your Complex Brain Season 1 podcast episode – ‘What’s it Going to Take to Solve Alzheimer’s?’
    Dr. Aleksandra Pikula’s Your Complex Brain Season 1 podcast episode – ‘The Rise of Stroke in Young Adults’ 

    The Your Complex Brain production team is Heather Sherman, Jessica Schmidt, Dr. Amy Ma, Kim Perry, Sara Yuan, Meagan Anderi, Liz Chapman, and Lorna Gilfedder.

    The Krembil Brain Institute, part of University Health Network, in Toronto, is home to one of the world's largest and most comprehensive teams of physicians and scientists uniquely working hand-in-hand to prevent and confront problems of the brain and spine, such as Parkinson's, Alzheimer's, epilepsy, stroke, spinal cord injury, chronic pain, brain cancer or concussion, in their lifetime. Through state-of-the-art patient care and advanced research, we are working relentlessly toward finding new treatments and cures.

    Do you want to know more about the Krembil Brain Institute at UHN? Visit us at: uhn.ca/krembil

    To get in touch, email us at krembil@uhnresearch.ca or message us on social media:
    Instagram - @krembilresearch
    Twitter - @KBI_UHN
    Facebook - https://www.facebook.com/KrembilBrainInstitute

    Thanks for listening!

    Chronic Pain & The Brain

    Chronic Pain & The Brain

    More than eight million Canadians are currently living with the effects of debilitating chronic pain.

    In this episode, we discuss the connection between chronic pain and the brain, including the latest & most effective treatments, the stigma - how do you study and treat something that you often can’t see? And, is there a way to build ‘pain resilience’?

    We’ll speak with Dr. Andrea Furlan, a senior scientist & physiatrist with the KITE Research Institute and Dr. Anuj Bhatia, an anesthesiologist and clinician investigator with the Krembil Brain Institute.

    We’ll also hear from Lara Pingue, about her personal experience living with chronic pain.

    Featuring:
    Dr. Anuj Bhatia - Anesthesiologist and pain medicine physician who is the Director of the Comprehensive Integrated Pain Program at UHN, a clinician investigator with the Krembil Brain Institute, and a Professor at the University of Toronto.

    Dr. Andrea Furlan - Senior Scientist at The KITE Research Institute and a physiatrist with the Toronto Rehabilitation Institute, at UHN.

    Lara Pingue - Editor for the Globe and Mail. She lives with her husband and children in Toronto.


    Additional resources:
    Comprehensive Integrated Pain Program at UHN
    ‘The Krembil Brain Institute’s chronic pain experts are using novel treatment approaches – and returning people to meaningful lives’ – Article in 2021 KBI Magazine, featuring Drs. Anuj Bhatia & Hance Clarke
    Dr. Andrea Furlan’s KITE Research Institute page
    Dr. Andrea Furlan’s Youtube Channel
    Dr. Andrea Furlan interviewed on UHN’s ‘Behind the Breakthrough’ podcast
    The Krembil Brain Institute’s ‘Your Complex Brain’ podcast episode about Trigeminal Neuralgia – ‘The Most Painful Brain Disease You’ve Never Heard Of’ featuring Dr. Mojgan Hodaie

    The Your Complex Brain production team is Heather Sherman, Jessica Schmidt, Dr. Amy Ma, Kim Perry, Sara Yuan, Meagan Anderi, Liz Chapman, and Lorna Gilfedder.

    The Krembil Brain Institute, part of University Health Network, in Toronto, is home to one of the world's largest and most comprehensive teams of physicians and scientists uniquely working hand-in-hand to prevent and confront problems of the brain and spine, such as Parkinson's, Alzheimer's, epilepsy, stroke, spinal cord injury, chronic pain, brain cancer or concussion, in their lifetime. Through state-of-the-art patient care and advanced research, we are working relentlessly toward finding new treatments and cures.

    Do you want to know more about the Krembil Brain Institute at UHN? Visit us at: uhn.ca/krembil

    To get in touch, email us at krembil@uhnresearch.ca or message us on social media:
    Instagram - @krembilresearch
    Twitter - @KBI_UHN
    Facebook - https://www.facebook.com/KrembilBrainInstitute

    Thanks for listening!

