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    How The Ketogenic Diet Supports Metabolism, Cancer Therapy, And Mental Health

    enNovember 20, 2023
    What is the primary goal of the ketogenic diet?
    How does the body adapt to fat burning?
    What role do mitochondria play in mental disorders?
    Which mental disorders have shown improvement with the ketogenic diet?
    Why is the ketogenic diet slow to be accepted in psychiatry?

    Podcast Summary

    • The ketogenic diet and its impact on our metabolism and energy levelsThe ketogenic diet promotes fat burning as the primary source of fuel, leading to weight loss and sustained energy by developing metabolic flexibility. Non-starchy vegetables are allowed.

      The ketogenic diet aims to train our bodies to burn fat as the primary source of fuel, rather than relying on carbohydrates. By reducing or eliminating carbs from our diet, our bodies undergo an epigenetic response that activates certain enzymes and gene systems to increase our metabolism of fats. This process, known as becoming fat-adapted, allows our muscles to efficiently burn fat for energy throughout the day. While carbohydrates provide a quick source of energy, they ultimately hinder our ability to tap into our fat stores. By developing metabolic flexibility through the ketogenic diet, we can derive a large portion of our energy from body fat, making weight loss and sustained energy possible. It's important to note that not all carbs are created equal, and non-starchy vegetables like broccoli can still be consumed on a ketogenic diet.

    • The Power of Ketones: Rethinking the Role of Carbohydrates in our DietOur bodies can thrive without carbs, as we have the capacity to produce energy from ketones. Adopting a ketogenic diet can help us regain control over our energy levels and promote overall well-being.

      Our brains do not actually require glucose from carbohydrates to function properly. Contrary to what we've been taught, there is no dietary requirement for carbohydrates in human nutrition. Our bodies have the ability to derive energy from ketones, which can be produced when we reduce our carbohydrate intake and rely on stored body fat. This elegant system allows us to not only survive but thrive for several days without food. Throughout most of human history, we did not have regular meals, but our bodies adapted to store excess energy for times of scarcity. Unfortunately, in today's society of abundance, we have lost the ability to balance our energy intake, leading to overeating and weight gain. By adopting a ketogenic way of eating, which involves cutting back on carbs to 50 grams or less per day, we can regain control over our energy levels and promote overall well-being.

    • The Benefits and Challenges of a Ketogenic DietShifting to a ketogenic diet can lead to improved metabolism and weight management, but it may also cause initial discomfort known as the "keto flu." It's important to stay properly hydrated and maintain a balanced nutrient intake.

      Shifting to a ketogenic diet requires time and adherence, but after a couple of weeks, your metabolism becomes more efficient. However, during the adaptation phase, some individuals may experience the "keto flu" due to a lack of fluids, sodium, and magnesium. The keto flu can make you feel achy, tired, and generally crappy as your brain craves glucose. Nevertheless, the liver can produce up to 750 calories of ketones per day, which the brain thrives on. When following a ketogenic diet, the body starts sparing amino acids and protein, using them only for structural purposes rather than as a source of energy. It's important not to overconsume calories, as excessive intake will prevent tapping into stored body fat. By cutting out starchy carbs and increasing fat intake, insulin levels decrease, making it easier to maintain a healthy weight.

    • The Benefits of a Low-Carb, Ketogenic DietA low-carb, ketogenic diet can aid in weight loss, diabetes management, and improved overall health by reducing hunger, controlling cravings, and improving insulin dependence.

      A low-carb, ketogenic diet can have significant benefits for weight loss and managing conditions like diabetes. Mark Hyman, a renowned expert in the field, emphasizes the importance of getting the right amount of protein, with a range of 75-120 grams per day for men being sufficient. He also challenges the traditional calorie counting approach, suggesting that protein should not even have a calorie assigned to it as it is primarily structural and doesn't get burned. By entering the "Keto zone," people can experience reduced hunger, appetite, and cravings, leading to better control over their eating habits. Additionally, a low-carb approach can lead to rapid and significant improvements in diabetes, allowing individuals to reduce or eliminate their reliance on insulin. This evidence challenges the prevailing belief in the effectiveness of low-fat diets and supports the adoption of a low-carb, ketogenic approach for lasting weight loss and better health.