    Unraveling the Genetics of a Rare Disease

    Unraveling the Genetics of a Rare Disease

    When Brynn Ladley was born, she was a smiling, happy and healthy baby, hitting all of her developmental milestones. Then, at six weeks old, she began having seizures and eventually was diagnosed with CDKL5, a rare and debilitating genetic disorder that has no cure.

    Upon Brynn’s diagnosis, her mother Natalie became an advocate and connected with Dr. James Eubanks, a Senior Scientist at the Krembil Brain Institute, who has made it his life’s mission to pioneer advanced research looking at how brain function is altered in specific rare, neurodevelopmental conditions, such as CDKL5 and Rett Syndrome

    He is also developing new therapeutic strategies to better treat, or one day even cure, these diseases.

    We’ll also hear from Brynn’s mother Natalie and from Richard Logan, Dr. Eubanks’ long-time lab manager, who are optimistic about advances in this research, in the years to come.

    Featuring:
    Dr. James Eubanks – Senior Scientist and Research Division Head at the Krembil Brain Institute, part of UHN.

    Natalie Ladly – President of CDKL5 Canada and mother to seven year-old Brynn Ladly, who is living with CDKL5.

    Richard Logan - Lab manager and senior technologist for Dr. Eubanks’ lab at the Krembil Brain Institute.

    Additional resources:
    CDKL5 Canada
    Ontario Rett Syndrome Association
    Krembil Brain Institute magazine article featuring Dr. Eubanks
    UHN Foundation’s ‘Know Your Heroes’ article featuring Dr. Eubanks
    Collingwood Today article about Bryn Ladley & her family
    Canadian Organization for Rare Disorders 

    The Your Complex Brain production team is Heather Sherman, Jessica Schmidt, Dr. Amy Ma, Kim Perry, Sara Yuan, Meagan Anderi, Liz Chapman, and Lorna Gilfedder.

    The Krembil Brain Institute, part of University Health Network, in Toronto, is home to one of the world's largest and most comprehensive teams of physicians and scientists uniquely working hand-in-hand to prevent and confront problems of the brain and spine, such as Parkinson's, Alzheimer's, epilepsy, stroke, spinal cord injury, chronic pain, brain cancer or concussion, in their lifetime. Through state-of-the-art patient care and advanced research, we are working relentlessly toward finding new treatments and cures.

    Do you want to know more about the Krembil Brain Institute at UHN? Visit us at: uhn.ca/krembil

    To get in touch, email us at krembil@uhnresearch.ca or message us on social media:
    Instagram - @krembilresearch
    Twitter - @KBI_UHN
    Facebook - https://www.facebook.com/KrembilBrainInstitute

    Thanks for listening!

    The Truth About Concussion

    The Truth About Concussion

    Every year, 40 million people worldwide sustain a concussion – a type of traumatic brain injury caused by a hit or jolt to the head.

    We often hear about concussions in the context of sports, but most occur as a result of everyday life, from running or biking, accidental falls and motor vehicle accidents.

    While the vast majority of those who suffer a concussion recover in time, there are many who experience lasting symptoms. Researchers and clinicians want to know why - including Dr. Charles Tator, who's made it his life's mission to educate the public and the healthcare community about the impact of concussion, and to advocate for change in youth and professional sports.

    In this episode, we speak with Dr. Tator, a neurosurgeon and researcher at the Krembil Brain Institute, and Fran Rider, an athlete and a leader in women's hockey.

    Featuring:
    Dr. Charles Tator - Neurosurgeon and researcher with the Krembil Brain Institute, as well Director of the Canadian Concussion Centre, at UHN.

    Fran Rider
    – Co-founder, President and CEO of the Ontario Women's Hockey Association.

    Additional resources:
    Canadian Concussion Centre (CCC)
    The Hull-Ellis Concussion and Research Clinic at UHN
    CCC Concussion Safety Webinar Series
    ‘The Quest to Solve the Concussion Problem’ – Your Complex Brain podcast featuring Dr. Carmela Tartaglia
    Toronto Star article – “Four high-profile Canadians to donate their brains for research into concussion effects in women”

    The Your Complex Brain production team is Heather Sherman, Jessica Schmidt, Dr. Amy Ma, Kim Perry, Sara Yuan, Meagan Anderi, Liz Chapman, and Lorna Gilfedder.

    The Krembil Brain Institute, part of University Health Network, in Toronto, is home to one of the world's largest and most comprehensive teams of physicians and scientists uniquely working hand-in-hand to prevent and confront problems of the brain and spine, such as Parkinson's, Alzheimer's, epilepsy, stroke, spinal cord injury, chronic pain, brain cancer or concussion, in their lifetime. Through state-of-the-art patient care and advanced research, we are working relentlessly toward finding new treatments and cures.

    Do you want to know more about the Krembil Brain Institute at UHN? Visit us at: uhn.ca/krembil

    To get in touch, email us at krembil@uhnresearch.ca or message us on social media:
    Instagram - @krembilresearch
    Twitter - @KBI_UHN
    Facebook - https://www.facebook.com/KrembilBrainInstitute

    Thanks for listening!

    The Mystery of our Memory

    The Mystery of our Memory

    When you think about your favourite memories, what comes to mind?

    Is it the championship win at your high school football game? Your child’s first words? Or the lyrics to a song you loved?

    In this episode, our experts tackle the big & thought-provoking questions, such as: How does our brain log & store memories? Where do memories go as we age? And why do we remember some things, and not others?

    Most importantly, are there any proven methods or tactics to help improve memory?

    The episode features neuropsychologists Dr. Mary Pat McAndrews and Dr. David Gold, as well as Dr. Samantha Audrain, a Postdoctoral fellow & trainee graduate from Dr. McAndrews’ lab.

    Featuring:
    Dr. Mary Pat McAndrews - Clinical neuropsychologist and senior scientist at the Krembil Brain Institute. She is also Division Head of Clinical and Computational Neuroscience at UHN. Dr. McAndrews’ work focuses on investigating memory and language in patients with memory disorders, including epilepsy and Alzheimer’s disease.

     Dr. David Gold - Neuropsychologist and clinician investigator with the Krembil Brain Institute. Dr. Gold primarily works with patients living with epilepsy and also regularly consults with UHN’s Memory and Neurosurgery clinics, as well as the Canadian Concussion Centre. 

    Dr. Samantha Audrain - Postdoctoral fellow at the National Institute of Mental Health, and a former graduate student of the University of Toronto and UHN. Her research focuses on understanding how long-term memories are formed and stored in the brain and how that process is disrupted in patients experiencing memory dysfunction.

    Additional resources:
    UHN Neuropsychology Clinic
    UHN Memory Clinic
    UHN News story – ‘How to make a memory’
    How being curious led Dr. Mary Pat McAndrews to a career in science
    Int’l Day of Women and Girls in Science event - Dr. Mary Pat McAndrews presents about her research into memory (@23:40)
    ECHOEpilepsy series – Dr. David Gold

    The Your Complex Brain production team is Heather Sherman, Jessica Schmidt, Dr. Amy Ma, Kim Perry, Sara Yuan, Meagan Anderi, Liz Chapman, and Lorna Gilfedder.

    The Krembil Brain Institute, part of University Health Network, in Toronto, is home to one of the world's largest and most comprehensive teams of physicians and scientists uniquely working hand-in-hand to prevent and confront problems of the brain and spine, such as Parkinson's, Alzheimer's, epilepsy, stroke, spinal cord injury, chronic pain, brain cancer or concussion, in their lifetime. Through state-of-the-art patient care and advanced research, we are working relentlessly toward finding new treatments and cures.

    Do you want to know more about the Krembil Brain Institute at UHN? Visit us at: uhn.ca/krembil

    To get in touch, email us at krembil@uhnresearch.ca or message us on social media:
    Instagram - @krembilresearch
    Twitter - @KBI_UHN
    Facebook - https://www.facebook.com/KrembilBrainInstitute

    Thanks for listening!