    • The Transformative Effects of a Whole Foods, Low-Carb, High-Fat Diet for Type 2 Diabetes PatientsA diet emphasizing non-starchy vegetables and limiting carb intake can benefit patients with type 2 diabetes, offering a variety of tasty food options and allowing for adaptation to different cultural backgrounds. Blood level measurements can determine nutritional ketosis.

      A whole foods, low-carb, high-fat, moderate protein diet can have transformative effects on patients with type two diabetes. This approach, as advocated by Mark Hyman, focuses on reducing total carb intake to under 30 grams per day, while emphasizing the consumption of non-starchy vegetables. Contrary to popular belief, this diet is not about giving up bread or other delicious foods. Instead, it offers a wide range of tasty options, such as bacon-cooked Brussels sprouts and macadamia keto bread. Moreover, this diet can be adapted to different cultural backgrounds while still adhering to the basic principles of low carb, high fat, moderate protein. To determine if an individual is in nutritional ketosis, their blood levels need to be measured, although the exact optimal level is still being researched.

    • The Benefits of Virta Hydroxybutyrate and Managing Type Two DiabetesVirta hydroxybutyrate has potential benefits in reversing type two diabetes and improving metabolic health, but careful consideration of diet and intervention timing is essential for maintaining the reversal and regaining insulin function.

      The hormone called Virta hydroxybutyrate has shown potential benefits beyond just reversing type two diabetes. Type two diabetes is primarily a disease of carbohydrate intolerance, and even individuals who are overweight but don't have diabetes can be insulin resistant. It is important to catch and address this condition early to prevent further metabolic health issues. While nutritional ketosis may not be necessary for everyone, some individuals may benefit from increasing their levels of Virta hydroxybutyrate. Reversing type two diabetes is a form of metabolic flexibility, where individuals become more metabolically resilient. However, it is crucial to carefully choose the type and amount of carbohydrates added back into the diet to maintain the reversal. It is also important to study how quickly intervention is needed and the factors that determine the potential for regaining insulin function.

    • The Impact of the Ketogenic Diet on Mental Disorders and Chronic IllnessesThe ketogenic diet, by removing carbohydrates and addressing underlying inflammation in the brain, has shown remarkable improvements in mental disorders and chronic illnesses, challenging the notion that some conditions are incurable.

      The ketogenic diet can have a profound impact on various mental disorders and chronic illnesses. Despite initial skepticism, there is evidence that removing carbohydrates, which are the root cause of many health problems, can lead to remarkable improvements in a matter of days to weeks. This evidence-based treatment has been shown to stop seizures, even when medication and surgery fail. Additionally, it has been effective in treating conditions such as schizophrenia, bipolar disorder, and others, leading to full remission and allowing patients to live without the need for medication. These results challenge the traditional belief that certain illnesses are chronic and incurable. By addressing the underlying biology of inflammation in the brain and exploring factors like diet, toxins, and hormonal imbalances, a treatment plan can be developed to improve the lives of those suffering from mental illnesses and reduce the economic and societal burden associated with these conditions.

    • The ketogenic diet and mental disorders: Exploring the role of mitochondria and metabolism.The ketogenic diet, by addressing mitochondrial function and metabolism, can lead to significant improvements in mental disorders, making it a promising alternative treatment option.

      The ketogenic diet has shown promising results in treating various mental disorders, including autism, Alzheimer's, epilepsy, and schizophrenia. However, the field of psychiatry has been slow to accept and implement this alternative treatment due to the lack of a clear mechanism of action. The key to understanding the effectiveness of the ketogenic diet lies in understanding the role of mitochondria and metabolism in mental disorders. By viewing mental disorders as metabolic disorders of the brain, it becomes evident that addressing mitochondrial function through the ketogenic diet can lead to significant improvements in neurotransmitter imbalances, brain inflammation, and insulin resistance. As more research supports this connection, psychiatrists are becoming more open to incorporating metabolic approaches, such as the ketogenic diet, into their treatment protocols.

    • The role of mitochondrial dysfunction in psychiatric illness and complex diseases like autism, heart disease, and Alzheimer's.By addressing mitochondrial function through interventions like the ketogenic diet and mitochondrial cocktails, there is hope for improving mental health and treating complex diseases.