    Using Virtual Reality to Restore Vision

    Using Virtual Reality to Restore Vision

    What happens when a vision researcher has a chance meeting with a pediatric oncologist and that collaboration leads to unexpected and promising results?

    In Episode 5 of Your Complex Brain, we’re talking about a homegrown vision rehabilitation program helping young brain cancer survivors, whose sight has been impacted by their tumours, improve their vision.

    The program, developed at University Health Network in Toronto, uses virtual reality to effectively retrain parts of the brain, allowing them to better perceive objects and obstacles.

    Joining us on the podcast today is neurobiologist, Dr. Michael Reber, and pediatric oncologist, Dr. Eric Bouffet. We’ll also hear from 18 year-old Jack Conway, one of the research participants in the study.

    Featuring: 
    Dr. Michael Reber - Senior Scientist at the Donald K. Johnson Eye Institute, part of the Krembil Research Institute, at University Health Network, and Associate Professor in the Department of Ophthalmology and Vision Sciences at the University of Toronto.

    Dr. Eric Bouffet - Past director of the Pediatric Neuro-Oncology program at the Hospital for Sick Children in Toronto, and the first Garron Family Chair in Childhood Cancer Research.

    Jack Conway - High school student who is passionate about video games, theme parks, and politics. Jack was diagnosed with an optic pathway glioma brain tumour as an infant, and recently was a research participant in the Vision Rehab Study.

    Additional resources:
    Donald K. Johnson Eye Institute at UHN
    Dr. Reber’s lab website
    The Hospital for Sick Children
    UHN Foundation story on this Vision Rehab Study
    Dr. Reber interviewed on UHN’s ‘Behind the Breakthrough’ podcast
    Dr. Bouffet addresses United Nations

    The Your Complex Brain production team is Heather Sherman, Jessica Schmidt, Dr. Amy Ma, Kim Perry, Sara Yuan, Meagan Anderi, Liz Chapman, and Lorna Gilfedder.

    The Krembil Brain Institute, part of University Health Network, in Toronto, is home to one of the world's largest and most comprehensive teams of physicians and scientists uniquely working hand-in-hand to prevent and confront problems of the brain and spine, such as Parkinson's, Alzheimer's, epilepsy, stroke, spinal cord injury, chronic pain, brain cancer or concussion, in their lifetime. Through state-of-the-art patient care and advanced research, we are working relentlessly toward finding new treatments and cures.

    Do you want to know more about the Krembil Brain Institute at UHN? Visit us at: uhn.ca/krembil

    To get in touch, email us at krembil@uhnresearch.ca or message us on social media:
    Instagram - @krembilresearch
    Twitter - @KBI_UHN
    Facebook - https://www.facebook.com/KrembilBrainInstitute

    Thanks for listening!

    A New Theory of Alzheimer’s

    A New Theory of Alzheimer’s

    Whether as a patient, a caregiver, a neighbour or a friend, chances are, one day, we will all be touched by Alzheimer’s or dementia.

    This disease steals our memories and cruelly robs us of our loved ones, often when we need them the most.

    But, there is hope and momentum in the world of Alzheimer's research. In fact, a new theory suggests that Alzheimer’s could even be an autoimmune disease.

    In this episode of Your Complex Brain, we speak with Dr. Donald Weaver and Dr. Saskia Sivananthan. We’ll also hear from Lindsay Bongard-Batori, who lost her mother Barbara to Alzheimer’s.

    Featuring:
    Dr. Donald Weaver – Neurologist, medicinal chemist & Senior Scientist with the Krembil Brain Institute at UHN. Dr. Weaver is an internationally recognized research leader in university-based drug design and discovery for neurological disorders.

    Dr. Saskia Sivananthan – Neuroscientist & Chief Science and Knowledge Translation Officer at the Alzheimer Society of Canada, overseeing the Alzheimer Society Research Program, a dementia research priority setting leader.