      Psychiatric illness and other complex diseases like autism, heart disease, and Alzheimer's are often connected to mitochondrial dysfunction. This means that the mitochondria, which are responsible for energy production and hormone regulation, play a significant role in mental health and overall health. Brain scans of autistic children have shown swollen and inflamed brains with high levels of inflammation and immune cells. Similarly, traumatic experiences can impact gene expression patterns and cortisol levels, affecting mental health. The traditional approach to psychiatric problems often overlooks the underlying mitochondrial issues, causing misdiagnosis and mistreatment. By addressing mitochondrial function through interventions like the ketogenic diet and mitochondrial cocktails, there is hope for improving mental health and treating complex diseases. It's a revolutionary approach that connects the bio-psychosocial models of mental illness and offers a comprehensive understanding of the complexities involved.

    • Understanding and addressing the root cause of metabolic and mental health issues to improve overall well-being.Identifying and addressing mitochondrial dysfunction through diet, exercise, stress management, and toxin reduction can have significant positive effects on metabolic and mental health conditions.

      There is no one-size-fits-all solution when it comes to addressing metabolic and mental health issues. Different individuals can experience these problems due to a variety of factors, such as autoimmune disorders, hormonal dysregulation, or nutrient deficiencies. The key is to identify and address the root cause, which often stems from mitochondrial dysfunction. Improving diet, exercise, managing stress, and reducing exposure to toxins can all play a role in optimizing mitochondrial function. Treatments may vary, from replacing thyroid hormone or addressing autoimmune disorders to providing vitamin B12 injections. The consequences of mitochondrial dysfunction can manifest in various ways, including ADHD, depression, seizures, or schizophrenia, depending on individual factors and environmental influences. Understanding and addressing these underlying issues can lead to significant improvements in overall health and well-being.

    • The Impact of Inflammation on Mental and Metabolic HealthPrioritize a healthy lifestyle to reduce inflammation and support mitochondrial health for overall well-being.

      Inflammation plays a significant role in mental and metabolic health. Infections, even mild ones, can lead to increased risk of mental disorders in both pregnant women and young children. This is because inflammation can impact neurobiology and overall body function. Furthermore, inflammation can have detrimental effects on mitochondrial function, which is crucial for brain health. The brain is the organ with the highest concentration of mitochondria and is highly sensitive to any impairment. Lifestyle choices, such as diet, exercise, and sleep, can have a profound impact on inflammation and mitochondrial health. It's important to prioritize removing unhealthy elements from our diets and incorporating beneficial practices to support overall well-being.

    • The Power of Self-Care and Functional Medicine in Overcoming Health ChallengesPrioritizing self-care and adopting a holistic approach to health, including addressing lifestyle factors, can have a significant impact on recovery from health challenges, regardless of the specific condition. Additionally, accepting help and embracing vulnerability is essential to healing.

      Prioritizing self-care, including good nutrition, exercise, rest, and stress reduction, can help the body reset and recover from health challenges. Mark Hyman shares his personal journey of dealing with stage four laryngeal cancer and how he applied his knowledge of Functional Medicine to support his recovery. By adopting a holistic approach and addressing lifestyle factors in addition to medical treatments, he experienced an incredible turnaround in his health. This highlights the potential of Functional Medicine to benefit not only those with cancer but also others facing different health conditions. Furthermore, he emphasizes the importance of receiving help from others and embracing vulnerability, challenging the notion that showing weakness is a flaw.

    • Mark Hyman's Cancer Journey: Balancing and Transforming for Better HealthEmbracing balance, seeking multiple opinions, and incorporating different approaches can lead to improved health outcomes in cancer treatment. Functional Medicine addresses underlying factors for personalized care.

      Mark Hyman's journey with cancer taught him the importance of revealing and expressing all aspects of oneself. He realized that imbalance and unbalance were triggers for his illness, and he needed to transform his life to live in a healthier way. Despite uncertainty, he sought multiple medical opinions and decided to incorporate different approaches, such as chemotherapy, radiation therapy, a ketogenic diet, and fasting before chemo. These methods helped him maintain his weight, minimize side effects, and improve the efficacy of treatment. Mark's experience highlights the power of Functional Medicine in addressing underlying factors and using a personalized approach to achieve better health outcomes.