    Lindsay Bongard-Batori
    - Lost her beloved mother Barbara to Alzheimer’s in 2020, and hopes her story will help others caring for their loved ones.

    Additional resources:

    Dr. Donald Weaver’s lab website
    UHN – Dementia & Neurodegenerative Disorders
    Alzheimer Society of Canada (for information on latest research awards, patient stories, help for caregivers, provincial chapters)
    Alzheimer Society of Canada Hotline
    Landmark Study: Navigating the Path Forward for Dementia in Canada
    (VIDEO) A New Theory of Alzheimer’s (featuring Dr. Weaver)
    (VIDEO) Living with Dementia: A Caregiver’s Perspective
    (VIDEO) Risk Factors for Alzheimer’s and Dementia
    (PODCAST) What is it Going to Take to Cure Alzheimer’s (featuring Dr. Weave

    The Your Complex Brain production team is Heather Sherman, Jessica Schmidt, Dr. Amy Ma, Kim Perry, Sara Yuan, Meagan Anderi, Liz Chapman, and Lorna Gilfedder.

    The Krembil Brain Institute, part of University Health Network, in Toronto, is home to one of the world's largest and most comprehensive teams of physicians and scientists uniquely working hand-in-hand to prevent and confront problems of the brain and spine, such as Parkinson's, Alzheimer's, epilepsy, stroke, spinal cord injury, chronic pain, brain cancer or concussion, in their lifetime. Through state-of-the-art patient care and advanced research, we are working relentlessly toward finding new treatments and cures.

    Do you want to know more about the Krembil Brain Institute at UHN? Visit us at: uhn.ca/krembil

    To get in touch, email us at krembil@uhnresearch.ca or message us on social media:
    Instagram - @krembilresearch
    Twitter - @KBI_UHN
    Facebook - https://www.facebook.com/KrembilBrainInstitute

    Thanks for listening!

    The Future of DBS

    The Future of DBS

    Deep brain stimulation (DBS) is complex brain surgery in which electrodes are placed at strategic, predetermined targets within a patient's brain. The electrodes are then connected to a battery pack which is surgically inserted under the skin of the chest, like a pacemaker.

    When DBS was first introduced as a treatment option for people living with Parkinson’s disease more than 20 years ago, it was a game changer.

    In this episode of Your Complex Brain, we’ll speak with Krembil Brain Institute neurosurgeon, Dr. Suneil Kalia, and neurologist, Dr. Alfonso Fasano, about the future of DBS – and how it could be used to help many more patients improve their quality of life, including those living with other neurological diseases.

    We’ll also hear from CBC journalist Harry Forestell about his DBS journey.

    Featuring:
    Dr. Suneil Kalia – Neurosurgeon & Senior Scientist at the Krembil Brain Institute & Associate Professor in the Division of Neurosurgery, Department of Surgery, University of Toronto. As a stereotactic and functional neurosurgeon, Dr. Kalia focuses on the surgical management of movement disorders, epilepsy and pain. He holds the R.R. Tasker Chair in Stereotactic and Functional Neurosurgery.

    Dr. Alfonso Fasano – Neurologist & Clinician Investigator with the Edmond J. Safra Program in Parkinson’s Disease, Morton and Gloria Shulman Movement Disorders Clinic, at the Krembil Brain Institute (Toronto Western Hospital). Dr. Fasano is a Professor of Medicine, Department of Neurology, at the University of Toronto. He holds the Chair in Neuromodulation at UHN.

    Harry Forestell – Long-time CBC journalist who has reported on some of the biggest stories of our time, and is the current host of CBC News New Brunswick at 6. At the age of 53, Harry was diagnosed with Parkinson’s disease and subsequently had DBS surgery. Harry is first and foremost a family man; he is married to Jennifer and they have two beautiful daughters.

    Additional resources:
    Krembil Brain Institute’s Movement Disorders Clinic (Toronto Western Hospital)
    Krembil Brain Institute’s DBS Surgery Information Page
    CBC story about Harry Forestell’s DBS experience & surgery
    VIDEO – Ha

    The Your Complex Brain production team is Heather Sherman, Jessica Schmidt, Dr. Amy Ma, Kim Perry, Sara Yuan, Meagan Anderi, Liz Chapman, and Lorna Gilfedder.

    The Krembil Brain Institute, part of University Health Network, in Toronto, is home to one of the world's largest and most comprehensive teams of physicians and scientists uniquely working hand-in-hand to prevent and confront problems of the brain and spine, such as Parkinson's, Alzheimer's, epilepsy, stroke, spinal cord injury, chronic pain, brain cancer or concussion, in their lifetime. Through state-of-the-art patient care and advanced research, we are working relentlessly toward finding new treatments and cures.

    Do you want to know more about the Krembil Brain Institute at UHN? Visit us at: uhn.ca/krembil

    To get in touch, email us at krembil@uhnresearch.ca or message us on social media:
    Instagram - @krembilresearch
    Twitter - @KBI_UHN
    Facebook - https://www.facebook.com/KrembilBrainInstitute

    Thanks for listening!

    A New Era in Women's Brain Health: Closing the Gap on Delayed Diagnosis

    A New Era in Women's Brain Health: Closing the Gap on Delayed Diagnosis

    Women make up nearly half of the world's population and have higher rates of neurological disorders, yet there is still a gap when it comes to better understanding and treating women living with brain-related illnesses. Many women also face systemic barriers and biases when they seek help, often leading to a delay in diagnosis and treatment.

    Featuring:
    Dr. Esther Bui - Neurologist and clinician educator at UHN’s Krembil Brain Institute and assistant professor at the University of Toronto. Her research includes the creation of Canada’s first accredited Women’s Neurology Clinic and training program.  Find her on Twitter: @womensneurology

    Dr. Mary Angela O'Neal - Director of the Women's Neurology program at the Brigham and Women's Hospital in Boston, and an assistant professor of neurology at Harvard University. Dr. O’Neal also directs a Harvard Medical School course in Women’s Neurology and Psychiatry.

    Nikki Ashworth – Experiencing seizures since she was a child, Nikki was only diagnosed with temporal lobe epilepsy in her 30s. Her seizures may come without warning, but she's been turning her experience into an art form with her dark and honest unintentional comedy. Find Nikki on IG: @strange_miss

    Roshan Malhan - A second-year medical student at the University of Toronto’s Temerty Faculty of Medicine, where he acts as a co-director for the Anesthesia Interest Group and Emergency Medicine Interest Group. He is currently exploring his interests in a number of medical specialties and looking forward to gaining additional insights during clerkship. 

    Additional resources:
    UHN Epilepsy Clinic
    UHN Foundation ‘Know Your Heroes’ Q&A with Dr. Bui
    Canadian Leader in Neurology: Dr. Bui
    Brigham and Women’s Hospital Women’s Neurology Program
    Women’s Health in Neurology – Dr. O’Neal (video)
    The Lullaby Project (Massey Hall & Roy Thomson Hall)

    The Your Complex Brain production team is Heather Sherman, Jessica Schmidt, Dr. Amy Ma, Kim Perry, Sara Yuan, Meagan Anderi, Liz Chapman, and Lorna Gilfedder.

    The Krembil Brain Institute, part of University Health Network, in Toronto, is home to one of the world's largest and most comprehensive teams of physicians and scientists uniquely working hand-in-hand to prevent and confront problems of the brain and spine, such as Parkinson's, Alzheimer's, epilepsy, stroke, spinal cord injury, chronic pain, brain cancer or concussion, in their lifetime. Through state-of-the-art patient care and advanced research, we are working relentlessly toward finding new treatments and cures.

    Do you want to know more about the Krembil Brain Institute at UHN? Visit us at: uhn.ca/krembil

    To get in touch, email us at krembil@uhnresearch.ca or message us on social media:
    Instagram - @krembilresearch
    Twitter - @KBI_UHN
    Facebook - https://www.facebook.com/KrembilBrainInstitute

    Thanks for listening!

    Your Complex Brain
    en-usApril 04, 2023