    • The Power of Forest Bathing and Functional MedicineModifying our lifestyle, connecting with nature through forest bathing, and embracing the holistic healing approach of Functional Medicine can greatly impact our health and well-being, including reducing the risk of cancer.

      Taking the time to modify our lifestyle and connect with nature can have profound effects on our health, including reducing the risk of cancer. This concept, known as forest bathing, has been studied and confirmed in Japan. Additionally, Functional Medicine emphasizes the importance of holistic healing, taking into account the mental, emotional, and spiritual aspects of a person's well-being. It involves working with nutrition, medicine, and lifestyle changes to support the body's natural healing processes. Mark Hyman's personal experience with cancer highlights the importance of finding balance in life and prioritizing self-care. Embracing uncertainty and seeking guidance and connections with others and the natural world are also key lessons. Overall, Functional Medicine offers a comprehensive approach to health and well-being.

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    • [11:45] Two tools to use to reverse non-alcoholic fatty liver disease

    • [15:00] Biomarkers to look at for lipids

    • [19:30] Importance of triglycerides and HDL in metabolic health 

    • [26:30] LDL controversies

    • [29:00] The Feldman Protocol 

    • [34:00] Metabolic health and mental health  

    • [38:30] Importance of muscle mass for insulin sensitivity

    • [45:00] Types of carbs to eat around workouts 

    ---

    Dr. Mike Hart is a Cannabis Physician and Lifestyle Strategist. In April 2014, Dr. Hart became the first physician in London, Ontario to open a cannabis clinic. While Dr. Hart continues to treat patients at his clinic, his primary focus has shifted to correcting the medical cannabis educational gap that exists in the medical community. 

    Connect on social with Dr. Mike Hart:

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    What is Metabolic Flexibility?

    What is Metabolic Flexibility?

    To learn more about The Flex Fam Membership, visit https://www.metflexlife.com/theflexfam

    Join Rachel’s weekly newsletter: https://www.metflexlife.com/newsletter 

    There are subjective and objective ways to measure metabolic flexibility, which is your ability to tap into either fat or sugar sources when it's warranted.

    Rachel Gregory is a Board-Certified Nutritionist, Strength and Conditioning Specialist, Podcaster, and founder of MetFlex Life. She is also the author of the international best-selling book, "21-Day Ketogenic Diet Weight Loss Challenge."

    Rachel received her Master’s Degree in Nutrition & Exercise Physiology from James Madison University and Bachelor’s Degree in Sports Medicine from the University of Miami. Rachel completed the first-ever human clinical trial looking at the effects of the Ketogenic Diet in non-elite CrossFit athletes, which is published in the International Journal of Sports and Exercise Medicine.

    Currently, in her day-to-day coaching business, Rachel guides her clients to becoming the best, most confident version of themselves. She has a passion for educating those dedicated to optimizing their physical and mental well-being while improving long-term health and fitness goals. Her most popular course, Keto for Women, has helped women all across the world learn how to ditch the restrictive, all-or-nothing mindset associated with keto and instead thrive through the power of metabolic flexibility.

    You can connect and learn more about Rachel's work by visiting her website www.metflexlife.com 

    Social Links:

    Primary Programs:

    Pauline Cox - Intermittent Fasting with Midlife Hormones

    Pauline Cox - Intermittent Fasting with Midlife Hormones

    Pauline has extraordinary knowledge of the human body and women’s health. How we operate and what we need to operate at our best, is her day to day and she is clearly passionate about every aspect of what she does.

    This is another jam-packed episode. Here, Pauline gives us a thorough lesson in understanding the sex hormones oestrogen and progesterone in how they work and what they do for us. We discuss the ketogenic diet, metabolic flexibility, how to get the best from intermittent fasting, weight management and how to overcome the evening snack-attack.

    As you may agree, Menopause shines a light on how we take care of ourselves, where we need to alter our priorities and even where we need to heal. Pauline is all too aware of this and supports women through the process of cleaning this up, especially from their 40’s onwards.

    As a heads up, we talk in some depth about emotional eating as a coping mechanism from adverse childhood experiences and eating as filling an emotional gap all of which is a sensitive subject for many.

    “It’s not you. You’re fighting a primal instinct.”

    And as a friendly reminder to everyone, the best of you is yet to come.

    You can find Pauline on her website https://sowandarrow.com

    @paulinejcox on IG

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